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Effects of flupyrazofos on liver microsomal cytochrome P450 in the male Fischer 344 rat
LEE, HYE SUK,LEE, HEE YONG,GU, HEE KYOUNG,HAN, SANG SEOP,YUN, CHUL-HO,KIM, JEONG HAN,KIM, JUNG-AE,LEE, EUNG-SEOK,NAM, DOO-HYUN,JEONG, TAE CHEON 영남대학교 약품개발연구소 2001 영남대학교 약품개발연구소 연구업적집 Vol.11 No.-
1. The effects of flupyrazofos on liver microsomal cytochrome P450 were investigated in the male Fischer 344 rat. When rats were treated intraperitonelly with flupyrazofos for 3 consecutive days, the activities of ethoxyresorufin O-deethylase and testosterone 2 B-hydroxylase were significantly reduce, wheceas the activities of pentoxyresorufin O-depentylase and testosterone 6B-and 7 ∝-hydroxylases were induced in liver microsomes. 2. Within 24 h after treatment with 50 m kg_(-1) flupyrazofos, most enzyme activities were decreased, indicating the interaction of flupyrazofos with cytochrome P450. 3. In Western immunoblotting, cytochrome P4502BI/2 proteins were clearly induced by treatment with flupyrazofos, wherea P4501A1/2 and 2C6 proteins were reduced in liver microsomes. 4. The present results indicated that flupyxazofos modulates the expression of cytochrome P450 in rat.
( Eung Gu Lee ),( Tae-hee Lee ),( Jiwon Ryoo ),( Jung Won Heo ),( Hye Seon Kang ),( Soon Seog Kwon ),( Yong Hyun Kim ) 대한결핵 및 호흡기학회 2020 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.128 No.-
Purpose IPF is a specific form of chronic and progressive fibrosing interstitial pneumonia of unknown cause. Pirfenidone has been proven to be effective and safe in the treatment of IPF. However, the dose of pirfenidone used in Korea is usually lower than the dose established in global clinical trial. The aim of this study was to evaluate the efficacy of relatively lower dose of pirfenidone on disease progression and survival of IPF patients in real-world. Methods This is a retrospective observational study based on IPF cohort in which IPF patients were enrolled at the time of diagnosis at a single center from 2008 to 2018. The clinical and laboratory data of these patients were collected prospectively using an IPF-specified protocol. We compared the clinical characteristics, overall survival and pulmonary function decline of the patients treated with variable dose of pirfenidone with patients not treated with pirfenidone. Results Of the total 295 patients with IPF, 100 (33.9%) received pirfenidone and 195 (66.1%) were not prescribed antifibrotic agents. Of the 100 patients who received pirfenidone, 24% (24/100), 50% (50/100), and 26% (26/100) were given 600mg, 1200mg, and 1800mg of pirfenidone, respectively. In unadjusted analysis, the survival of the patient group using pirfenidone was significantly better than that of the group not using pirfenidone (HR: 0.69, 95% CI: 0.48-0.99, p = 0.04). After adjusted for age, gender, BMI and GAP score, the survival remained higher in the patients using pirfenidone (HR: 0.56, 95% CI: 0.37-0.85, P = 0.006). In the analysis of pulmonary function, the decline in FVC, FEV1 and DLCO was significantly lower (p = 0.0068, p = 0.0007 and p = 0.0034, respectively) in the group using pirfenidone compared to the group not using it. Conclusion Low dose pirfenidone provided beneficial effects on survival and pulmonary function decline in real-life practice.
( Eung Gu Lee ),( Youlim Kim ),( Yong Il Hwang ),( Kwang Ha Yoo ),( So Eun Lee ),( Kyung Yoon Jung ),( Yong Bum Park ),( Chin Kook Rhee ) 대한결핵 및 호흡기학회 2021 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.129 No.-
Introduction The prescriber considers the risk and benefits of choosing different maintenance therapies to treat chronic obstructive pulmonary disease (COPD). Pneumonia is a common infectious disease in COPD and is also risk associated with inhaled corticosteroid use. However, risk factors for pneumonia in COPD have not been fully elucidated. Aims and objectives: This study compares the incidence of pneumonia in COPD patients and associated risk factors, comparing cohorts of patients prescribed with either long-acting muscarinic antagonist (LAMA) or inhaled corticosteroid plus long-acting beta-agonist (ICS+LABA). Methods This nationwide cohort study used Korean National Health Insurance claims data to select patients who received either LAMA or ICS+LABA from Jan 2005 to April 2015, with COPD diagnostic code. We have enrolled patients with good adherence, defined as a medication possession ratio ≥ 80%. The observation period for pneumonia was a minimum of 12 months and a maximum of 136 months. Results The incidence rate of pneumonia per 1,000 person per year was 90.20 in LAMA (n=3,479) and 147.09 in ICS+LABA (n=1,220) with P value < 0.0001. Adjusted hazard ratio (HR) [95% confidence interval (CI)] for pneumonia in ICS+LABA was 1.431 [1.213- 1.689] compared with LAMA (P < 0.001). In multivariable analysis, other risk factors for pneumonia included age≥75 (HR [95% CI]: 1.431 [1.235-1.657]), low social economic status (1.464 [1.143-1.875]), previous history of pneumonia (2.400 [1.978-2.911]). Conclusions The incidence of pneumonia was higher in COPD patients prescribed with ICS+LABA compared with LAMA.
