정신분열병 환자의 인지기능 상태

이지혜,오소영,윤정흠,김선경,이귀행 圓光大學校 醫科學硏究所 2008 圓光醫科學 Vol.23 No.1

목적: 정신분열병 환자의 적응 상태와 증상 형성에 영향을 주는 것으로 생각되는 인지기능 상태를 주의력, 형태 인식, 단어에 대한 구별과 종합 기능을 평가해봄으로써 알아보고자 하였다 방법: 정신분열병 환자 27명과 대조군 27명을 대상으로 하였고, 평가 도구로써 주의력은 K-WAIS의 숫자외우기 문제로, 형태 인식은 K-WAIS의 모양 맞추기 문제와 숨은 그림 찾기로, 단어 기능은 K-WAIS의 공통성 문제와 단어 차이 검사로 각각 이루어졌다. 통계 처리는 SPSS 11.5를 이용하여 Chi-Square test와 Student's t-test로 검증을 하였다. 결과: 정신분열군은 숫자외우기, 숨은 그림 찾기, 모양 맞추기에서는 대조군보다 낮은 점수를 보였다. 단어 차이 검사와 공통성 문제에서는 양군에서 차이를 보이지 않았다. 결론: 본 연구에서 정신분열군의 인지 기능은 정상인 대조군에 비해 주의력과 형태 인식 기능이 유의하게 떨어져 있었으며, 단어들을 구분하고 종합하는 능력은 차이가 없었다. 이런 결과는 임상적으로 정신분열병에서 보이는 망상이 언어적인 측면에서는 어느 정도 전달이 되는 현상과 일치하지만 주의나 형태인지와 같은 기본적인 과정에서 장애가 있다는 추정을 하게 한다. Purpose: This study aimed to investigate the cognitive function in patients with schizophrenia by assessing attention, recognition of a shape, and verbal function. Methods: The subjects were 27 patients with schizophrenia group and 27 control group. Attention was assessed by the digit span task(K-WAIS subtest). The recognition of a shape was assessed by the object assembly task(K-WAIS subtest) and hidden figure task. Verbal function was assessed by Similiarities(K-WAIS subtest) and the different word task. Analysis was performed by the Chi-Square test and Student's t-test via SPSS 11.5. Result: Schizophrenia group had statistically lower scores than control group in digital span, hidden figure and object assembly. There was no difference between two groups in dimensions of difference in words and similarity. Conclusion: This study showed that patients with schizophrenia had impairments in attention and recognition of shape, and no difference between two groups in verbal ability. These explained the partial communicative function of delusion in verbal level. The formation of delusion might be related to the more basic elements such as attention and recognition of shape.

간질환자의 출생 순위에 관한 임상적 연구

이민수,조숙행,한선호,서광윤,이병윤 大韓神經精神醫學會 1981 신경정신의학 Vol.20 No.2

To provide data on the clinical issues related to the birth order and other characteristic background in epilepsy, 331 idiopathic epileptic patients were evaluated and analyzed phenomenologically. The patients had been treated at the neuropsychiatric department of the Korea University Hospital during 1974 to 1980. The age at onset ranged from 1 to 45 years, with the mean age of 16.65 years. Males were 1.36 times more than females. Seventeen (5.13%) of the subjects had the family history of epilepsy. Attacks in the daytime only occurred in 67.67% (N=224) of the subjects, while 23.56% (N=78) had their seizures only at night, and 8.77% (N=20) had their seizures both at daytime and night. Grand mal was the most frequent type of seizure, followed by psychometer and petit mal. There was a higher incidence among the first born than the subsequent siblings and the children born second had a somewhat higher frequency of epilepsy than the subsequent children.

子宮摘出이 家兎 卵巢의 機能에 미치는 影響에 關한 實驗的 硏究

金善行,羅重烈,李壽鍾 고려대학교 의과대학 1983 고려대 의대 잡지 Vol.20 No.3

To understand effects of hysterectomy on the retained ovarian function in the rabbits, pseudopregnancy was induced in seven rabbits, control group, by injection of 50㎍ of ethinyl estradiol and 100 IU of hCG subcutaneously. And a week after hysterectomy of another seven rabbits, hysterectomized group, pseudopregnancy was induced with 50㎍ of ethinyl estradiol and 100 IU of hCG. The serum levels of progesterone and estrogen were determined every 3 day by radioimmunoassay and microscopic examination of the ovaries was performed in each group. Both findings in each group was compared and obtained following results. 1. Luteal phase in hysterectomized group was prolonged about 6 days compared to control group. 2. Histologic examination of ovaries revealed functional corpora lutea in hysterectomized group up to 30 days of experiment. 3. Serum estradiol level and histological picture of the ovarian follicles showed no significant differences between two groups during experiment. 4. These findings show that experimental hysterectomy has inhibitory effect on regressive change of the corpora lutea but has no effect on ovarian follicle. These results suggest that PG is the luteolytic hormone in the rabbit. But, it was presumely concluded that the result in estrogen showed which PGF₂α or some other substances in the uterus might be related to the mechanism of folliculogenesis in ovary according to references.

