Impact of White Matter Changes on Activities of Daily Living in Mild to Moderate Dementia

Moon, So Young,Na, Duk L.,Seo, Sang Won,Lee, Jun-Young,Ku, Bon D.,Kim, Seong Yoon,Park, Kyung Won,Shim, Yong S.,Youn, Young Chul,Chung, Chan-Seung,Cheong, Hae-Kwan,Choi, Seong Hye,Cha, Kyung Ryeol,Kim S. Karger AG 2011 European neurology Vol.65 No.4

<P>The association between white matter changes and activities of daily living (ADL) in a large, well-defined cohort of patients with mild-to-moderate dementia (either Alzheimer’s disease or subcortical vascular dementia) were investigated. A total of 289 patients were divided into three groups (140 mild, 99 moderate, and 50 severe) depending on the degree of white matter changes as indicated on brain magnetic resonance image scans. Further, we analyzed the three groups’ performances on basic and instrumental ADL. The degree of white matter changes was associated with greater age, hypertension, previous history of stroke, higher Hachinski Ischemic Score, worse global cognitive and functional status, and an increased impairment of basic ADL and instrumental ADL. The increased impairment with regard to the severe group’s performance on both the basic and instrumental ADL remained significant after adjustment for age and hypertension. Tasks involving physical activities were most significant. This was the first study investigating the association between white matter changes and ADL in a large, well-defined dementia cohort. The present study suggests that severe white matter changes may be associated with higher impairment on both basic and instrumental ADL.</P><P>Copyright © 2010 S. Karger AG, Basel</P>

Synchronized Oxygen Delivery and Its Optimization Method: A Bench Study

Lee, Gil Jun,Cha, Seung Keun,Oh, Seung Kwon,Shin, Choongsoo S.,Lee, Tae Soo Korean Society for Precision Engineering 2013 International Journal of Precision Engineering and Vol.14 No.4

Long-term oxygen therapy (LTOT) has been widely used to treat patients with chronic obstructive pulmonary disease. The traditional oxygen delivery methods used for LTOT are continuous flow oxygen (CFO) and demand oxygen delivery (DOD). CFO wastes a considerable amount of oxygen, whereas DOD often makes patients feel uncomfortable because it abruptly supplies a large amount of oxygen at the onset of inhalation. Hence, we developed an algorithm for predicting the onset of inhalation, which allowed oxygen to be supplied smoothly before inhalation. Moreover, we minimized the discomfort index (DI) to offer more comfortable oxygen delivery. By integrating the prediction algorithm and the minimization of DI, the previous synchronized demand oxygen delivery (SDOD) method was modified. We constructed a bench model to validate the modified SDOD. The results showed that the proposed algorithm accurately predicted the onset of inhalation. The difference in the real-time measured and predicted values for the beginning of inhalation was less than 0.10 s. Using the proposed minimization technique, the DI was decreased by 50% under 20 breaths per minute when compared with the DI calculated from a previous study. In conclusion, the modified SDOD could supply oxygen more comfortably while synchronizing with patient breathing patterns.

산란대기하에서 광위성 통신 업링크의 양각에 따른 송신 안테나의 설계

김영권,이종규,전석빈,한종석,김준환 延世大學校 電波通信共同硏究所 1996 電波通信論文誌 Vol.2 No.1

Today's wireless communication needs the super-high speed for picture transmission and high-speed data transmission as well as voice. The optical(laser) communication is suitable for this demands because of the very wide optical bandwidth. But to fulfill the optical communication, the atmospheric attenuation of cloudy weather must be overcome. Under the weather condition of haze, fog, rain, and snow, the atmospheric attenuation, which affects on the optical satellite up-link communication between geo-satellite and earth station, was studied in this paper. In this case, the scattering attenuation and absorption is the most serious effect. The poiting error weaken the optical receiving power, too. These three attenuation factors directly influence the diameter of optical transmitting antenna. In this paper, the anttena diameter of the earth station was calculated according to the elevation angle, weather condition and transmission rate. The specification of this paper's simualtion was the 10[W] ?? laser as an optical source, and the binary FSK as a modulation method and the optical heterodyne receiver. The diameter of the optical cassegrain receiving antenna was assummed 1[m], the coding gain was set to 10[dB], and the BER(Bit Error Rate) was set to ???. As a result, the diameter of the transmitting antenna is distributed from centimeters to about 100 meters according to the weather condition, elevation angle and transmission rate. In case of the 10[Mbps] transmission rate, the receiving anttena diameter under the condition of haze is designed below 2[cm]. Fog makes the anttena diameter over 5[m]. Rain makes the anttena diameter below 3[m]. And snow makes over 10[m] anttena. Above values was calculated in the region of 30° ~ 90° elevation angle.

