溫經湯에 關한 文獻的 考察

김연도,김철원,유심근,박병렬 한국한의학연구원 1996 한국한의학연구원논문집 Vol.2 No.1

Through the study of successive literatures form the Han-dynasty(漢代) when 《Keumjweyeuliak(금궤요략)》 was written to modern age, we inspected many types of Onkyungtang(溫經湯) and prescriptions including the term of ' Onkyung(溫經)' or Chokyung(調經)', and look into their composition and symptoms respond to administration of this medicine. The results of this study were as follows; 1. The medicine which makes up Onkyungtang was 38 kinds from the Han-dynasty to the Chung-dynasty(淸代), and up to the present it summed into 43 kinds. 2. Onkyungtang which was composed of different kinds of medicine was 10 types from the Han-dynasty to the Chung-dynasty and added 11 types in modern days. Therefore it sumed up into 21 types. 3. No Onkyungtang is seen more common than that of the same composition as in 《Keumjweyeuliak》 in successive literature. The next is the same constituents as in 《Buinyangbangdaejeon(婦人良方大全)》. Others were rare. 4. Onkyungtang in《Keumjweyeuliak》was used to treat cold syndrome of the penetration and conception vessles or uterus of deficiency type and that in 《Buinyangbangdaejeun》was for cold syndrome of the penetration and conception vessels or uterus of excess type. 5. Other names of Onkyungtang in《Keumjweyeuliak》were Daeonkyungtang(大溫經湯), Chokyungsan(調經散), Chokyungtang(調經湯), Chunkeumchokyungtang(千金調經湯), Chunkeumchokyungsan(千金調經散) and Soonkyungtang(小溫經湯). And the prescription in the same constitution was also called Chungkyungonkyungtang(仲景溫經湯), Keumkweonkyungtang(금궤온경탕) and Sibbionkunghwan(十二溫經丸). 6. Onkyungtang in 《Buinyangbangdaejeon》was called Soonkyungtang(小溫經湯) and the very prescription was also called in the name of Yangbangonkyungtang(良方溫經湯), Jinmionkyungtang(指迷溫經湯), Kungkwiinkyungtang and Jinssionkyungtang(陳氏溫經湯).

난소 및 난소 종양 염전의 초음파 소견

오연희,이현경,이원재,이성우,박수성,윤혜원,임문환,심재철,김용탁,김성숙,김정란 동국대학교 경주대학 1993 東國論集 Vol.12 No.-

Acute torsion of the ovary and ovarian mass is a recognized surgical emergency, but rarely has the diagnosis been made preoperatively on the basis of imaging studies. The sonographic findings in 14 cases of surgically proven torsion of the ovary and ovarian mass are described. Mostly cystic ovarian mass, engorged vessel, dilated uterine tube, beak-like echo(torsion site), smooth mass wall thickening an free-fluid collection in cul-de-sac are described. More significant in terms of specificity were the demonstration in 6 cases(42.9%) of the smooth mass wall thickening and in 8 cases(57.1%) of a free fluid in the cul-de-sac. We report the sonographic findings of ovary and ovarian mass torsion that may suggest the preoperative diagnosis of this condition.

간경변으로 입원한 환자 33례에 대한 분석

최서형,심민,김태수,민지연,최영규,Choi, Seo-Hyoung,Sim, Min,Kim, Tae-Soo,Min, Ji-Yeon,Choi, Young-Gyoo 대한한방내과학회 2005 大韓韓方內科學會誌 Vol.26 No.4

Objective : Liver cirrhosis is a disease of the liver in which normal cells are replated by scar tissue. Chronic liver disease and liver cirrhosis are the foutth ranked causes of death in Korea. However, clinical data on liver cirrhosis is not accumulated in oriental medicine. Therefore, clinical characteristics of 33 liver patients admitted to Hana Oriental Hospital from May 2004 to May 2005 were studied. Methods : Clinical characteristics of liver cirrhosis, such sex, age, causes, Child-Pugh class, chief complain, abdomen ultrasonography, disease duration, past history, blood test and urinalysis were reviewed. Results : The results of this study were as follows: 1 The distribution of sex and age in our study is similar to already reported statistics. 2. Hepatitis B and alcohol are the major factors to cause the liver cirrhosis. Diabetes and hypertention contribute more to cause than they have in previous histories. 3. Major symptoms are following: fatigue 87.9%, ascites 84.8%, jaundice 78.8%, leg edema 72.7%, dyspepsia 45.5%. 4. Most liver cirrhosis patients have pancytopenia. Standard Deviation accentuates the big differences between total bilirubin and serum amonia. 5. In urinalysis, Urobilinogen 19 patients (57.6%), bilirubin 12 patients (36.4%), blood 15 patients (45.5%) are positive. 11 cases of 15 in blood positive results scored $3{\sim}4+$. Contusions : In oriental medicine, it will be necessary to research and develop oriental medical therapies for liver disease including liver cirrhosis.

