정안침요법(整顔鍼療法)을 응용하여 호전된 후천성 사경환자 치험 2례

박서영,김재수,홍의재,이윤경,이봉효,임성철,정태영,이경민,Park, Seo-Young,Kim, Jae-Su,Hong, Eui-Jae,Lee, Yoon-Kyoung,Lee, Bong-Hyo,Lim, Seong-Chul,Jung, Tae-Young,Lee, Kyung-Min 대한침구의학회 2008 대한침구의학회지 Vol.25 No.4

Objectives : This report intended to estimate effects of Jung-an acupuncture on the acquired torticollis caused by muscle contraction. Methods : The patients were treated by Jung-an acupuncture, herb medication and Physical treatment daily. The improvement of the patients was judged by Toronto Western Spasmodic Torticollis Rating Scale(TWSTRS), Tsui's score and Visual Analogue Scale(VAS). Results : After 7 days of treatment, the 2 patients' neck pain and cervical movement were improved. Also, TWSTRS score, Tsui's score and VAS were all reduced. Conclusions : As the Jung-an acupuncture's theological base is organized with meridian theory and myofacial release therapy, We considered the Jung-an acupuncture is effective not only for the skin disease but also for the muscle problem such as torticollis.

정신분열병에 대한 리스페리돈의 효과 및 안정성

이민수,김용구,김영훈,연병길,오병훈,윤도준,윤진상,이철,정희연,강병조,김광수,김동언,김명정,김상훈,김희철,나철,노승호,민경준,박기창,박두병,백기청,백인호,손봉기,손진욱,양병환,양창국,우행원,이정호,이종범,이홍식,임기영,전태연,정영조,정영철,정인과,정인원,지익성,채정호,한상익,한선호,한진희,서광윤 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.1

