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CISH is induced during DC development and regulates DC‐mediated CTL activation
Miah, Mohammad Alam,Yoon, Cheol‐,Hee,Kim, Joonoh,Jang, Jinah,Seong, Young‐,Rim,Bae, Yong‐,Soo WILEY‐VCH Verlag 2012 European journal of immunology Vol.42 No.1
<P><B>Abstract</B></P><P>The cytokine inducible SH2‐domain protein (CISH) is a well‐known STAT5 target gene, but its role in the immune system remains uncertain. In this study, we found that CISH is predominantly induced during dendritic cell (DC) development from mouse bone marrow (BM) cells and plays a crucial role in type 1 DC development and DC‐mediated CTL activation. CISH knockdown reduced the expression of MHC class I, co‐stimulatory molecules and pro‐inflammatory cytokines in BMDCs. Meanwhile, the DC yield was markedly enhanced by CISH knockdown via cell‐cycle activation and reduction of cell apoptosis. Down‐regulation of cell proliferation at the later stage of DC development was found to be associated with CISH‐mediated negative feedback regulation of STAT5 activation. In T‐cell immunity, OT‐1 T‐cell proliferation was significantly reduced by CISH knockdown in DCs, whereas OT‐2 T‐cell proliferation was not affected by CISH knockdown. CTLs generated by DC vaccination were also markedly reduced by CISH knockdown, followed by significant impairment of DC‐based tumor immunotherapy. Taken together, our data suggest that CISH expression at the later stage of DC development triggers the shutdown of DC progenitor cell proliferation and facilitates DC differentiation into a potent stimulator of CTLs.</P>
Miah Lee,Eunju Ko,Dayun Jeong 글로벌지식마케팅경영학회 2016 Global Marketing Conference Vol.2016 No.7
Since the arrival of omni-channel retailing, which promotes seamless experience for consumers and zero effort commerce, channel integration has been a big issue in both the domestic and the international retail industry. Some researchers have identified problems that can occur in the process of channel integration, such as cannibalization and channel conflict (Coelho & Easingwood, 2003). However, many studies on channel integration report its positive impact on a firm’s revenue growth through improved trust (Schramm-Klein & Morschett, 2006), higher consumer conversion rates (Neslin et al., 2006), and greater cross-selling opportunities (Berry et al., 2010). Regarding the issue of effectively establishing channel integration in order to bring positive synergy to a company, the present study intends to identify a solution within a company’s internal factors. This study aims to provide a strategic perspective on channel integration formation of domestic fashion retailers by identifying some of the key organizational components that drive a firm’s channel integration in this omni-channel era, when the boundaries between online and offline markets are disappearing. This study predicts that organizational structure and strategic orientation are the key components of a fashion retailer’s channel integration implementation in an omni-channel environment. As shown in previous studies, channel integration has a positive impact on a firm’s performance through active and innovative transformation of the organization’s hardware and software (Cao & Li, 2015; Yan, Wang, & Zhou, 2010). In particular, this study introduces channel (extension) strategies (number of different types of channels in both online and offline markets) into channel integration as one of the crucial variables, in addition to the two existing variables. The data were collected through a survey targeting mid-level executives or above, within a business unit of Korea’s fashion companies with over $10 million revenue. Through this selection, a total of 120 samples were used in the final analysis. Hierarchical regression modeling was used to prove the study’s hypothesis. The revenue size of a parent company and SBU was used as a control variable in the level 1 model; channel strategies in the level 2 model; organizational structure in the level 3 model, and organization strategic orientation in the level 4 model, which was used as an independent variable. Integrated back-end system and integrated human resource management, which are the highest levels of channel integration (Cao & Li, 2015; Oh, Teo, & Sambamurthy, 2012), have been used as dependent variables. The main findings of this study are as follows: In a back-end system integration model, organization strategic orientation was identified as the highest level when the organizational structure becomes more centralized, whereas the system integration level is the highest when the model is competitor-oriented and innovation-oriented. In the human resource management integration model, the human resource management integration level is at its highest when the organizational structure becomes formalized and specialized, and organization strategic behavior becomes more competitor-oriented and innovation-oriented.
