Lidocaine 이 흰쥐 해마박편에서 CA 1 추체세포의 활성에 미치는 영향

김형룡,민승기,김대업,오상천,유형근,김은철,고건일,원진숙 원광대학교 생명공학연구소 1995 생명공학연구소보 Vol.3 No.1

비만세포주에서 Histamine 유리에 관한 연구

김형룡,국윤아,신민,이홍수,원진숙,김형민,이영미,정헌택,이혜숙,안녕형 원광대학교 생명공학연구소 1995 생명공학연구소보 Vol.3 No.1

栽培年數에 따르는 人蔘精油量

金愛子,金英順,李榮子(B),李明淑 梨花女子大學校 藥學硏究所 1961 梨花藥學硏究 Vol.- No.2

해방공간의 한국미술 : 서구문화 수용과 민족정체성 구현의 문제

김형숙 서울대학교 미술대학 2001 造形 FORM Vol.- No.24

Following the Korean War and Independence in 1945, South Koreans attempted to establish a modem Korean government and to construct a new society. This reconstruction called for the adoption of Western culture and embodiment of Korean identity at the same time. This was reflected in Korean art of the 1950s, which combined Japanese influence during colonization and Western influence after the Korean War. This paper will examine modem Korean art by asking the question, How was Korean traditional art reinterpreted when modern Korean artists accepted the influence of Western culture? The relationships between artists, the art world, and art education are investigated, in order to understand the 50's cultural environment. Previous studies have looked at art or the art world, or art education in isolation from one another, and therefore they could not explain the big picture of art, the art world, art education within the context of the 50's Korea. During the 50s, when Korean artists accepted the Western art world, they reconstructed modern Korean art, was organized during this time and exhibited the academic style of artworks by Ko Heedong, Lee Jong-woo, and Do Sang-bong, all influenced by Impressionism in Japanese art. Additionally, with the publication of the first art journal in 1956 and the opening of the modem structure of galleries at the center of Seoul, Korean artists had more diverse opportunities to exhibit their works of art. Artists in the 50s interpreted the Korean tradition newly and formed a Korean identity by accepting the Western artistic style and methods in Expressionism, Informel, and Abstract Expressionism. Park Soo-keun painted people struggling to survive after the Korean War, reflecting the atmosphere in Korean at the time. He made the thick matre of white, black, and gray oil paint like Korean granite on canvas made of cardboard and veneer board. Lee Joong-seup was interested in Korean traditional motifs such as cows and children, experimenting with improvisational and expressive brushstrokes as seen in Expressionism of 20th-Century Western Art. Kim Hwan-ki's artworks established a modern picture of the calligraphic school with the use of materials of Western art and Korean traditional motifs such as mountains, moon, trees, and so on. When the first generation of Korean artists in the 50s received modem art education, they were much more positive and open to accepting Western art. Young artists of the and the attacked the ward-heeling politics of and searched for a universal visual language that could keep step with the International world, particularly Western culture. Having been exposed to modern Japanese art and art books, Korean artists were interested in the trends of Informel in Europe and Abstract Expressionism in the United States. Like Jackson Pollock's action painting, Korean Informel artists dripped the paints on the surface of canvases and created Korea's own calligraphy. After Independence in 1945, the art world of Korean traditional painting and sculpture also tried new ways to modernize traditional Korean art by overcoming Japanese influence. Lee Sang-bum, Byun Kwan-sik, and Park Ryae-hyun maintained the style of Korean traditional painting while also adopting the style and materials of Western art. Park kept the materials of Korean painting such as Hanji and Korean paints; however, she also positively adopted the style of Cubism and Abstract Expressionism. Before the 50s, Korean sculptors remained in Japan and learned modern sculpture from modern Japanese artists. However, following Independence, Korean sculptors came to a turning point in practicing modern sculpture. Kim Jong-young in the 50s produced abstract sculpture, which seemed to be influenced by Constantin Brancusi in Western art. Additionally, modern art education also opened after Independence when Korea accepted the system of Western art education. From 1945 to 1956, Ewha Women's University, Seoul National University, and Hong Ik University shaped the modern structure of art education and produced new young artists. Japanese influence on Korean art education was a serious problem that had to be overcome in the 50s. Additionally, art textbooks 'Do Hwa ° § Gong Jack' in Japanese Colonization had been transformed to Mi Sool.' Instead of Japanese art education, ‘New Education,’ based on the 'Creative-Self Expressionism' of 'Progressive Education' of the early 20th century, was emphasized in the field of modern education. When the UN and the United States offered economic and political help to reconstruct Korean society after the war, went to Korea and introduced and experimented with John Dewey's philosophy of Education. For Koreans, Dewey's theories and practices of Progressive Education from the United States provided a hope to overcome old Japanese structures and thoughts in Korean education. The 1950s' Korean art, art world, and art education went through the Korean War, and are considered to be a stepping stone between modem Korean art under Japanese influence and modem art of universal international language.

