한국의 발톱진균증 환자의 삶의 질에 관한 연구

조백기,박종갑,김형옥,김성욱,백승철,김진우,김시용,안규중,전재복,오지원,김낙인,이규석,오칠환,김수남,김상태,손숙자,신용우,김동석,이원우,권경술,서대헌,황규왕,이종석,고재경,강원형,정기양,최응호,김기홍,박석돈,강승주,함정희,명기범,김방순,구상완,김병수,원영호,김한욱,송은섭,정병수,노병인,홍창권,박장규,한지윤,김광중,구대원,김종민,김재홍,유희준,양경미 대한의진균학회 1998 대한의진균학회지 Vol.3 No.2

Background: Onychomycosis, especially toenail onychomycosis has become one of the common fungal infection and has historically been regarded as a cosmetic rather than medical problem by many patients, even by physicians. Recently, however, there are several reports that is a refractory disease which may cause a deleterious effect on patiets quality of life (QOL). Objective: The purpose of this study was to investigate the impact of toenail onychomycosis on QOL in Korea and to assess the chandes of QOL after treatment. Methods: Total 1004 patients with toenail onychomycosis which was confirmed by clinical findings and KOH preparation were were enrolled at 47 dermatologic centers in Korea, and interviewed with standardized QOL questionnaire before and after sytemic antifungal treatment. Responses to the questionnaire were scored by 5-point scale (1∼4) and averaged, and were analyzed for 5 dimensions of emotional impact, social impact, symptorn and functional impact, patients views concerning treatment, and relationship with doctor. Results: 1. Before and after treatment, the most serious impact was emotional dimension showing 1.90 and 1.30 in average score (AS), and social (AS: 1.14 and 0.83) and symptom and functional impact (AS: 1.05 and 0.92) was also affected. 2. In female rather than male, statistically more significant impact on patients QOL was observed in all dimensions. 3. After treatment, 3 of 5 dimensions were improved significantly - emotional dimension (AS : from 1.90 to 1.30), social dimension (AS: from 1.14 to 0.83), patients view concerning treatment (AS: from 1.34 to 1.02). 4. The drgree of patients satisfaction at the therapeutic effect was very high- 62.4% (immediately after treatment) and 65.8% (9 months affer initiation of treatment) of patients answered excellent or good. Conclusion: This study confirms that toenail onychomycosis has significant impact on the overall QOL of patients. Also the effect of antifungal therapy on patients QOL were watisfactory. Therefore, both doctor and patient should pay more attention to the treatment of onychomycosis. [Kor J Med Mycol 3(1): 115∼124]

Lack of Mitochondrial DNA Sequence Divergence between Two Subspecies of the Siberian Weasel from Korea: Mustela sibirica coreanus from the Korean Peninsula and M. s. quelpartis from Jeju Island

Koh, Hung-Sun,Jang, Kyung-Hee,Oh, Jang-Geun,Han, Eui-Dong,Jo, Jae-Eun,Ham, Eui-Jeong,Jeong, Seon-Ki,Lee, Jong-Hyek,Kim, Kwang-Seon,Kweon, Gu-Hee,In, Seong-Teak The Korean Society of Systematic Zoology 2012 Animal Systematics, Evolution and Diversity Vol.28 No.2

The objective of this study was to determine the degree of mitochondrial DNA (mtDNA) divergence between two subspecies of $Mustela$ $sibirica$ from Korea ($M.$ $s.$ $coreanus$ on the Korean Peninsula and ($M.$ $s.$ $quelpartis$ on Jeju Island) and to examine the taxonomic status of ($M.$ $s.$ $quelpartis$. Thus, we obtained complete sequences of mtDNA cytochrome $b$ gene (1,140 bp) from the two subspecies, and these sequences were compared to a corresponding haplotype of ($M.$ $s.$ $coreanus$, downloaded from GenBank. From this analysis, it was observed that the sequences from monogenic ($M.$ $s.$ $quelpartis$ on Jeju Island were identical to the sequences of four ($M.$ $s.$ $coreanus$from four locations across the Korean Peninsula, and that the two subspecies formed a single clade; the average nucleotide distance between the two subspecies was 0.26% (range, 0.00 to 0.53%). We found that the subspecies $quelpartis$ is not genetically distinct from the subspecies $coreanus$, and that this cytochrome $b$ sequencing result does not support the current classification, distinguishing these two subspecies by pelage color. Further systematic analyses using morphometric characters and other DNA markers are necessary to confirm the taxonomic status of ($M.$ $s.$ $quelpartis$.

