비만증 환자에서 한약제에 의한 체중 감소효과

Oh, Seung-Joon,Jeong, In-Kyung,Kim, Young-Seol,Choi, Young-Kil,Paeng, Jeong-Ryung,Bae, Jung-Hwan,Shin, Hyun-Dae 경희대학교 동서의학연구소 1999 INTERNATIONAL SYMPOSIUM ON EAST-WEST MEDICINE Vol.1999 No.1

Seung-Joon Oh, In-Kyung Jeong, Young-Seol Kim, Young-Kil Choi, Jeong-Ryung Paeng¹, Jung-Hwan Bae and Hyun-Dae Shin²Department of internal Medicine, College Medicine, Endocrine Research Institute¹. Department of Rehabilitation, College of Oriental Medicine², Seoul, korea. Bady Fat Reduction Effects of Red Ginseng Compound Preparation on the Patients with Obesity. Proceedings of International Symposium on East-West Medicine, Seoul. 244-254, 1999.-Obesity can be defined as a metabolic disease due to an increased state of fat tissues caused by an imbalance of calorie intake and use. Recently, in Korea by improvement and westernization of food intake, along with decrease in exercise activities, the prevalence of obesity has increased greatly. Our objectives were to study stability and effects of decrease in body fat by administering red ginseng compound preparation (known to have body fat decreasing effects in laboratory animals) to obesity patients on low calorie diets. Changes in weight and body fat were measured while carrying out calorie-restricted diets on patients for 4 weeks, then administering red ginseng compound preparation for another 4 weeks. The patients were 20 people whose BMI were 25kg/㎡ or over and whose percent body fat was also 30% or over when tested by bioelectrical conductivity. 1. Changes in weight were from 70.04kg(base line) to 67.43kg(after taking red ginseng compound preparation). 2. In similar sense, BMI decreased from 27.12kg/㎡(base line) to 26.56kg/㎡(after dieting), and further to 26.01kg/㎡ (after taking red ginseng compound preparation). The BMI seemed to decrease significantly compared to the baseline after the use of red ginseng compound. 3. Waist hip ratio was changed from 0.8858(base line) to 0.8728, but it was statistically insignificant. 4. The percent body fat was 35,16%(base line), 33.87%(after dieting), and 31.68%(after taking red ginseng compound preparation). 5. Complete blood cell count and blood chemisrty remained unaffected by the administration. 6. In concern to endocrinologic studies, T3 decreased from 118.7 to 98.2ng/dL, and T4 increased from 8.8 to 9.2㎕/ dL. Epinephrine showed a tendency to decreased from 0.27 to 0.25 ng/mL, and norepinephrine increased from 0.39 to 0.44ng/mL. 7. Leptin was not changed. 8. Some patients complained adverse effects; constipation(5 patients, may be due to diet therapy), fatigue (2 patients), pruritus(2 patients), flushing(s patients), dizziness(3 patients) and epigastric discomfort(2 patients). However their symptoms were mild, so medication did not stopped. In conclusion, loss of weight without significant side effects was observed during low calorie diet and red ginseng compound preparation administration. This is thought to be in relation to sympathetic nerve system rather than adrenal gland. Also, further long0term studies should be required, since the observed results were based on short-term changes in weight.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

친환경농업 농가 컨설팅에 대한 반응 조사

오환중,차광홍,정우진,김길용,박노동 全南大學校 農業科學技術硏究所 2011 農業科學技術硏究 Vol.46 No.-

The interactions between Environment-Friendly Agriculture Research Center (EFARC) and farmers in Jeonnam Province area who have practiced environment-friendly agriculture (EFA) under guidances of EFARC were investigated through enquete. The enquete was conducted during July - September, 2010. One hundred and eighty nine farmers responded all inquiries among 200 farmers. The main results are summarized as follows: 1. Rice was the predominant crop grown by farmers (49%), and the next major was hot pepper (12%). Most farmers (95.3%) have practiced environment-friendly agriculture at the levels of no-pesticide (55.6%), lower pesticide (32.8%), and organic (6.9%). 2. Major motivations of practicing EFA are for the production of safe foodstuffs (52.6%) and for an increase of income (40.1%). 3. Around 3 quarters of the environment-friendly agriculture products are shipped through Nonghyup, the cooperative marketing. The price margin between ordinary agriculture products and EFA products was of 5~10% for 63.5% farmers, of 10~20% for 14.3% ones, and of 20~30% for 14.8% ones. 4. Bottlenecks for practicing EFA are in the order of the unstability of shipping price (34.9%), cultivation techniques (20.1%), excess labor input (19.6%), and control of disease and insect pest (18%). 5. It turned out that more than 90% farmers who have practiced EFA under guidance of EFARC recognized the consulting activities of EFARC as to be helpful for them. 6. Establishment of national organizations which are specialized in consultation for EFApracticing farmers has been suggested.

