Ki-1 임파종 1 예

김용진,김경재,박재복,이지현,안기성,강민모,최석문,황기석 대한내과학회 1993 대한내과학회지 Vol.45 No.4

A 60-year-old man was admitted to our hospital complaining of fever with chillness and anarexia for 12 weeks. Physical examination revealed supraclavicular lymphadenopathy and left inguinal lymphadenopathy. Abdominal CT scan showed the evidence of maked lymphadenopathy on retraperitoneal, external iliac, obturator, left inguinal, and celiac lymph nodes. A pathologic diagnosis of Ki-1(+) lymphoma was made by the biopsed supraclavicular lymph node because the node consisted of large cells with pleomorphic nuclei, scanty cytoplasm, large basophilic nucleoli, atypical vacuoli and large cells were positive for leukocyte common antigen, Ber-H2, marker, and B-cell marker.

정상인에서 베타3-아드레날린 수용체 유전자의 변이가 복부 비만도 및 지질대사에 미치는 영향

김영선,윤석기,김철희,서교일,김학선,김극배,변동원,유명희 순천향의학연구소 1998 Journal of Soonchunhyang Medical Science Vol.4 No.1

The β₃-adrenergic receptor is expressed in visceral adipose tissue in humans and is thought to contribute to the regulation of the resting metabolic rate and lipolysis. We studied the influence of a mutation in the β₃ -adrenergic receptor gene(Trp64Arg) on body fat distribution, central obesity, lipid metabolism in 65 healthy young male adults. One out of 65 subjects were homozygous (Arg/Arg) for the trp64Arg mutation, 17 subjects were heterozygous (Trp/Arg), and 47 lacked the mutation(Trp/Trp). The body weight, height, body mass index, waist-to-hip ratio were similar between the subjects with- and without the mutation. Total body fat, abdominal fat amount, body fat distribution, serum total- and HDL-cholesterol, triglyceride, glucose, and insulin concentrations were also not different according to the presence or absence of the mutation. These results suggested that Trp64Arg mutation in β₃-adrenergic receptor gene is not a major contributing factor for central obesity or change in lipid metabolism in Korean young adults.

Benzoate, m-Toluate, Phenol의 Pseudomonas putida에 의한 생분해

김장규,김석형,김태환,이대광,김남기 成均館大學校 科學技術硏究所 1993 論文集 Vol.44 No.1

It this study, basic data were obtained for the treatment of industrial waste water which includes aromatic compounds. Substrate concentrations used were 100ppm, 500ppm, and 1,000pprn and initial pH's were pH6, pH7, and pH8 in order to obtain the optimum conditions for treating benzoate, m-toluate, and phenol by Pseudomonas putida(KCTC 1644). Durations were 20hrs for 100ppm, 40hrs for 500ppm, and 60hrs for 1,000ppm before the static growth of Pseudomonas putida. 100% of 100ppm benzoate(0.31g cell/1) was biodegraded at pH6, pH7, and pH8 before 20hrs, 52.8% of 500ppm at pH8 in 40hrs, and 27.9% of 1,000ppm at pH8 in 60hrs. The best initial pH was pH8 for the biodegradation and the growth of Pseudomonas putida in benzoate medium. For m-toluate, the best initial pH was also pH8. At this pH, 40.6% of 10Dppm(0.31 cell/1), 21.9% of 500ppm, and 14.1% of 1,000ppm m-toluate were biodegraded respectively in limited time. But for phenol, the best initial pH was pH7. At this point, 9.8% of 100ppm(0.218 cell/1), 7.1% of 500ppm, and 4.7% of 1,000ppm phenol were biodegraded respectively. Therefore, the best carbon source in this experiment was benzoate. Pseudomonas putida was also able to biodegrade m-cresol, p-hydroxybenzoic acid, and benzaldehyde.

항갑상선제로 치료한 그레이브스병 환자의 관해예측인자

남일송,윤여일,김선규,김용현,이주영,목지오,윤석기,김철희,김영선,변동원,서교일,유명희 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

Background: Most cases of Graves' disease have been treated by antithyroid drugs in Korea. The major drawbacks of antithyroid drugs are the relative high rate of relapse and the inconvinience of long term therapy. Measurement of TBII and TRH stimulation test have been considered as the most reliable tests predicting relapse, but the predictive power is not high enough to use in clinical situation. This study was performed to find good prognostic indicators in Graves' disease patients after the discontinuation of antithyroid drug therapy. Subjects and methods : We restrospectively evaluated 96 patients with Graves' disease who showed normal TRH test at the end of antithyroid drug therapy and were followed for more than one year. Serum T3, T4, T3/T4 ratio, TBII, Anti-TPO Ab and TGAb levels were measured at the time of diagnosis and at the end of therapy. Two to three months after withdrawal of antithyroid medication, serum TSH and free T3 responses to TRH were examined. These parameters were compared between the relapse group and the remission group. Results : Among the 96 patients, 22 patients(22.9%) relapsed(Group Ⅱ) and 74 patients(77.1%) remained in remmision(Group Ⅰ). No significant difference was observed between the relapse and the remission group in clinical parameters, serum T3, T4, TSH, T3/T4 ratio, TBⅡ and Anti-TPO Ab determined before and after treatment. Serum TSH and free T3 levels measured after TRH stimulation were also similar in both groups. Serum TGAb levels determined at the end of treatment were significantly higher in the remission group(p<0.05). Relapse following the discontinuation of therapy occured within 24 months in 72.7% of the relapsed cases. After 24 months, relapse rate was reduced significantly. Conclusion : These results suggest that high serum TGAb levels could be a favorable prognostic indicator for the long term remission of Graves' disease treated with antithyroid drugs, and may suggest that Hashimoto's thyroiditis is combined with Graves' disease in those patients.

