재발 또는 불응성 비호즈킨 림프종 환자에서 CDME 구제항암화학요법 후 고용량 항암화학요법 및 자가말초혈액 조혈모세포이식의 효과

김세형,한강원,배상병,김찬규,이남수,이규택,박성규,원종호,홍대식,박희숙 순천향의학연구소 2004 Journal of Soonchunhyang Medical Science Vol.10 No.1

Background and objectives : The long-term survival in patients with non-Hodgkin's lymphoma (NHL) after conventional dose chemotherapy is about 35% and the rest of the patients tend to have relapse. So, in relapsed or refractory NHL, we compared the outcome of patients undergoing high-dose chemotherapy with autologous peripheral blood stem cell transplantation(APBSCT) with only salvage chemotherapy of cisplatin, dexamethasone, mitoxantrone, and etoposide(CDME). Materials and methods : From June 1993 to December 1999, 25 patients with relapsed or resistant NHL were treated with CDME regimen as salvage chemotherapy. Twelve patients were received four cycles of CDME chemotherapy, and 13 patients were received high-dose chemotherapy with APBSCT following two cycles of CDME chemotherapy. Results : The median follow-up duration was 12.8 months(range:4-68). The overall response rate was 41.7% (complete response rate 25%, partial response rate 16.7%) in 12 patients with CDME only. Thirteen patients who were treated with high-dose chemotherapy with APBSCT achieved 61.5% complete response rate and 15.4% partial response rate, with an overall response rate of 76.9%. The estimated 3-year progression-free survival rate was significantly higher among patients who received high-dose therapy than patients who received CDME only(41.5% vs 20.0%, p<0.05). And, 3-year overall survival rate was significantly higher among patients who received high-dose therapy(51.3% vs 25.0%, p <0.05). Conclusions : In relapsed or refractory NHL, CDME chemotherapy is an effective salvage chemotherapy and allow peripheral blood stem cell collection. Also, high-dose chemotherapy with APBSCT following CDME is superior to CDME salvage chemotherapy only.

어린 개에서 발생한 선천성 특발성 거대도식증 1례

서동규,박형진,송근호,서경원 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

Three-month-old, intact male, weighting 2.6 kg. Dachshund dog visited to the Veterinary Medical Teaching Hospotal of Chungnam National University with history of regurgitation. Result of blood analysis was in the normal range. On the radiographic examination, diffuse esophageal dilatation was observed. On the esophagram, esophageal dysmotility was observed. Acetylcholine receptor antibody titer was in the normal range. On the endoscopy, esophagitis was observed. Diagnosis was congenital idiopathic megaesophagus. This is the case report of congenital idiopathic megaesophagus.

개에서 발생한 파열된 전이성 비장 혈관육종 1례

서동규,박형진,송근호,서경원 忠南大學校 獸醫科大學 附設 動物醫科學硏究所 2012 動物醫科學硏究誌 Vol.19 No.1

Twelve-year-old, catrated male, weighting 8 kg, Miniature Schnauzer dog was referred to the Veterinary Medical Teaching Hospital of Chungnam National University with history of depression. Result of blood analysis revealed anemia, thrombocytopenia, azotemia, elevated ALP, ALT and CK. On the radiographic examination, splenomegaly and loss of abdominal serosal detail were observed. Abdominal ultrasonography showed rounded mass of spleen and liver, ascites were observed. Splenectomy was performed and found that splentic tail had been ruptured and two samples from nodules on liver were obtained for histopathology. The result of biopsy revealed that hemangiosarcoma of spleen metastasized to the liver. Carboplatin was chosen as the patient had congestive heart failture. During chemotherapy hemangiosarcoma was metastasized into peritoneum and abdominal cavity. Intraperitoneal chemotherapy was preceded at this moment. After 99 days of initial visit, patient was euthanized due to severe anemia and thrombocytopenia.

