직장 카르시노이드 종양에서 Ki-67 발현의 예후적 중요성

홍수민 ( Su Min Hong ),김유선 ( You Sun Kim ),문정섭 ( Jung Seop Moon ),김진남 ( Jin Nam Kim ),오명기 ( Myoung Ki Oh ),권선옥 ( Sun Ok Kwon ),정성연 ( Seong Yeon Jeong ),홍성우 ( Seong Woo Hong ),강윤경 ( Yun Kyung Kang ) 대한소화기학회 2013 대한소화기학회지 Vol.61 No.2

Background/Aims: Rectal carcinoid tumors can be resected with endoscopy, and it is important to assess their prognostic factors. We evaluated the potential of Ki-67 expression as a prognostic factor in rectal carcinoid tumors. Methods: We retrospectively reviewed the medical records of 37 patients with rectal carcinoid tumors who got endoscopic resection from January 2001 to January 2011 at Inje University Seoul Paik Hospital. We analyzed their endoscopic and histologic findings, Ki-67 expression, clinical outcome, and prognosis. Results: The mean age (±SD) of the patients was 56.3±10.7 years, and the male : female ratio was 3.6:1. The mean tumor size was 0.5±0.4 cm, 33 patients showed grade 1 tumors (89.2%) and the average Ki-67 expression was 0.7±1.2%. Thirty five patients underwent endoscopic mucosal resection, and two required endoscopic submucosal dissection. Eight patients had positive margins after resection, but no cases of lymphovascular invasion were identified. The median follow-up duration was 21.4±25.4 months, and no recurrences were observed. Conclusions: In low grade rectal carcinoid tumors which are lack of central depression on colonoscopy, the expression of a molecular marker of malignant potential, Ki-67, was low. Therefore, endoscopic resection seemed to be a safe and effective treatment for these tumors.

中風病辨證診斷標準에 의한 臨床的 硏究

任長信,文祥官,高昌男,權正男,曺基湖,金永錫,裵亨燮,李京燮 경희대학교 1997 慶熙醫學 Vol.13 No.3

월악산 지역의 리기다소나무 조림지에서 간벌후의 갱신 특성

정택상,권기철,김홍은 忠北大學校 農業科學硏究所 2002 農業科學硏究 Vol.19 No.-

The objective of this study was to examine the growth and regeneration patterns of hardwood saplings after thinning of Pinus rigida planted at Mt Worak After thinning of P. rigida, r-selection species such as Rubus crataegifolius B, Lespedeza maximowiczii C, Aralia elata var canescen N., Rubus oldham M and Quercus spp were mainly appeared Regarding to numbers of young trees appearance, Q. mongolica F, Q acutissima C, Q. serrata T and Q variabilis B1 were appeared respectively At the study area after thinning, Q. mongolica F was regenerated by sprouts on the other hands, Q. acutissima C, Q serrata T and Q. variabilis B1 were regenerated by seedlings. The results of this study indicated that Q mongolica F tended to dominate as a natural regenerated species after thinning of the P. rigida. At the humid area, Q serrala T tended to dominate. While, at the dry area, Q. mongolica F. tended to dominate. In the case of Q. variabilis B1, no significant influence was found due to small number of population.

Tabes Dorsalis의 핵자기공명영상 및 전기생리학적 소견

권기한,김성민,권석범,이병철,조광호,주정희 대한신경과학회 1999 대한신경과학회지 Vol.17 No.3

측두하악관절 내장증 환자의 임상증상과 자기공명영상 소견의 비교 연구

권기정 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.2

Purpose : To determine the clinical correlation of magnetic resonance imaging (MRI) findings of temporomandibular joint internal derangements. Materials and Methods : The MR images of 150 TMJs in 75 patients were analyzed. The clinical symptoms were pain in the preauricular area and masticatory muscles and TMJ sounds. Results : There was a statistically significant relationship between the MRI diagnoses of different types of disc displacements and clinical findings of pain, clicking, and crepitus. The risk of TMJ pain was increased when the disc displacement without reduction occurred at the same time in combination with the osteoarthrosis and effusion. Conclusion : Regardless of the results, the data indicate that each of these MR imaging variables may not be regarded as the unique and dominant factor in defining TMJ pain occurrence.

교정치료 전 환자의 측두하악관정에 관한 방사선학적 연구

권기정 大韓口腔顎顔面 放射線學會 2001 Imaging Science in Dentistry Vol.31 No.4

Purpose : To determine whether there is a relationship between abnormal temporomandibular joint radiographic findings and age or gender in a sample of preorthodontic patients. Materials and Methods : Individualized corrected sagittal tomographs of 188 temporomandibular joints in 94 preorthodontic patients, aged 11 to 29 years, were taken and viewed by an observer blinded to clinical records. The study population was divided into 2 aged groups (11-15 years and 16-29 years) for comparative purposes. Temporomandibular joint radiographic findings were classified as normal or abnormal. Results : There was no difference in ratio of abnormal to normal findings between the both aged groups. The frequency of osseous abnormalities was similar with that of abnormalities of condylar position. Abnormalities in CP and JS were most frequent in all aged groups. Conclusion : There is no significant difference between ages or genders for temporomandibular joint radiographic abnormalities. (Korean J Oral Maxillofac Radiol 2001; 31 : 193-7)

