부산지역 무균성 뇌막염 원인 바이러스의 분리 및 동정 : 1998년을 중심으로

김영희,정영기,김기순,지영미,윤재득,김병준,구평태,민상기,정구영,김만수,조경순 동의대학교 기초과학연구소 2000 基礎科學硏究論文集 Vol.10 No.1

The incidence of aseptic meningitis infection is ensuing and threatening the health of children. Enteroviruses are the major agents of aseptic meningitis and identification of virus has been a clue to diagnosis and epidemiology. The outbreak of aseptic meningitis occurred in Pusan, 1998. Patients were concentrated from April through November. Children were more susceptible than adults. Among 306 cases of specimens from stool, throat swab tested, only 7.2% were positive on virus isolation, 12 cases from stool and 10 from throat, respectively. All isolated 7 serotypes of viruses represented cytopathic effect on cultured cells. Three types of echovirus 6, 25, 30 and coxsackievirus B2, B3, B4, B6 were identified by neutralizing anti body test. Isolated coxsackievirus and echovirus were observed by an electron microscope with negative staining.

정신분열병과 N-Methyl-D-Aspartate 수용체 유전자와 연관된 VNTR 표지자인 D9S158 다형성의 연합

김종원,채영규,정은기,김길숙,박강규,이영호,최인근,양병환,한진희 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

정신분열병과 NMDA 수용체와 연관된 D9S158 유전적 표지자와의 연관성을 알아보기 위해 75명의 정신분열병 환자군과 87명의 정상대조군을 대상으로 중합효소연쇄반응을 이용하여 연합연구를 시행하여 다음과 같은 결론을 얻었다. D9S158 유전좌위에는 모두 8개의 대립유전자가 있었고, 각 대립유전자는 cytosine-adenine염기가 반복되는 217염기쌍에서 233염기쌍의 형태였다. 먼저 정신분열병 환자와 정상대조군의 대립유전자의 빈도를 비교해 본 결과 통계적으로 유의한 차이를 보이지 않았다(p〉.05). 환자군을 좀 더 동질적으로 만들기 위해 정신분열병의 가족력 유무, 음성 및 양성증상, 연성신경학적 징후, DSM-IV 임상아형에 따라 환자군을 나누어 대립유전자의 빈도를 비교해 본 결과, 특정 임상양상과 관련이 있는 대립유전자를 발견하지 못하였다. 결론적으로 본 연구에서는 D9S158 유전좌위와 정신분열병의 연관성을 입증하지 못하였으나 NMDA 수용체 유전자주위의 다른 표지자나 좀 더 유전적으로 동질한 환자군을 대상으로 한 추후연구가 필요할 것으로 생각된다. An association study with Korean schizophrenic patients(N=75) and normal controls(N=87) was performed to find the relationship between D9S158 polymorphism and schizophrenia using polymerase chain reaction. Eight different alleles of a dinucleotide polymorphism on D9S158 locus were observed in both group. When we compared the frequencies of alleles between schizophrenics and normal controls, there was no significant difference between two groups. To increase homogeneity of schizophrenic group, we divided schizophrenic group by clinical phenotypes such as family history, negative and positive symptoms(PANSS), soft neurologic signs(NES-K) and DSM-IV diagnostic subtypes. Then we compared the frequencies of alleles among subgroups of clinical phenotypes, and there were no significant differences between subgroups(p〉.05). Although our findings fail to provide an evidence of association between schizophrenia and D9S158 locus, further investigation of other loci that are linked to NMDA receptor gene may be needed in genetically homogeneous subgroups of schizophrenia.

