식도암과 위암이 동시에 발생한 원발성 중복암 1예

윤혜원,심기남,나선경,송도경,정정화,정가영 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

Double primary cancers are two independently developed cancers in an individual. There have been some reports on double primary cancer since Billroth reported it for the first time in 1879. Double primary cancer of the stomach and esophagus has been revealed a very low incidence worldwide. The incidence of an esophageal cancer with another primary cancer is reported to be 9.5∼27%, but double primary cancers in the esophagus and stomach have been rarely reported to our knowledge. In this study, we present here a case of double primary esophageal and stomach cancer in a 66-year-old man because of progressive dysphagia.

캡슐내시경과 단일풍선 소장내시경으로 진단된 공장의 간질종양 1예

송도경,심기남,태정현,김경진,송명은,송하응,윤혜원,정가영,정정화 이화여자대학교 의과학연구소 2012 EMJ (Ewha medical journal) Vol.35 No.2

Gastrointestinal stromal tumors (GISTs) are common mesenchymal tumors that arise in the wall of the gastrointestinal tract. We report a case of obscure gastrointestinal bleeding due to a GIST of the jejunum successfully documented by videocapsule endoscopy (VCE) and single-balloon enteroscopy (SBE). A 36-year-old man with hematochezia was referred for further evaluation of no evidence of bleeding focus on esophagogastroduodenoscopy and colonoscopy. A VCE showed a suspicious ulcerative hyperemic mass that located in about 1 hour apart from duodenal second portion. SBE revealed a nonbleeding 4×2 cm mass with an ulcer at the proximal jejunum. The patient underwent laparoscopic resection without complication. Histological examination revealed a well circumscribed, dumbbell-shaped firm mass comprised of spindle cells. Immunohistochemical staining for CD 117 was diffusely positive, whereas staining for S-100, CD 34 and MIB-1 was all negative. It was confirmed to be a low-grade GIST at the proximal jejunum.

The difference in the urine D-chiro-inositol level according to the characteristics of type 2 diabetes mellitus patients

( Hye Won Jang ),( Min Kyeong Kim ),( Kyong Hye Jeong ),( Koon Soon Kim ),( Hyun Jin Kim ),( Young Suk Jo ),( Minho Shong ),( Bon Jeong Ku ) 대한내과학회 2011 대한내과학회 추계학술발표논문집 Vol.2011 No.1

Background/Aims: D-chiro-inositol is known as a mediator of insulin`s action and it has been shown to lower the blood glucose concentration in type 2 diabetes mellitus patient. This study aims to compare the urine D-chiro-inositol levels between normal controls and type 2 diabetes mellitus patients and we also searched for the relationship between the clinical characteristics of diabetes mellitus patients and the urine D-chiro-inositol concentration. Methods: 103 normal controls and 111 type 2 diabetes mellitus patients were recruited. Urine D-chiro-inositol was measured by the high performance liquid chromatography/mass spectrometry method. Results: Excretion of urinary D-chiro-inositol was increased in the diabetic subjects (p=0.000). In the diabetic group, the D-chiro-inositol level demonstrated a statistically significant positive correlation with HbA1c(r=0.264, p=0.007), microalbumin (r=0.252, p=0.021) and blood urea nitrogen (r=0.259, p=0.008) and it showed an inverse correlation with albumin (r=-0.198, p=0.045), ALT (r=-0.237, p=0.019) and the GFR (r=-0.200, p=0.043)(Table 2). Only the fasting plasma glucose level (ß=0.003, p=0.043) and the total cholesterol (ß=0.008, p=0.024) were found to be significant variables on the multiple regression analysis. When diabetic subjects were divided into two groups according to the HbA1c level, the subjects with a HbA1c level more than 8% presented a higher level of urinary D-chiro-inositol (p=0.019). Conclusions: The urinary D-chiro-inositol excretion of the diabetic subjects was increased. For the subjects whose HbA1c level exceeded more than 8%, the urinary excretion level of D-chiro-inositol was also increased. So we can expect more effectiveness of pinitol treatment in this poor glucose control group.

