The Clinical Characteristics of Angioedema with Eosinophilia

( Hyo Jung Cho ),( Hye Soo Yoo ),( Mi Ae Kim ),( Yoo Seob Shin ),( Young Min Ye ),( Dong Ho Nahm ),( Joo Hee Kim ),( Jeong Hee Choi ),( Sun Young Park ),( Hae Sim Park ) 대한내과학회 2013 대한내과학회 추계학술발표논문집 Vol.2013 No.1

Angioedema with eosinophilia (AE) is a very rare allergy disease, case reports of which have been published sporadically since 1984. Here, we retrospectively analyzed the clinical features of 10 AE patients in Korea. Nine of the 10 subjects were young females, ranging from 23 to 38 years old. Twenty percent of the subjects had episodic-type AE with high serum IgM and eosinophil counts, while 80% were non-episodic type with normal serum IgM levels but high eosinophil counts. All patients had used systemic corticosteroids to control AE. One patient with refractory EAE was treated with anti-IgE antibody. This is the first study to evaluate the clinical characteristics of AE in a Korean population.

율동 훈련의 폐경기 여성의 불편감, 혈중지질 농도 및 삶의 질에 미치는 영향

최정안,최명애 서울대학교 간호대학 간호과학연구소 1999 간호학 논문집 Vol.13 No.2

Regular long term dance movement is considered to be one of the effective ways to change blood lipids level and to decrease menopausal discomforts, and then to induce improvement of quality of life in menopausal women. This study was focused on the effect of dance movement training on total cholesterol concentration, HDL-cholesterol concentration, LDL-cholesterol concentration, triglyceride concentration, atherognic index, menopausal discomforts, and quality of life. Thirty subjects, aged between 45 and 59 years who have experienced menopausal discomforts in Kyung Gi province, were chosen. Fifteen experimental groups subjects participated in a 12 week dance movement program. The dance movement program was developed on the basis of Korean traditional dance and music. The program consists of 50 minutes of dance, 3 times a week for 12 weeks. In the 50 minute workout, there were 15 minutes of warm-up dance, 25 minutes of conditioning dance and 10 minutes of cool-down dance. The intensity for the conditioning phase was at between 50% and 70% of age-adjusted maximum heart rates. Total cholesterol concentration, HDL-cholesterol concentration, LDL-choleserol concentration, triglyceride concentration, atherogenic index, menopausal discomforts, and quality of life were measured prior to and after the experimental treatment. The data were analysed using the SPSSWIN program. Ordinary statistical methods were applied to calculations of mean values and standard deviations. The independent two tailed t-test and Fisher's exact test were used to compare the general characteristics, extraneous variables, and the other variables between the experimental and control group. The independent one tailed t-test was used for testing the significance of the difference. The results were obtained as follows: 1) Score of menopausal discomforts of the experimental group was significantly lower than that of the control group after 12 weeks of dance movement training(t=-2.73, p=.006) 2) No significant differences in total cholesterol concentration(t=.407, p=.344), LDL-cholesterol concentration (t=.342, p=.368), triglyceride concentration (t=-.849, p=.202), and atherogenic index(t=-.793, p=.218) were observed between the experimental groups and control and the other variables between the experimental and control group. The independent one atherogenic index(t=-.793, p=.218) were observed between the experimental group and control group. And HDL-cholesterol concentration (t=2.056, p=.025) after 12 weeks of dance movement training was significantly higher than that of the control group. 3) Score of quality of life of the experimental groups was significantly higher than of the control group after 12 weeks of dance movement training (t=3.456, p=.002).

