Validation of the Korean Version of the Anosognosia Questionnaire for Dementia

Gi Hwan Byeon,Woo Jin Kim,Min Soo Byun,Jun Ho Lee,So Yeon Jeon,Kang Ko,Kiyoung Sung,Dongkyun Han,Haejung Joung,Younghwa Lee,Gijung Jung,Han Na Lee,Dahyun Yi,Dong Young Lee 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.4

Objective Anosognosia is a common phenomenon in individuals with dementia. Anosognosia Questionnaire for dementia (AQ-D) is a well-known scale for evaluating anosognosia. This study aimed to establish a Korean version of the AQ-D (AQ-D-K) and to evaluate the reliability and validity of the AQ-D-K in patients with Alzheimer’s disease (AD) dementia. Methods We translated the original English version of AQ-D into Korean (AQ-D-K). Eighty-four subjects with very mild or mild AD de-mentia and their caregivers participated. Reliability of AQ-D-K was assessed by internal consistency and one-month test-retest reliability. Construct validity and concurrent validity were also evaluated. Results Internal consistencies of the AQ-D-K patient form and caregiver form were high (Cronbach alpha 0.95 and 0.93, respectively). The test-retest reliability of AQ-D-K measured by intra-class correlation coefficient was 0.84. Three factors were identified: 1) anosognosia of instrumental activity of daily living; 2) anosognosia basic activity of daily living; and 3) anosognosia of depression and disinhibition. AQ-D-K score was significantly correlated with the clinician-rated anosognosia rating scale (ARS), center for epidemiological studies-de-pression scale (CES-D) and state-trait anxiety inventory (STAI). Conclusion The findings suggest that the AQ-D-K is a reliable and valid scale for evaluating anosognosia for AD dementia patients us-ing Korean language. Psychiatry Investig 2021;18(4):324-331

CD44-Targeting PLGA Nanoparticles Incorporating Paclitaxel and FAK siRNA Overcome Chemoresistance in Epithelial Ovarian Cancer

Byeon, Yeongseon,Lee, Jeong-Won,Choi, Whan Soo,Won, Ji Eun,Kim, Ga Hee,Kim, Min Gi,Wi, Tae In,Lee, Jae Myeong,Kang, Tae Heung,Jung, In Duk,Cho, Young-Jae,Ahn, Hyung Jun,Shin, Byung Cheol,Lee, Young Jo American Association for Cancer Research 2018 Cancer Research Vol.78 No.21

<P>These findings demonstrate the efficacy of a novel, selective, two-in-one delivery system to overcome chemoresistance in epithelial ovarian cancer.</P><P>Chemotherapy is commonly used in the treatment of ovarian cancer, yet most ovarian cancers harbor inherent resistance or develop acquired resistance. Therefore, novel therapeutic approaches to overcome chemoresistance are required. In this study, we developed a hyaluronic acid-labeled poly(d,l-lactide-co-glycolide) nanoparticle (HA-PLGA-NP) encapsulating both paclitaxel (PTX) and focal adhesion kinase (FAK) siRNA as a selective delivery system against chemoresistant ovarian cancer. The mean size and zeta potential of the HA-PLGA-NP were 220 nm and -7.3 mV, respectively. Incorporation efficiencies for PTX and FAK siRNA in the HA-PLGA-NPs were 77% and 85%, respectively. HA-PLGA-NP showed higher binding efficiency for CD44-positive tumor cells as compared with CD44-negative cells. HA-PLGA (PTX+FAK siRNA)-NP caused increased cytotoxicity and apoptosis in drug-resistant tumor cells. Treatment of human epithelial ovarian cancer tumor models HeyA8-MDR (<I>P</I> < 0.001) and SKOV3-TR (<I>P</I> < 0.001) with HA-PLGA (PTX+FAK siRNA)-NP resulted in significant inhibition of tumor growth. Moreover, in a drug-resistant, patient-derived xenograft (PDX) model, HA-PLGA (PTX+FAK siRNA)-NP significantly inhibited tumor growth compared with PTX alone (<I>P</I> < 0.002). Taken together, HA-PLGA-NP acts as an effective and selective delivery system for both the chemotherapeutic and the siRNA in order to overcome chemoresistance in ovarian carcinoma.</P><P><B>Significance:</B> These findings demonstrate the efficacy of a novel, selective, two-in-one delivery system to overcome chemoresistance in epithelial ovarian cancer. <I>Cancer Res; 78(21); 6247–56. ©2018 AACR</I>.</P>