여름 캠프활동에 관한 연구 : 서울여대 부속유치원 여름 캠프활동을 중심으로

민행난;최윤선;최인경;민혜원;임양선;이윤희;이상희 서울여자대학교 1998 아동연구 Vol.3 No.-

[초록없음]

정신분열증 환자의 신체증상과 인구통계학적, 임상인자들과의 관련성

윤정흠,김선경,전현태,이귀행 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1

배경 : 이 연구의 목적은 정신분열병 환자의 신체증상과 인구통계학적, 임상인자들과의 관련성을 알아보기 위함이다. 방법 : 연구 대상군은 입원중인 63명의 정신분열병 환자를 대상으로 하였다. 신체 증상의 정도는 한국어판 신체증상목록을 사용하여 측정하였다. SPSS 11.5를 이용하여 신체증상의 정도와 우울, 불안, 교육정도, 적응상태와의 관계를 피어슨 상관분석을 통하여 평가하였다. 결과 : 1) 신체증상의 정도는 교육기간과 입원 당시의 적응 상태와는 부적 상관을 보였다(p<0.05). 2) 신체증상의 정도는 우울, 불안과는 정적 상관을 보였다(p<0.05). 3) 정신분열병 환자의 신체 증상의 빈도는 다음 순이었다: 두통, 피로, 수면장애, 건강염려, 현기증, 오심, 위장장애, 근력 약화, 허리나 등의 통증, 복부의 가스. 결론 : 정신분열병의 신체증상의 정도는 교육기간이 길고 입원 당시의 적응상태가 좋을수록 감소하였다. 그리고 신체 증상은 우울, 불안의 증상이 심할수록 증가하였고, 이는 특히 신체증상이 우울, 불안과 관련이 있다는 것을 알 수 있었다. Background : The purpose of this study was to examine the correlation between somatic symptoms and demographic and clinical variables in schizophrenia patients. Methods : The subject were 63 schizophrenia patients ; male(n=35, mean age =39), female(n=28, mean=age 40). The degree of somatic symptoms was measured using the Korean versions of Wahler Physical Symptom Inventory(WPSI). The relationship among somatic symptoms, anxiety, depression, education period and adjustment was evaluated by Pearson correlation with SPSS 11.5. Results : 1) The degree of somatic symptoms showed negative correlation with education period and current adjustment at admission(p<0.05). 2) The degree of somatic symptoms was significantly correlated with degree of the depression and the anxiety(p<0.05). 3) The frequent somatic symptoms were as follows in order : headaches, feeling tired, difficulty sleeping, poor health in general, dizzy spells, nausea, intestinal or stomach trouble, muscular weakness, backaches and excessive gas. Conclusion : The somatic symptoms of schizophrenia were decreased in the group of the long education period and the good current adjustment at admission. The more depression and anxiety were increased, the more somatic symptoms were revealed. It suggests that somatic symptoms of schizophrenia may be related to depression and anxiety.