혈액 투석 환자에서 중심정맥 협착에 대한 스텐트 삽입술 : Wallstent Placement

임대승,노상필,이유선,정승현,김보영,이정우,강정아,김정희,이민수,정준용,최시완,정진옥,성인환,이강욱,신영태 충남대학교 의과대학 의학연구소 2002 충남의대잡지 Vol.29 No.1

Stenosis of central vein is a common complication arising after percutaneous subclavian vein catheter insertion performed for temporary vascular access in chronic renal failure patients undergoing hemodialysis. There are several treatment methods for the condition like percutaneous angioplasty(PTA), stent insertion, and surgery, but recent trend is toward PTA and stents. Among the patients diagnosed with chronic renal failure from March 1993 to May 2002 and undergoing hemodialysis through AV fistula, the 14 Patients in whom central vein stenosis arose were selected for the study. A total of 28 percutaneous interventions(5 PTA and 23 stent placement) were performed, and restenosis rate and the time taken till the restenosis in de novo lesions and instant lesions were compared. All 28 cases were operated successfully. The 14 cases that received both anigioplasty and stent placement initially. (de novo lesion : 14 cases), Among the 10 cases with de novo lesion that followed up more than 1 year, 3 cases are currently undergoing hemodialysis without restenosis, and the remaining 7 cases have recurred stenosis with the mean time to restenosis of 10.9 months. In the 7 cases in whom stenosis recurred, 11 interventions were done(instent lesion: 11 cases). 4 of these were using only ballon angioplasty with 100% restenosis rate and the mean time of 3 months until restenosis. The remaining 7 cases were using both balloon angioplasty and stent placement, also with 100% restenosis rate but with the mean time of 12 months until restenosis, which was later than the group receiving only balloon angioplasty. In treating the patients with central vein stenosis, stent placement seems to be more advantageous over PTA in terms of restenosis rate and the mean duration of patency. In the case of instent lesion, inserting the stent for the second time after stenosis recurred lengthened the duration of patency compared to performing balloon angioplasty alone.

The Safety and Efficacy of Daclatasvir and Asunaprevir with Chronic HCV Genotype 1 Infection and Hemodialysis

( Myeong Jun Song ),( Jung Hyun Kwon ),( Soon Woo Nam ),( Tae Hee Lee ),( Young Woo Kang ),( Ji Woong Jang ),( Seok Hyun Kim ),( Byung Seok Lee5 ),( Sea Hwan Lee ),( Hong Soo Kim ),( Ji Hoon Kim ),( S 대한간학회 2017 춘·추계 학술대회 (KASL) Vol.2017 No.1

Aims: We aimed to evaluate the efficacy and safety of Daclatasvir (DAV) and Asunaprevir (ASV) in patients with chronic hepatitis C virus (HCV) and chronic renal failure (CRF). Methods: 22 chronic hemodialysis patients with HCV infection at 12 medical centers have prospectively enrolled from Feb, 2016 to Feb, 2017 (NCT02580474). Of those, 9 patients who were followed 12 weeks after treatment ended were included. We evaluated the virological responses at each week 4, 12, 24 and the 12-week sustained virologic response (SVR12). The tolerability and safety of patients were also evaluated. Results: Of these 20 patients, there had no resistance-associated variant of NS5A (NS5A RAVs) and 2 patients showed indeterminate NS5A RAVs. 12 patients (54.5%) completed the 24 weeks treatment of DAV and ASV. 6 patients (27.2%) have continued, but 4 patients discontinued study prior to 12 weeks. Overall, all patients (n=9) achieved SVR12. Virologic response at week 4, 12 and 24 showed 94.4% (17/18), 93.3% (14/15), and 100% (12/12) respectively. DCV and ASV were well tolerated among the majority of patients and discontinuation of the treatment due to adverse events (hypertension, bradycardia, leukemia) was occurred in 3 patients. In two patients with indeterminate NS5A RAVs, one achieved SVR12 but the other showed viral breakthrough and discontinued treatment. Conclusions: In this study, DAV and ASV combination therapy for chronic hemodialysis patients with HCV infection achieved high sustained virological response with few adverse events. Close monitoring of safety and tolerability may be necessary when treating chronic hepatitis C patients with CRF receiving DCV and ASV.

Cu<SUB>47.5</SUB>Zr<SUB>47.5</SUB>Al₅ 벌크 비정질 합금의 고온 변형 및 성형 특성

이수은(S. E. Lee),이광석(K. S. Lee),전현준(H. J. Jun),장영원(Y. W. Chang) 한국소성가공학회 2010 한국소성가공학회 학술대회 논문집 Vol.2010 No.10

Plastic deformation of a CU47.5Zr47.5Al? ternary bulk metallic glass in the supercooled liquid region was investigated. The appropriate working temperature-strain rate combination for optimum solid-to-solid forming was deduced to be between (710 K, 3×10?⁴ s?¹) and (735 K, 3×10?² s?¹) by constructing a processing map superimposed with the time-temperature transformation curve indicating crystallization. Furthermore, the actual formability around this processing window was not only confirmed by overlapping the laboratory-scale extrusion deformability but also estimated by applying finite element analysis.