음향 측정치와 상호 다중 모델을 이용한 수중 물체 식별

석기현(Gi-Hyun Suk),고보성(Bo-Sung Ko),변민수(Min-Su Byeon),최형준(Hyeong-Jun Choi),유민정(Min-Jeong Yoo),송진우(Jin-Woo Song) 대한전기학회 2024 대한전기학회 학술대회 논문집 Vol.2024 No.7

전라남도 고흥군 우량 산림습원의 군락구조 및 천이경향

이준혁(Jun Hyuk Lee),이정은(Jeong Eun Lee),변준기(Jun Gi Byeon),안종빈(Jong-Bin An),김호진(Ho Jin Kim),윤충원(Chung Weon Yun) 한국습지학회 2024 한국습지학회지 Vol.26 No.1

본 연구는 전라남도 고흥군 소재 우량 산림습원 2개소를 대상으로 군락구조를 파악하고 그에따른 천이경향을 구명하고자 수행되었다. 2023년 5월부터 10월까지 Z-M학파의 식물사회학적 방법에 의해 식생조사를 실시하였고 이 자료를 토대로 군락을 분류하여 현존식생도를 작성하였다. 그 결과, 골풀아재비군락, 꽝꽝나무-진퍼리새군락, 오리나무?진퍼리새군락, 진퍼리새군락, 오리나무-소나무군락, 오리나무군락의 총 6개 군락으로 분류되었다. 각 층위별 중요치를 분석한 결과, 골풀아재비군락에서는 절대습지식물인 골풀아재비의 중요치가 높게 나타났으며 나머지 5개 군락의아교목층과 관목층에서는 습지의 극상종인 오리나무, 절대육상식물인 소나무와 꽝꽝나무가, 초본층에서는 중간습원의대표종인 진퍼리새의 중요치가 높게 나타났다. 조사지 내 출현한 모든 관속식물을 습지선호도에 따라 분류한 결과, 골풀아재비군락에서는 절대습지식물의 출현율이 높게 나타났으나 나머지 5개 군락에서는 절대육상식물의 출현율이높게 나타났다. 골풀아재비군락을 제외한 나머지 5개 군락에서는 우량 산림습원을 구성하는 식물 중 육상식물의 출현비율이 높고, 습지가 건조화되는 단계에서 나타나는 진퍼리새가 번성하고 있어 습지의 천이 및 육화가 진행되고 있는것으로 판단되었다. This study was conducted to identify the community structure of two outstanding forest wetlands in Goheung-gun, Jeollanam-do, and to investigate their succession trends. vegetation survey was conducted using the Z-M phytosociological method From May to October, 2023, and based on this data, the Actual vegetation map was created by categorizing communities. This resulted in the classification of six communities. namely, Rhynchospora faberi community, Alnus japonica-Molinia japonica community, Ilex crenata-M. japonica community, M. japonica community, A. japonica-Pinus densiflora community and A. japonica community. The results of each layer's importance value (IV) analysis results indicated that in the R. faberi community, that of R. faberi, an obligate wetland plant, was high. In the subtree and shrub layers of the other five communities, A. japonica, a key species in wetland ecosystems, and Pinus densiflora and I. crenata, both obligate upland plants, exhibited higher IV. In the herb layer, the IV of M. japonica, a representative species of intermediate wetlands, was notably high. The results of classifying all observed plant species in the survey area based on their wetland preference revealed that in the R. faberi community, the occurrence rate of obligate wetland plants was high. However, in the other five communities, the occurrence rate of obligate upland plants was predominantly observed. Excluding the R. faberi community, in the other five communities constituting the outstanding forest wetlands, the occurrence rate of upland plants among the forest plants was high. It was observed that M. japonica which typically appears during the transition of wetlands to drier stages, was flourishing, indicating that the wetland was undergoing vegetation succession and terrestrialization.

필드 스크린을 위한 휴대용 전자코 시스템의 구현

변형기 ( Byeon Hyeong Gi ),이준섭 ( Lee Jun Seob ),김정도 ( Kim Jeong Do ) 한국센서학회 2004 센서학회지 Vol.13 No.1

There is currently much interest in the development of instruments that emulate the senses of humans. Increasingly,there is demand for mimicking the human sense of smell, which is a sophisticated chemosensory system. An electronicnose system is applicable to a large area of industries including environmental monitoring. We have designed a protableelectronic nose system using an array of commercial chemical gas sensors for recognizing and analyzing the variousodours. In this paper, we have implemented a portable electronic nose system using an array of gas sensors for recognizingand analyzing VOCs (Y31a1i1e Organic Compounds) in the field. The accuracy of a portable electronic nose system maybe lower than an instrument such as GCMS (Gas ChromatographyMass Spectrometer). However, a portable electronicnose system could be used on the field and showed fast response to pollutants in the field. Several different algorithmsfor odours recognition were used such as BP (Back-Propagation) or LM-BP (Levenberq-Marquardt Back-Propagation). Weapplied RBF (Radial Basis Function) Network for recognition and quantifying of odours, which has simpler and fastercompared to the previously used algorithms such as BP and LM-BP.

