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난치성 정신분열병환자에서 Alprazolam의 병용 투여 및 혈청 Prolactin치 변화
오동열,김영란,김철규 대한신경정신의학회 1995 신경정신의학 Vol.34 No.1
The purposes o f this study were to investigate the adjunctive effects o f alprazolam and the changes of serum P RL level in the refractory schizophrenics. The subjects were seventeen hospitalized chronic schizophrenic patients who met Kane et al,s(1988) criteria. The subjects were randomly assigned to two groups, alprazolam-placebo administration group and placeboalprazolam administration group. The duration of study was 13 weeks with a double-blind crossover design. The maximum dosage of alprazolam was 4.5lng/day and the schedule of alprazolam administration was conducted in 3 stages-the 1st stage was the period of dose increment of 2 weeks, the 2nd stage was the period of maintenance of 4 weeks and the 3rd stage was the tappering period of one week Clinical evaluation with Brief Psychiatric Rating Scale (BPRS) was done weekly on the double-blind method and checked the serum P R L level at the baseline, the end o f the 3rd and the 9th week The results were as follows : 1) Alprazolam administration did not show any statistically significant differences in total BPRS scores but showed statistically significant reduction of the scores in the subscales of anxiety, emotional withdrawal, psychomotor retardation and conceptual disorganization compared with plcebo administration. 2) There was no significant relationship in the serum prolactin level because alprazolm and also placebo administration increased the serum prolaction level. 3) In the future, this kind of study should be done in more homogenous group of patients and try to find out any biological markers, indicating therapeuic effects. So that alprazolam could be tried for some refractory schizophrenics.
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유비쿼터스 환경의 인증 및 권한 메커니즘 동향을 통한 분산 인증기법 방안 연구
오동열,성경상,김배현,오해석 한국융합보안학회 2008 융합보안 논문지 Vol.8 No.1
사용자가 접하는 정보 시스템과 어플리케이션에 대한 관리가 중요한 문제로 대두되면서 시스템 접근과 관리를 위한 방법론이 제기되고 있다. 여러 가지 형태의 인증 기술이 사용되고 있지만, 복잡한 인증 관리 및 운용에 따른 비효율성은 유무선 환경의 다양하고 새로운 비즈니스의 성공적인 전개를 위해서는 부적절하다. 또한 서로 다른 인증 방식을 사용하는 모바일 컴퓨팅 환경 하에서 유연하고 연속적인 서비스를 기대하기란 매우 어렵다. 유비쿼터스 컴퓨팅 환경하에서는 상호운용성 및 보안성이 지원되는 분산 인증 방안을 연구개발하는 것은 매우 중요한 사안이다. 이에 따라 본 논문에서는 유선(fixed) 컴퓨팅 환경에서뿐만 아니라 이동(mobile) 컴퓨팅 환경까지 고려한 유비쿼터스 컴퓨팅 환경으로 확장 가능한 분산 인증의 관리 및 운용 방안에 대한 요구사항과 권한 메커니즘에 대해 살펴봄으로써, 향후 진정한 유비쿼터스 환경에서의 분산형 인증기법에 관한 적극적인 참여를 유도할 수 있을 것으로 기대한다. While an information system and administration for an application that a user contacts with raise a head by an important problem, a system approach and methodology for administration are mentioned. Authentication technology of various configuration is used, but non-efficiency by complicated authentication administration and operation inappropriate use are for a successful expansion of various and new business of wire/wireless environment. In addition, under the mobile computer environment with different authentic method each other, it is difficult at all to expect flexible and continuous service. Under the ubiquitous computing environment, It is very important thing plan to research and develop compatibility and the side of variance authentication plan that preservation characteristics are helped. Hereby, This paper look around an requirement items and authority mechanism for the administration and the operation mechanism of the distributed authentication considering expansion possibility of the ubiquitous computing environment not only fixed computing environment but also mobile computing. In future, we expect it by can guide participation about distributed authentication technique of the genuine ubiquitous environment.
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Naltrexone influences protein kinase Cε and integrin α7 activity in SH-SY5Y neuroblastoma cells
오동열,정경화,양병환,이정석,최인근,채영규 생화학분자생물학회 2006 Experimental and molecular medicine Vol.38 No.1
Alcohol influences the neuroadaptation of brain cells where receptors and enzymes like protein kinase C (PKC) exist. Naltrexone acts on opioid receptors. However, other mechanisms of action remain unknown. We prepared SH-SY5Y neuroblastoma cells, and fed them with 150 mM ethanol for 72 h followed by treatment with naltrexone for 24 h. We performed microarray analysis and reversetrans-criptase-polymerase chain reaction. Our results showed that PKCε increased 1.90 times and showed an overall decreasing pattern as time increased. Phosphorylated ERK also increased 2.0 times according to the change of PKCε. Integrin α7 increased 2.32 times and showed an increasing pattern as time increased. In conclusion, naltrexone influences PKCε neuronal signaling system and endothelial adhesion molecule integrin α7 in addition to the well-known opioid system.
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