Water-soluble Genistin Glycoside Isoflavones Upregulate Antioxidant Metallothionein Expression and Scavenge Free Radicals

Chung, Mi-Ja,Kang, Ah-Young,Jun, Hee-Jin,Kim Sang-Yeon,Moon, Tae-Hwa,Park, Kwan-Hwa,Lee, Sung-Joon 생명자원연구 2005 생명자원연구 Vol.13 No.-

16주간의 자전춤 참여가 중년비만고혈압여성의 관상동맥위험인자에 미치는 영향

곽정자(Kwak Jung-Ja),김종경(Kim Jong-Kyung),최현민(Choi Hyun-Min),노호성(Nho Ho-Sung) 한국체육과학회 2008 한국체육과학회지 Vol.17 No.2

It is generally known that cardiovascular and metabolic diseases such as hypertension, diabetes, hyperlipidemia increase morbidity and mortality in postmenopausal women. This study investigated the effects of Jajun-Dance to coronary heart disease of middle age women with hypertension. Thirteen sedentary women (55.8±5.2 yrs) were recruited for this study, and completed 16 weeks of Jajun-Dance program. All subjects were diagnosed as essential hypertension patients. Blood-sugar level (FBG), total cholesterol (TC), triglyceride (TG), systolic blood pressure (SBP), diastolic blood pressure (DBP) and visceral fat area (VFA) were measured. The Jajun-Dance program included 10 minutes warm up (exercise for flexibility), 40 minutes Jajun-Dance, and 10 minutes cool down. The subjects participated in Jajun-Dance program three times a week. Exercise was maintained at exercise intensity corresponding to rating of perceived exertion (RPE) 13-15. The results showed that FBG, SBP, and DBP (6.0 ㎜Hg) were significantly decreased after Jajun-Dance program. TG and VFA tended to decrease, but there were no significant differences. This study suggests that hypertensive middle-aged women could modify coronary risk factors with regular exercise, and that the aerobic Jajun-Dance program could effectively reduce high blood pressure.

간호대학생의 영적안녕에 관한 연구

강은실(Kang Eun-Sil),김숙자(Kim Sook-Ja),강성년(Kang Sung-Nyun),최성은(Choi Sung-Eun) 고신대학교 전인간호과학연구소 2008 전인간호과학학술지 Vol.3 No.-

The purpose of this study was to describe the spiritual well-being of nursing students to provide a basic data for the development the curriculum of Spiritual Nursing Care in nursing collages. The subjects for this study were consist of 58 nursing students in K University of Pusan city in Korea. All of them were educated about Spiritual Nursing Care for 100 minutes in a week, during totally 8 weeks in one semester. The data were collected during 7days from July 11 to July 18,2004 by using structured questionnaire method. The measurement of the spiritual well-being was performed with 6 points-index which is composed of 21 items and is modified by Sang-Soon Choi(1990)from Palau tzian & Ellison(1983) s. Its high score means that the degree of spiritual well-being of the subject is high. The data were analyzed by using the SPSS WIN 10.1 program according to the purpose of this study. The general characteristics of the subjects were analyzed by calculating the real quantity and the percentage, and the spiritual well-being scores were identified through calculating the mean value of individual domain. The significant difference of the general characteristics with the spiritual well-being was analyzed by t-test and ANOVA, Scheffe s test. The results of this study were as follow; 1.The spiritual well-being of the subjects The average value for the spiritual well-being of the subjects was 97.78(SD=±10.53) among the possible ranges of 21-126. The mean value of all items was 4.66(SD=±0.502) and high relatively. 2. The spiritual well-being according to general characteristics of subjects The analysis of the spiritual well-being according to general characteristics of the subjects showed statistically significant difference on the degree of life satisfaction in faith(F=4.327, P= .004),the degree of recognition about God s initiation in their daily life(F=3.933, P= .013),the degree of satisfaction about Nursing as their major(F=6.608, P= .000), their assurance of salvation(t=4.557,P= .037). among the personal religious actions, praising(F=3.32,p= .017), The group of nursing students responded that they were satisfied in their faith life, always God has the initiative in their daily lives personally, they were satisfied about Nursing as their major very much, and they have their assurance of salvation showed the highest degree of the spiritual well-being than any other group. In conclusion, in this study we observed that the spiritual well-being of nursing students was high relatively. The general characteristics of subjects were related to the spiritual well-being of them were the degree of satisfaction in their faith lives,their recognition about God s initiation in their daily life, their satisfaction about Nursing as their major, among the personal religious actions, regular praising and their assurance of salvation. Therefore this study s results can be used for developing a spiritual nursing education and program to strengthen nursing student s spirituality to practice in spiritual nursing care.