관리기 부착형 다목적 파종기 개발

조성찬,한충수,전형규,이재석,이호필,장재수,서정헌 충북대학교 한국과학재단 지정 첨단원예기술개발 연구센터 2002 연구보고서 Vol.6 No.-

This study was conducted to develop a multi purpose seeder as an attachment to a small cultivator, and its design criteria has been investigated through the laboratory and field trials. It was also found that our new seeder with small cultivator might control row spacing and hill distance and this new system could be applied for seedling of many kinds of plants.

X-Y 테이블에 사용되는 볼 스크류의 열팽창 억제에 관한 연구

전언찬,이승수,김민주,곽창식,장성규,한근조,김중완,박홍식,전태옥,박정보 동아대학교 공과대학부설 생산기술연구소 1997 生産技術硏究所硏究論文集 Vol.2 No.2

In this paper, we have studied about the thermal expansion of the ball screw used for the X-Y table. The hollow ball type is used for the vall screw. We have compared the conventional cooling system and function with the improved cooling system and function which is developed the path providing cooling oil in hollow ball screw. That is, the temperature variation and positioning accuracy are analyzed of the ball screw. We have obtained the following result through this experiment. 1) The improved cooling system of the hollow ball screw for X-Y table was developed. 2) The improved cooling system of the hollow ball screw has a large effectiveness on restraining the thermal expansion of the ball screw. 3) The positioning accuracy of the ball screw was improved about 2∼4㎛ using temperature-controlled colling oil.

박리성대동맥류에 관한 임상적 관찰 : 진단 및 치료의 최근 현황

김준수,박영배,김성국,전은석,최윤식,이영우 대한내과학회 1986 대한내과학회지 Vol.30 No.3

A retrospective clinical study was done on 37 cases of aortic dissection who had been admitted to Seoul National University Hospital from January, 1981 to June, 1985. 1) Aortic dissection was seen a little more frequently in men than women with M:F ratio of approximately 1.2:1. The peak incidence was in the fifth and sixth decades, with the range being 22 to 77 years of age. Most cases with age of less than 35 were associated with Marfan syndrome, Takayasu's disease, or suspected Behcet's disease. 2) Aortic regurgitation and pulse deficits were important features of proximal dissection, and bruits and pulsating masses were important features of distal dissection. 3) Echocardiography, abdominal ultrasonography, and/or CT scan may be useful screening or diagnostic procedures, before performing aortography. 4) In surgically indicated cases(18 cases), the hospital death rates were 75% in medically treated group(12 cases) and 17% in surgically treated group(6 cases).

Satisfaction with mammography in the National Cancer Screening Programme participants of age 40s in Korea

JEON, B.Y.,LEE, H‐,Y.,PARK, E‐,C.,CHOI, K.S.,JUN, J.K.,KIM, Y.,HAN, M.A.,YOON, N‐,H.,KIM, E.J.,JEON, S.M. Blackwell Publishing Ltd 2011 European journal of cancer care Vol.20 No.6

<P>JEON B.Y., LEE H‐Y., PARK E‐C., CHOI K.S., JUN J.K., KIM Y., HAN M.A., YOON N‐H., KIM E.J. & JEON S.M. (2011) <I>European Journal of Cancer Care</I><B>20</B>, 803–809</P><P><B>Satisfaction with mammography in the National Cancer Screening Programme participants of age 40s in Korea</B></P><P>The aim of this study was to evaluate satisfaction with the National Cancer Screening Programme of mammography in Korea and to examine the association between subscales of satisfaction and general satisfaction. We conducted a cross‐sectional telephone survey for women who had obtained a National Cancer Screening Programme mammographic screening at general hospitals between May and October 2008. The present study included 2005 women in their forties. We performed multivariate linear regression using dependent variable as general satisfaction and independent variables as subscales of satisfaction, such as pre‐screening information transfer, staff interpersonal skills, physical surroundings and results reporting. Participants were stratified according to the result of their mammogram as negative or positive. Mean score of satisfaction was above 2.5 of 4 for all subscales. Women who received positive results were less satisfied with all of subscale factors. Staff interpersonal skills were the most important factor that contributed to general satisfaction. Future efforts such as staff training programme of communication/attitude skills, ensuring privacy and explanation of possible discomfort of the screening would be needed.</P>