The difference in the urine D-chiro-inositol Level according to the characteristics of type 2 diabetes mellitus patients

( Hye Won Jang,),( Min Kyeong Kim ),( Kyong Hye Jeong ),( Koon Soon Kim ),( Hyun Jin Kim ),( Young Suk Jo ),( Minho Shong ),( Bon Jeong Ku ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.-

Identification of Gene Expression Signatures in the Chicken Intestinal Intraepithelial Lymphocytes in Response to Herb Additive Supplementations

Won, Kyeong-Hye,Song, Ki-Duk,Park, Jong-Eun,Kim, Duk-Kyung,Na, Chong-Sam Asian Australasian Association of Animal Productio 2016 Animal Bioscience Vol.29 No.10

Anethole and garlic have an immune modulatory effects on avian coccidiosis, and these effects are correlated with gene expression changes in intestinal epithelial lymphocytes (IELs). In this study, we integrated gene expression datasets from two independent experiments and investigated gene expression profile changes by anethole and garlic respectively, and identified gene expression signatures, which are common targets of these herbs as they might be used for the evaluation of the effect of plant herbs on immunity toward avian coccidiosis. We identified 4,382 and 371 genes, which were differentially expressed in IELs of chickens supplemented with garlic and anethole respectively. The gene ontology (GO) term of differentially expressed genes (DEGs) from garlic treatment resulted in the biological processes (BPs) related to proteolysis, e.g., "modification-dependent protein catabolic process", "proteolysis involved in cellular protein catabolic process", "cellular protein catabolic process", "protein catabolic process", and "ubiquitin-dependent protein catabolic process". In GO analysis, one BP term, "Proteolysis", was obtained. Among DEGs, 300 genes were differentially regulated in response to both garlic and anethole, and 234 and 59 genes were either up- or down-regulated in supplementation with both herbs. Pathway analysis resulted in enrichment of the pathways related to digestion such as "Starch and sucrose metabolism" and "Insulin signaling pathway". Taken together, the results obtained in the present study could contribute to the effective development of evaluation system of plant herbs based on molecular signatures related with their immunological functions in chicken IELs.

Comparison of quality characteristics by green bean (Phaseolus vulgaris L.) variety.

Hye Jeong Kwon,Shin Jae Jeon,Won Kyung Lee,Kyeong Won Kim,Ki Jin Park,Jae Hee Won 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10

The quality characteristics of green beans (Phaseolus vulgaris L.) were compared for 5 types including slenderette, blue lake 274, provider, greentop, and greensbeans chaedoo. On May 10, 2021, it was directly sown at the plastic house of the Gangwon-do Agricultural Technology Institute in Chuncheon and harvested from the end of June to the end of July. Harvested green beans were 12.5 to 14.8 cm in length, 8.3 to 9.4 mm in diameter, 5.9 to 8.1 g in weight, and 2.12 to 2.94 kg/㎠ in hardness. For quality analysis, green beans were freeze-dried after harvest and powdered. The proximate composition were analyzed by AOAC method. Moisture 5.89∼7.34%, protein 19.78∼24.05%, lipid 0.70∼1.09%, ash 6.82∼9.35%, carbohydrate 59.71∼64.02%. The product quantity was 1,300kg/10a green beans chaedoo, 1,059kg/10a green top, 990kg/10a slenderette, 494kg/10a provider, 323kg/10a blue lake 274 323kg/10a. The varieties with high yield were Green Beans Chaedoo, Green Top, and Slenderette. It is thought that it is necessary to select a variety of green beans in consideration of cultivation stability, quality, and consumer preference.