수령독재 하에서 권력과 이권을 둘러싼 갈등 동학 그리고 장성택 숙청

박형중 ( Hyeong Jung Park ),최대석 ( Dae Seok Choe ),김학성 ( Hank Sung Kim ),박영자 ( Young Ja Park ),장인숙 ( In Suk Jang ) 북한연구학회 2014 北韓硏究學會報 Vol.18 No.1

수령독재 하에서는 수령 지위를 차지하고자 하는 권력 투쟁은 존재하지 않는다. 그러나 수평적으로 주요 기관과 엘리트 개인의 권력과 이권의 지분을 확대하기 위한 경쟁이 존재한다. 이러한 경쟁은 수령에 대한 ‘충성경쟁’이라는 외피를 갖는다. 권력 세습 기간 동안 이러한 경쟁이 현저히 증가한다. 권력 세습은 수령독재가 기반하는 통치연합을 재편성하는 과정이기 때문이다. 김정일에서 김정은으로의 권력 세습 과정에서 기관과 엘리트 사이에 권력 및 이권 관련경쟁에서 두 가지가 두드러지게 나타났다. 그 하나는 권력 세습 과정에서의 주도적 세력이 되고자 하는 경쟁 즉 후견권을 둘러싼 경쟁이다. 그 다른 하나는 기관별로 권력과 이권의 지분을 확대하기 위한 경쟁이다. 장성택은 이 두 가지 경쟁에서 모두 주역이었다. 그의 숙청도 이와 관련되어 있었다. Under the Suryong dictatorship, by definition, there is no political completion for Suryong`s status. There are, however, horizontal competitions to expand power and interest carried out by major power organizations and elites. Apparently they are loyalty competition devoted to the Suryong. During the power succession, as the ruling coalition is reconstructed, they intensify themselves. Two features have been pronounced during the hereditary succession from Kim Jong-il to Kim Jong-un in regard to competition for power and interest among power organizations and elites: the one is the competition for regency, i.e. to advance oneself as the dominant force in the promotion of the power succession; the other is the competition for increasing share of power and interest by power organizations and elites. Jang Sung-taek has stood in the center of these two competitions and he was purge thereof.

Defect Estimation of a Crack in Underground Pipelines by CMFL type NDT System

Kim, Hui Min,Yoo, Hui Ryong,Cho, Sung Ho,Kim, Dong Kyu,Koo, Sung Ja,Park, Gwan Soo Journal of International Conference on Electrical 2013 Journal of international Conference on Electrical Vol.2 No.4

A defect which is axially oriented with small size is hard to detect in conventional system. CMFL(Cricumferential Magnetic Flus Leakage) type PIG(Pipelines Inspection Gauge) in the NDT(Nondestructive Testing), is operated to detect this defect called axially oriented cracks in the pipe. It is necessary to decompose the size and shapes of cracks for the manintenance of underground pipelines. This article is focused on the decomposing method of the size and shape of the axially oriented cracks by using inspection signal data for defect.