도로교통소음의 수평·수직적 전달 및 감쇠 특성

최형일,채희정,김연풍,조도호,설동화,정숙경,김정애 조선대학교 생산기술연구소 2007 生産技術硏究 Vol.29 No.1

This study has been conducted to achieve the following objectives: First, in order to understand the horizontal propagation and attenuation characteristics for the road traffic noise, we selected actively developed areas within 100 meters away from the road to measure the level of traffic noise near a road. To measure the noise near a railroad, we selected areas within 100 meters away from the road. In this way, we analyzed the horizontal propagation and attenuation characteristics for the traffic noise occurring in diversified areas. Second, in order to understand the vertical propagation and attenuation characteristics for the road traffic noise, we measured and analyzed the distributional characteristics of vertical sound pressure levels on each floor of multi-storied apartment buildings according to changes of traffic load and types, and the existence or nonexistence of soundproof walls. For the case of the road traffic noise, we also selected we measured and analyzed the different noise levels on each floor of multi-storied apartment buildings from the soundproof wall. The results of Horizontal propagation and attenuation characteristics for the road traffic noise are as follows: In cases of the soundproof wall + raising ground, raising ground, cutting land, and flat land as distance increases, the sound pressure level steadily decreases. The soundproof wall + raising ground has an especially high distance decrease compared to the other areas, and the sound pressure level for the raising ground is higher than that of the cutting land with a measurement of 10.7~12.1dB(A). Vertical propagation and attenuation characteristics for the road traffic noise are as follows: The amount of sound pressure level decrease is 12.6- 14.5dB(A) for first floor when measuring the vertical sound pressure levels at soundproof wall, which indicates a fairly large decrease. At fifth and sixth floor, the amount of decrease is 2.3dB(A), which indicates a small decrease.

신체활동의(Physical activity)의 개념분석

최정안,최명애 대한기초간호자연과학회 2004 Journal of korean biological nursing science Vol.6 No.1

The purpose of this study was to analyze the concept of physical activity. The method was based on the steps of concept analysis by Walker and Avant(1988). The result of this study were as follows ; Upon the concept analysis, physical activity is defined as a series of bodily movements which is performed voluntarily by individual. The defining attributes of physical activity were a series of bodily movements, energy expenditure, goal-directedness, and self-control of the body. The antecedents of physical activity were neuromusculoskeletal function, cardiopulmonary function and cognitive function. And the consequences of physical activity were improvement of physical function, induction of fatigue, and need(physiopsychosocial) satisfaction. Further studies are needed to develop the concept of physical activity using the Hybrid model. In addition, considering personal characteristics it is important to study the facilitating factors of physical activity.

우울증 환자의 부모양육행동, 대상관계 및 자아존중감에 관한 연구

최지애,최영민,이정호,이동우 大韓神經精神醫學會 2008 신경정신의학 Vol.47 No.5

Objectives : The aim of this study was to examine the relationship between the Object Relations, Parenting Behaviors, and Self-esteem with Depression. Methods : This study included 60 Depression patients and 90 healthy individuals. Parent Behavior Inventory (PBI), Bell Object Relation Inventory (BORI), Self-Esteem Scale (SES) and Beck Depression Inventory (BDI) were used for measuring parenting behaviors, object relations, self-esteem and severity of depression in orderly. Results : Depression was negatively associated wi self-esteem, and positively associated with four subscale of Object relation. Also, depression was positively associated with maternal intrusiveness, Parental negligence and negatively associated with maternal affection. The most potent variable to explain depression was self-esteem, and the second was insecure attachment. Maternal affection was the most explainable variable of self-esteem, and the most potent variable of insecure attachment was maternal intrusiveness. Correlation analysis with insecure attachment and self-esteem as control variable individually, there was weak correlation among variables. Conclusion : This study shows object relation, parent behavior, and self-esteem are related with depressive symptoms. Object relation (especially, insecure attachment) and self-esteem is more important and proximal cause in depression than Parental behavior. Result of the present study indicated that inadequate parental behavior m childhood foster insecure object relation and low self-esteem, then they contribute to depression through their interaction.