보통모멘트골조의 Pushover해석을 이용한 내진성능평가에 관한 연구

정길수,김진상 인제대학교 2008 仁濟論叢 Vol.23 No.1

본 연구는 층고비가 다른 비정형 보통모멘트굴조의 동적거동에 대하여 Pushoverr해석을 이용한 내진성능평가에 관한 연구이다. 실험모델로 1층에 층고비가 다른 5층 보통모멘트골조를 사용하였고 등가정적 해석 및 응답스펙트럼해석을 수행하여 지진하중, 층전단력, 전도모멘트, 최대변형을 구하였다. 그리고 Pushover해석을 이용한 구조물의 보유 능력을 산정하고 능력스펙트럼(CSM)의 원리를 적용하여 구조물의 비선형 최대변형과 요구내력을 평가하였다. 층고비가 2.0일 때 선형해석 및 비선형해석에서도 최대변위와 최대전단력이 발생한다는 것을 알 수가 있었다. In this study, the dynamic behaviors of building structures with a soft story are investigated using Capacity Spectrum Method. Nonlinear Static Pushover Analysis, Response Spectrum Analysis, and Equivalent Seismic Analysis of Linerly Elastic Method is used. The OMF(Ordinary Moment Frame) studied are three-dimentional building frame with 5 story having a soft story (layer ratio is 2 0 to 1). Earthquake-loads, story shear forces, overturning moments, and maximum displacement are calculated by pushover analysis. Next, nonlinear maximum displacement and demand of building are evaluated by CSM principles. When layer ratio is 2.0, maximum displacement and maximum shear force are developed both linear and nonlinear analyses.

골반내에 발생한 Proximal-type 유상피성 육종 1예

길준철,이상수,전병화,김성훈,손우석,목정은,박양순,강길현 대한부인종양 콜포스코피학회 2003 Journal of Gynecologic Oncology Vol.14 No.4

유상피성 육종은 매우 드문 악성 연조직 육종으로, 전형적인 경우들은 주로 젊은 남성의 수부, 전완부와 같은 신체의 원위부에 피하 혹은 심재성 피부 종괴로 발생하며, 조직학적 소견상 적은 비정형성을 나타내는 유상피성 세포와 방추형 세포의 증식에 의한 다발성 결절 형태의 배열을 보인다. 최근에 전형적인 유상피성 육종과 조직학적 유사성을 가지나 더 공격적인 형태인 proximal-type 유상피성 육종이 보고되었으며, proximal-type은 전형적인 유상피성 육종에 비하여 현저한 유상피성 세포의 발현과 매우 심한 비정형성을 나타내며, 세포가 매우 크고, 소포성 핵과 뚜렷한 핵소체를 보이며, 자주 rhabdoid 세포의 양상을 띈다. 임상적으로는 전형적인 형태에 비하여 호발 연령이 조금 늦고, 주로 체간부에, 특히 골반, 회음부, 생식기 등과 같은 심부에 발생하고, 더욱 공격적인 양상을 나타낸다. 저자들은 13세 소녀에서 원발부위를 알 수 없는, 골반내에 발생한 proximal-type 유상피성 육종 1예를 경험하여, 문헌 고찰과 함께 보고하는 바이다. Epithelioid sarcoma is a rare malignant soft-tissue sarcoma with an unknown histiogenesis, typically presenting as a subcutaneous or deep dermal mass lesion in the distal portions of the extremities of young adults. Recently, a more aggressive, so-called 'proximal-type' epithelioid sarcoma has been reported. In contrast to conventional epithelioid sarcoma, the proximal type is characterized by a predominantly large cell epithelioid cytomorphology, marked cytologic atypia, and frequent occurrence of rhabdoid features in most patients. Proximal-type epithelioid sarcoma has a predilection for appearing in the genitalia, especially the vulva, penis, pelvis and buttocks. Also this lesion appears to be somewhat more aggressive or at least metastasizes earlier than the conventional epithelioid sarcoma. We report a 13-year-old girl who presented with a buge mass filling the pelvic cavity which was painful, hard and fixed on palpation, and was radiologically diagnosed as a malignant germ cell tumors on the CT scan. The mass was surgically excised and pathologically proved to be an proximal-type epithelioid sarcoma of unknown origin.