Treatment outcomes of neoadjuvant concurrent chemoradiotherapy followed by esophagectomy for patients with esophageal cancer

Kim, Yong-Hyub,Song, Sang-Yun,Shim, Hyun-Jeong,Chung, Woong-Ki,Ahn, Sung-Ja,Yoon, Mee Sun,Jeong, Jae-Uk,Song, Ju-Young,Nam, Taek-Keun The Korean Society for Radiation Oncology 2015 Radiation Oncology Journal Vol.33 No.1

Purpose: To evaluate treatment outcomes and determine prognostic factors in patients with esophageal cancer treated with esophagectomy after neoadjuvant chemoradiotherapy (NCRT) Materials and Methods: We retrospectively evaluated 39 patients with esophageal cancer who underwent concurrent chemoradiotherapy followed by esophagectomy between 2002 and 2012. Initial clinical stages of patients were stage IB in 1 patient (2.6%), stage II in 5 patients (12.9%), and stage III in 33 patients (84.6%). Results: The median age of all the patients was 62 years, and the median follow-up period was 17 months. The 3-year overall survival (OS) rate was 33.6% in all the patients. The 3-year locoregional recurrence-free survival (LRFS) rate was 33.7%. In multivariate analysis with covariates of age, the Eastern Cooperative Oncology Group performance status, hypertension, diabetes mellitus, tumor length, clinical response, clinical stage, pathological response, pathological stage, lymphovascular invasion, surgical type, and radiotherapy to surgery interval, only pathological stage was an independent significant prognostic factor affecting both OS and LRFS. The complications in postoperative day 90 were pneumonia in 9 patients, anastomotic site leakage in 3 patients, and anastomotic site stricture in 2 patients. Postoperative 30-day mortality rate was 10.3% (4/39); the cause of death among these 4 patients was respiratory failure in 3 patients and myocardial infarction in one patient. Conclusion: Only pathological stage was an independent prognostic factor for both OS and LRFS in patients with esophageal cancer treated with esophagectomy after NCRT. We could confirm the significant role of NCRT in downstaging the initial tumor bulk and thus resulting in better survival of patients who gained earlier pathological stage after NCRT.

Feasibility of Extracorporeal Life Support for Out-of-Hospital Cardiac Arrest Patients who are Unresponsive to Conventional Cardiopulmonary Resuscitation

Sung Woo Moon,이성우,신재승,Jae Ho Jung,Won Jae Jung,Kwang Ja Kim,홍윤식,Jan Kurt Horn 대한응급의학회 2009 大韓應急醫學會誌 Vol.20 No.6

Purpose: To determine the feasibility of using extracorporeallife support (ECLS) for out-of-hospital cardiac arrest(OHCA) patients who are unresponsive to conventional cardiopulmonaryresuscitation (CPR) techniques. Methods: This study was a case series of consecutive nontraumaticOHCA patients aged 18~75 years who receivedECLS in the emergency department (ED) of a universityteaching hospital. We analyzed outcomes, physiologiceffects, and complications associated with ECLS. To compareoutcomes of ECLS and conventional CPR, we selecteda conventional CPR subgroup, those who were aged 18to 75 years, who experienced cardiac arrest with pre-hospitalCPR, who had no terminal illness, and who had CPR formore than 40 minutes. Results: Of 14 attempts to initiate ECLS, 13 patientsreceived ECLS and one patient failed catheterization. Ninepatients achieved return of spontaneous circulation (ROSC)more than 20 minutes later; 4 of the 9? patients survivedmore than 24 hours; 2 patients were successfully weanedoff ECLS; 1 patient was discharged alive without neurologiccomplications. Median (minimum-maximum) duration ofCPR before ECLS (pre-hospital and in-hospital) was 84(41to 167) minutes. Blood gas parameters obtained 3 hoursafter the start of ECLS were significantly improved comparedwith those obtained pre-ECLS. Four patients whoarrested from acute myocardial infarction received interventionas during ECLS support to correct the causes of thearrest. Serious complications of ECLS causing mortalitywere catheterization failure, intracranial hemorrhage, andmassive hemothorax. The ECLS group showed a higherROSC rate than patients who received conventional CPRwithout ECLS (64.3% vs. 7.1%, p=0.002). Conclusion: ECLS in the ED is feasible for OHCA patientswho are unresponsive to prolonged CPR. ECLS provides abridge to evaluation and definitive care in refractory OHCA byimproving early hemodynamic and physiologic status. Earlierapplication of ECLS and reduction of complications associatedwith ECLS may improve the survival of OHCA patients.

