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Lim, Tae-Gyu,Jeon, Ae Ji,Yoon, Ji Hye,Song, Dasom,Kim, Jong-Eun,Kwon, Jung Yeon,Kim, Jong Rhan,Kang, Nam Joo,Park, Jun-Seong,Yeom, Myeong Hun,Oh, Deok-Kun,Lim, Yoongho,Lee, Charles C,Lee, Chang Yong,L UNKNOWN 2015 INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE Vol.35 No.5
<P>The aim of the present study was to determine the mechanisms through which 20-O-beta-D-glucopyranosy120(S)-protopanaxadiol (20GPPD) promotes the production of hyaluronic acid (HA) in human keratinocytes. 20GPPD is the primary bioactive metabolite of Rb1, a major ginsenoside found in ginseng (Panax ginseng). We sought to elucidate the underlying mechanisms behind the 20GPPD-induced production of HA. We found that 20GPPD induced an increase in HA production by elevating hyaluronan synthase 2 (HAS2) expression in human keratinocytes. The phosphorylation of extracellular signal-regulated kinase (ERK) and Akt was also enhanced by 20GPPD in a dose-dependent manner. The pharmacological inhibition of ERK (using U0126) or Akt (using LY294002) suppressed the 20GPPD-induced expression of HAS2, whereas treatment with an epidermal growth factor receptor (EGFR) inhibitor (AG1478) or an intracellular Ca2+ chelator (BAPTA/AM) did not exert any observable effects. The increased Src phosphorylation was also confirmed following treatment with 20GPPD in the human keratinocytes. Following pre-treatment with the Src inhibitor, PP2, both HA production and HAS2 expression were attenuated. Furthermore, the 20GPPD-enhanced ERK and Akt signaling decreased following treatment with PP2. Taken together, our results suggest that Src kinase plays a critical role in the 20GPPD-induced production of HA by acting as an upstream modulator of ERK and Akt activity in human keratinocytes.</P>
Complete Assignments of the 1H and 13C NMR Data of Flavone Derivatives
Yoongho Lim,Youngshim Lee,Choonshik Shin,Byoung-Ho Moon 대한화학회 2005 Bulletin of the Korean Chemical Society Vol.26 No.4
The 1H and 13C chemical shifts of flavone and its five derivatives were determined completely using the basic 1D and 2D NMR experiments and molecular modeling. Of the six compounds used for our experiments, the NMR data of three compounds were published previously, but we found that the data of two compounds included wrong assignments. Therefore, we report the corrected data and the complete assignments of NMR data of the other three compounds.
Development of LTD₄ antagonists using QSAR
Lim, Yoongho,Oh, Mina,Koh, Dongsoo,Park, Kwanha,Lee, Seungho,Lee, Hyeseung 영남대학교 약품개발연구소 1999 영남대학교 약품개발연구소 연구업적집 Vol.9 No.-
In order to discover new Leukotriene D. antagonists, Quantitative Structure-Activity Relationships(QSAR) were applied based on the known data. A series of chalconc derivatives were selected for the training set. A candidate was predicted using QSAR and synthesized, and its biological activity was tested. (Receivcd September 4, 1998; accepted October 15, 1998)