불안(각성)-경기수행 관계 이론에 대한 비판적 접근

朴亨夏,趙珍奎 釜慶大學校 1996 釜慶大學校 論文集 Vol.1 No.2

Relationship between arousal and athletic performance has been of central importance throughout the history of sportpsychology. Because these variables such as stress, arousal, and anxiety are associated with athletic performance. Therefore, many psychologiests referred to the arousal(anxiety)-performance relationship. Then, since the later 1990s, most sport psychologists have emphasized the nation that an optimal level of arousal is associated with best performance. Accordingly, the drive theory and inverted-U hypothesis have become a stable principle in both the academic and professional sport psychology literature. In recent years, however, most sport psychologists have emphasized the nation that anxiety is associated with best performance. According to the these current research status and directions, purpose of this study was focused on critical understanding and application about the arousal-anxiety-athletic performance relationship theories. Results of this study are as follows : First, many of the earlier theories have examined the arousal construct, whereas more recent theories were developed based on anxiety construct. Two relatively early theories that were proposed and tested in the sport and motor performance context were the drive theory and the inverted-U hypothesis. More recently, however, + additional theories have been advanced. That is, these include Hanins optimal zones of arousal hypothesis, multidimensional theory of anxiety, catastrophe theory,reversal theory, and so forth. Second, terms such as arousal, stress, drive, attention, activation, motivation, alertness, and anxiety have been used interchangebly, although numerous theoretical distinctions have been made among them. Accordingly We must resolve the inconsistent use of these-related terminology. Third, in general, internal reaction phenomena of human such as stress, anxiety, and emotion could be explained by arousal reactation. Becase these reactions are phenomena for maintenance of athletes' internal ho- meostasis. So, these reaction mechanisms must be deemed the same context as a- rousal phenomenon. In the results, we must try to control about athlete's emotional-physiolocal- psychological phenomenon and sports competition conditions in use of these theories.

Prospidin이 Mouse의 간장에 미치는 영향

이규식,정호삼,이민형,백두진,기춘석 한양대학교 의과대학 1986 한양의대 학술지 Vol.6 No.1

Prospidin, a new alkylating agent, has antimitotic and anticancer effect. Incubation with prospidin increases the stability of DNA and suppresses the incorporation of uridine into RNA by 15-20 percent. Prospidin is cytostatic for suspension culture and cells are blocked in G₂ phase of the cell cycle. The authors have demonstrated the effect of prospidin on the liver of mice histologically and histochemically and observed the cellular changes, loss of pyroninophilic granules and accumulation of fat in the hepatic parenchymal cells. Sixty-five healthy mice of ICR strain, average weight being 20g, were divided into two groups; control and prospidin-treated groups. All experimental animals were administered foo and water ad libitum. Animals of the prospidin-treated groups were administered prospidine 500mg per kg of body weight intraperitoneally fter dilution in the water for injection. Animals of the control group were administered only water for injection. Prospidin treated animals were sacrificed at intervals of 6, 12, 24, 36 and 48 hours after administration of prospidin. Histological preparations were made by way of hematoxylin and eosin stain for the cellular changes, methyl green-pyronin stain for pyroninophilic granules and oil red O stain for fat accumulation in the mouse liver. The results obtained are as follows. 1. Cellular swelling associated with vesicular formation were observed in the hepatic parenchymal cells of entire hepatic lobule at 24 and 36 hours after administration of prospidin. 2. A marked reduction of the pyroninophilic granules were observed in the hepatocyte of he whole hepatic lobule at 24, 36 and 48 hours following drug administration. 3. Fat deposits in the hepatic lobule were seen at 36 hours after administration of prospidin. It is suggested that prospidin acts as a cytotoxic agent and causes cellular swelling with vesicular formation, loss of pyroninophilic granules, and fat accumulation in the parenchymal cells of the liver.

