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EGFR 돌연변이와 ROS1 전위를 동시에 가진 폐선암 환자의 Erlotinib 치료 1예
김민환,박예현,박혜정,지아영,송창호,진무년,김영주,김선욱,이중희,김인수,김혜련,김주항,조병철 Ewha Womans University School of Medicine 2014 EMJ (Ewha medical journal) Vol.37 No.1
The rearrangement of c-ros oncogene 1 (ROS1) has been recently identified as an important molecular target in non small cell lung cancer (NSCLC). ROS1 rearrangement and epidermal growth factor receptor (EGFR) mutation were mutually exclusive each other in previous studies, and the clinical implication of co-existence of the two genetic alterations has not been determined. We report a case of 46-year-old female never-smoker NSCLC patient whose tumor harbored ROS1 rearrangement and EGFR mutation concomitantly. She had undergone curative surgery for stage IIIA NSCLC, and the recurrence in left pleura and brain occurred at 2 years after the surgery. She received several lines of chemotherapy including docetaxel plus carboplatin, erlotinib, pemetrexed, and gemcitabine. Erlotinib therapy showed a favorable treatment response with progression-free survival of 9.5 months and partial response of tumor on radiologic evaluations. This case represents a successful erlotinib treatment in a NSCLC patient with concurrent ROS1 rearrangement and EGFR mutation.
주의력결핍과잉행동장애와 Alpha-1C-Adrenergic 수용체 유전자와의 연관성에 대한 연구
조수철,김재원,김붕년,황준원,박미라,김순애,조대연,유희정,정운선,손정우,박태원 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.1
Objectives : Neurobiological and pharmacological research has suggested that the dysregulation of the central noradrenergic systems might be involved in the pathophysiology of ADHD. The aim of this study was to examine the association of the alpha-1C-adrenergic receptor gene (ADRA1C) with ADHD in Korean subjects. Methods : In a case-control study, we assessed 186 DSM-IV ADHD probands and 150 normal controls. One hundred and eight trios were studied in a family-based association analysis. Psychiatric diagnoses were derived through structured diagnostic interviews. For the clinical evaluation of the ADHD subjects, the Child Behavior Checklist (CBCL), the ADHD Rating Scale-IV (ARS) and the Junior Temperament and Character Inventory (JTCI) were administered. A computerized continuous performance test (CPT) was used to measure the inattention and impulsivity of the ADHD children. Results : There were no significant differences in the genotype or allele frequencies of the ADRA1C PstI polymorphism between the ADHD and control group (p>0.05). The transmission disequilibrium test (TDT) analysis observed no evidence for biased transmission of any of the alleles of the PstI polymorphism. There were no significant differences in the CPT or JTCI profiles between those ADHD subjects with the CC genotype and those with the other (CT+TT) genotypes at the PstI polymorphism. Conclusion : The results of this study do not support the ADRA1C as a major genetic susceptibility factor in ADHD.
정상 면역 환자에서 천공과 출혈을 동반한 거대세포바이러스 대장염
김선욱,차윤진,김민환,진무년,이중희,박혜정,장수연,이혁 이화여자대학교 의과학연구소 2014 EMJ (Ewha medical journal) Vol.37 No.2
Cytomegalovirus (CMV) infection in immunocompromised patients is associated with significant morbidity, mortality, and adverse clinical outcome. However, CMV infection in immunocompetent patients has been considered to have subclinical and self-limited course, and does not require treatment. We reports a case of CMV colitis, presented with colon perforation and lower gastrointestinal bleeding in a immunocompetent 31-year-old young male. After conservative treatment, colonoscopy revealed multiple ulcers in transverse colon. CMV colitis was confirmed by microscopic findings and immunohistochemistry. After successful treatment with ganciclovir, the patient improved without invasive procedure.