이주 노동자들의 생물학적 노출 지표와 건강 실태 : 2005년 특수건강진단 결과 자료 토대

송윤희,김규상,이선웅,최선행 大韓産業醫學會 2008 대한직업환경의학회지 Vol.20 No.2

목적: 이 연구의 목적은 2005년 특수건강진단 자료를 이용하여 이주 노동자들의 유해 요인 노출 실태와 일반 적인 건강 실태를 국내 노동자와 비교하여 파악하고자 하였다. 방법: 2005년 특수건강진단 자료 중 이주 노동자 25,086명의 자료와 같은 해 경인지역 3개 기관에서 특수 건강진단을 시행한 국내 노동자 19,616명의 자료를 이용하여,생물학적 노출지표와 몇 가지 주요 임상 검사 결과를 국내 노동자와 이주노동자로 나누어 비교 분석하였다. 동칠한 표본의 비교를 위해 이주 노동자 자료에서 경인 지역의 동일 3개 기관의 결과만을 선발하여 비교하고(국내 19,616명,이주 1,886명), 전체 대상으로 확장하여서 비교하였으며 (국내 19,616명,이주 19.616명), 마지막으로 동일 업종, 3년 미만 근로기간, 50인 미만 규모로 제한하여 비교하였다(국내 2,910명,이주 노동자10,022명) 임상 검사는 3개 기관의 20대와 30대만을 선발하여 비교하였다. 결과: 동질 표본의 비교에서 혈중 납은 국내 6.09 μg/dl. 이주 8.37μg/L로 혈중 카드뮴은 국내 0.29 μg/dl, 이주 0.36μg/L로 나와 국내 노동자에 비해 이주 노동자들이 더 높게 나왔다. 하지만 유기용제의 생물학적 노출지표는 반대로 국내 노동자에게서 더 높게 나왔다. 주요 임상 검사 결과로는 간 수치 중 AST/ ALT가 국내 8.1/6.8%, 이주 5.7/5.4%로 국내 노동자들이 더 간 건강이 좋지 않은 것으로 나왔고 빈혈은 국내 9.0%,이주11.0%로 이주 노동자에게서 그 유병율이 더 높게 나왔다. 결론: 이주 노동자들이 국내 노동자들에 비해서 중금속에 한한 더 열악한 작업환경에 근무하고 있다는 것을 유추해 볼 수 있었다. 하지만 유기용제의 노출 지표에 대해서는 명확한 해석을 하기 어려웠으며 이에 대해서는 추후 더욱 체계화된 연구가 필요할 것으로 판단된다. Objectives: To investigate the general health status and seventy of exposure to hazardous agents - with a focus on heavy metals - of migrant workers utilizing the 2005 Special Health Examination data. Methods: With data from the 2005 Special Health Examination, we examined the biologic exposure indices and several major clinical exam items of 25,086 migrant workers in the whole country in comparison with those of 19,616 native Korean workers in Kyunggi-do province. Of these we chose homogeneous samples from the same 3 health service centers in Kyunggi-do. (native workers: 19,616, migrant workers: 1,886)to be more precise. Results: The results from the samples of the 3 centers were as follows. Blood lead (natives: 6.09 μg/dl, migrants: 8.37 μg/L) and cadmium (natives: 0.29 μg/dl, migrants: 0.36 μg/L) were higher in the migrant workers than in the native Korean workers, whereas the biologic exposure indices of organic solvents were higher in the native workers. As for major clinical exam items, the liver battery was worse in the natives with incidence of abnormal AST/ALT level (natives: 8.1/6.8% migrants: 5.7/5.4%, p-va1ue<0.01 for AST). Anemia was more prevalent in the migrant workers (natives: 9.0% migrants: 11.0%, p-va1ue<0.05). Conclusions: Migrant workers in Korea are more frequently or more severely exposed to a hazardous working environment containing heavy metals. However, we were not able to explain the results for the exposure indices or organic solvents, and such an explanation will require further study in the future.

대혈관 전위증의 병리

조수연,오미혜,김정선,이용희,강행지,서정욱 한국소아심장연구회 2003 소아심장 Vol.7 No.2

THE KOMPSAT-I PAYLOADS OVERVIEW

Park, Hong Yul,Choi, Gi Hyuk,Yoon, Hyeong Sik,Lee, Seunghoon,Woo, Sun Hee,Shim, Hyung Sik,Oh, Kyoung Hwan,Cho, Young Min,Yong, Sang Soon,Lee, Sang Gyu,Heo, Haeng Pal 대한원격탐사학회 1998 International Symposium on Remote Sensing Vol.14 No.1

Korea Aerospace Research Institute (KAKI) is developing a Korea Multi-Purpose Satellite I (KOMPSAT-1) which accommodates Electro-Optical Camera (EOC), Ocean Scanning Multi-spectral Imager (OSMI), and Space Physics Sensor (SPS). The satellite has the weight of about 500kg and will be operated on the 10:50 AM sun-synchronized orbit with the altitude of 685 km. The satellite will be launched in 1999 and its lifetime is expected to be over 3 years. The main mission of EOC is the cartography to provide the images from a remote earth view for the production of 1/25000-scale maps of KOREA. EOC collects 510 - 730 nm panchromatic imagery with the ground sample distance(GSD) of 6.6 m and the swath width of 17 km by push broom scanning. EOC also can scan ±45 degree across the ground track using body pointing method. The primary mission of OSMI is worldwide ocean color monitoring for the study of biological oceanography. It will generate 6 band ocean color images with 800 km swath width and 1km GSD by whiskbroom scanning. OSMI is designed to provide on-orbit spectral band selectability in the spectral range from 400 nm to 900 nm through ground command. This flexibility in band selection can be used for various applications and will provide research opportunities to support the next generation sensor design. SPS consists of High Energy Particle Detector (HEPD) and Ionosphere Measurement Sensor (IMS). HEPD has missions to characterize the low altitude high-energy particle environment and to study the effects of radiation environment on microelectronics. IMS measures densities and temperature of electrons in the ionosphere and monitors the ionospheric irregularities at the KOMPSAT orbit.