로버스트 능형회귀 추정법

김부용,박형숙 숙명여자대학교 자연과학연구소 1999 자연과학논문집 Vol.- No.10

회귀분석을 위한 자료에는 회귀이상점이 포함되어 있으며, 동시에 다중공선성이 존재하는 경우가 있다. 이상점들만 포함되어 있는 경우에는 로버스트 추정법을 적용할 수 있으며, 다중공선성만 존재하는 경우에는 능형회귀 추정법을 적용할 수 있다. 그러나 회귀이상점과 다중공선성은 상호 관련을 가지므로 어느 한 문제만을 해결하는 것은 완전한 것일 수가 없다. 따라서 회귀이상점과 다중공선성이 동시에 존재하는 상황에서의 효과적인 추정 방법을 제안하고자 한다. Statisticians have suggested many methods for the problems of multicollinearity and outliers seperately. However, we usually encounter many data sets which have both problems. Thus, we propose a procedure that is called the robust ridge estimation and is very effective to deal with the problems simultaneously. The proposed procedure employs the LMS estimate to determine the bias parameter of ridge regression. In addition, it is verified by simulation studies that the proposed iterative method is more effective, in terms of the stability of estimates and squared distances, than the existing procedure based on the least squares estimates.

Pilocarpine에 의한 경련과 기억력 저하에 Cycloheximide와 Dexamethasone이 미치는 영향

김용민,박정숙,한형수 慶北大學校 醫科大學 1996 慶北醫大誌 Vol.37 No.3

목적 : Cycloheximide 또는 dexanethasone이 pilocarpine으로 유발된 경련의 발생과 뇌조직 손상으로 인한 기억력 저하에 어떤 영향을 미치는지 연구하였다. 대상 및 방법 : 생쥐에 pilocarpine(250 ㎎/㎏)을 투여하여 야기된 경련 및 기억장애가 10㎎/㎏의 cycloheximide 또는 1.5㎎/㎏ 의 dexamethasone을 전처치하였을 때 나타나는 작용을 비교하였다. 기억력검사는 Morris water maze방법을 이용하였다. 결과 : Dexamethsone 또는 cycloheximide의 전처치로서 pitocarpine에 의한 경련 시작 시간이나 경련의 강도에 영향을 주지 않았다. Pilocarpine 투여 17 일 후 기억력을 검사한 결과, reference memory을 working memory 장애가 야기되었으나, cycloheximide 및dexamethasone은 pilocarpine 투여 7일후 4일간 투여하였을 때 cycloheximide만이 pilocarpine에 의해 기억력이 저하되는 것을 억제하였다. 결론 : Cycloheximide는 항경련 작용 없이도 pilocarpine에 의한 기억력 저하를 억제할 수 있는 것으로 미루어 경련과 기억력저하의 유발과정이 다를 수 있는 것으로 보여진다. The effect of cycloheximide, inhibitor of protein synthesis, and dexamethasone, synthetic glucocorticoid, on the genesis of pilocarpine-induced seizure and seizure-related memory deficit was observed in mice. Twenty days after pilocarpine(250 ㎎/㎏) administration showed memory deficit. Cycloheximide (10㎎/㎏/day) and dexamethasone (1.5 ㎎/㎏/day) were given once a day during 7 to 10 days following pilocarpine treatment. Pretreatment with cycloheximide or dexamethasone did not influence on the onset of seizure and behavioral seizure activity induced by pilocarpine. In contrast to dexamethasone, cycloheximide treatment inhibited pilocarpine-induced memory defect on the basis of reference and working memory version of Morris water maze. These results show that cycloheximide, not dexmethsone, can reduce pilocarpine-induced memory deficit without anticonvulsant property.