저장 기간에 따른 사과의 품질특성과 항산화 활성 변화

진소연,심기현,이은지,구혜진,김명현,한영실,박정수,김용훈,Jin, So-Yeon,Sim, Ki Hyeon,Lee, Eun Ji,Gu, Hae Jin,Kim, Myung Hyun,Han, Young Sil,Park, Jung Su,Kim, Yong-Hoon 한국식품영양학회 2014 韓國食品營養學會誌 Vol.27 No.6

$20^{\circ}C$에서 15일 동안 저장기간별 사과의 변화를 살펴본 결과는 다음과 같다. 사과의 중량과 수분은 저장기간 경과에 따라 점차적으로 감소하는 결과를 보였으며, 사과의 저장 중 가용성 고형물 함량은 저장 4일차까지 최고치로 증가하였다가 서서히 낮아지는 경향을 나타냈다. 사과의 저장 중 유기산 산도는 저장 5일차에 급격히 감소하다가 완만히 감소하였으며, pH는 저장기간에 따라 완만히 증가하는 경향을 나타내었다. 저장 중 사과 껍질의 색상을 측정한 결과, L값은 저장기간에 따라 서서히 증가하였으며, a값은 저장 3일까지 감소하였고, 저장 5일에 증가되었다가 그 이후 점진적으로 감소하였다. b값은 저장 6일에 최저치를 보인 후 서서히 증가하는 경향을 보였다. 사과의 조직감을 측정한 결과, 저장기간이 증가됨에 따라 사과의 경도는 전반적으로 감소하였다. 저장 기간에 따른 사과의 총 페놀과 총 플라보노이드 함량을 측정한 결과, 총 페놀 함량은 저장 기간이 길어질수록 감소하는 경향이 나타났으며, 저장 3일차에서 저장 4일차에 큰 폭 감소하였다. 총 플라보노이드의 변화 결과, 1일차에 비교적 크게 감소하였고, 실험 7일차에서 8일차 사이에 급격히 감소하였다. 저장 기간에 따른 사과의 DPPH 전자공여능 측정결과, 저장기간이 증가할수록 DPPH 전자공여능은 감소하였으며, Vit. C 함량의 경우 저장 기간이 길어질수록 감소하였는데, 특히 저장 4일차에 비교적 크게 감소하였다. 사과의 관능평가 수행 결과, 저장기간이 경과함에 따라 외관의 좋은 정도는 0일차에 6.75에서 15일차 2.83으로 크게 감소하였으며, 신맛의 좋은 정도는 저장 기간에 따라 유의적인 차이를 보이지 않았으나, 전반적으로 감소하는 경향이었다. 단맛의 좋은 정도와 아삭함의 좋은 정도에서는 0일차에 각 6.25, 5.33으로 가장 높았으며, 15일차에 각 3.92, 2.83으로 유의적으로 감소하였다. 종합적인 기호도에서는 7일차와 8일차 사이에 5.00에서 3.50으로 비교적 큰 폭 감소하였으며, 15일차에 2.00으로 저장 기간에 지남에 따라 유의적으로 감소하였다. 이상의 실험결과, 사과 저장 시 3~4일차에 유의적인 차이를 보였으며, 저장 8일 이후에는 모든 항목에 있어 측정감이 크게 변화하는 경향을 나타내었다. 따라서 $0{\sim}1^{\circ}C$에서 장기 저장한 사과를 $20^{\circ}C$ 전후에서 저장 및 판매할 경우, 최고의 품질을 위해서는 3일 내에 판매할 것을 권장하며, 8일 이내에 재고를 소진할 수 있도록 유통 기간을 조정하는 것이 바람직할 것으로 사료된다. This study was performed in order to compare the changes in Korean apples' qualities and antioxidant activity when stored at room temperature, $20^{\circ}C$, for fifteen days. The results showed that the weight, moisture content, soluble solid content, acidity, and hardness levels decreased as the storage period increased. However, pH and color value L increased as the storage period increased. Total phenol contents, total flavonoids contents, DPPH free radical scavenging activity, and vit. C contents of apples significantly decreased with increased storage period. Sensory parameters, such as appearance, sweetness, sourness, crunchiness, and overall acceptability of apples, also decreased as the storage period increased. Based on these results, if, the apple are being stored around $20^{\circ}C$, then, to have the highest quality, the apples should be sold within three days, We also suggested that it is desirable not to store the apples fore more than eight days.