주의력 결핍 과잉 운동장애에 대한 Methylphenidate의 임상 효과

사공정규,박형배,이종범 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.2

The objectives of this study were to evaluate the effect of methylphenidate on attention deficit hyperactivity disorder, using child attention problem checklist to 42(male : 29, female : 13) attention deficit hyperactivity disorder patients from March 1992 to February 1993. The results were as follows : There was significant improvement on symptoms in the scores rated by teachers in 7th & 28th day after methylphenidate administration compared to baseline score(p<0.05) and 28th day score showed significant improvement compared to 7th day scores(p<0.05). There was significant improvement on symptoms in the scores rated by parents in 28th day after methylphenidate administration compared to baseline score(p<0.05) and 28 th day score showed significant improvement compared to 7th day score. In single administration of methylphenidate in Sunday morning, there was significant improvement on symptoms in morning score compared to afternoon score(p<0.05). In the administration of methylphenidate of same dosage, the 7th day rating score of teacher showed significant improvement on symptoms compared to the Sunday morning rating score of parents(p<0.05) and the 28th day comparision was also showed signigicant improvement on symptoms in the scores rated by teachers compared to the scores rated by parents(p<0.05).

매복 과잉치 발거시의 전후방적 위치선정

최형준,손흥규,최병재,황동환 大韓小兒齒科學會 1996 大韓小兒齒科學會誌 Vol.23 No.3

Surgical removal of impacted mesiodens can be performed easily when exact position of mesiodens is identified. This case report is argued about methodological approach of exact antero-posterior postioning of mesiodens using conventional cross-sectional occlusal film and periapical film. The author concludes, 1. Among various methods of positioning mesiodens, exact position of mesiodens can be determined with occlusal film and periapical film. 2. On operation, exact antero-posterior position of mesiodens can be determined with comparing occlusal images of adjacent teeth and anatomic structure to real ones. 3. It is important that exact removal course of mesiodens has to be determined in addition to exact determination of one's position, and that it has to be determined in regard to position, morphological basis, direction of impacted pattern of mesiodens and adjacent anatomic structure. 4. In 2 cases presented, both are mesiodens of inverted conical type, and impacted direction are class Ⅰ and Ⅲ respectively according to classification author suggested, and surgery can be performed with ease by different approach directions.

복합 치아종에 관한 증례보고

최형준,최병재,손흥규,양호정 大韓小兒齒科學會 1995 大韓小兒齒科學會誌 Vol.22 No.2

The odontoma is relatively a common odontogenic tumor. It has come to mean as a growth in which both the epithelial and the mesenchymal cell exhibit complete differentiation, with the result that functional ameloblast and odontoblast form enamel and dentin. The etiology of it is unknown, but it has been suggested that local trauma or infection may lead to the production of such a lesion. Odontma is divided into 2 types. One is compound odontoma that is at least superficial anatomic simiarity to normal teeth, and the other is complex odontoma, that calcified dental tissues are simply an irregular mass bearing no morphologic similarity even to rudimentary teeth. Somtimes this malformation is not easily identified because its lacking of calcification. So, if permanant tooth is delayed to erupt, one should take a careful look the radiographic film to find that whether the cause of it is odontoma or not. In this case report, 3 patients with odontoma who visited Dept. of Pediatric Dentistry in Yonsei Dental College, were treated by means of surgical removal. The obtained results were as follows: 1. The odontoma is usually related to impacted tooth, and it is occurred neighboring to the crown of impacted tooth that have normally developed. So, in the case of missing tooth and delayed eruption, its presence should be investigated. 2. The odontoma can be seen vaguely radiographically, so, it is difficulty to make diagnosis. 3. The treatment of odontoma is a surgical removal. And, if it is completely removed, its occurrence is rare. 4. In the case of impacted tooth being associated with compound odontoma, continuous management is necessary for the eruption of impacted tooth after the surgical extraction of odontoma. 5. It resembles the ameloblastic odontoma radigraphically, and if it is the case, the treatment may vary, so the confirmation through histologic examination after removal of mass is necessary.