콩과 아열대채소 ‘Green beans’ 유전자원별 고랭지 생육 및 수량특성 비교

권혜정(Hye-Jeong Kwon),서현택(Hyun-Taek Seo),박영식(Young-Sik Park),이원경(Won-Kyung Lee),김경원(Kyeong-Won Kim),원재희(Jae-Hee Won) 한국원예학회 2022 한국원예학회 학술발표요지 Vol.2022 No.11

베게너 육아종증 환자에서 발생한 대장염

원혜진 ( Hye Jin Won ),한성훈 ( Seong Hoon Han ),박혜경 ( Hye Kyeong Park ),안효승 ( Hyo Seung Ahn ),임현민 ( Hyun Min Lim ),김정연 ( Jung Yeon Kim ),최원충 ( Won Choong Choi ) 대한류마티스학회 2007 대한류마티스학회지 Vol.14 No.4

Wegener`s granulomatosis is an uncommon disease that is characterized by granulomatous necrotizing vasculitis affecting small vessels. It typically targets the upper and lower respiratory tract and the kidney, but gastrointestinal involvement is rare. A 41-year-old man who has been already diagnosed with Wegener`s granulomatosis by nasal cavity biopsy was admitted with bloody diarrhea and high fever. He had discontinued taking the immunosuppressive medication. His colonoscopic finding revealed colitis and ulcer lesions which biopsies show vasculitis and ill-defined granuloma. Therefore he was treated with systemic steroid and improved dramatically.

관상동맥 조영술을 시행한 환자에서 조영제 신독성 발생에 관한 임상연구

최원 ( Won Choi ),임현민 ( Hyun Min Lim ),원혜진 ( Hye Jin Won ),박혜경 ( Hye Kyeong Park ),이반석 ( Ban Suck Lee ),안효승 ( Hyo Seung Ahn ),주혜원 ( Hye Won Joo ),김상현 ( Sang Hyun Kim ),박원도 ( Won Do Park ) 대한신장학회 2008 Kidney Research and Clinical Practice Vol.27 No.1

대상: 당뇨병과 고혈압 환자의 증가, 노인인구의 증가, 진단 및 치료 기술의 발달로 관상동맥 조영술의 기회가 많아지고 있다. 방사선 조영제 사용의 증가로 인하여 조영제에 의한 급성신부전은 병원에서 발생하는 급성신부전의 3번째 흔한 원인이며 이로 인하여 이환율과 사망률을 증가 시킨다. 조영제에 의한 급성신부전은 정의, 조영제의 종류 및 투여량, 대상 환자, 예방적 처치 등에 따라서 상이한 결과가 보고되었다. 이에 관상동맥 조영술을 시행한 환자에서 조영제에 의한 급성신부전의 발생빈도와 임상양상에 관한 연구를 시작 하였다. 방법: 2004년 1월 1일부터 2005년 12월 31일까지 2년동안 인제대학교 상계백병원에 입원하여 관상동맥 조영술을 시행 받은 555명을 연구 대상으로 하여 환자들의 의무기록의 분석하였다. 조영제에 의한 급성신부전은 일반적으로 방사선조영제에 노출된 후 48-72시간 이내에 혈청 크레아티닌 값이 기저치의 50% 이상 증가하거나 혈청 크레아티닌 절대 값이 0.5 mg/dL 이상 증가하는 경우로 정의 하였다. 관상동맥 조영술시에 급성신부전이 발생한 군과 발생하지 않은 대조군의 연령, 성, 키, 체중, 체질량 지수, 혈압, 당뇨병 유무, 고혈압 유무, 혈압약 종류, 응급 조영술 유무, 심혈관 조영전의 저혈압 유무, 이전의 심혈관 조영술 유무, 3일 이내의 조영제 사용 유무, 심박출량 등의 임상 소견과 헤모글로빈, 헤마토크리트, 단백질, 알부민, 콜레스테롤, 요산, 당, 혈중 요소질소, 혈청 크레아티닌 등을 후향적으로 조사 하였다. 결과: 전체 555명의 환자 중에서 17명에서 조영제에 의한 신독성이 발생하여 3.2%의 발생 빈도를 보였다. 이 환자들의 평균 연령은 66.5±8.9세였으며 남자가 8명 여자가 9명이었다. 조영제에 의한 신독성이 발생은 신기능 저하 (p<0.001), 심부전증 (p=0.004), 수축기 및 이완기 혈압 (p<0.001), 높은 요산치 (p<0.001), 빈혈 (p=0.049) 등에서 유의하게 차이를 보였다. 65세 이상, 혈청 크레아티닌치 1.4 mg/dL 이상의 신기능 저하, 고요산혈증에서 조영제에 의한 신독성이 발생이 의미 있게 높았다. 관상동맥 조영술 전에 존재하는 신기능 저하, 요산의 증가, 심부전증, 수축기 혈압과 이완기 혈압의 증가 등이 조영제에 의한 신독성의 독립적인 위험 인자로 조사되었다. 결론: 신기능 저하환자, 높은 요산치, 빈혈 및 심부전이 동반된 환자에서 조영제에 의한 급성신부전의 발생빈도가 높았다. 신기능 저하환자, 높은 요산치 및 심부전이 동반된 환자에서는 수액 투여와 N-acetylcysteine의 사용 등 조영제에 의한 급성신부전의 예방에 대한 전향적인 연구가 필요 할 것으로 사료된다. Purpose: Contrast media-induced nephropathy (CIN) following coronary angiography is associated with an increased mortality and morbidity. We investigated the incidence of nephrotoxicity, clinical characteristics, laboratory characteristics and risk factors of CIN in patients undergoing coronary angiography. Methods: We retrospectively evaluated the medical records of 555 patients who had undergone coronary angiography at the Sanggye Paik Hospital, from January 2004 to December 2005. We defined CIN as any increase in the creatinine value of more than 0.5 mg/dL or 50% of baseline value. Results: Among 555 patients, CIN developed in 10 of 48 patients (20.8%) with renal insufficiency (serum creatinine≥1.4 mg/dL) and in 7 of 507 patients (1.4%) without renal insufficiency (p<0.001). Decreased renal function, congestive heart failure, higher baseline uric acid, lower baseline albumin and age ≥65 years were the significant predictors of CIN. There were no statistical differences in contrast type and volume according to the development of CIN. Conclusion: Our data supported the assumption that renal insufficiency, congestive heart failure, hyperuricemia and anemia may be the risk factors of developing CIN.