Traditional Coconut Farming in the Rural Landscape of Meghna Floodplain in Bangladesh
Miah, Md. Danesh,Islam, Mohammed Ohidul,Hossain, Md. Aktark,Shin, Man Yong Korean Society of Forest Science 2005 한국산림과학회지 Vol.94 No.5
An exploratory survey was performed to assess the present status of distribution and production of coconut palm (Cocos nucifera Linn.) in the rural landscape of Meghna floodplain of Bangladesh. A multistage simple random sampling technique was adopted to identify the study area and respondents. A total of 50 households were selected randomly for the study. Traditional knowledge on cultivation, management, and production of coconut palm was emphasized. Marketing of coconut palm products and income derived from coconut palm cultivation was taken into consideration. Perceptions of farmers, traders and professionals were described in due context of opportunities and constraints of coconut palm cultivation. Coconut palm cultivation was found to play an important role in household economy in rural Bangladesh sharing considerable contribution to the total income. About 10% of their total annual income was reported to come from coconut husbandry. Highest number of the coconut palms, 24%, was found to grow in the homestead compounds and in the pond banks. About one-third lands of the households were found to be covered by the coconut palms. Maximum, 19%, coconut palms were found in the 16-20 years age-class. Production of coconut was found highest at the age-class 11-15 years. The study found some important opportunities and constraints of coconut farming in rural Meghna floodplain area of Bangladesh. The results of this study would be useful for the rural development practitioners in Bangladesh.
Miah, Raisuddin 한국분석과학회 1995 분석과학 Vol.8 No.4
In industrial field, a large volume of regenerants (acid and caustic soda) and their washing effluents are regularly disposed off from the water demineralization plant during regeneration of the ion-exchanger units. Of these waste effluents, a part of the wash water discharged from the single bed Anion and Mixed Bed units can be utilized at a certain stage of their washing cycles when its conductivity is fallen down and becomes considerably less than that of the input raw water. The main aim of this specific waste effluent utilization is to dilute the TDS concentration of the input raw water (fed into the single bed ion-exchanger units) by blending. The achievement is the increase of the longevity of the production cycles of the I.E. units along with the improvement of the production quality and decrease of the regeneration frequencies. As a result, regenerant consumption would be saved because of the reduction of ionic load in feed water which will ultimately reduce the water purification cost. At the same time, the environment pollution will also be protected to a considerable extent. This operational measure is quite effective and useful specially where high TDS water is demineralized only by single bed ion-exchangers. In such case, the water treatment plant is very often found to suffer from both production quality and quantity in addition to carrying out of random and restless regenerations. Proper reuses of the aforesaid wash water effluents of the Anion and MB units excellently minimizes the difficulties experienced in practice. This paper contains the utilities and techniques of reuses of the different kinds of waste effluents of the industrial water treatment plant in addition to the specific reuses of the post-regeneration wash waters of the Anion and MB ion-exchanger units.
Performance Analysis of ILEACH and LEACH Protocols for Wireless Sensor Networks
Miah, Md. Sipon,Koo, Insoo The Korea Institute of Information and Commucation 2012 Journal of information and communication convergen Vol.10 No.4
In this paper, we examine the problems of the low energy adaptive clustering hierarchy (LEACH) protocol and present ideas for improvement by selecting the cluster head node. The main problem with LEACH lies in the random selection of cluster heads. There exists a probability that the formed cluster heads are unbalanced and may remain in one part of the network, which makes some part of the network unreachable. In this paper, we present a new version of the LEACH protocol called the improved LEACH (ILEACH) protocol, which a cluster head is selected based on its ratio between the current energy level and an initial energy level, and multiplies by the root square of its number of neighbor nodes. The simulation results show that the proposed ILEACH increases the energy efficiency and network lifetime.
Miah, Md. Danesh,Hossain, Mohammed Anwar,Muhammed, Nur,Sin, Man Yong Korean Society of Forest Science 2006 한국산림과학회지 Vol.95 No.5
Neem tree (Azadirachta indica), native to the Indian sub-continent, has been known since the ancient time for its medicinal and insect repellent properties. In recent years, Neem has attracted global attention due to its potential as a source of natural drugs and also environment-friendly pesticides. In the households. The distribution and traditional practice on Neem can be important to the agriculturist, ethno-pharmaceutical developers and to the rural development practitioners in Bangladesh. An exploratory survey on the distribution and traditional practice on Neem tree in the rural homesteads of Chittagong coastal plain, Bangladesh, was conducted over a period of three months from September 2002 to November 2002. It was found that maximum, 64% households used seedling as planting material having 40% maximum sources Within the major tree species present in the homesteads, Neem accounted for 12% among the total individuals. It was found that the availability of Neem trees was found maximum, 31%, in the homesteads of medium sized households. Maximum, 42% individuals of Neem were found within the DBH of 10.1 to 20 cm; and 37% within the 3.1 to 6 m height classes. Neem trees were found to be used maximum, 88% for furniture. The findings of the study will be of immense importance for the rural development practitioners and ethno pharmacological developers in Bangladesh.