A Sensitive and Rapid LC-MS/MS Method for Determination of Berberine in Human Plasma

Kim, Jae Hee,Mai, Xuan-Lan,Kim, Kyu Yeon,Sim, Min-Seok,Lee, So-Yeon,Seo, Hee-Won,Lee, Gunhee,Kim, Dae-Jung,Kim, Kyeong Ho Korean Society for Mass Spectrometry 2019 Mass spectrometry letters Vol.10 No.2

Coptidis Rhizoma (CR) has been used widely in traditional medicine to treat common diseases. This study aimed to develop a high-sensitivity liquid chromatography-tandem mass (LC-MS) spectrometry method for the evaluation of the pharmacokinetics of a new natural product that contain CR extract with the main bioactive compound, berberine, at trace concentrations. Human plasma samples were pretreated with methanol by a protein precipitation method. Berberine was analyzed on a Kinetex C18 column ($2.1mm{\times}50mm$, $100{\AA}$, $1.7{\mu}m$) using a mobile phase of 10 mM ammonium formate/0.1% formic acid in water (A) and acetonitrile (B) (50:50, v/v) with a flow rate of 0.25 mL/min. The analyte was detected by using electrospray ionization in positive mode with multiple reaction monitoring (MRM). The method was sensitive, with a lower limit of quantification of 1 pg/mL, which has not been previously obtained. The method was validated (over the range of 1-50 pg/mL) and applied successfully for the pharmacokinetic study of human plasma samples.

Epidural Steroid Injection in Korean Pain Physicians: A National Survey

Kim, Eun Jung,Moon, Jee Youn,Park, Keun Suk,Yoo, Da Hye,Kim, Yong Chul,Sim, Woo Seog,Lee, Chul Joong,Shin, Hwa Yong,Kim, Jae Hun,Kim, Yeon Dong,Lee, Se Jin The Korean Pain Society 2014 The Korean Journal of Pain Vol.27 No.1

Background: Epidural steroid injection (ESI) is one of the most common procedures for patients presenting low back pain and radiculopathy. However, there is no clear consensus on what constitutes appropriate steroid use for ESIs. To investigate optimal steroid injection methods for ESIs, surveys were sent to all academic pain centers and selected private practices in Korea via e-mail. Methods: Among 173 pain centers which requested the public health insurance reimbursements for their ESIs and were enrolled in the Korean Pain Society, 122 completed questionnaires were returned, for a rate of 70.5%; also returned were surveys from 39 academic programs and 85 private practices with response rates of 83.0% and 65.9%, respectively. Results: More than half (55%) of Korean pain physicians used dexamethasone for ESIs. The minimum interval of subsequent ESIs at the academic institutions (3.1 weeks) and the private practices (2.1 weeks) were statistically different (P = 0.01). Conclusions: Although there was a wide range of variation, there were no significant differences between the academic institutions and the private practices in terms of the types and single doses of steroids for ESIs, the annual dose of steroids, or the limitations of doses in the event of diabetes, with the exception of the minimum interval before the subsequent ESI.

Freshness change of squid (Todarodes pacificus) according to storage period and temperature

Yeon-Ju Sim,Du-Min Jo,So-Yeon Noh,Ye-Bin Jang,Mi-Ru Song,Young-Mog Kim 한국수산과학회 양식분과 2023 한국수산과학회 양식분과 학술대회 Vol.2023 No.6

FIRST ATLAS DOMESTIC STANDARD PROBLEM (DSP-01) FOR THE CODE ASSESSMENT

Kim, Yeon-Sik,Choi, Ki-Yong,Kang, Kyoung-Ho,Park, Hyun-Sik,Cho, Seok,Baek, Won-Pil,Kim, Kyung-Doo,Sim, Suk-K.,Lee, Eo-Hwak,Kim, Se-Yun,Kim, Joo-Sung,Choi, Tong-Soo,Kim, Cheol-Woo,Lee, Suk-Ho,Lee, Sang Korean Nuclear Society 2011 Nuclear Engineering and Technology Vol.43 No.1

