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Mi Xie,Liying Gao,Zhiming Liu,RuiYing Yuan,Dongzhi Zhuoma,Dikye Tsering,Yuefei Wang,Shan Huang,Bin Li 한국식품영양과학회 2022 Journal of medicinal food Vol.25 No.12
Diabetic patients are more prone to developing nonalcoholic fatty liver disease (NAFLD) compared with healthy people. As a plant homologous to both medicine and food, Malus toringoides (Rehd.) Hughes has been used as an intervention for both NAFLD and diabetes. However, the effect and mechanism of M. toringoides on NAFLD on type 2 diabetes mellitus (T2DM) is unclear. The current investigation was designed to evaluate the ameliorative effects and mechanism of M. toringoides ethanol extract (CBTM-E375) on T2DM, and to identify the compounds in these extracts. The effects of CBTM-E375 on T2DM were verified using a high-fat diet-/streptozotocin-induced diabetic rat and free fatty acid (0.5 mM)-induced human hepatocellular carcinoma cell (HepG2) models. The components of CBTM-E375 were identified by high performance liquid chromatography-mass spectrometry/mass spectrometry. Our results demonstrate that CBTM-E375 ameliorated lipid accumulation (total cholesterol, triglyceride), oxidative stress (superoxide dismutase, catalase, malondialdehyde, glutathione peroxidase), and inflammation (tumor necrosis factor-α [TNF-α], interleukin [IL]-1β, IL-6, C-reactive protein [CRP]) in vivo and in vitro, these effects were associated with a CBTM-E375-mediated downregulation of SREBP-1c (sterol regulatory element binding protein 1c) and the NF-κB (nuclear factor κB) signaling pathway. A total of 20 chemical compounds were identified in CBTM-E375, including phlorizin, isoquercitrin, chlorogenic acid, quercetin, naringenin, and trigonelline, which have been reported to have positive effects on diabetes or on NAFLD.
Mi Lin,Qi-Yue Chen,Chao-Hui Zheng,Ping Li,Jian-Wei Xie,Jia-Bin Wang,Jian-Xian Lin,Chang-Ming Huang 대한암학회 2021 Cancer Research and Treatment Vol.53 No.4
Purpose This study aimed to evaluate the effect of preoperative tumor staging deviation (PTSD) on the long-term survival of patients undergoing radical gastrectomy for gastric cancer (RGGC). Materials and Methods Clinicopathological data of 2,346 patients who underwent RGGC were retrospectively analyzed. The preoperative tumor-lymph node-metastasis (TNM) under-staging group (uTNM) comprised patients who had earlier preoperative TNM than postoperative TNM, and the no preoperative under-staging group (nTNM) comprised the remaining patients. Results There were 1,031 uTNM (44.0%) and 1,315 nTNM cases (56.0%). Cox prognostic analysis revealed that PTSD independently affected the overall survival (OS) after surgery. The 5-year OS was lower in the uTNM group (41.8%) than in the nTNM group (71.6%). The patients less than 65 years old, with lower American Society of Anaesthesiologists score, 2-5 cm tumor located at the lower stomach, and cT1 or cN0 preoperative staging would more likely undergo D1+ lymph node dissection (LND) in uTNM (p < 0.05). Logistic analyses revealed that tumor size > 2 cm and body mass index ≤ 22.72 kg/m2 were independent risk factors of preoperative TNM tumor under-staging in patients with cT1N0M0 staging (p < 0.05). Conclusion Underestimated tumor staging is not rare, which possibly results in inadequate LND and affects the long-term survival for patients undergoing RGGC. D2 LND should be carefully performed in patients who are predisposed to this underestimation.