흰쥐에서 다시마 식이가 메트폴민의 체내동태 및 당 흡수에 미치는 영향

최한곤,장보현,이종달,김정애,유봉규,용철순 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.3

Drug interactions with food, on occasion, led to serious nutritional and functional changes in the body as well as alterations of pharmacological effect. It, therefore, should be necessary to take drug interactions with food into consideration for effective and safe therapeutics. Diabetes mellitus is a heterogeneous group of disorders characterized by abnormal glucose homeostasis, resulting in hyperglycemia, and is associated with increased risk of microvascular, macrovascular, and neuropathic complications. However, the precise mechanism of diabetes mellitus remins unclear. Three basic objectives in the care of diabetic patients are maintaining optimal nutrition, avoiding hypo-or hyperglycemia and preventing complications. Laminaria japonica is a brown macroalgae which can be used as a functional diet due to high content of diatery fiber. the purpose of this study was to investigate the effect of Laminaria japonica diet on the pharmacokinetics of metformin which are frequently used in the treatment of diabetes. Diabetic rats induced by strep-tozotocin were employed in this study. Blood concentrations of oral hypoglycemic agent, metformin, were measured by HPLC and resultant pharmacokinetic parameters were calculated by RSTRIP. The mechanisms of drug interaction with food were evaluated on the basis of pharmacokinetic parameters such as k_(a), t_(1/2), C_(max), t_(max), and AUC, C_(max), and k_(a), and increase in t_(max), compared to those with normal diet. This oral glucose test showed that Laminaria japonica diet could lower blood glucose level probably through either inhibiting the activity of disaccharidases, intestinal digestive enzymes, or delaying the absorption of glucose. More studies should be followed to fully understand pharmacokinetic changes of metformin caused by ong-term Laminaria japonica diet.