생활체육참여자의 여가활동 유형이 생활만족에 미치는 영향

김의영,김의영,김영숙,윤대중,이병기 龍仁大學校 體育科學硏究所 2002 體育科學硏究論叢 Vol.12 No.1

This research is designed to make a comparative analysis of the types of leisure activities and the degree of and life satisfaction by demographic background variable and to present basic materials necessary for the development of programs for local policies on leisure in accordance with the local autonomous system with a view to determining the relationship between life satisfaction by type of leisure activity. The following are the findings. First, the survey failed to test a statistically significant difference between family member's mutual satisfaction, or the subordinate variable of age, job and health and general life satisfaction, or the subordinate variable of income. But there was a statistically significant difference in life satisfaction by gender, age, education, job, income and health at a level of 1 percent. Second, the survey on the influences of the types of leisure activities on leisure satisfaction and life satisfaction revealed that there was a statistically significant influences in all the subordinate variables of and life satisfaction.

장기입원 만성정신질환자의 실태에 관한 조사

김영미,조병만,장기용,정영인 大韓神經精神醫學會 1999 신경정신의학 Vol.38 No.4

연구목적 : 부산지역내 정신보건시설에 1년 이상 장기입원하고 있는 만성정신질환자의 실태를 조사하여, 인구사회학적 특성과 장기입원에 영향을 미치는 요인 가운데 직접적인 의료적 요인보다는 주로 간접적인 의료외적인 요인을 알아보고, 이를 바탕으로 향후 만성정신질환자의 효율적 관리를 위한 기초자료를 얻고자 본 연구를 시도하였다. 방 법 연구대상은 1998년 7월1일 현재 부산지역 정신보건시설에서 1년 이상 장기입원중인 3,477명의 만성 정신질환자들이었다. 조사대상기관으로는 10개의 정신병원, 8개의 정신질환자 요양시설이었다. 조사방법은 저자들이 사전에 작성한 자료조사표의 양식을 부산광역시 보건과의 협조를 받아 이들 정신병원과 정신질환자 요양시설에 보내 작성하게 한 다음, 부산광역시의 행정계통을 통해 회수하였다. 자료조사표에는 성별, 연령, 진단명, 정신보건시설의 종류(정신병원, 정신질환자 요양시설), 정신보건법에서 규정한 입원형태(동의입원, 시?? 도지사에 의한 입원, 자의입원). 결혼상태, 교육수준, 요양급여형태, 연고자 유무, 면회횟수 등의 10개의 독립변수가 포함되었다. 자료분석은 입원기간에 따른 대상환자의 분포가 정규분포를 나타내지 않아 독립변수항목들과 입원기간간 의 관련성을 검증하는데는 비모수 방법인 Spear-man 상관계수, Mann-Whitney 검증, Kruskal-Wallis 검증을 사용하였다. 결 과 1) 본 연구의 대상인 1년이상 장기입원중인 환자는 전체입원환자의 70.7%에 해당하였으며 이들 대상 환자의 입원기간의 중앙값은 5.5년이었다. 2) 정신보건시설별 전체환자에 대한 대상환자의 비율은 정신병원과 정신질환자 요양시설이 각각 46.3%, 95.1%로서 정신질환자 요양시설이 정신병원에 비해 장기입원환자의 비율이 높았다. 3) 본 연구에서 설정한 10개 항목의 독립변수 모두에서 입원기간의 유의한 차이를 보여, 이들 변수 모두가 장기입원에 영향을 미치는 것으로 나타났다. 결 론 : 만성정신질환자들의 장기입원에는 상당수의 의료외적인 간접적 요인들도 중요한 역할을 하고 있는 것으로 나타났고, 이는 국내 정신의료서비스의 후진성을 보여주는 것으로 판단되었다. Objectives : In an attempt to identify the demographic characteristics and the factors influencing long-term hospitalization of chronically mentally-ill patients, a survey on the chronically mentally-ill patients who had been staying longer than 1 year in mental health facilities was conducted. Methods : Checklist including some demographic data that were regarded as independent variables was applied to 3,477 subjects through administration system of Pusan Metropolitan City. Statistical analyse were done using distribution-free, non-parametric tests. Results : 1) Subjects who had been staying longer than 1 year were 70.7% of the total inpatients of mental health facilities, and median duration of their hospitalization was 5.5 years. 2) In mental hospitals and asylums, the ratio of chronically mentally-ill subjects to the total inpatients in each facilitiy was 46.3% and 95.1%, respectively. 3) All of the 10 independent variables had an influence on the hospitalization duration. Conclusions : These results indicated that many indirect, extramedical factors had an influence the long-term hospitalization of chronically mentally-ill patients, and it is likely to reflect the underdevelopment of mental health services in Korea.