공기압 실린더의 위치제어기 선정에 관한 연구

김일수,김기우,정영재,손준식,송창재,박주석 한국공작기계학회 1999 한국생산제조학회지 Vol.8 No.6

This paper concentrates on the position control of a pneumatic cylinder under parameter variation. A closed-loop control is proposed to design the different controllers(P, PI, PID, PD controller) in order to choose the best controller based on the fast and accurate control of the system. It is shown that the control algorithm is robust and effective in attaining the fast and accurate position control of system under time-dependent parameter variation. Experimental results showed that PD controller law is effective to obtain the fast response and to increase the stability of the system. The method is a useful control algorithm which always automatically adjusts the position control in accordance with the error, using carrier wave of triangle type regardless of changes on the operating condition and physical differences between components.

최소걸침나무 문제의 해법과 확장

김기석 釜山大學校 商科大學 2001 釜山商大論集 Vol.72 No.-

The minimum spanning tree problem arises in a number of applications, both as a stand- alone problem and as a subproblem in a more complex problem setting. We begin this paper by describing several such applications. We next present three algorithms with illustrative examples for the minimum spanning tree problem: Prim's algorithm, Kruskal's algorithm, and Sollin's algorithm. We compare their efficiency by evaluating the computational complexity and practical performance of each algorithm. We also survey applications and algorithms for some extensions of the minimum spanning tree problem. The first type of the extensions is the problem of finding a minimum spanning tree with various constraints: degree-constrained minimum spanning tree(DMST), leaf-constrained minimum spanning tree(LMST), and capacitated minimum spanning tree(CMST). The second type is the problem of finding a minimum spanning tree with nonlinear objective functions: multi-criteria minimum spanning tree(mc-MST). The third type is the problem of finding a minimum spanning tree for a specified subset of the node set: generalized minimum spanning tree(GMST), k-minimum spanning tree(k-MST), and Steiner tree.

位置從屬 車輛經路問題 解法의 改善

김기석 釜山大學校 商科大學 1999 釜山商大論集 Vol.70 No.-

In the classical vehicle routing problem, a fleet of vehicles deliver goods from a central depot to a set of customers with known demands. The objective of the problem is to form minimum cost routes for the delivery vehicle, while serving all the customer demands. One of the practical variants of the vehicle routing problem is found when there are compatibility problems between some of the customer sites and some of the heterogeneous fleet of vehicles. Only one heuristic algorithm for this vehicle routing with site dependencies is known to this date. This paper presents a mathematical model of the problem of vehicle routing with site dependencies, and analyzes the existing algorithm of the problem. Then this paper considers possible improvements of the existing algorithm in two ways. In the first one, the generalized assignment heuristic (GAH) is adopted to form a more balanced cluster of customers and thus to reduce the total routing cost. In the second one, the tabu search (TS) metaheuristic is utilized to further improve suboptimal solutions obtained by the existing algorithm. Implementations of these improvements remain as a topic of future research on the problem.

스프레드시트를 이용한 라인 밸런싱

김기석 釜山 大學校 經營 經濟 硏究所 2007 經營 經濟 硏究 Vol.26 No.1

最大閉鎖問題의 應用과 擴張

金基錫 釜山 大學校 經營 經濟 硏究所 1995 經營 經濟 硏究 Vol.14 No.1

본 논문은 네트워크상에서 정의되는 최대폐쇄문제의 다양한 응용분야를 제시하였으며, 또한 최대폐쇄문제의 확장에 관하여 논의하였다. 최대폐쇄문제의 응용분야로는, 군 공격목표의 파괴방법 최적화, 노천굴에서 채광할 블락군 결정, 의존적인 투자안들의 포트폴리오 결정, 만기일이 있는 경우의 일정계획 등의 직접적인 응용과 화물처리 터미널의 선정, 데이터베이스에서의 레코드 분할, 현장수선궤의 공구/예비부품 선정 등의 간접적인 응용을 제시하였다. 본 논문에서 다룬 최대폐쇄문제의 확장은 두 가지로서, 최대비율 폐쇄문제와 제약조건하의 최대 폐쇄문제이다. 이들 문제에 대한 해법으로 지금까지 알려진 것은 본문에서 소개하였으나, 앞으로 더욱 효율적인 해법의 개발이 요망된다. 특히 응용사례에 따라 네트워크의 구조가 달라지므로, 그 구조적 특성을 반영한 고유해법의 개발이 향후 연구과제의 하나이다.

企業 倒産의 豫測에 關한 小考

金基錫 啓明大學校 産業經營硏究所 1980 經營經濟 Vol.13 No.1

The purpose of this paper is to review the models and the empirical tests of business failure prediction. Once established, companies are expected to continue and prosper as a going concern, but some of them fail to continue and do great damage to the parties concerned. The damage might be prevented, or at least lessened, if business failure could be predicted in advance. In Part II, the causes and the predictability of business failures are discussed. On the assumption that business failures are predictable, many models of the prediction of business failure have been suggested employing mainly finanical ratios as predictors of business failure. Five of these models-profile analysis, dichotomous classification test, analysis of likelihood ratios, the index method, and discrimination analysis-are classified into two broad categories, univariate models and multivariate models. Each is described with its limitation in part III. In part Ⅳ, the empirical tests of the models attempted by Beaver (4,5), Altman (3), Blum(6), and Edmister(7) are summarized. According to them, business failures prove to be predictable with a high probability a few years in advance. Finally, in Part Ⅴ, voluntary and legal settlement in cases of business failure are considered.