연구목적 : 본 시험의 목적은 임상시험 시작전에 연구자들을 대상으로 PANSS Workshop을 통하여 PANSS, ESRS에 대한 국내에서의 표준화 작업을 구축하고 새로운 정신병 치료제인 리스페리돈의 효과와 안정성을 재확인하여 리스페리돈 사용에 대한 적정화를 이루는데 있다. 연구방법 : 1996년 4월부터 1996년 9월까지 국내 39개 대학병원 정신과에 입원중인 혹은 증상이 악화되어 입원하는 정신분열병 환자 377명을 대상으로 다시설 개방 연구를 시행하였다. 1주일간의 약물 배설기간을 가진후, 리스페리돈을 8주간 투여하였고, 기준점, 1주, 2주, 4주, 그리고 8주후에 평가되었다. 용량은 제1일에는 리스페리돈 1mg씩 1일 2회, 제2일에는 2mg씩 1일 2회, 제3∼7일에는 3mg씩 1일 2회 투여하였다. 이후 환자의 임상상태에 따라 임의로 증량할 수 있으며, 최대 일일 16mg을 초과하지 않도록 하였다. 추체외로 증상을 조절하기 위한 투약을 허용하였다. 임상증상 및 부작용의 평가는 PANSS(Positive and Negative Syndrome Scale), CGI(Clinical Global Impression) 그리고 ESRS(Extrapyramidal Symptom Rating Scale)을 사용하였다. 연구결과 : 377명중 343명(91%)이 8주간의 연구를 완결하였다. 치료 종결시점인 8주후 PANSS 총점수가 20% 이상 호전된 경우를 약물 반응군으로 정의할때, 약물반응군은 81.3%였다. 리스페리돈에 반응하는 예측인자로는 발병연령, 이전의 입원 횟수, 유병기간이 관련 있었다. 리스페리돈은 1주후부터 PANSS양성, 음성, 및 일반정신병리 점수상에 유의한 호전을 보여 효과가 빨랐다. CGI의 경우도 기준점에 비해 1주후부터 유의한 감소를 나타내었다. ESRS의 경우, 파킨슨 평가점수는 기준점과 비교해 투여 1주, 2주, 4주후 유의하게 증가되었다가 8주후 기준점과 차이가 없었다. Dystonia 평가점수는 1주후만 유의한 증가를 보였으며, dyskinesia 평가점수는 유의한 차이가 없었다. 혈압, 맥박수의 생명징후 및 일반 혈액학 검사, 생화학적 검사, 심전도 검사에서 유의한 변화는 없었다. 결 론 : 이상의 다시설 개방 임상 연구를 통해 리스페리돈은 정신분열병 환자에서 양성증상뿐만 아니라 음성증상 및 전반적인 증상에도 효과적인 것으로 사료된다. 보다 명확한 평가를 위해서는 다른 항정신병약물과의 이중맹검 연구가 필요할 것으로 생각되며, 또한 장기적 치료에 대한 평가도 함께 이루어져야 하겠다. Objective : The purpose of this study was to investigate the efficacy and safety of risperidone in the treatment of Korean schizophrenic patients. Method : This multicenter open study included 377 schizophrenic patients drawn from 39 university hospitals. After a wash-out period of 1 week, the schizophrenic patients were treated with risperidone for 8 weeks and evaluated at 5 points ; at baseline, and 1, 2, 4 and 8 weeks of treatment. The dose was increased from 2mg/day(1mg twice daily) to 6mg/day(3mg twice daily) during the first week and adjusted to a maximum of 16mg/day over the next 7 weeks according to the patient's clinical response. Medication to control extrapyramidal symptoms was permitted. The psychiatric and neurological status of the patients was assessed by PANSS, CGI, and ESRS scales. Results : 343(91%) of 377 patients completed the 8-week trial period. Clinical improvement, as defined by a 20% or more reduction in total PANSS score at end point, was shown by 81.3% of patients. The predictors of response to risperidone were associated older age, shorter duration of illness, fewer previous hospitalization. Risperidone had rapid onset of action ; a significant decrease of the total PANSS and three PANSS factor(positive, negative, general), and CGI was already noticed at the end of first week. For the ESRS, parkinsonism rating scores were significantly increased until week 4 comparing with baseline. Dystonia rating scores were significantly increased until week 1, and dyskinesia rating scores were not significantly changed during the study. Laboratory parameters including vital sign, EKG, hematological, and biochemical values showed no significant changes during the trial. Conclusions : This study suggests that risperidone is generally safe and effective against both the positive and negative symptoms in our group of patients.

급성전골수성백혈병에서 백혈구성분채집술에 이은 치명적인 뇌출혈 2예

오윤정,박소윤,김윤정,한동석,김현수,최진혁,남동기,임호영,김효철,주희재 아주대학교 의과학연구소 1998 아주의학 Vol.3 No.1

The aim of this study is to report 2 cases of acute promyelocytic leukemia who died from intracranial hemorrhage following leukapheresis and to provide proper preventive measures against hemorrhage following leukapheresis. From 1994 to 1997, a total of twenty-six patients with leukemia underwent leukapheresis to control hyperleukocytosis at Ajou University Hospital. Two patients with acute promyelocytic leukemia received all-trans retinoic acid but developed drug-induced hyperleukocytosis. Shortly after leukapheresis, they died from intracranial hemorrhage. The risk factors for fatal hemorrhage are thought to be coexisting disseminated intravascular coagulation(DIC), thrombocytopenia aggravated by leukapheresis, exacerbated coagulopathy related to mechanical trauma through leukapheresis and the excess use of citrate during leukapheresis. To reduce the risk of the bleeding associated with leukapheresis, it is necessary to replace platelet sufficiently before and after leukapheresis and to give calcium to correct coagulopathy induced by excess citrate which is used as anticoagulant as well as the correction of disseminated intravascular coagulation.