경부의 범발성 특발성 골격과골 증후군에 의한 연하곤란 : 1례 보고 A Case Report

김영우,장호근,정종철,이기병 대한척추외과학회 2003 대한척추외과학회지 Vol.10 No.3

cis-platin에 의한 급성구토예방의 Dexamethasone의 4가지 정주량의 비교

김원,강지은,서영선,이동민,서정균,신병철,정기영,박유환,정춘해 조선대학교 부설 의학연구소 2002 The Medical Journal of Chosun University Vol.27 No.1

B5-hydroxytryptamine _3수용체(5-HT_3) 길항제와 dexamethasone의 동시투여가 cis-platin에 의한 급성 구토를 막는데 가장 효과적이다. 그러나 현재까지 가장 적절한 정주dexamethasone의 용량이 알려져 있지 않았다. 이에 dexamethasone의 4가지 다른 용량을 투여하여 그 효과를 비교하였다. 환자는 임의 추출되어 cis-platin 투여 45분전에 15분 동안 정주로 각각 dexamethasone 5, 10, 15, 20 mg을 투여 받았다. cis-platin 투여 30분전에는 ondansetron 8 mg이 부가하여 정주 되었다. 1999년 3월부터 2000년 2월까지 54명의 환자가 연구에 등록되어졌고 53명의 환자가 연구 대상으로 실험에 4군 (dexamethasone 5 mg 13명, 10 mg 14명, 15 mg 13명, 20 mg 13명)으로 나뉘어 평가 되어졌다. 급성구토와 구역질의 완전한 예방은 dexamethasone 5 mg을 투여 받은 환자에서 각각 69.2%, 60.9%, dexamethasone 10 mg을 투여 환자에서 69.1%, 61%, dexamethasone 15 mg 투여 환자에서 78.5%, 66.9%, dexamethasone 20 mg을 투여 환자에서 83.2%, 71.0%로 나타났다. 구토로부터 완전한 예방은 dexamethasone 20 mg을 투여 환자에서 5, 10 mg을 투여 환자와 비교하여 높았고, dexamethasone 15 mg을 투여 군에 비교하여서는 약간 우수한 효과만 있었다. 구역질으로부터의 완전한 예방도 월등한 것은 아닐지라도 20 mg을 받은 환자에서 높았다. 항 구토 치료는 특별한 불편 없이 조절되었고, 부작용의 발생에서 4가지그룹간에는 커다란 차이가 발견되지 않았다. Dexamethasone의 20 mg 정주양이 cis-platin으로 인한 급성구토를 예방하는데 가장 효과적인 예방량으로 사료되어진다. Background and objective: A 5-hydroxytryptamine _3(5-HT_3) receptor antagonist plus dexamethasone is the most efficacious antiemetic prophylactic treatment for the prevention of cis-platin induced acute emesis, but the optimal intraveous (Ⅳ) dose of dexamethasone is unknown. This prompted us to perform a randomized, double-blind, dose-finding study that compared four different doses of dexamethasone. Materials and Methods: Patients were randomized to receive dexamethasone, either 5, 10, 15, 20 mg, administered by 15-minute Ⅳ infusion 45 minutes before cis-platin. Ondansetron 8 mg was added to dexamethasone and was administered Ⅳ 30 minutes before cis-platin. From March 1999 to February 2000, 54 patients were enrolled onto the study and 53 were assessable according to the intention-to-treat principle (13 patients received 5 mg; 14 patients, 10 mg; 13 patients, 15 mg and 13 patients, 20 mg of dexamethasone). Results: Complete protection from acute vomiting and nausea was achieved by 69.2% and 60.9% of patients, respectively, who received 5 mg of dexamethasone, by 69.1% and 61.0% of those who received 10 mg, by 78.5% and 66.9% of those who received 15 mg, and by 83.2% and 71.0% of those who received 20 mg of dexamethasone. Complete protection from vomiting was significantly superior in patients who received 20 mg compared with those who received 5 and 10 mg of dexamethasone (P<05) and was superior, but not significantly, compared with those who received 15mg. Complete protection from nausea was superior, but not significantly, in patients who received 20 mg of dekamethasone. Multifactorial analysis confirmed these results. Antiemetic treatment was well tolerated, and no significant difference was found among the four groups in the incidence of adverse events. Conclusion: A 20mg single Ⅳ dose of dexamethasone should be considered the most efficacious prophylactic dose for the prevention of ois-platin induced acute amesis in treatment of cancer.

