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김미영,김영수,신용운,권계숙,조영업,김준미,김선후 대한소화기내시경학회 1996 Clinical Endoscopy Vol.16 No.6
A 38-year-old woman was admitted for evaluation of cyst-like lesion of the pancreas, which was incidentally found on physical check up. She has been well until the lesion was found except epigastric pain. On endoscopic retrograde pancreatogram, pancreatic head portion revealed a 2 x 2 cm sized cystic mass with marginal calcification. There was no definitive communication between pancreatic duct and cyatic mass, but amylase level of cystic content was increased. Surgical excision was performed, Microspically, the cystic wall showed flat lining epithelium with dense fibrosis and dysplastic calcification accompanied by chronic pancreatitis of adjacent pancreatic tissue.
담즙내 Deoxycholate가 Immunoglobulin G가 콜레스테롤 핵화에 미치는 영향
권계숙(Kye Sook Kwon),신용운(Yong Woon shin),김영수(Young Soo Kim),김진주(Jin Ju Kim),조영업(Young Up Cho),김원곤(Won Gon Kim) 대한소화기학회 1996 대한소화기학회지 Vol.28 No.6
N/A Rackground/Aims: Gal]stones are now considered to be the aggregated expression of a metabo]ic disease of liver (lithogenic bi]e), nucleation (a kinetic event), crystallization in gel matrices (stasis) ;md gallbladder dysmotility (increased residence time). To evaluate the role of biliary deoxycholate and Immunoglobulin (Ig) in the cholesterol lithogenesis. 1) Comparing the biliary Ig (IgG, IgA & IgM) concentrations in pati<nts with and without gallstones. 2) Correlating the level of biliary immunoglobulins witb the nucleation time of gallbladder(GB) bile. 3) Comparing the biliary deoxycholate(DCA)/cholate(( A) ratio and nucleation time in patients with & without gallstones. Methods: 12 (3B bile samph.s (6 cholesterol stones, 6 contro]s) were collected by needle aspiration <>f the CiB at the operati<m Hiliary Ig concentrations were measured using Rate-Nephelometry (Kallestad QM300). Biliary t>I]e acicL composition was analyzed using HPLC. Nucleation time was determined hy polarizing niicroscopic observation of cholesterol crystals (daily fc>r 21 days). Results: Hiliary IgG concentration in gallstone group was significantly higher than control group (55.9 I 17.6mg/dL vs 6.9 + 3.3mg/dL, p<0.05) but IgA and IgM concentrations were not different .etween gallstone group a,id control group. Biliary DCA/CA ratio in gallstone group was significantly higher than control group (0.42 + 0.12 vs 0.13 + 0.05, p<0.05). And, nucleation time m gallstone group was significantly shorter than control group (2.8 days vs 2l days, p<0.05). Conclusions: Vatients with cholesterol gallstones have a higher biliary IgG concetration and DC.A/CA ratio. There were I:iverse correlations between nucleation time and IgG concentration and lC!1/CA ratio. J'his study suggests that biliary IgG and DCA may play an important role in the p,thovc.:iesis of cholestero1 ,allstone formation.(Korean J Gastroenterol 1996; 845-852)