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RISS 인기검색어
- 검색키워드
- 저자 : Kyueng-Whan Min (검색결과 16 건)
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Min, Kyueng-Whan,Park, Moon Hyang,Hong, Sung Ran,Lee, Heejung,Kwon, Sun Young,Hong, Sook Hee,Joo, Hee Jae,Park, In Ae,An, Hee Jung,Suh, Kwang Sun,Oh, Hoon Kyu,Yoo, Chong Woo,Kim, Mi Jin,Chang, Hee Kyu Raven Press 2013 International journal of gynecological pathology Vol.32 No.1
<P>Accurate diagnosis of ovarian clear cell carcinoma (CCC) is important because of its poor prognosis with chemoresistance and a high recurrent rate. The clinicopathologic characteristics and prognostic significance of the cell cycle regulator [early mitotic inhibitor-1 (Emi1)] and galactoside-binding protein (Galectin-3) were evaluated. Among 155 CCCs from 18 hospitals in Korea between 1995 and 2006, 129 pure CCCs were selected with consensus using immunohistochemical stains for hepatocyte nuclear factor-1β, Wilms' tumor protein, and estrogen receptor. The expressions of Emi1, Galectin-3, p53, and Ki-67 labeling index were analyzed with clinicopathologic parameters and the patient's survival. The mean age of the patients was 49.6 yr; the tumors were bilateral in 10.9%, and the average size was 12 cm. Adenofibromatous component was found in 7%, and endometriosis in 48.1% of the cases. Psammoma body was seen in 16.3%. Disease-free survival and overall survival rates were 78.3% and 79.1%, respectively. The International Federation of Obstetrics and Gynecology (FIGO) stage was the most important prognostic indicator. Emi1 expression (>5%) was seen in 23.3% of CCCs, and associated with high FIGO grades and poor overall survival (P<0.05). High Galectin-3 (80%) expression was seen in 59.7% of CCCs, and associated with FIGO stages III and IV, and high Ki-67 labeling index. High Ki-67 labeling index (50%) and p53 expression (50%) were seen in 27.1% and 18.6% of CCCs, respectively, but there was no clinicopathologic and prognostic significance. On the basis of the fact that the expression of Emi1 in CCC was correlated with a high histologic grade and worse overall survival, target therapy using inhibitors of Emi1 may be tried in the management of CCC patients with Emi1 expression.</P>
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Microscopic Polyangiitis Following mRNA COVID-19 Vaccination: A Case Report
So Daeyoung,Min Kyueng-Whan,Jung Woon Yong,Han Sang-Woong,Yu Mi-Yeon 대한의학회 2022 Journal of Korean medical science Vol.37 No.19
Coronavirus disease 2019 (COVID-19) is one of the most widespread viral infections in human history. As a breakthrough against infection, vaccines have been developed to achieve herd immunity. Here, we report the first case of microscopic polyangiitis (MPA) following BNT162b2 vaccination in Korea. A 42-year-old man presented to the emergency room with general weakness, dyspnea, and edema after the second BNT162b2 vaccination. He had no medical history other than being treated for tuberculosis last year. Although his renal function was normal at last year, acute kidney injury was confirmed at the time of admission to the emergency room. His serum creatinine was 3.05 mg/dL. Routine urinalysis revealed proteinuria (3+) and hematuria. When additional tests were performed for suspected glomerulonephritis, the elevation of myeloperoxidase (MPO) antibody (38.6 IU/mL) was confirmed. Renal biopsy confirmed pauci-immune anti-neutrophil cytoplasmic antibody (ANCA)-related glomerulonephritis and MPA was diagnosed finally. As an induction therapy, a combination of glucocorticoid and rituximab was administered, and plasmapheresis was performed twice. He was discharged after the induction therapy and admitted to the outpatient clinic 34 days after induction therapy. During outpatient examination, his renal function had improved with serum creatinine 1.51 mg/dL. We suggest that MPA needs to be considered if patients have acute kidney injury, proteinuria, and hematuria after vaccination.