베이즈 방법을 이용한 신규 원자력발전소 EDG신뢰도의 추정에 관한 연구

류부형,심규박 동국대학교 경주대학 1997 東國論集 Vol.16 No.1

A commercial nuclear power plant contains at least two emergency diesel generaters(EDG) to control the risk of severe core demage during the station blackout accidents. Therefore the reliability of the EDG's to start and load-run on demend must be maintained at a sufficiently high level. Until now, Wyckoff estimators, a simple start and load-run successful rates, were used to calculate the EDG's reliability. however, this method has been many defects in various points at a situation has not enough the operation data of EDG/ In recent, K.B. Shim et al.(1996) was proposed that Bayes estimator method is more reasonable our situation. In this paper, we will apply Wyckoff method and Bayes method to estimate the reliability of EDG at construction stage and show Bayes method are more reasonable in our situation with various sides.

Y 대학교 치과대학병원 교정과 내원환자의 지역분포와 부정교합 분류에 관한 연구

유형석,유영규,이장열 대한치과교정학회 1999 대한치과교정학회지 Vol.29 No.2

본 연구는 1992년부터 1997년까지 6년간 연세대학교 치과대학 부속병원 교정과에 내원하여 진단을 받은 부정교합환자중에서 진단용 석고모형과 진료기록부가 잘 보존되고 지역 거주지가 확실한 9159명을 대상으로 연도별 내원 환자의 성별 분포, 연령별 내원 환자의 분포, Angle씨 부정교합 분류, 제 I급 부정교합 양상의 분류 및 지역적 분포 특성들을 조사하여 다음과 같은 결론을 얻었다. 1. 본 원 교정과에 내원한 환자의 수가 1992년에 비해 1997년 86%가 증가하였으며 1995년 이후 매년 증가하는 추세를 보였다. 2. 연령별 내원 분포에서 19세 이상군의 비율이 39.9%로 가장 높게 나타났으며 사춘기전 아동의 비율은 점차 감소하는 반면, 성인 교정환자의 비중이 점차 높아지는 경향을 나타내었다. 3. Angle씨 부정교합 분류에 의한 내원 환자 분포에서 제Ⅲ급 부정교합자가 38.1%로 가장 높은 비율을 나타내었으며, 제Ⅰ급 부정교합이 33.3%, 제 II급 부정교합은 28.6%의 빈도를 보였다. 4. 제 I급 부정교합자중 총생(crowding)을 주소로 내원한 환자가 32.6%로 가장 높게 나타났다. 연도별 변화에서는 돌출(protrusion)환자는 점차 증가 양상을 보여 96년에는 33.9%로 가장 높은 비율을 보였으며 개교합과 반대교합 환자는 감소하는 추세로 나타났다. 5. 내원 환자의 지역적 분포를 보면 서울시 환자가 전체 내원 환자의 70%이상 차지하는 것으로 조사되었으며 서울시내원환자중 연세대학교 치과병원을 중심으로 반경 3-6km의 거주자가 32.3%로 가장 높게 나타났고 반경 9km이내에서 전체의 69%를 차지하였다. Distribution trends were examined in 9159 malocclusion patients who had been examined and diagnosed at department of Orthodontics, College of Density, Yonsei University over a 6 year-period from 1992 to 1997. The results were as follows: 1. The total number of orthodontic patients in 1997 increased in comparing with that of 1992(86%) and after 1995, the number of annual patients showed an increase. 2. Age distribution had shown over-19 year-old group being the largest(39.9%) but percentages of pre-adolescent patients had been decreasing while that of adult patient had gradually increased. 3. Distributions in the types of malocclusion, the Angle`s Classification had shown : 33.3% for Class I, 28.6% for Class II and the largest 38.1% for Class Ⅲ. 4. Among Class I patients, crowding showed the largest(32.6%) and protrusion group had gradually increased to 33.9% in 1996.Otherwise openbite and crossbite groups tend to decrease, annually. 5. Geographic distribution showed a majority of patients from Seoul(above 70%). Among the patients from Seoul, group within the distance 3-6Km from Yonsei dental hospital was the largest(32.3%) and group within 9Km showed 69% of total patients.