Comparison of Left Ventricular Hypertrophy, Fibrosis and Dysfunction According to Various Disease Mechanisms such as Hypertension, Diabetes Mellitus and Chronic Renal Failure.

Koh, Yoon-Seok,Jung, Hae-Ok,Park, Mahn-Won,Baek, Joo-Yeoul,Yoon, Sung-Gyu,Kim, Pum-Joon,Ihm, Sang-Hyun,Chang, Kiyuk,Oh, Yong-Seog,Youn, Ho-Joong,Baek, Sang Hong,Chung, Wook-Sung,Seung, Ki-Bae,Kim, Jae Korean Society of Echocardiography 2009 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.17 No.4

<P>Left ventricular hypertrophy (LVH) has been known as an important predictor of prognosis of cardiovascular disease. Carboxy-terminal propeptide of procollagen type I (PIP) is related with myocardial fibrosis. We sought to analyze the differences in the characteristics of LVH, myocardial fibrosis, and LV functions among hypertension (HBP), diabetes mellitus (DM) and chronic renal failure (CRF).</P>

Fatal occupational injuries in Korea, 1993-2007

Ki-Hyun Lee,Jin-Ha Yoon,Sung-Kyung Kim,In-Jung Cho,Sung-Soo Oh,Bong-Suk Cha,Kyung-Suk Lee,Hye-Seon Chae,Sang-Baek Koh 대한직업환경의학회 2011 대한직업환경의학회 학술대회 논문집 Vol.2011 No.11

수은화합물이 마우스 복강대식세포와 EMT-6 세포에 미치는 효과

고대하,염정호,기노석,오경재,권근상,김성엽,김남송 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

Balb/c 마우스의 복강대식세포 및 유선암에서 기원한 EMT-6 세포를 배양하는 조건에 여러농도의 수은을 첨가하여 nitrite와 nitrate 생성의 변화를 관찰한 결과는 다음과 같다. 복강대식세포 및 EMT-6 세포가 생성하는 nitrite와 nitrate 양은 배양시작 12시간째의 생성량에 비해 24시간 후에는 2배, 36시간 후에는 3배의 농도로 측정되어 된다. 이때 nitrite와 nitrate 농도사이에는 매우 높은 상관관계를 나타냈다. 수은첨가에 따라 nitrite 및 nitrate 생성량은 용량의존적 관계로 현저한 감소를 보이며, 24시간 또는 36시간 후의 세포생존률도 역시 수은농도에 비례하여 감소되는데, 복강대식세포의 생존률이 EMT-6 세포의 생존률보다 더욱 큰 폭으로 감소하였다. 이상의 결과로 배양조건에 수은의 첨가로 인하여 nitrite 및 nitrate 생성량이 감소하는 바 수은이 면역세포의 대사과정에 영향을 주어 nitric oxide 생 성능을 억제시키며, 결국 세포성 면역을 저하시키는 것으로 사료된다. The effect of treatment of mercury chloride on the nitrite and nitrate synthesis was observed in peritoneal macrophages from Balb/c mice and EMT-6 cells in vitro. The cells were cultured in Dulbecco's modified Eagle's medium (DMEM) with cytokines. Amounts of nitrite and nitrate in the culture media after 24 and 36 hours of culture were about 2-fold, 3-fold of those measured after 12 hours respectively. There were very close associations between the amounts of nitrite and nitrate measured in the culture media, according to culture time. The survival rate of peritoneal macrophages was significantly decreased by mercury chloride added into the media in dose-dependent manner, however the survivals of EMT-6 cells were not influenced by mercury chloride concentration in media. Nitrite and nitrate syntheses were dose-dependently decreased by mercury chloride added in culture media. These results reported here suggest that the disorder of cell mediated immunity by mercurials could be related to the inhibition of nitric oxide synthesis which seems to be caused by the inhibition of metabolism of cells.