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Primary Synovial Sarcoma of the Thyroid Gland
Jang, Ki-Seok,Min, Kyueng-Whan,Jang, Si-Hyong,Paik, Seung Sam,Tae, Kyung,Jang, Se Jin,Park, Moon Hyang KOREAN ACADEMY OF MEDICAL SCIENCE 2007 JOURNAL OF KOREAN MEDICAL SCIENCE Vol.22//SUP No.-
<P>Synovial sarcoma is a rare but distinct soft tissue neoplasm, most commonly occurring in para-articular regions of the extremities of young adults and also occurring in the head and neck region. To the best of our knowledge, only one case of primary synovial sarcoma of the thyroid has been previously reported. Here, we report a 15-yr-old man who had a chief complaint of a palpable neck mass. The neck computed tomography revealed a relatively well-demarcated solid mass in the left thyroid gland. After fine needle aspiration cytology, total thyroidectomy and lymph node dissection were performed. Grossly, the mass was covered by the same capsule as the thyroid gland, measuring 6×5×5 cm in dimensions and weighing 78 gm. The cut surface showed a well demarcated, lobulated, grayish tan, and rubbery solid tumor. Histologically, this tumor was a biphasic synovial sarcoma. Immunohistochemical, ultrastructural, genetic studies, and cytologic findings were all consistent with synovial sarcoma. When synovial sarcomas arise in this unusual site, recognition and differential diagnosis become more difficult. The differential diagnosis of a spindle epithelial tumor with thymus-like differentiation is very difficult due to their similar clinical, histological, and immunohistochemical features. Ultrastructural and cytogenetic studies for synovial sarcoma are necessary to establish a definitive diagnosis.</P>
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Primary Synovial Sarcoma of the Thyroid Gland
Ki-Seok Jang,Kyueng-Whan Min,Si-Hyong Jang,백승삼,태경,Se Jin Jang,박문향 대한의학회 2007 Journal of Korean medical science Vol.22 No.S
Synovial sarcoma is a rare but distinct soft tissue neoplasm, most commonly occurring in para-articular regions of the extremities of young adults and also occurring in the head and neck region. To the best of our knowledge, only one case of primary synovial sarcoma of the thyroid has been previously reported. Here, we report a 15-yr-old man who had a chief complaint of a palpable neck mass. The neck computed tomography revealed a relatively well-demarcated solid mass in the left thyroid gland. After fine needle aspiration cytology, total thyroidectomy and lymph node dissection were performed. Grossly, the mass was covered by the same capsule as the thyroid gland, measuring 6×5×5 cm in dimensions and weighing 78 gm. The cut surface showed a well demarcated, lobulated, grayish tan, and rubbery solid tumor. Histologically, this tumor was a biphasic synovial sarcoma. Immunohistochemical, ultrastructural, genetic studies, and cytologic findings were all consistent with synovial sarcoma. When synovial sarcomas arise in this unusual site, recognition and differential diagnosis become more difficult. The differential diagnosis of a spindle epithelial tumor with thymus-like differentiation is very difficult due to their similar clinical, histological, and immunohistochemical features. Ultrastructural and cytogenetic studies for synovial sarcoma are necessary to establish a definitive diagnosis.
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Soohwan Choi,Hyung Suk Kim,Kyueng-Whan Min,Yung-Kyun Noh,Jeong-Yeon Lee,Ji-Yong Moon,Un Suk Jung,Mi Jung Kwon,Dong-Hoon Kim,Byoung Kwan Son,Jung Soo Pyo,Sun Kyun Ro 대한의학회 2024 Journal of Korean medical science Vol.39 No.2
Background: Tumor spread through air spaces (STAS) is a recently discovered risk factor for lung adenocarcinoma (LUAD). The aim of this study was to investigate specific genetic alterations and anticancer immune responses related to STAS. By using a machine learning algorithm and drug screening in lung cancer cell lines, we analyzed the effect of Janus kinase 2 (JAK2) on the survival of patients with LUAD and possible drug candidates. Methods: This study included 566 patients with LUAD corresponding to clinicopathological and genetic data. For analyses of LUAD, we applied gene set enrichment analysis (GSEA), in silico cytometry, pathway network analysis, in vitro drug screening, and gradient boosting machine (GBM) analysis. Results: The patients with STAS had a shorter survival time than those without STAS (P < 0.001). We detected gene set-related downregulation of JAK2 associated with STAS using