항암 치료를 받은 아동의 치아 발육 장애

김민정,이형숙,김신,정태성 大韓小兒齒科學會 2009 大韓小兒齒科學會誌 Vol.36 No.4

The malignant tumor in childhood is one of the main causes of children s death due to disease. The traditional treatment for the malignancy is known for the radiation therapy and the chemical therapy or both. However, the treatments tend to induce intraoral complications. Different from adults, almost all children on cancer therapy are expected to have dental complications, because their permanent teeth are on the developmental stage. The degree of dental complication depends on the patient's age, type of chemical and other factors-radiation dose and frequency. In this report, 3 children who had experienced the anti-cancer therapy on their age between 1 and 4 years were selected and dental complications were examined. The children have chance for the various oral complications including the developmental problems such as agenesis, microdontia and hypoplasia of the teeth. Therefore, it's important to understand the side-effects of anticancer therapy during the permanent teeth had been developmental stage in young patients. Also, oral health care specialists, including pediatric and hospital dentist can support the oncology team by providing basic oral care, implementing oral care protocols, delivering emergency dental treatment undergoing anticancer treatment. 소아기의 악성 종양은 질병으로 인한 소아 사망의 가장 흔한 원인이다. 이에 대한 대표적인 치료 방법으로 항암 화학 요법과 방사선 요법의 단독 사용 혹은 이들의 병용을 들 수 있다. 그러나 이러한 치료 방법은 다양한 구강 내 합병증을 동반한다. 성인과 달리 소아 환자는 항암치료 시기에 일부 영구치가 활발한 발육단계에 있으므로 발육중인 치아에 치과적 합병증이 예상된다. 치과적 합병증의 정도는 화학약물의 종류, 용량 및 방사선 조사 빈도와 치료 당시 환자의 나이에 따라 달라진다. 본 증례들에서는 특정 영구치의 발육단계에 있는 만 1-4세경에 종양의 치료를 위해 항암 화학 요법과 방사선 치료를 받은 어린이 3명을 대상으로 치료 내용과 치아 발육 상황을 검토해 보았다. 이환된 치아의 수나 그 정도에 차이는 있으나, 각각의 환자에서 영구치 치배의 선천 결손, 왜소치, 치근 저형성 등 발육장애 관련 소견이 관찰되었다. 항암치료를 받은 병력이 있는 소아에 있어서 항암치료 이후에 나타날 수 있는 일반적인 구강 합병증 이외에 발육시기 동안 치아에 미치는 영향을 고려하여, 공간 문제를 포함하여 향후 발생 할 수 있는 다앙한 문제점 예방을 위한 장기적인 관찰과 관리가 필요할 것으로 생각된다.

Cyclic AMP analog와 PGE2가 마우스 조골세포의 활성에 미치는 영향

김형룡,김장숙 원광대학교 생체재료·매식연구소 1996 원광생체재료·매식 Vol.5 No.2

To maintain its functional integrity, bone is continuously remodelled by a process involving resorption by osteoclasts and bone formation by osteoblasts. In order to respond to changes in the physical environment or to trauma with the relevant action, this process is strictly regulated by locally synthesized or systemic fators. Prostaglandin E_2(PGE_2) is perhaps one of the best studied of these factors, having been known to affect bone cell function for several decades. PGE_2 has both anabolic and catabolic activities. Excess levels of PGE_2 have been implicated in a number of pathological states associated with bone loss such as a number of chronic inflammatory conditions such as periodontal disease and rheumatoid arthritis. PGE_2 and other arachidonic acid metabolites have been shown to be potent stimulators of osteoclastic bone resorption in organ culture. The anabolic effects of PGE_2 were first noticed when an increase in periosteal woven bone formation was seen after the infusion of PGE_2 into infants in order to prevent closure of the ductus arteriosus. The cellular basis for the catabolic actions of PGE_2 has been well characterized. PGE_2 increase osteoclast recruitment in bone marrow cell cultures. PGE_2 also has a direct action on osteoclast serving to inhibit activity and can also indirectly activate osteoclast via other cells in the vicinity, presumably osteoblast. The cellular mechanisms for the anabolic actions of PGE_2 are not nearly so well understood. The purpose of this paper is to study the anabolic actions of PGE_2 on osteoblastic clone MC3T3E1 cells. The effects of DBcAMP and PGE_2 on the induction of alkaline phosphatase(ALP) was investigated in osteoblastic clone MC3T3E1 cells cultured in medium containing 0.4% fetal bovine serum. DBcAMP and PGE_2 stimulated ALP activity and MTT assay in the cells in a dose-dependent manner at concentrations of 10-500ng/ml. Cycloheximide, protein synthesis inhibitor, inhibited the stimulative effect of PGE_2 and DBcAMP on ALP activity in the cells. PGE_2 also increased the intracellular cAMP content in a dose-dependent fashion with a maximal effect at 500ng/ml. Our present results suggest that PGE_2 stimulate the differentiation of osteoblasts and are involved in bone formation in vivo, as well as in bone resorption.