중환실 환자의 임상적 고찰 : 제 2 보:1975. 3. 1 ~ 1982. 2. 28

고신옥,오흥근,백상기,오태숙 대한마취과학회 1983 Korean Journal of Anesthesiology Vol.16 No.1

The ICU at Severance Hopital was opened with 7 beds on October 18, 1968 and expanded to 19 beds on February 2, 1981. From 1970-977, We statistically analyzed 3,072 ICU patients. During the period of years from March 1975 to February 1982, We have analyzed clinically 4,348 ICU patients. The Results were as Follows: 1) During the 7 years the total number of patients was 4,383. ln 1981, 1063 patients were admitted to the ICU: this number being almost twice that of in 1980. 2) During the 7 years, the overall mortality was 15.1%, highest in 1976(30.1%) and lowest in 1979(11.5%). It has decreased annually, 12.4% in 1980, 12.3% in 1981. 3) Total admission days in ICU were 18,148 days, the average patient stay in ICU being 4.17 days. The majority of the patients(81.2%) stayed in ICU less than 5 days. The number of patients staying in ICU more than 6 days increased every year from 14.2% in 1975 to 22% in 1981. 4) About 50% of the patients admitted were under the forties-age group. The number under the teens old group was 19%, this group representing the highest number of patients admitted to the ICU. The highest mortality(18.5%) occurred in the 1 to 10 yearold-age group. 5) The number of patients admitted to the department of internal medicine was 1,574 cases, which was the highest among all departments. The mortality rate was highest in the neurosurgery department(41.9%). In 1981, the number of ICU patients in cardiac surgery and pediatrics was increased three time compared with that of 1975. 6) All ICU patients have been divided into two categories, operative and non-operative cases. The operative cases were 2,150, non-operative cases 2,198 cases. Mortality rate was 10% in operative cases, 20% in non-operative cases. 7) Case expired from march 1981 to February 1982: The number of expired parients including those with a poor prognosis was 183 cases. The number of patients that expired under the 10-year-age group was the highest, 78 cases. The cases that expired in internal medicine and pediatrics were 63 and 58 cases respectively. The causes of death were due to damage of central nervous system, cardiovascular system, respiratory system in that order. From the above results, it can be concluded that in spite of an increase in patients, the mortality rate has decreased annually.

Effect of sec-O-glucosylhamaudol on mechanical allodynia in a rat model of postoperative pain

Koh, Gi-Ho,Song, Hyun,Kim, Sang Hun,Yoon, Myung Ha,Lim, Kyung Joon,Oh, Seon-Hee,Jung, Ki Tae The Korean Pain Society 2019 The Korean Journal of Pain Vol.32 No.2

Background: This study was performed in order to examine the effect of intrathecal sec-O-glucosylhamaudol (SOG), an extract from the root of the Peucedanum japonicum Thunb., on incisional pain in a rat model. Methods: The intrathecal catheter was inserted in male Sprague-Dawley rats (n = 55). The postoperative pain model was made and paw withdrawal thresholds (PWTs) were evaluated. Rats were randomly treated with a vehicle (70% dimethyl sulfoxide) and SOG ($10{\mu}g$, $30{\mu}g$, $100{\mu}g$, and $300{\mu}g$) intrathecally, and PWT was observed for four hours. Dose-responsiveness and ED50 values were calculated. Naloxone was administered 10 min prior to treatment of SOG $300{\mu}g$ in order to assess the involvement of SOG with an opioid receptor. The protein levels of the ${\delta}$-opioid receptor, ${\kappa}$-opioid receptor, and ${\mu}$-opioid receptor (MOR) were analyzed by Western blotting of the spinal cord. Results: Intrathecal SOG significantly increased PWT in a dose-dependent manner. Maximum effects were achieved at a dose of $300{\mu}g$ at 60 min after SOG administration, and the maximal possible effect was 85.35% at that time. The medial effective dose of intrathecal SOG was $191.3{\mu}g$ (95% confidence interval, 102.3-357.8). The antinociceptive effects of SOG ($300{\mu}g$) were significantly reverted until 60 min by naloxone. The protein levels of MOR were decreased by administration of SOG. Conclusions: Intrathecal SOG showed a significant antinociceptive effect on the postoperative pain model and reverted by naloxone. The expression of MOR were changed by SOG. The effects of SOG seem to involve the MOR.