The HSS3/4 enhancer of Crlzl-IgJ locus is another target of EBF in the pre-B cell stage of B cell development

Kim, Ja-Yeon,Park, Sung-Kyun,Kim, Hong-Gi,Cho, Sun-Jung,Kim, Ji-Young,Kang, Chang-Joong 경희대학교 생명자원과학연구원 2007 생명자원과학연구원 연구논문집 Vol.26 No.-

Cytotoxic Constituents of Amanita subjunquillea

Kim, Ki-Hyun,Choi, Sang-Un,Park, Ki-Moon,Seok, Soon-Ja,Lee, Kang-Ro 대한약학회 2008 Archives of Pharmacal Research Vol.31 No.5

As part of our systematic study of Korean toxic mushrooms, we have investigated the constituents of Amanita subjunquillea. The column chromatographic separation of the MeOH extract of A. subjunquillea led to the isolation of four ergosterols, two cerebrosides and four cyclopeptides. Their structures were determined by spectroscopic methods to be (22E,24R)-$5{\alpha},8{\alpha}$-epidioxyergosta-6,9,22-triene-$3{\beta}$-ol (1), (22E,24R)-$5{\alpha},8{\alpha}$-epidioxyergosta-6,22-dien-$3{\beta}$-ol (2), (22E,24R)-$5{\alpha},6{\alpha}$-epoxyergosta-8,22-diene-$3{\beta},7{\beta}$-diol (3), (24S)-ergost-7-en-$3{\beta}$-ol (4), 8,9-dihydrosoyacerebroside I (5), soyacerebroside I (6), $\beta$-amanitin (7), phalloin (8), $\alpha$-amanitin (9), and phalloidin (10). The compounds 1-6 and 8 were isolated for the first time from this mushroom. The isolated compounds were evaluated for the cytotoxicity against A549, SK-OV-3, SKMEL-2 and HCT15 cells. Compound 9 exhibited significant cytotoxic activity against A549, SKOV-3, SK-MEL-2 and HCT15 with $ED_{50}$ values of 1.47, 0.26, 1.57 and $1.32\;{\mu}M$, respectively.

Concentration and Environmental Loading of Veterinary Antibiotics in Agricultural Irrigation Ditches

Kim, Sung-Chul,Chung, Doug Young,Kim, Kye Hoon,Lee, Ja Hyun,Kim, Hyo Kyung,Yang, Jae E.,Ok, Yong Sik,Almarwei, Yaser A.O. Korean Society of Soil Science and Fertilizer 2012 한국토양비료학회지 Vol.45 No.6

The concentration of veterinary antibiotics in aqueous and sediment matrices was measured in agricultural irrigation ditches bordering several animal-feeding operations (AFOs) and then compared to its concentration in the watershed. Analytical determination in aqueous samples was based on solid phase extraction (SPE) and appropriate buffer solutions were used to extract residuals in sediment samples. Separation and detection of extracted veterinary antibiotics were performed with high performance liquid chromatograph tandem mass spectrometry (HPLC/MS/MS). In general, higher concentrations of antibiotic were observed in the aqueous phase of irrigation ditches, with the highest concentration of erythromycin hydrochloride (ETM-$H_2O$) of $0.53{\mu}g\;L^{-1}$, than in aqueous watershed samples. In contrast, higher concentrations were measured in river sediment than in irrigation ditch sediment with the highest concentration of oxytetracycline of $110.9{\mu}g\;kg^{-1}$. There was a high calculated correlation ( > 0.95) between precipitation and measured concentration in aqueous samples from the irrigation ditches for five of the ten targeted veterinary antibiotics, indicating that surface runoff could be an important transport mechanism of veterinary antibiotics from field to environment. Further, environmental loading calculation based on measured concentrations in aqueous samples and flow information clearly showed that irrigation ditches were 18 times greater than river. This result suggests the likelihood that veterinary antibiotics can be transported via irrigation ditches to the watershed. The transport via surface runoff and likely environmental loading via irrigation ditches examined in this study helps identify the pathway of veterinary antibiotics residuals in the environment.