Liying Gao,Mi Xie,Xiayu Zhang,Zhenhan Qiu,Zhen Pu,Shan Huang,Bin Li 대한피부과학회 2023 Annals of Dermatology Vol.35 No.6
Background: Acne vulgaris (AV) is a common adolescent skin condition which is mainly caused by Cutibacterium acnes overcolonization and subsequent inf lammation. Objective: Our previous studies demonstrated that ethanol extracts of Meconopsis quintu- plinervia Regel (EMQ) possess significant antimicrobial properties. However, their protec- tive effects and potential mechanisms against AV remain unclear. Methods: In the present study, the EMQ treatment potential for AV was evaluated in a C. acnes -induced mouse ear edema model, and the EMQ anti-inf lammatory mechanism was evaluated in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells. Results: The results showed that EMQ alleviated edema formation and inf lammatory cell infiltration in an acne mouse model by suppressing inf lammatory cytokines interleukin (IL)-6, IL-1β, and tumor necrosis factor α expression. Moreover, EMQ inhibited the phos- phorylation of MAP kinases (MAPKs) such as p38, JNK, and ERK, the phosphorylation and degradation of IκB-α and the nuclear translocation of nuclear factor kappa B (NF-κB) p65 in LPS-induced RAW264.7 cells. Conclusion: These findings suggest the potent anti-inf lammatory activity of EMQ is pos- sibly through the regulation of the MAPKs and NF-κB signaling pathways. Inhibition of C. acnes activity combined with a powerful anti-inf lammatory effect of EMQ indicated its potential as a novel therapeutic option for AV.
의료기관의 처방검토시스템 설치에 따른 의약품사용 양상변화의 분석
김춘섭,이숙향,오정미,김종주,오옥희,신현택 숙명여자대학교 약학연구소 2004 약학논문집-숙명여자대학교 Vol.21 No.-
Drug use patterns were analyzed before and after the implementation of a commercially available computerized drug utilization review (DUR) system (Drug Information Framework-Korea, First DataBank, Inc.) in a community hospital. The DUR criteria for analysing drug use patterns were drug-drug interaction, drug dosing in pediatric, adult and geriatric patients and age-drug contra-indications. The prescription data of January 2004 right before the implementation were analyzed and compared with the data of June and July 2004 after the implementation of the system. The event rate of DUR conflicts in all the criteria except KFDA-labelled drug dosing in adult patients was decreased in June after the implementation of the system. However, the event rate of DUR conflict in July was increased in drug dosage in adult patients, drug interaction and age-drug contra-indication whereas the event rate was decreased in drug dosage in geriatric and pediatric patients. Over all drug use patterns were not significantly changed after the implementation of DUR system. Although further studies are needed for clarifying the baseline reasons for the non-compliance for the DUR standards, more intensive interventions are needed for improving clinicians' prescribing behaviors to minimize the conflict events with the DUR standards which may result in potential harmful effects in medication uses.
Cao, Chunyan,Xie, Along,Zhou, Tianliang,Zhong, Haichang,Lu, Xiangjun,Xie, An,Noh, Hyeon Mi,Jeong, Jung Hyun Elsevier 2020 Journal of luminescence Vol.217 No.-