^161, ^163Dy의 0.003eV~50keV의 중성자 포획 단면적 측정
민영기,윤정란,노태익,김귀년,이삼열 東亞大學校附設基礎科學硏究所 2002 基礎科學硏究論文集 Vol.19 No.1
교토대학 원자로 연구소의 46MeV 전자선형가속기를 사용하여 중성자 TOF 방법으로, 에너지 영역 0.003eV∼50keV의 ^161, 163Dy sample의 중성자 포획 단면적을 측정하였다. 본 실험에서 사용된 Bi_4Ge_3O_12(BGO) 섬광 검출기는 sample의 핵반응에서 나오는 즉발 포획 감마선 측정에 사용하였다. 이 검출기는 중성자 선원으로부터 거리 12.7±0.02m 위치에 12개의 블록으로 되어 있으며, sample에 포획되는 중성자 flux의 절대치를 구하기 위해 Sm(n, γ) 및 ^10B(n, αγ) 반응을 이용하였다. ^161, 163Dy에 대한 포획 단면적 측정결과는 ENDF/B-VI 결과와 비교하였다. The neutron capture cross sections of ^161, 162Dy has been measured in the energy region from 0.003eV 50keV by using the neutron time-of-flight(TOF) promptγmethod with a 46MeV electron linear accelerator at the Research Reactor Institute, Kyoto University. An assemble of twelve pieces of BGO scintillation detectors, which was placed at a distance of 12.7±0.02mm from the neutron source, was employed as a total energy absorption detector for the prompt capture gamma-ray measurement, to obtain the absolute capture cross section value. The sample of ^161, 163Dy is a form of metallic plate. An enriched boron sample was employed to monitor the neutron flux/spectrum of the TOF beam using the standard reference cross section of the ^10B(n, αγ) reaction. Previous measurements and evaluated data in ENDF/B-VI was compared with the present results.
저체중 또는 과체중 청소년에서 캠프 프로그램을 이용한 영양 교육효과에 관한 연구
성미경,승정자,류화춘,박재년,박동연,최미경,조경옥,최선혜,이윤신,김유경,이은주 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.4
This study was performed to evaluate the effectiveness of a nutrition education program developed for nutritionally imbalanced adolescents. A summer nutrition camp was held for 23 overweight and 16 underweight subjects. Its effectiveness with regard to was evaluated at the end of the camp and 6 months later. Nutrition knowledge, nutritional attitude, food behavior, nutrient intake, exercise habit and ideal body figures desired by the subjects. The results showed significantly higher nutrition knowledge scores at the end of the camp as compared to those obtained prior to the camp program, and these scores were maintained for at least six months. Nutrition attitude scores also improved after the education program, and these improved scores also lasted for 6 months. However, the food behavior scores measured 6 months after the education program were not significantly different from those obtained prior to the camp. Also, the exercise habit, the ideal body figures and the body figures desired by the subjects remained unchanged. When nutrient intakes of subjects were assessed before the program and 6 months later, the mean daily vitamin C intake was significantly increased after the education program. Also, the intake of iron from plant food sources increased in the overweight subjects, while less iron from animal source were consumed by the underweight subjects. Both groups tended to consume more vegetables and fruits 6 months after the education program which may have contribute to the higher vitamin C and plant-based iron intakes. These results indicate that a 4-day nutrition education camp program sustained changes in nutrition knowledge and nutrition attitude for 6 months. The increased intake of vegetables and fruits was also achieved through this education program. However, changes in dietary behavior in adolescents may require repeated education.