단순 액체의 점탄성 운동에 관한 연구

정길환 全北大學校 敎育大學院 1986 敎育論叢 Vol.6 No.-

A molecular dynamics investigation of the microscopic behavior of a liquid subjected to shearing is carried out. The dynamical response of a liquid system and of a highly densified glassy system to various shear strain histories is outlined. At low shear rates, the data agree with the predictions of linear response theory. At higher shear rates, nonlinear behavior is observed. In the glassy system there is some evidence of a transition from viscoelastic to plastic behavior at high stress levels.

Halothane 마취중 Vecuronium과 Pancuronium 투여가 심혈관계 및 회복시간에 미치는 영향

길기진,김종열,이정은,김혜자,최세진 충남대학교 의과대학 지역사회의학연구소 1986 충남의대잡지 Vol.13 No.2

This study was taken to abserve the effect on cardiovascular response and recovery time with pancuronium and vecuronium. The patients was composed of 20 healthly both sex adults who belong to class I of ASA physical status. Vecuronium 0.1mg/kg(N=10) and pancuronium 0.1mg/kg(N=10) was injected independently at 20 minutes after intubation by succinylcholine 1mg/kg and thiopental sodium. The results were as follow. 1. There were not a significant difference in arterial blood pressure and pulse rate before and after vecuronium injection. 2. After pancuronium administration, arterial blood pressure was not significant change but pulse rate showed significant increasing. 3. In the recovery time when T_1 was recovered to 25% after administration of muscle relaxants respectively, there were 26±7.2 min, vecuronium and 67±11.2 min, in pancuronium. 3. EKG was not change before and after vecuronium.

단순 액체의 운동 양상에 관한 분자 역학적 연구

정길환 全北大學校 敎育大學院 1983 敎育論叢 Vol.3 No.-

A molecular dynamics investigation of microscopic behavior of a liquid subjected to shearing is outlined and the results are compared with the predictions of the available theories. At low shear rates, the data agree with the predictions of linear response theory. At high shear rates, nonlinear behavior is observed. The normal pressure behavior at high rates of shear seems to have a significant component resembling the elastic solid.

층밀리기 점성의 층밀리기 율의 의존성에 관한 연구

鄭吉煥 全北大學校 1995 論文集 Vol.40 No.-

A molecular dynamics investigation of the microscopic behavior of a liquid subjected to shearing is carried out. The dynamical response of a liquid system and of a highly densified glassy system to various shear strain histories is outlined. At low shear rates, the data agree with the predictions of linear response theory. At higher shear rates, nonlinear behavior is observed. The shear rate dependence of the shear viscosity in the high shear regime seems to be best fitted by Ree-Eyring theory.

홍국균의 최적배양조건에 관한 연구

정순택,임종환,박양균,황금택,박현진,안찬영,강성국,문길만 木浦大學校 工業技術硏究所 1994 工業技術硏究誌 Vol.4 No.-

Cell growth and pigment productivity of Monascus anka KCCM 11832 and Monascus sp. has isolated from the Korean Maeju(soybean koji) were determined for effect of culture medium composition and incubation conditions. Increase of NH₄NO₃, and KH₂PO₄ concentration as mineral source promoted mycelium growth, and the highest cell growth was showed in the medium with 0.05% KH₂PO₄ when C/N ratio is 20:1, but pigment production was significantly inhibited at higher concentration than this level. Cell growth and pigment production in porato dextrose medium were higher than those in czapeck-dox broth and malt extract medium. In terms of temperature, the highest cell growth was showed at 34℃, but pigment productivity was the highest at 26℃.