피로를 유발하는 등속성 수축시와 회복기 혈중젖산 및 외측광근의 EMG Power Specturm 변화

정정진,조현철,김기진,윤성원,오수일,홍관이,손태열 龍仁大學校 體育科學硏究所 1991 體育科學硏究論叢 Vol.1 No.1

To examine the change of blood lactate concentration, EMG power spectrum, and Torque during fatiguing isokinetic contraction and recovery phrase, 6 sprinters performed maximal isokinetic knee extension at angular velocity of 3.14 rad.sec??(180°sec??) to 75% decreasing point (25%PT) using CybexⅡ system. In exercise phase, there was significant correlation between the decrement of peak EMG and median frequency and that of torque, and decrement of torque was greater than that of EMG . In recovery phase, EMG was restituded as normal value rapidly in a minute, but torque was restituded more slowly, and blood lactate concentration increased gradually from 50%PT to 3 minute after recovery. As a result of this study, it is suggested that muscle fatique due to decreasing of metabolic substrate and accumulation of metabolic products in peripheral site of muscle, and that inhibitory factors act neuromuscular junction in the end of exercise from rapid restitution of EMG in recovery phase.

건선 병변부 및 병변주위부 피부의 Cytokines 유전자 발현

윤기성,김도원,정상립,김문규,김정철 경북대학교 병원 1997 경북대학교병원의학연구소논문집 Vol.1 No.1

It has been proposed that cytokines may be involved in mediating the characteristic pathological changes in psoriasis, including epidermal hyperplasia, compromised keratinocyte differentiation, and dermal and epidermal infiltration by polymorphonuclear leukocytes and mononuclear cells. The purpose of this study os to assess the pattern of cytokine gene expression in psoriatic skin lesion. To investigate the cytokine expression pattern, we examined the transcripts of cytokine genes using reverse transcription and polymerase chain reaction (RT-PCR) method with 13 cytokine-specific primers. The Results were as follow; 1. Only the TGF-β gene was expressed in the normal skin. 2. IL-1α, IL-1β, IL-8, and TGF-β were detected in both lesional and perilesional psoriatic skin. The lesions showed more prominent expression. 3. IL-10 and GM-CSF were weakly detectable in three lesional psoriatic skin respectively, and IL-2R in two lesional psoriatic skin. 4. IL-2,IL-4,IL-5,IL-6 TNF-α, IFN-γ were not detectable on both lesional and perilesional psoriatic skin. Therefore, distinct differences in the cytokines gene expression were noted between normal and psoriatic skin. The patterns of cytokines gene expression in perilesional skin were similiar to those of lesional psoriatic skin.

豚皮를 添加한 Sausage의 製品特性 및 豚皮 安定性에 관한 硏究

정인철,문윤희 慶星大學校 1991 論文集 Vol.12 No.2

Experiments were carried out to investigate properties of product among pork sausage not added pork skin and pork sausage, fish sausage, mixtured sausage added 10% pork skin, and analyzed the storage stability of these products of 3。C and 20。C . The results obtained are summerized as follow : 1.Sausages added pork skin were high in processing yield and moisture content, but there were low in the contents of crude fat and protein. The total contents of moisture, crude fat and crude protein were above 90% in all products. 2. There was not over the permitted value of remainder content of NO₂for all products, and the concentration of salt of mixtured sausage was relative higher than other products. 3. Water-holding capacity and gel strength of sausage added pork skin were lower than sausage added pork skin, but the percentage of fat loss was lower. 4. The extractability of salt soluble protein and water soluble protein was high generally in fish, but the extractability of stroma protein was high slightly in pork sausage added pork skin. There are significant differences the pattern of using sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) of salt soluble and water soluble protein between pork and fish sausage. 5. During the storage periods, moisture content and water activity was decreased and there showed large in high storage temperature. 6. During the storage periods, both pork sausage added pork skin and pork sausage not added pork skin were not different in pH value and VBN content. The pH value wes great slightly in fish and mixtured sausage and VBN content seemed to be not difference in all products until 6 weeks. 7. The TBA value was higher in pork sausage added pork skin than in pork sausage not added pork skin, and in fish sauasge than pork asausage. 8. Fish sausage was relative lower than other products in total plate counts. The coliform groups were not found until the end of storage.