직렬 리액터를 이용한 계통연계형 태양광 발전 시스템

金大均,鄭春炳,全基英,李丞煥,吳鳳煥,李勳九,金容珠,韓慶熙 명지대학교 산업기술연구소 2005 産業技術硏究所論文集 Vol.24 No.-

Since the residential load is an AC load and the output of solar cell is a DC power, the photovoltaic system needs the DC/AC converter to utilize solar cell. In case of driving to interact with utility line, in order to operate at unity power factor, converter must provide the sinusoidal wave current and voltage with same phase of utility line. Since output of solar cell is greatly fluctuated by insolation, it is necessary that the operation of solar cell output in the range of the vicinity of maximum power point. In this paper, DC/AC converter is three phase PWM converter with smoothing reactor. And then, feedforward control used to obtain a superior characteristic for current control and digital PLL circuit used to detect the phase of utility line.

정신분열병 환자의 가족력 유무와 연성 신경학적 특성

김은남,장기용,강병조 대한생물치료정신의학회 1995 생물치료정신의학 Vol.1 No.2

본 연구는 정신분열병 환자들의 연성 신경학적 증상을 알아보고 또한 가족력 유무에 따른 연성 신경학적 증상의 차이를 살펴보기 위한 것이다. 1995년 7월부터 동년 10월까지 국립부곡정신병원에 입원치료중이며 DSM-IV 진단 기준에 의해 정신분열병으로 진단된 환자를 대상으로 하였다. 이중 병록지와 환자 가족의 정보를 근거로 하여 1차 인척 중에서 정신분열병의 기왕력이 있는 환자들을 가족력이 있는 환자군으로 분류하였다. Buchanan과 Heinrich의 신경학적 평가척도의 한국어판을 이용하여 가족력이있는 정신분열병 환자군20명, 가족력이 없는 정신분열병 환자군 20명 그리고 정상대조군 20명 사이의 연성 신경학적 이상소견을 비교하였다. 이 연구의 결과는 다음과 같다. 1) 연성 신경학적 평가척도의 총점은 정신분열병 환자군은 23.93±6.66, 정상대조군은 3.55±2.46으로 두 군간에 유의한 차이를 나타내었다(P<0.0001). 정신분열병 환자군은 감각통합 영역, 운동조정 영역, 복합활동순서화 영역, 그리고 기타 영역에서 정상대조군 보다 유의하게 높은 점수를 나타내었다(P<0.0001) 2) 연성 신경학적 이상 소견은 정신분열병 환자의 가족력의 유무와 유의한 상관관계는 없었다. 가족력이 있는 환자들이 신경학적 평가척도의 모든 영역에서 가족력이 없는 환자들보다 평균 점수가 높게 나타났으나 통계적으로 유의한 차이는 없었다. 이상의 결과에서 정상대조군보다 정신분열병 환자군에서 연성 신경학적 이상소견이 많이 나타났다. 이는 생물학적 표지로서의 연성 신경학적 증상의 중요성을 보여준다고 할 수 있다. 그러나 가족력 유무에 따른 연성 신경학적 이상 소견에 유의한 차이가 없었으므로 이 생물학적 표지가 trait marker인지 state marker인지는 좀더 연구를 해 보아야 할 것 같다. This study was performed to assess neurologic soft sign(NSS) in schizophrenics and to know the relationship between NSS and family history of schizophrenia. All Patients were hospitalized in Bugok National hospital during the period from July, 1995 to October, 1995 and diagnosed as schizophrenia based on DSM-IV criteria. Schizophrenics were classified as familial schizophrenics if at least one first-degree relative had a clear history of schizophrenia, based on review of any medical records and reports of family informants. The authors evaluated NSS using the structured tool for measuring neurological abnormalities, Neurological Evaluation Scale-Korean Version(NSE-K). A comparison of NSS score was made among three groups subjects consisting of 20 familial schizophrenics, 20 non-familial schizophrenics and 20 normal controls. The results were as follows : 1) the schizophrenics were significantly more impaired than normal controls on total scores of sensory integration, motor coordination, sequencing of complex motor acts and other areas(P<0.0001). 2) NSS scores were not correlated with family history of schizophrenia. Mean item scores of familial schizophrenics were higher than non-familial schizophrenics but there were statistically no differences between two groups. these findings suggest that abnormal NSS may be one of possible biological markers of schizophrenics. But there were statistically no differences in NSS scores between familial schizophrenics and non-familial schizophrenics. therefore, A further study is needed to investigate whether NSS is a trait marker of schizophrenics.