Effects of Huang Bai (Phellodendri Cortex) and Three Other Herbs on GnRH and GH Levels in GT1–7 and GH3 Cells

Lee, Sun Haeng,Kwak, Sung Chul,Kim, Dong Kwan,Park, Sang Woug,Kim, Hyun Soo,Kim, Young-Sik,Lee, Donghun,Lee, Ju Won,Lee, Chang Gon,Lee, Hae Kyung,Cho, Sung-Min,Shin, Yu Jeong,Lee, Jin Yong,Kim, Hocheo Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-

<P>The present study was to evaluate the effects of Huang Bai, Zhi Mu, Mai Ya, and Xia Ku Cao on hormone using the GT1–7 and GH3 cells. The GT1–7 and GH3 cell lines were incubated with DW; DMSO; and 30, 100, or 300 <I>μ</I>g/mL of one of the four extract solutions in serum-free media for 24 hours. The MTT assay was performed to determine the cytotoxicity of the four herbs. The GT1–7 and GH3 cells were incubated in DW, estradiol (GT1–7 only), or noncytotoxic herb solutions in serum-free medium for 24 hours. A quantitative RT-PCR and western blot were performed to measure the GnRH expression in GT1–7 cells and GH expression in GH3 cells. Huang Bai, Zhi Mu, Xia Ku Cao, and Mai Ya inhibited the GnRH mRNA expression in GT1–7 cells, whereas Huang Bai enhanced GH mRNA expression in GH3 cells. Additionally, Xia Ku Cao inhibited GnRH protein expression in GT1–7 cells and Huang Bai promoted GH protein expression in GH3 cells. The findings suggest that Huang Bai can delay puberty by inhibiting GnRH synthesis in the hypothalamus while also accelerating growth by promoting GH synthesis and secretion in the pituitary.</P>

토마토 잿빛곰팡이병균 약제저항성 간이 판별법

이문행 ( Mun Haeng Lee ),이희경 ( Hee Kyoung Lee ),김성은 ( Sung Eun Kim ),이환구 ( Hwan Gu Lee ),이순계 ( Sun Gye Lee ),유승헌 ( Seung Hun Yu ),김영식 ( Young Shik Kim ),김상우 ( Sang Woo Kim ),이윤수 ( Youn Su Lee ) 한국균학회 2013 韓國菌學會誌 Vol.41 No.3

Grey mold infection rate in tomato was investigated with the inoculation of dead flowers on Botrytis selective media. The grey mold infection rate of flower after fruiting were higher in the order of after 45 days, after 25 days, and fruiting day with 100%, 87% and 65%, respectively. The number of infected flowers were increased with time increase after the flowering before fruiting. B5M (Botrytis selective medium) was used to check grey mold infection rate depending on the flowering stage and cultivar. Grey mold infection rate depending on the flowering stage was similar in all the beef-tomato cultivar as 1.5~5% at pre-￢flowering, 1.5~45% at flowering and 75~90% at fruiting. On the other hand, cherry tomato cultivar KoKo had lower infection rates of 0~3.5% at pre-flowering, 1 O~30% at flowering and 20~50% at fruiting. These resulted from the fact that beaf-tomato cultivar have much bigger flowers and larger amount of pollens compared to those of cherry tomato cultivar. The amounts of falling pollens of Botrytis spp. were checked for beaf-tomato cultivar and cherry tomato cultivar using B5TM. The amounts of falling pollens were increased as growth period was extended, and the amount of spores increased rapidly during the outbreak of grey mold. Twelve field trials in Buyeo and lksan areas showed that Fluazinam, and Diethofencarb+Carbendazim were effective fungicides to control tomato grey mold, and these results were similar to those of field trials with B5TM. This is the first report of Fluazinam as a effective fungicide for the control of grey mold of tomato even though it has not been registered yet for the control of gray mold in tomato.