반복 작업 근로자들에서의 경견완장애에 관한 연구

최재욱,염용태,송동빈,박종태,장성훈,최정애 大韓産業醫學會 1996 대한직업환경의학회지 Vol.8 No.2

본 연구는 근골격계 질환중에서 대표적인 질환인 경견완장애를 대상으로 일부 제조업 및 전화교환수 근로자에서의 경견완장애의 유병실태 파악, 경견완장애의 정확한 분류 및 향후 진단기준의 개발에 필요한 기초적인 자료 수집에 목적을 두었다. 조사대상은 반복동작에 폭로되는 생산직 근로자 98명, 모전화국의 전화교환수 115명을 대상으로 근골격계 증상호소, 이학적 검사 및 신경학적검사와 기타 혈중 효소등의 임상검사 및 악력의 차이 등을 조사하였다. 조사대상 사업장 중 B사업장은 전자부품을 생산하는 사업장으로, 제품 조립라인의 작업형태는 주야 2교대 근무이며, 앉아서 하는 작업과 서서하는 작업이 혼재 되어있다. A사업장은 전화교환작업, 즉 컴퓨터단말기를 취급하는 작업으로 전원 앉아서 하는 작업이며, 주야 2교대 작업이다. 조사대상 집단의 일반적 특성은 다음과 같다. A사업장 근로자의 평균 연령은 37.9세, 평균 근속년수는 17년이며, B사업장은 평균 연령 37.7세, 평균 근속년수 10.4년이었다. A 사업장은 대상 근로자 115명이 전원 여자였으며, B사업장은 대상근로자 98명 중 남자 68(69.4%)명, 여자 30(30.6%)명이었다. 조사 결과는 다음과 같다. 사업장별 자각 증상 호소율은 A 사업장의 경우 경부 85.2%, 견관절 81.7%, 주관절 34.8%, 완관절 73.0%의 순으로 특히 경부 및 견관절, 완관절의 증상 호소율이 높았으며, 반면 B 사업장은 경부 51.2%, 견관절 56.1% 주관절 23.5%, 완관절 31.3%의 순이었다. 근속년수별 자각증상 호소율은 경부와 견관절의 자각증상 호소율이 40%이상으로 주관절 및 완관절의 지각 증상 호소율에 비해서 상대적으로 높았으며, 경부와 완관절은 근속년수가 증가함에 따라 자각증상에 호소율이 통계적으로 유의하게 증가하였다. A 사업장, B 사업장 모두 최소 22.8% 이상의 근로자(증상 경험자중)가 병원이나 약국을 방문하여 치료를 받았다고 응답하였으며, 사업장 간의 차이는 보이지 않았다. 조사 대상자 전원에게 신경학적 검사와 근전도 검사를 포함한 정밀건강진단을 실시하였다. 정밀건강진단 결과 A 사업장은 질병자가 10명(8.6%), 요주의자가 31명(26.9%), 재검자가 2(1.7%)이었으며, B 사업장은 질병자가 16(16.3%), 요주의자가 12명(12.2%), 재검자 2명(2.0%)이었다. 이러한 이상자의 질병별 유형은 긴장성 경부증후군에 해당하는 사람이 46명으로 이 중 질병자는 13명, 요주의자 30명 재검자 3명이었으며, 수근관증후군은 16명으로 질병자 3명, 요주의자 8명, 재검자 5명이었다. 기타 드퀘르뱅씨병은 5명으로 질병자 4명, 요주의자 1명이었으며, 외측상과염 3명, 이두근개건염 3명, 회전근개건염 3명, 내측상과염 2명, 경추디스트증후군이 5명 등이었다. 사업장별로는 A 사업장의 경우 긴장성경부증후군이 11명, 수근관증후군이 8명, 드퀘르뱅씨병 3명, 경추디스크증후군이 1명이었으며, B 사업장은 긴장성경부증후군이 35명, 수근관증후군이 8명, 드퀘르뱅씨병 2명등의 순이었다. 이러한 결과는 A 사업장의 경우 작업 조건이 의자에 앉아서 실시하는 컴퓨터 작업인데 반하여 B 작업장은 대부분 기립작업, 반복 조립으로 이러한 작업조건에 차이에 기인하는 것으로 판단된다. 경견완장애의 이상소견과 관련이 있는 성별, 연령, 빈도 위험도 점수 및 힘 위험도를 독립변수로 설정하여 다단계 로지스틱 회귀분석을 실시하였다. 경견완장애 이상소견에 통계적으로 유의한 영향을 미친 변수는 성별(p=0.0005), 연령(p=0.0093)이었으며, 힘위험도는 p값이 0.0567, 빈도위험도는 0.0983으로 유의하지 않았다. The purpose of this study is to investigate the current status of and to collect the basic informations of musculoskeletal diseases of upper extremities in manufacturing and telecommunication companies. The subjects were 213 workers, consisted of 98 manufacturing workers and 115 telephone operators. The musculoskeletal symptom survey, job safety analysis(JSA), and medical examinations including neurologic and nerve conduction velocity(NCV) test were conducted. All workers were women in company A, while the other composed of 68(69.4%) men and 30(30.6%) women. The results were as follows: 1. The rates of self-reporting symptoms in each company were 85.2% at the neck, 81.7% at the shoulder joint, 73.0% at the wrist joint and 34.8% at the elbow joint in company A, while 56.1% at the shoulder joint, 51.2% at the neck and 23.5% at the elbow joint in company B in order. 2. No relationship was observed between the work duration and symptom rate in company A, but the highest symptom rate was observed at the neck in 10-19 year work duration group, at the shoulder, elbow and wrist joint in 5-9 year work duration group in company B. 3. Over the 22.8% of total workers in this study having symptoms got medical treatment at the medical clinics or drug stores, but there was no statistical difference between both companies. 4. In company A, 16(13.9%) workers were classified as D category, 12(10.4%) workers as C category and 2(1.7%) workers as R category among 115 workers. And D category was 10(10.2%), C category 31(31.6%) and R category 4(4.0%) among 98 workers in company B. D category means disease category needed futher treatment, C category means disease category needed no treatment and R category means recheck category needed futher evaluation. 5. The types of musculoskeletal disorders including D, C, and R category were 46 cases(D 13, C 30, R 3)of tension neck syndrome (TNS), 16 cases(D 3, C 8, R 5) of carpal tunnel syndrome (CTS), 5 cases of De Quervain's disease, 3 cases of lateral epicondylitis, 3 cases of bicipital tendinitis, 3 cases of rotator cuff tendinitis, 2 cases of medical epicondylitis, and 5 cases of cervical disc syndrome. 6. In company A, the total cases of 11 TNS, 8 CTS, 3 De Quervain's disease, 3 lateral epicondylitis, 3 rotator cuff tendinitis and 1 cervical disc syndrome were diagnosed and so were total cases of 35 TNS, 8 CTS and 4 cervical disc syndrome in company B. 7. By stepwise multiple regression analysis with dichotomization of musculoskeletal disease, the following odds ratios were significantly high(p<0.05)-sex(2.707) and age (1.926).