방사선 조사선량에 따른 백서 악하선의 caspase-3 발현양상

권기정,최용석,황의환,이상래,고광준 대한구강악안면방사선학회 2006 Imaging Science in Dentistry Vol.37 No.1

Purpose : To investigate the caspase-3 expression in the acinar and ductal cells of rat submandibular glands after the irradiation of various doses. Materials and Methods: The male Sprague-Dawley rats weighing approximately 250 gm were used for this study. The experimental group was irradiated with a single absorbed dose of 2, 5, 10, and 15 Gy on the head and neck region. The rats were sacrificed on the 1st, 3rd, 7th, 14th, 21st, and 28th day after irradiation. The specimens including the submandibular gland were sectioned and observed using histopathological and immunohistochemical methods. Results : The local destruction of the acinar and ductal cells and the karyopyknotic nuclei of the acinar cells were observed in the 2 Gy and 5 Gy irradiation groups later than in the 10 Gy and 15 Gy irradiation groups. And the expression of caspase-3 was prominent only in the ductal cells in the 2 Gy and 5 Gy irradiation groups. Conclusion : This experiment suggests that radiation-induced apoptosis in the ductal cells of rat submandibular glands was induced by a low dose radiation associated with the activation of caspase-3 and radiation-induced necrosis was induced by a high dose radiation. (Korean J Oral Maxillofac Radiol 2006; 36 : 7-15)

디지탈방사선촬영술을 이용한 인접면 치아우식증 진단에 관한 실험적 연구

권기성,황의환,이상래 慶熙大學校 齒科大學 1994 慶熙齒大論文集 Vol.16 No.1

The purposes of this study were clinical comparison and evaluation between digital radiography and conventional radiography for the detection of artificial interproximal caries. Four freshly extracted, unrestored posterior teeth were obtained and canes was simulated by drilling semicircled defect with variable size at the interproximal surface of each tooth. The experiments were performed with IBM-PC/32 bit-DX compatible, video camera(VM-S8200, Hitachi Co., Japan), color monitor(Multisync 3D, NEC, Japan). Sylvia Image Capture Board for the ADC(analog to digital converter) was used, and spatial resolution was 512 x 480 with 256 gray levels. The obtained results were as follows: 1. At the condition of under exposure, the radiographs were superior to the digital images in readability. Also, as the size of the artificial lesion was increased, readability of the radiographs was elevated. 2. The digital images were superior to the radiographs in readability especially under over exsposure. 3. As the exposure time and size of lesion was increased, the gray level of region of interest of the digital image was decreased proportionally. 4. As the F-value of average gray level of region of interest at individual exposure time and size of lesion, gray level of the all lesion sizes was decreased in comparison with that of the normal enamel.

두개의 탐촉자를 사용한 등방성 균일 고체의 초음파 속도 및 두께 동시 측정법

이정기,김영환,권진오 韓國非破壞檢査學會 1999 한국비파괴검사학회지 Vol.19 No.5

시험체의 두께나 초음파 속도를 측정하기 위해서 초음파 펄스-에코법이 널리 사용되고 있다. 초음파 속도를 결정하기 위해서는 초음파 송수신 장치를 포함한 오실로스코우프와 같은 초음파 측정 장치를 사용하여 시험편에서의 초음파 진행 시간을 측정하고, 초음파 진행 거리에 해당하는 시험편의 두께를 버어니어 캘리퍼스 또는 마이크로미터와 같은 길이 측정 도구를 사용하여 측정한다. 그리고 초음파를 이용하여 시험편의 두께를 측정할 때에는 초음파 속도를 알고 있는 대비 시험편으로 기준을 설정하여야 한다. 본 연구에서는, 대비 시험편 없이 재료의 두께와 초음파 속도를 동시에 구하는 방법을 제시하었다. 재질과 두께를 달리한 여러 시험편에서 측정된 초음파 속도와 두께가 기존의 방법에 의해 측정한 값과 잘 일치하였다. Ultrasonic pulse-echo methods measuring the transit time through specimens have been widely used in determination of ultrasonic velocity and thickness of specimens. Usually, to determine the velocity of the ultrasonic, the transit time of the ultrasonic pulse through specimen is measured by using the ultrasonic measuring equipment such as the oscilloscope including ultrasonic pulser/receiver and the thickness of the specimen is measured by using the length measuring instrument such as micrometer or vernier calipers etc., i.e. each parameter is measured by using each measuring method. In the case of the measuring the thickness of a specimen by using the ultrasonics, the ultrasonic equipments, which measure the thickness such as the ultrasonic thickness gauge must by calibrated by using the reference block of which the ultrasonic velocity is known beforehand. In the present work, we proposed a new method for simultaneous measurement of ultrasonic velocity and thickness without reference blocks. Experimental results for several specimens show that proposed method have good agreements with those by traditional ultrasonic method.

영아에 발생한 하마종

정정권,윤규호,전인성,김기엽,김현우,권순욱 大韓顎顔面成形再建外科學會 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.5

The ranula is a form of mucocele which specifically occurs in the floor of the mouth. The ranula is classfied into simple ranula and plunging ranula according to the mechanism of development such as the salivary duct obstruction or the extravasation. Clinically this lesion develops as a slowly enlarging painless, fluctuant mass on one side of the floor of the mouth and the mucosa may have a translucent bluish color. An 8-month-old male infant visited our hospital with the chief complaint of the left submandibular swelling and the mass on the floor of the mouth. We tentatively diagnosed a simple ranula. The marsupialization was performed but the sign and the symptom did not subside, so we took the MRI. By the MRI we diagnosed a plunging ranula and excised the sublingual gland via the intraoral approach. The correct diagnosis is essential for the most effective treatment, which is the excision of the sublingual gland.