노인의 공적, 사적이전소득이 삶의 만족도, 자존감에 미치는 영향

원경혜(Won, Kyeong-Hye),이상혁(Lee, Sang-Hyeok) 한국산학기술학회 2015 한국산학기술학회논문지 Vol.16 No.6

본 연구는 노인의 공적 이전소득과 사적이전 소득이 노인의 삶의 만족도, 자존감에 어떠한 영향을 미치는가를 이해하 는 데 목적을 두고 있다. 분석방법으로는 빈도분석, T-test, 아노바, 회귀분석을 실시하였다. 연구결과 다음과 같은 점을 논의 하였다. 첫째, 노인의 공적이전소득과 사적이전소득에 따른 삶의 만족도, 자존감이 유의하게 나타났다. 둘째, 사적이전소득 중 자녀로 부터의 보조금과 공적이전소득은 많을수록 삶의 만족도와 자존감이 높게 나타났다. 셋째, 사적이전 소득 중 민간. 개인보조금은 적을수록 자존감이 높게 나타났다. 이와 같은 결과에 근거하여 다음과 같은 제언을 하였다. 노인의 경제적 자립 이 자존감을 높이는 계기가 됨을 알 수 있었다. 따라서 좀 더 실질적이고 구체적인 공적이전체계가 뒷받침되어야 한다. 또한 사적이전소득 중 자녀로 부터의 보조금이 삶의 만족도에 영향을 주므로 가족 간의 지속적인 관심과 유대가 필요하다. The purpose of this study is public and Private transfers in the elderly life satisfaction , self-esteem any influence to understand. Analysis of the frequency analysis, T-test, ANOVA, regression analysis was performed. Study the following points were discussed. First, the elderly public transfer and Private transfers in accordance with life satisfaction, self-esteem was significant. Second, private transfers from children in public transfer income subsidies and the more life satisfaction and self-esteem, respectively. Third, the private sector of private transfers. Individual grants fewer higher self-esteem. Based on these results, the following suggestions were Economic independence of the elderly a chance to increase the self-esteem that was found. Therefore, a more practical and should be supported by specific public transfer system.