침자가 성장기 및 성숙기 웅성 흰쥐의 혈액성분에 미치는 영향

윤범철,이성동,류정록,최태암 高麗大學校 倂設 保健大學 保健科學硏究所 2001 保健科學論集 Vol.27 No.2

Acupuncture, an over 2500 years old therapeutic method stemming from traditional oriental medicine, is nowadays wide open to modern medical science. With the widespread usage of acupuncture, the number of article about biomechanical or therapeutic effects of acupuncture from animal experiments and clinical trials is largely reported. In a previous study, we have reported that Joksamlee(ST36) acupuncture increases serum protein and glucose but decrease serum lipid and cholesterol. For further study, we was examined effects of Shenshu(B23) and Samumgyo(SP6) acupuncture stimulation on differential blood components in growing and adult male rate. 24 male Sprague-Dawley rats were randomly assigned into three groups; A1 (B23 and SP6 acupuncture in adult rats) group, A2 (B23 acupuncture in growing rats) group, and control group. The results obtained were as follows; 1. Body weight was significantly decreased in A1 and A2 groups. 2. Serum TP level was not changed, but albumin level was significantly increased in A2 group. 3. Serum glucose level was significantly increased in A1 group. 4. Serum TG level was significantly decreased in A2 group: PL level was significantly decreased in both A1 and A2 groups; FFA level was not changed. 5. Serum T.CHO, HDL-C and LDL-C levels were not changed in both A1 and A2. 6. Serum amylase activity was significantly increased in A1 group.

저지방 프레스햄의 제조와 품질특성에 관한 연구

정인범,정인철,문윤희 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.5

돈육의 적육을 70%로 하여 등지방을 첨가하지 않고 저지방 프레스햄(A)을 제조하고, 또 돈육과 등지방 배합비를 각각 60%와 10%(B), 55%와 15%(C) 및 50%와 20%(D)로 하여 모두 4종류의 프레스햄을 제조하였다. 이 때에 적육과 등지방 이외의 모든 재료와 제조 조건은 동일하게 하였다. 제조된 프레스햄의 일반성분, 보수력 및 기호성을 비교하고, 이것을 4℃에서 60일간 냉장하면서 10일 간격으로 조직특성의 변화 정도를 비교하였다. 저지방 프레스햄(A)은 수분 71.3%, 조단백질 함량 23.4%로 다른 제품보다 높았으며, 저지방 함량은 2.8%로 현저히 낮았다(p<0.05). 저지방 프레스햄의 보수력은 74.5%로 다른 제품보다 높았다. 저지방 프레스햄의 표면색도 중 명도(L)는 61.6 황색도(b)는 5.9로 다른 제품보다 높게 나타났다. 저지방 프레스햄은 경도가 70,.2, 탄성 85%, 씹힘성 0.49㎏, 뭉침성 2.0% 및 파쇄성이 0.7㎏으로 다른 제품보다 높은 편이었고 응집성의 경우 D제품보다 낮은 값을 보였다. 저지방 프레스햄의 향과 조직감은 다른 제품보다 열등하였으나 맛이 우수하였으며 기호성도 좋은 편이었다. This study was conducted to investigate the possibility of production for low fat press ham which was made without fat added. Four kinds of press ham were prpared ; A(pork 70%, fat 0% : low fat press ham), B(pork 60%, fat 10%), C(pork 55%, fat 15%) and D(pork 50%, fat 20%). The press ham samples were stored at 4±2℃. The physico chemical properties of press hams were analyzed during storage 60 days at 4℃. The contets of moisture(71.3%) and crude protein(23.4%) of low fat press ham were higher than those of other products, and crude fat content(2.8%) was remarkably lower(p<0.05). The water holding capacity of press ham was higher than other products. Hunter's L(61.6) and b-value(5.9) of low fat press ham were lower than other products, but a-value(11.7) was higher. Hardness(70.2dyne/㎝), springiness(85%), chewiness(0.49㎏), gumminess(2.0㎏) and brittleness(0.7㎏) of low fat press ham were higher than those of other products, but cohesiveness was lower than D product. Aroma and texture of low fat press ham were inferior to other, but taste and palatability of that were superior.