<P><B>Abstract</B></P> <P>Some lutetium molybdenum oxides were synthesized through a solid-state reaction method. By adjusting the molar ratios of raw materials of Lu<SUB>2</SUB>O<SUB>3</SUB> (Eu<SUB>2</SUB>O<SUB>3</SUB>) to MoO<SUB>3</SUB>, Eu<SUP>3+</SUP> doped lutetium molybdenum oxides Lu<SUB>2</SUB>MoO<SUB>6</SUB>, Lu<SUB>2</SUB>Mo<SUB>2</SUB>O<SUB>9</SUB>, Lu<SUB>2</SUB>(MoO<SUB>4</SUB>)<SUB>3</SUB>, and Lu<SUB>6</SUB>MoO<SUB>12</SUB> were obtained. The materials were characterized by X-ray diffraction (XRD) patterns, scanning electron microscope (SEM) images, energy-dispersive spectra (EDS), diffuse reflection (DR) spectra, photoluminescence (PL) excitation and emission spectra, luminescence decay curves, and temperature dependent integrated emission spectra. Enhanced excitation and emission spectra were recorded at high temperatures. Possible energy transfer processes were proposed to explain the excitation and emission spectra. By combining some phosphors with near ultraviolet (NUV) chips, the obtained light emitting diodes (LEDs) gave red light under forward bias current. The results suggest that the obtained Eu<SUP>3+</SUP> doped lutetium molybdenum oxides have potential applications in phosphor converted based NUV LEDs.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Eu<SUP>3+</SUP> doped Lu<SUB>2</SUB>MoO<SUB>6</SUB>, Lu<SUB>2</SUB>Mo<SUB>2</SUB>O<SUB>9</SUB>, Lu<SUB>2</SUB>(MoO<SUB>4</SUB>)<SUB>3</SUB>, and Lu<SUB>6</SUB>MoO<SUB>12</SUB> were obtained. </LI> <LI> The materials present different structures, morphologies, optical properties, and luminescece decay behaviors. </LI> <LI> Eu<SUP>3+</SUP> concentration dependent optical properties in Lu<SUB>2</SUB>MoO<SUB>6</SUB> were researched. </LI> <LI> Enhanced excitation and emission spectra were recorded under high temperatures in some materials. </LI> <LI> Red LEDs were obtained by packaging phosphors to NUV LED chips. </LI> </UL> </P>
김영섭(Yong-Xie Jin),박수희(Su-Hui Park),한혜경(Hye Kyung Han),양미란(Mi Ran Yang),최애진(Ae-Jin Choi),이상훈(Sang Hoon Lee),최용민(Youngmin Choi) 한국식품영양과학회 2018 한국식품영양과학회지 Vol.47 No.1
본 연구에서는 식생활에서 많이 섭취되고 있는 국내 다소비식품 중의 비타민 D 함량을 분석하고자 하였다. 정기적으로 CRM 시료에 대한 분석을 통하여 분석방법의 정확성을 확인하였고 품질관리 시료에 대한 분석을 거쳐 분석 결과에 대한 품질관리를 진행하였다. 국제 분석 관리프로그램에 참여하여 숙련도 테스트를 진행한 결과 Z-score가 허용 범위에 들어 분석능력의 신뢰도를 검증받았다. 본 연구에서 분석한 곡류 및 그 제품(84점), 감자류 및 전분류(10점), 당류(4점), 두류(26점), 견과류 및 종실류(11점), 채소류(221점), 버섯류(24점), 과일류(74점), 육류(85점), 난류(5점), 우유 및 유제품(30점), 유지류(6점), 차류(14점), 음료류(14점), 주류(8점), 조미료류(26점), 조리가공식품(32점), 기타(15점) 등 689점의 다소비식품에서 비타민 D가 검출된 것은 36점에 불과하였으며 검출된 시료에서 육류가 27점으로 많은 비중을 차지하였다. 비타민 D가 검출된 2점의 우유제품은 비타민 D 강화에 의한 결과로 생각되며 대부분의 시료에서는 비타민 D가 검출되지 않았다. 비타민 D는 인체에 필수적인 영양소이며 햇빛에 의한 합성이 많은 비중을 차지하고 있는데 실생활에서는 자외선 차단제를 많이 사용하고 있어 비타민 합성이 감소하고 있다. 따라서 비타민 D를 충분히 섭취하기 위해서는 다소비식품에 비타민 D를 강화하고 인체에서의 섭취효율을 높이기 위한 추가적인 연구가 절실히 필요하다고 생각된다. This study was aimed to analyze vitamin D contents of frequently consumed foods in Korea. The accuracy and precision of the vitamin D analysis method were quantified by liquid chromatography tandem mass spectrometry (LC-MS/MS) using external standard methods. The recovery rates of the standard reference material (SRM) were 96.72% and 104.51%, and all analysis was under the control line based on the quality control chart for vitamin D. The Z-score for vitamin D in the Food Analysis Performance Assessment Scheme (FAPAS) proficiency test was −1.4, confirming reliability of analytical performance. The vitamin D contents of 689 frequently consumed foods were analyzed. The contents of vitamin D ranged from 0.00 to 44.74 μg/100 g. The highest content of vitamin D was 44.74 μg/100 g in egg yolk. However, vitamin D contents in most of the frequently consumed foods were not detected. These results can be used as important basic data for utilization and processing of various frequently consumed foods, management of school meals, information for dietary life, and national health for Koreans