GSEA. Low JAK2 expression was related to poor prognosis and a low CD8+ T-cell fraction. In GBM, JAK2 showed improved survival prediction performance when it was added to other parameters (T stage, N stage, lymphovascular invasion, pleural invasion, tumor size). In drug screening, mirin, CCT007093, dihydroretenone, and ABT737 suppressed the growth of lung cancer cell lines with low JAK2 expression. Conclusion: In LUAD, low JAK2 expression linked to the presence of STAS might serve as an unfavorable prognostic factor. A relationship between JAK2 and CD8+ T cells suggests that STAS is indirectly related to the anticancer immune response. These results may contribute to the design of future experimental research and drug development programs for LUAD with STAS. Background: Tumor spread through air spaces (STAS) is a recently discovered risk factor for lung adenocarcinoma (LUAD). The aim of this study was to investigate specific genetic alterations and anticancer immune responses related to STAS. By using a machine learning algorithm and drug screening in lung cancer cell lines, we analyzed the effect of Janus kinase 2 (JAK2) on the survival of patients with LUAD and possible drug candidates. Methods: This study included 566 patients with LUAD corresponding to clinicopathological and genetic data. For analyses of LUAD, we applied gene set enrichment analysis (GSEA), in silico cytometry, pathway network analysis, in vitro drug screening, and gradient boosting machine (GBM) analysis. Results: The patients with STAS had a shorter survival time than those without STAS (P < 0.001). We detected gene set-related downregulation of JAK2 associated with STAS using GSEA. Low JAK2 expression was related to poor prognosis and a low CD8+ T-cell fraction. In GBM, JAK2 showed improved survival prediction performance when it was added to other parameters (T stage, N stage, lymphovascular invasion, pleural invasion, tumor size). In drug screening, mirin, CCT007093, dihydroretenone, and ABT737 suppressed the growth of lung cancer cell lines with low JAK2 expression. Conclusion: In LUAD, low JAK2 expression linked to the presence of STAS might serve as an unfavorable prognostic factor. A relationship between JAK2 and CD8+ T cells suggests that STAS is indirectly related to the anticancer immune response. These results may contribute to the design of future experimental research and drug development programs for LUAD with STAS.
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( Jae Yoon Jeong ),( Yeon Won Park ),( Joo Hyun Sohn ),( Dae Won Jeon ),( Kyueng Whan Min ),( Yongsoo Kim ) 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1
Aims: To investigate the diagnostic accuracy of liver fibrosis using liver stiffness measurement (LSM) by real-time shear wave elastography (SWE) in patients with chronic viral hepatitis and to compare the diagnostic performance of SWE with serum liver fibrosis markers. Methods: We consecutively analyzed 92 patients with chronic viral hepatitis (45 with hepatitis B, 46 with hepatitis C and 1 with hepatitis B+C). Liver fibrosis was staged from F0 to F4 according to the Batts and Ludwig scoring system. The accuracy of prediction for liver fibrosis for SWE, hyaluronic acid (HA), type 4 collagen, AST to Platelet Ratio Index (APRI), FIB-4, Forns index and red cell volume distribution width-to-platelet ratio (RPR) was analyzed using receiver operator curve (ROC) analysis. Results: There were 10, 30, 20, and 32 patients at stages F0-1, F2, F3, and F4, respectively. The overall diagnostic accuracies of LSM and serum markers, as determined by the area under ROC, were LSM=0.909, APRI=0.810, FIB-4=0.768, type IV collagen=0.763, Forns index=0.750, RPR 0.717 and HA=0.712 and for predicting significant fibrosis (≥F2); LSM=0.861, type IV collagen=0.804, HA=0.801, RPR=0.770, Forns index=0.768, FIB-4=0.767, and APRI=0.728 for predicting advanced fibrosis (≥F3); and LSM=0.860, Forns index= 0.822, HA=0.817, FIB-4=0.816, RPR=0.799, type IV collagen= 0.783, and APRI=0.723 for predicting cirrhosis (=F4). LSM was superior to HA (P=0.029) and Forns index (P=0.049) for predicting significant fibrosis, and to APRI for predicting advanced fibrosis (P=0.011) and cirrhosis (P=0.011). Conclusions: SWE was the most accurate method to predict the degree of liver fibrosis in patients with chronic viral hepatitis. Also, the majority of six liver fibrosis markers were comparable to SWE to assess liver fibrosis.
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