동결온도가 진공포장 동결육의 품질에 미치는 영향

정인철,김도완,문귀임,강세주,김기영,문윤희 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.4

본 연구는 진공포장 동결육의 품질에 미치는 영향을 검토하기 위하여 수행하였다. 해동드립은 -3℃와 -20℃ 동결이 60일째 각각 5.23% 및 5.17%로 동결기간이 경과함에 따라 현저하게 증가하였다. 가열감량은 water bath와 pan에서 가열한 것이 모두 동결초기보다 동결기간이 경과함에 따라 현저하게 증가하였다. 그러나 -3℃와 -20℃ 사이에는 현저한 차이가 없었다. 염용성 단백질의 추출성은 동결기간이 지남에 따라 감소하였고, -20℃ 동결이 -3℃보다 추출성이 더 높았다. 수용성 단백질의 추출성은 동결기간이 경과하면서 증가하였고 -3℃ 동결이 -20℃보다 현저하게 높았다. 그리고 L, a 및 b값은 저장초기가 동결저장 중보다 높다. Myoglobin의 변성율은 -3℃ 동결이 -20℃보다 비교적 높게 나타났는데, -3℃ 동결의 15일째가 96.0%로 가장 높게 나타났다. 전단력가는 동결저장 중 현저한 변화가 없었고, 근원섬유의 소편화도는 동결초기보다 동결저장이 더 높았지만 동결저장 중에는 변화가 없었다. pH는 -3℃와 -20℃ 동결저장 모두 45일까지 감소하다가 그 이후에는 증가하는 경향이었다. This study was carried out to investigate the effects of freezing temperature on quality of vacuum packaging freezed beef. In case of thaw drip loss, the freezing of -3℃ and -20℃ were 5.23% and 5.17% to 60 days respectively, were increased significantly during freezing. The cooking loss of water bath and pan were increased significantly during freezing than the beginning of freezing, but were no different between -3℃ and -20℃. The salt soluble protein extractability was decreased during freezing, the -20℃ freezing was higher than -3℃ freezing. The water soluble protein extractability was increased during freezing, the -3℃ freezing was higher than -20℃ freezing. The L, a and b value of the beginning of freezing higher than during freezing. The myoglobin denatured percentage of the -3℃ freezing was higher than -20℃ freezing, the 15 days storage of -3℃ freezing was highest to 96%. The shear force value was not change during freezing, the myofibrillar fragmentation index during freezing was higher than the beginning of freezing, but was not change during freezing. The pH was decreased to freezing 45 days, after that increased.

살균방법을 달리한 시유의 저장성

정인철,권수득,문윤희 慶星大學校 1994 論文集 Vol.15 No.2

Experiments were carried out to investigate market milk treated by LTLT, HTST, UHT methods and analysed storage stability of these products at 5℃ and 30℃ by 24 hour interval. In case of LTLT, storage periods were possible to 6 days in 5℃, thermophile bacteria was more than HTST and UHT. Storage stability during stored in 30℃ was impossible only one day, psychrophile bacteria was more than HTST and UHT. In case of HTST, storage periods were possible to 6 days in 5℃, psychrophile bacteria was more than LTLT and UHT. Storage stability during stored in 30℃ was impossible only one day. In case of UHT, storage periods were possible to 7 days in 5℃, storage stability except boiling test was safe to 1st and thermophile bacteria was more than LTLT, HTST during stored in 30℃.