杜?(Eucommiae Cortex)抽出物이 動物性 癌細胞 增殖抑制에 미치는 影響

崔貞愛,黃祐翊 고려대학교 의과대학 1984 고려대 의대 잡지 Vol.21 No.3

뽕잎추출액코팅농도에 따른 뽕잎쌀밥의 품질에 관한 연구

김애정,노정옥,우경자,최원석 한국조리과학회 2003 한국식품조리과학회지 Vol.19 No.5

The purpose of this study was to assess the optimum coating ratio for rice, using various ratios of mulberry leaves extract, 1.0, 1.5, and 2.0%, and to determine the optimum ratio of added water, in proportion to the total weight of mulberry rice. The moisture content of the soaked rice, and the optimum water uptake rate, moisture content of the cooked rice, as well as its blue and color values, mechanical characteristics, internal structure and sensory evaluation, were analyzed. The statistical data analyses were completed using the SAS program. The results are summarized as follows: The moisture content of mulberry rice was less than that of raw rice. The average optimum water uptake of the soaked mulberry rice at the different water temperatures, 10, 20 and 30℃, was 20% of the total weight of the raw mulberry rice. As for the results of the sensory evaluation; 140% water, in proportion to the total weight of raw mulberry rice, was judged to be the optimum. The average moisture content of the cooked mulberry rice was 45~50%, but there was no significant difference in the various coating ratios. The blue value of the cooked mulberry rice awas highest on the first day of cooking. The L- and a-values decreased with increasing coating ratio, but the b-value increased under the same conditions. As for the mechanical characteristics,; the adhesiveness, hardness and springiness decreased during 2 days of storage. The internal structure of the mulberry rice, observed by SEM, showed a close structure on increasing the coating ratios of mulberry leaves extracts. It was concluded that the optimum coating ratio of mulberry rice and ratio of added water for cooking whereas 1.5 and 140%, respectively, in proportion to the total weight of raw mulberry rice.

「장애인 등에 대한 특수교육법」에 따른 교육과정적 통합교육 실시에 대한 초등학교 특수교사와 일반교사의 인식

김의정,김애화,최혜승,권택환 이화여자대학교 교과교육연구소 2011 교과교육학연구 Vol.15 No.4

본 연구에서는 .장애인 등에 대한 특수교육법.에 따른 교육과정적 통합교육 실시에 대한 초등학교 특수교사와 일반교사의 인식을 알아보기 위하여 포커스 그룹 인터뷰를 실시하였다. 총 30명의 교사(특수교사 15명과 일반교사 15명)가 포커스 그룹 인터뷰에 참여하였고, 인터뷰는 5개의 개방형 질문에 따라 진행되었다. 인터뷰 데이터를 전사한 후 3차에 걸쳐 코딩하였으며, 이를 통해 .장애인 등에 대한 특수교육법.에서 요구하는 교육과정적 통합교육 실시에 대한 특수교사와 일반교사의 인식과 관련된 4개의 주제와 이들 주제 하에 특수교사 13개, 일반교사 16개의 범주가 도출되었다. 주요 연구 결과를 요약하면 다음과 같다. 첫째, 통합교육에 대한 특수교사와 일반교사의 견해에 차이가 있었다. 둘째, 교육과정적 통합교육을 실시하는 데 있어서의 어려움, 요구 사항 및 해결방안에는 특수교사와 일반교사 간 공통점과 차이점이 동시에 나타났다. 셋째, 교육과정적 통합교육을 위해 필요한 특수교사와 일반교사 고유의 전문성에는 두 교사 집단 간 뚜렷한 인식의 차이가 있는 것으로 나타났다. 마지막으로, 특수교사와 일반교사는 기본적인 교사로서의 사명감 및 자질을 교육 과정적 통합교육을 실시하는데 필요한 특수교사와 일반교사 공통의 전문성으로 인식하는 것으로 나타났다. In this study, focus group interviews were conducted to explore the perceptions of elementary special and general education teachers on curricular inclusion. Thirty teachers (15 special education teachers and 15 general education teachers) participated in focus group interviews; the interviews involved five open-ended questions. The interview data were transcribed, and then coded three times. Through the coding processes, four themes with thirteen sub-categories emerged for the special education teachers; sixteen sub-categories emerged for the general education teachers. The major findings of this study are summarized as follows. First, the special and general education teachers perceived inclusion differently. Second, the findings revealed both commonalities and differences between the special and general education teachers about difficulties, needs, and solutions for curricular inclusion. Third, the special and general education teachers felt that the unique expertise of both special and general education teachers is needed for successful curricular inclusion. Lastly, they felt that the commitment and qualities of teachers should be their common expertise in the implementation of curricular inclusion.