Kim, Hye-Jin,Kwon, Sojung,Nam, Seo Hee,Jung, Jae Woo,Kang, Minkyung,Ryu, Jihye,Kim, Ji Eon,Cheong, Jin-Gyu,Cho, Chang Yun,Kim, Somi,Song, Dae-Geun,Kim, Yong-Nyun,Kim, Tai Young,Jung, Min-Kyo,Lee, Kyun The Federation of American Societies for Experimen 2017 The FASEB Journal Vol.31 No.4
<P>Membrane proteins sense extracellular cues and transduce intracellular signaling to coordinate directionality and speed during cellular migration. They are often localized to specific regions, as with lipid rafts or tetraspanin-enriched microdomains; however, the dynamic interactions of tetraspanins with diverse receptors within tetraspanin-enriched microdomains on cellular surfaces remain largely unexplored. Here, we investigated effects of tetraspan(in) TM4SF5 (transmembrane 4 L6 family member 5)-enriched microdomains (T5ERMs) on the directionality of cell migration. Physical association of TM4SF5 with epidermal growth factor receptor (EGFR) and integrin alpha 5 was visualized by live fluorescence cross-correlation spectroscopy and higher-resolution microscopy at the leading edge of migratory cells, presumably forming TM4SF5-enriched microdomains. Whereas TM4SF5 and EGFR colocalized at themigrating leading region more than at the rear, TM4SF5 and integrin a5 colocalized evenly throughout cells. Cholesterol depletion and disruption in TM4SF5 post-translational modifications, including N-glycosylation and palmitoylation, altered TM4SF5 interactions and cellular localization, which led to less cellular migration speed and directionality in 2-or 3-dimensional conditions. TM4SF5 controlled directional cell migration and invasion, and importantly, these TM4SF5 functions were dependent on cholesterol, TM4SF5 post-translational modifications, and EGFR and integrin alpha 5 activity. Altogether, we showed that TM4SF5 dynamically interacted with EGFR and integrin a5 in migratory cells to control directionality and invasion.-Kim, H.-J., Kwon, S., Nam, S. H., Jung, J. W., Kang, M., Ryu, J., Kim, J. E., Cheong, J.-G., Cho, C. Y., Kim, S., Song, D.-G., Kim, Y.-N., Kim, T. Y., Jung, M.-K., Lee, K.-M., Pack, C.-G., Lee, J. W. Dynamic and coordinated single-molecular interactions at TM4SF5-enriched microdomains guide invasive behaviors in 2-and 3-dimensional environments. FASEB J. 31, 1461-1481 (2017). www.fasebj.org</P>
Kim, Jung-Nyun,Choi, Jung-Hwa The Korean Society of Systematic Zoology 2006 Animal Systematics, Evolution and Diversity Vol.22 No.1
Two caridean shrimps, Eualus biunguis (Rathbun, 1902) and Argis toyamaensis (Yokoya, 1933), collected from the Korean continental slope of the East Sea at depths of 850-870 m are reported as new to the Korean caridean fauna with brief descriptions and illustrations. A hippolytid shrimp, E. biunguis, is distinguished from the congeners by the minute che1alike appearance of dactyli of the last three pereopods and the large pyriform eye. A crangonid shrimp, A. toyamaensis, differs from the Korean species of the genus in having the posterior acute spines of submedian carinae on the sixth abdominal somite.
Two Hippolytid Shrimps (Crustacea: Decapoda: Caridea) from the Deepwater of the East Sea, Korea
Kim, Jung-Nyun,Choi, Jung-Hwa,Hong, Byeong-Gyu,Hwang, Kang-Seok,Chun, Young-Yull The Korean Society of Systematic Zoology 2007 Korean Journal of Systematic Zoology Special Issue Vol.23 No.2
Two hippolytid shrimps, Spirontocaris spinus (Sowerby, 1805) and Lebbeus unalaskensis (Rathbun, 1902) are described on the basis of material collected from the deepwater of the East Sea, Korea at 310-810 m. The former has been incorrectly known as Spirontocaris arcuata Rathbun, 1902 in Korea and the latter is a new member of the Korean fauna. Morphological and distributional accounts of these species are presented with illustrations.
New Records of Two Penaeoid Shrimps (Crustacea: Decapoda) from Korean Waters
Kim, Jung-Nyun,Choi, Jung-Hwa,Oh, Taeg-Yun,Hwang, Kang-Seok,Kim, Jong-Bin,Choi, Kwang-Ho,Lee, Dong-Woo The Korean Society of Fisheries and Aquatic Scienc 2010 Fisheries and Aquatic Sciences Vol.13 No.4
Two penaeoid shrimps, Hadropenaeus lucasii (Bate, 1881) and Sicyonia truncata (Kubo, 1949), were collected from the northeastern waters of Jeju Island, Korea. These represent the only Korean reports of a member of the genus Hadropenaeus, family Solenoceridae and of a member of family Sicyonidae, respectively. Morphological descriptions and illustrations with a color photograph of each species are given. Korean Penaeoidea presently includes 27 species in three families.