정신분열증환자에서 Haloperidol과 Reduced Haloperidol 사이의 상호변환에 있어 Haloperidol Reductase에 관한 연구

김민정,정은기,오동열,김이영,양병환 大韓神經精神醫學會 1994 신경정신의학 Vol.33 No.5

Haloperidol is metabolized through reductation by the enzyme haloperidol reductase at the benzylic ketone to form an alcohol metabolite, known as reduced haloperidol. The basic and clinical pharmacology of reduced haloperidol and also haloperidol reductase is the main subject of haloperidol study, as the reduced metabolite can be converted back to the parent drug which has some neuroleptic effect. This study was undertaken to investigate correlations between haloperiol reductase activity in RBC and reduced haloperidol formation, also the difference of haloperidol reductase activity between responding and nonresponding schizophrenic patient. The results were as follows : 1) The haloperidol reductase activity of schizophrenic patients in RBC at 2 weeks was 12.8±4.3ng/30 min/200ul RBC, 16.0±11.9 at 4 weeks and 22.3±71 in control group. There was statistically significant difference of haloperidol reductase activity in RBC between schizophrenic patient and control group at 2 weeks but no difference at 4 weeks. 2) We divided the patient into responding and nonresponding group by the percentage of improvement in total BPRS score as more or less than 31% respectively and there was no significant difference of haloperidol reductase activity in RBC among two groups. 3)) There was no significant relationship between haloperidol dose of administration and haloperidol reductase activity in RBC. Considering the above results, haloperidol reductase activity in schizophrenic patients showed different results according to the duration of drug administration, so the study which deal with the factors, influencing the activity of haloperidol reductase, should be undertaken in the future.

Ether 및 Halothane마취시 정맥혈에서의 Lactate, Pyruvate 및 Excess lactate치의 변화에 대한 연구

김익수,최세진,백문기,황병두 대한마취과학회 1977 Korean Journal of Anesthesiology Vol.10 No.3

Venous blood lactate, pyruvate and excess lactate have been measured by the enzymatic method and calculated in 24 patients over a period of 2 hours during operation under general anesthesia. When the anesthetic was diethyl, ether, lactate and dyruvate levels showed a gradual increase significantly from 30 minutes and 60 minutes after induction of anesthesia respectively. Excess lactate appeared 30 minuts after induction of anesthesia, being increased slightly thereafter. When halothane was used, lactate level rose significantly in 120 minutes but no significant change in pyruvate and excess lactate was observed. In comparison to the results obtained in arterial blood during ether anesthesia by others, the levels of lactate and pyruvate found in this study were higher than those observed in arterial blood, whereas there was no considerable difference in change with duration of anesthesia and excess lactate. From the above results we suggested that venous blood lactate, pyruvate and excess lactate were essentially the same as those of arterial blood for evaluating tissue hypoxia during general anesthesia.