水泳一스트레스에 의한 血裝 Corticosterone 증가에 미치는 水溫, Clonidine 및 Bromazepam의 영향

金炯健,申炅浩,金庚旭,全普權,千然淑 고려대학교 의과대학 1989 고려대 의대 잡지 Vol.26 No.2

Recently, many reports suggested that warm water swim-stress induces an opioid-analgesia, while cold water swim-stress produces a nonopioid form of analgesia. And Hong et. al. reported that the increase of plasma corticosterone (p-CS) in response to swim-stress at 20℃(20-SS) was significantly attenuated by swim-stress at 4℃ (4-SS) was affected by CL but markedly suppressed by BA. In this paper, the influences of CL-500㎍/㎏ and BA-5㎎/㎏ on the change of p-CS in response to 20-SS or 4-SS were studied in male mice comparing with those of morphine and naloxone. The 20-SS induced increase of p-CS was significantly inhibited by CL and BA, respectively, while the 4-SS induced increase was not affected by CL but markedly inhibited by BA. And the 20-SS or 4-SS induced increase of p-CS was slightly inhibited by naloxone,2mg/kg but not affected by morphine, 2㎎/㎏. The increase of p-SS in response to three times repeated 20-SS or 4-SS with one hour interval was little affected by B-pretreatment, but CL-pretreatment slightly attenuated the 4-SS induced increase of p-CS and significantly inhibited the 20-SS induced increase. The increase of p-CS induced by the repeated SS was little affected by the treatment of BA 30 minutes before the last SS, but the such treatment of CL slightly attenuated the p-CS increase induced by the repeated 20-SS but significantly enhanced the p-CS increase by the repeated the repeated 4-SS. And during the experiment of repeated 4-SS, 55.6% of mice pretreated with BA were drowned. The results demonstrate that there are some pharmacological differences between the mechanisms of hypothalamo-adenohypophysial responses to 20-SS and 4-SS, respectively.

들깨풀 첨가가 열무 물김치의 발효에 미치는 영향

김형렬,박정은,장명숙 한국조리과학회 2002 한국식품조리과학회지 Vol.18 No.3

An optional ingredient Perilla Seed paste was adopted to improve the quality of Yulmoo Mul-kimchi during fermentation. The final weight percentage of perilla seed paste in Yulmoo Mul-kimchi was adjusted to 0, 10, 20, 30, and 40% per water respectively. Chemical and sensory characteristics were determined during fermentation at 10℃ for 25 days. The effect was varied depending on the amounts of perilla seed paste, but Yulmoo Mul-kimchi fermented with 20% perilla seed paste was most favored for color, smell, sour taste, carbonated taste, texture and overall acceptability in the sensory evaluation. The pH decreased with the increase of total acidity. The total vitamin C content increased initially to the certain level at a certain time of fermentation depending on the level of perilla seed paste, and then decreased later. In case of reducing sugar, the 20% treatment showed the highest content. Turbidity values were generally increased in all samples during fermentation, even though the extents were limited. Total plate count and the number of lactic acid bacteria were gradually increased and then decreased showing the maximum microbial counts during fermentation. The optimum levels of perilla seed paste in Yulmoo Mul-kimchi obtained through experiments were between 20 and 30% of added water content, preferably 20% for color, fermentation-retarding effect, and sensory taste of the product.