신속 조형 모형을 이용한 악 교정 수술의 정확성 예측에 관한 연구

고세욱,오승환,민승기 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.4

Rapid Prototyping(RP) models in facial asymmetry patients are used mainly for assisting diagnosis, planning treatment. It provides an easy way to measure discrepancies due to asymmetry on the model directly, and opportunity to study the bony structures of the patient and to manipulate them as required before the actual surgery. The purpose of this study was to evaluate the surgical prediction of orthognathic surgery using RP model in facial asymmetry patients. In 26 patients with facial asymmetry. We compared patient cephalogram and skull posterior-anterior view with RP model after surgery. Surfery methods were sagittal split ramus osteotomy(SSRO), intraoral vertical ramus osteotomy(IVRO), inverted L osteotomy, Le FortⅠosteotomy. Difference of two groups was analyzed and compared statistically. The results were no difference between patients and RP model is useful in selection of surgery method and prediction of surgery. In facial asymmetry, we knew that IVRO in mandibular surgery is better method than others.

Treatment results of anterior choroidal artery aneurysms treated mostly with coil embolization: A single-center experience

Hyun Ki Roh,Eun-Oh Jeong,Kyung Hwan Kim,Hee-Won Jeong,Han-Joo Lee,Seung-Won Choi,Seon-Hwan Kim,Hyeon-Song Koh,Jin-Young Youm,Hyon-Jo Kwon 대한뇌혈관외과학회 2022 Journal of Cerebrovascular and Endovascular Neuros Vol.24 No.4

Background: Anterior choroidal artery (AchA) aneurysms are usually small in diameter because of the size of the involved artery and are often wide-necked. Coil embolization of AchA aneurysm is thus challenging because of serious risks, such as thromboembolic occlusion of artery and perforation of aneurysm dome. Therefore, aneurysmal neck clipping remains widely performed despite a recent increase in the use of coil embolization for aneurysm treatment. We report the treatment results of AchA aneurysms mostly (92.3%) treated with coil embolization at our institute. Methods: The database and medical records of patients who underwent coil embolization for AchA aneurysms were retrospectively analyzed. The clinical and imaging results and procedure-related complications were investigated after coil embolization performed between January 2006 and March 2022 at our institute. Results: In total, 96 AchA aneurysms comprising 65 unruptured and 31 ruptured aneurysms, including only 1 ruptured aneurysm (1.0%) re-embolized at postoperative day 192 because of coil compaction, were evaluated. After the initial coil embolization, complete occlusion was attained in 41, residual neck in 45, and residual aneurysm in 10 patients. Follow-up radiological studies after 6–174 months were performed for 80 aneurysms. Complete occlusion was noted in 57 patients, residual neck in 22, and residual aneurysm in 1. The dysarthria experienced by one (1.0%) patient was the only symptomatic procedure-related complication. After coil embolization, neither delayed new rupture nor re-rupture was observed. Conclusions: The results of this study demonstrate that coil embolization is a safe and effective treatment option for patients with AchA aneurysms.

봄배추의 물 절약형 관개기준 설정

엄기철(Ki-Cheol Eom),정필균(Pil-Kyun Jung),고문환(Mun-Hwan Koh),김상희(Sang-Hee Kim),유성녕(Sung-Yung Yoo),박소현(So-Hyun Park),허승오(Seung-Oh Hur),하상건(Sang-Keun Ha) 한국토양비료학회 2010 한국토양비료학회지 Vol.43 No.6

1. 우리나라 전국을 45개 지역으로 구분하여 최근 30년간의 기상자료 분석에 의한 5월~6월의 일평균 PET는 2.99 mm day<SUP>-1</SUP> 이었다. 2. 토성별 유효토양수분보유량 (AWS)은 사양토 16.0%~미사질양토 24.7% 범위이었다. 3. 봄배추의 45개 지역별, 3개 토성 및 5개 순별, 총 675경우의 재배여건에 적합한 물 절약형 적정 관개간격 및 1회 관개량을 산정하였다. Water management is the most important and difficult problems in crop cultivation. The farmers are doing irrigation, those when to irrigate and how much to irrigate, depending on their experiences. The irrigation manual as water saving is possible, those irrigation interval and amount of irrigation, are developed based on the lysimeter experiments carried out by the RDA for 11 years about potential evapotranspiration, crop coefficient. The manual can be used with easy to the farmer without soil sampling and any kinds of sensors measuring soil water status.