KAERI has been operating an integral effect test facility, ATLAS (Advanced Thermal-Hydraulic Test Loop for Accident Simulation), for accident simulations of advanced PWRs. Regarding integral effect tests, a database for major design basis accidents has been accumulated and a Domestic Standard Problem (DSP) exercise using the ATLAS has been proposed and successfully performed. The ATLAS DSP aims at the effective utilization of an integral effect database obtained from the ATLAS, the establishment of a cooperative framework in the domestic nuclear industry, better understanding of thermal hydraulic phenomena, and an investigation of the potential limitations of the existing best-estimate safety analysis codes. For the first ATLAS DSP exercise (DSP-01), integral effect test data for a 100% DVI line break accident of the APR1400 was selected by considering its technical importance and by incorporating comments from participants. Twelve domestic organizations joined in this DSP-01 exercise. Finally, ten of these organizations submitted their calculation results. This ATLAS DSP-01 exercise progressed as an open calculation; the integral effect test data was delivered to the participants prior to the code calculations. The MARS-KS was favored by most participants but the RELAP5/MOD3.3 code was also used by a few participants. This paper presents all the information of the DSP-01 exercise as well as the comparison results between the calculations and the test data. Lessons learned from the first DSP-01 are presented and recommendations for code users as well as for developers are suggested.

레지오넬라 폐렴의 진단용 바이오마커의 발굴 : A/J 마우스 감염 모델에서 Legionella pneumophila의 독력 유전자들의 발현양상 분석

김승민,심희선,김희남,심호기,윤영경,김정연,박윤선,박대원,손장욱,김민자 대한감염학회 2010 감염과 화학요법 Vol.42 No.1

Background: Legionella pneumophila is the causative agent of Legionnaires’ disease, a severe form of pneumonia. After L. pneumophila is inhaled through contaminated aerosols, it is phagocytized by alveolar macrophages, multiplies in a specialized phagosome approximately 10 h postinfection, and eventually leads to the death of host cells. Currently available diagnostic tests for Legionella pneumonia have some limitations. This study was conducted to find diagnostic biomarkers for Legionella pneumonia using virulence gene expression profiling in a murine experimental model. Materials and Methods: A/J mice were intranasally inoculated with L. pneumophila serogroup 1, and lungs were harvested 4, 8, 24, and 48 h postinfection. The strain grown in buffered yeast extract broth was used as reference samples. Cy-dye labeled cDNA samples were prepared with total RNA from lungs or broth culture, and hybridized on the oligo-microarray slide containing 2,895 genes of L. pneumophila serogroup 1. Virulence gene expression patterns were analyzed using a MIDAS software from TIGR (www.tigr.org). Results: Among a total of 332 virulence genes examined, 17 genes including sidA, lepB, the genes related to flagella assembly (fliR and fliP), LPS lipid A biosynthesis, and the enhanced entry protein EnhA were up-regulated at all four time points. We further confirmed by quantitative real-time reverse transcription PCR that the expression of fliP gene was highly expressed in lung tissue as well as in bronchoalveolar lavage fluids from the mouse infected with L. pneumophila serogroup 1. Conclusions: Through gene expression analysis of L. pneumophila in a mouse model, several candidate biomarkers for diagnosing Legionnaires’ disease could be identified.

Feasibility Study of the Decay Heat Removal Capability Using the Concept of a Thermosyphon in the Liquid Metal Reactor

Kim, Yeon-Sik,Sim, Yoon-Sub,Kim, Eui-Kwang The Korean Society for Energy 2001 에너지공학 Vol.10 No.4

A new design concept for a decay heat removal system in a liquid metal reactor is proposed. The new design utilizes a thermosyphon to enhance the heat removal capacity and its heat transfer characteristics are analyzed against the current PSDRS (Passive Safety Decay heat Removal System) in the KAL IMER (Korea Advanced LIquid MEtal Reactor) design. The preliminary analysis results show that the new design with a thermosyphon yields substantial increase of 20∼40% in the decay heat removal capacity compared to the current design that do not have the thermosyphon. The new design reduces the temperature rise in the cooling air of the system and helps the surrounding structure in maintaining its mechanical integrity for long term operation at an accident. Also the analysis revealed the characteristics of the interactions among various heat transfer modes in the new design.