( Eung Gu Lee ),( Hye Seon Kang ),( Bo Mi Gil ),( Ah Young Shin ),( Chang Dong Yeo ),( Ju Sang Kim ),( Yong Hyun Kim ),( Sang Haak Lee ) 대한결핵 및 호흡기학회 2019 대한결핵 및 호흡기학회 추계학술대회 초록집 Vol.127 No.-
Introduction: Interstitial lung abnormalities (iLA) were defined as nondependent changes affecting more than 5% of any lung zone, including reticular or ground-glass abnormalities, diffuse centrilobular nodularity, nonemphysematous cysts, honeycombing, and traction bronchiectasis on chest CT. The presence of iLA at diagnosis of stage IV non-small cell lung cancer (NSCLC) patients has already proved as an independent marker for poor clinical outcome. However, it is still lack of research about the effects of iLA in patients with small cell lung cancer (SCLC). We investigated whether iLA is associated with increased mortality in patients with SCLC. Methods: This study included 189 patients with a pathological diagnosis of SCLC, who were included in the Lung Cancer Cohort of the Catholic University of Korea from 2014 to 2018. Presence of iLA was visually determined in the pretreatment baseline CT. Clinical characteristics and overall survival (OS) were compared in patients with and without iLA. Results: iLA was present on 77 (40.7%) patients. The presence of iLA significantly associated with male gender (93.5%, 72/77 vs. 82.1%, 92/112, p = 0.028). iLA was not significantly associated with smoking status or COPD (chronic obstructive pulmonary disease). There was no significant difference in pulmonary function test between the iLA and non-iLA groups. The presence of iLA was not related to OS in the total SCLC population. However, in patients with limited disease (LD) with iLA, there was a tendency to increase the difference in OS more than in the absence of iLA (541.63 49.02 vs. 400.44 45.05 days, p = 0.067). In the multivariate analysis, presence of iLA was an independent prognostic factor affecting the shorter OS (HR = 1.779, p = 0.033). Conclusion: Baseline iLA was associated with shorter OS, and independent prognostic factor for poor clinical outcome in patients with LD-SCLC.
왕겨재를 혼입한 콘크리트의 동결융해 저항성에 관한 실험적 연구
이준구 ( Lee Joon Gu ),박광수 ( Park Kwang Su ),이응찬 ( Lee Eung Chan ),김한중 ( Kim Han Joong ) 한국농공학회 1999 한국농공학회 학술대회초록집 Vol.1999 No.-
After researching the physical properties of the concrete included Rice Husk Ash(RHA concrete) and workability of fresh concrete admixed RHA, we have tested durability of RHA -concrete against freezing and thawing in the winter using rapid freezing and thawing test method(KS F 2456). There are two hypotheses to explain the failure mechanism of a freezing and thawing action. First, the hydraulic pressure in the pores of freezing concrete make an internal stress of concrete structures outbreaking micro crack in the face of concrete. Second, Frost action causing damage to cement paste repeatedly come from soil frost action, freezing water in the capillaries. Initial Relative Dynamic Modulus of Elasticity (DME) was biggest in case of unit binder weight 600kgf/m<sup>3</sup> and relative dynamic modulus of elasticity increased until 300cycles. In general, initial relative DME was proportional to unit binder weight. Relative DME was decreased in proportion to unit binder weight in the case of 300, 400, 500kgf/m<sup>3</sup>, but relative DME of the others remained more than 90% until 300 cycles. It was not good effect of il1termixed RHA to concrete in case of below unit binder weight 300kgf/m<sup>3</sup> and the resistance of freezing and thawing was not good either.
유응구(Eung Gu You),김정숙(Jeong Sook Kim),이용규(Yong Kyu Lee),이금석(Keum Suk Lee),홍영식(Young Sik Hong) 한국정보과학회 1998 한국정보과학회 학술발표논문집 Vol.25 No.1B
한자 코드는 개발자에 따라서 독자적으로 정할 수도 있으나 통신 등의 측면을 고려하면 상호 호환성을 유지하는 방향으로 나아가는 것이 바람직하다. 그러나 국가 표준 KSC-5601 한자코드는 한자의 배열방법, 글자의 수, 한자의 선택 등에서의 문제가 많음을 지적할 수 있다. 특히 현재는 조합형, 완성형 코드 모두 4,888자만 쓸 수 있어, 학술자료를 입력하기에는 많은 수의 한자가 부족한 것이 사실이다. 여기에 유니코드라는 범용 문자 체제(multilingual code set)가 제정되기에 이르렀으나, 이 유니코드를 기반으로 한 윈도우 NT에서도 유니코드로 한자를 온전하게 입력할 수 없다. 본 연구에서는 이러한 문제점을 해결하고자 유니코드로 한자를 입력할 수 있는 시스템을 윈도우 NT에서 개발하였다. 유니코드에 있는 한자들에 대해 음을 달고, 각 음에 해당하는 코드들로 분류하여, 한글의 음에 해당하는 한자로 변환하는 음전환 방식의 입력 시스템이다.