Comparison of Residual Characteristics between Two Formulations (WG and EC) of Pyraclostrobin on Persimmons

Joo Yeong Byeon,Hyeong Wook Jo,Gi Jun Hwang,Min Hye Kim,Sang Hyun Sohn,Byeom Haeng Cho 한국농약과학회 2016 한국농약과학회 학술발표대회 논문집 Vol.2016 No.4

Threshold Voltage Control and Longevity Improvement for Multi-layered MoS₂ via Bi-layered Encapsulation of SAM-Hydrophobic Polymer

Jin Heon Jeong,Seung Gi Seo,Jong Ik Baek,Yeong Uk Lee,Hyeong Cheol Park,Young Jun Byeon,Sung Hun Jin 대한전자공학회 2019 대한전자공학회 학술대회 Vol.2019 No.6

계방산과 오대산 일대 분비나무 자생지 군집 구조 및 하층식생 특성

천광일,변준기,김정인,박병주,Cheon, KwangIl,Byeon, Jun-Gi,Kim, Jung-In,Park, Byeong-Joo 한국환경복원기술학회 2022 한국환경복원기술학회지 Vol.25 No.5

This study was conducted to investigated woody species community classification and understory vegetation characteristics of Abies nephrolepis forest in Mt. Gyebang and Mt. Odae designated as Protected Area for Forest Genetic Resource Conservation and National Park. Vascular plants were surveyed as following; 55 family, 148 species, 3 sub species, 14 variety, 2 form 167 taxa. As an analysis of the species estimator of Jackknife 1, 29 survey plots could be representative of vegetation in study site. Results of the woody species, 3 communities were divided by cluster analysis(A=Abies nephrolepis-Tilia amurensis, B=Betula ermanii-Abies nephrolepis, C=Quercus mongolica-Abies nephrolepis). Using MRPP-test, there were significant differences between the communities indicating analysis of the appropriate group classification(p<0.01). The basal area and altitude were analyzed by negative relationship for NMS ordination. By analyzing plexus diagram of woody species, Acer pseudosieboldianum is strong associated with Quercus mongolica and Rhododendron schlippenbachii. Magnolia sieboldii is strong associated with Acer pictum subsp. mono etc.

용현자연휴양림 일대의 산림군락분류와 식생구조

신재권 ( Jae-kwon Shin ),변준기 ( Jun-gi Byeon ),윤충원 ( Chung-weon Yun ),구본열 ( Bon Youl Koo ),김한결 ( Han-gyeoul Kim ),김인식 ( In-sik Kim ),김동갑 ( Dong-kap Kim ) 한국환경생태학회 2017 한국환경생태학회지 Vol.31 No.2

본 연구는 국립용현자연휴양림일대 산림의 식생조사를 통하여 산림의 군락분류와 식생구조를 연구하였다. 2014년 4월부터 9월까지 약 26개의 방형구(20×20m)를 설치하여 식생조사를 실시하였다. 그 결과 신갈나무군락, 굴참나무군락, 고로쇠나무군락의 3개 군락으로 구분되었으며, 신갈나무군락은 소나무군과 전형군, 고소뢰나무군락은 회나무군과 전형군의 4개 군으로 세분되었다. 국립용현자연휴양림일대 산림식생유형은 3개 군락 4개군의 분류체계를 가졌으며, 총 5개의 식생단위로 구분되었다. 식생단위별 중요치 분석을 보면 교목 및 관목의 목본식물에서 식생단위 1은 소나무 (65.1%), 식생단위 2는 신갈나무(73.6%), 식생단위 3은 굴참나무(75.1%), 식생단위 4는 회나무(33.3%), 식생단위 5는 비목나무(21.7%)가 높게 나왔으며, 초본층에서 식생단위 1은 주름조개풀(19.3%), 식생단위 2는 실새풀(16.9%), 식생단위 3은 땅비싸리(17.3%), 식생단위 4와 5는 개별꽃이 각각 14.8%, 24.7%로 높게 나왔다. 지표종 분석결과 총 33종이 유의한 종으로 분석되었다(p<0.05). This study was carried out to investigate the forest community classification and vegetation structure in NYNRF(National Yonghyeon Natural Recreation Forest). We studied by 26 plots(20×20m) from April to September 2014. NYNRF were classified into the Quercus mongolica Community, Quercus variabilis community and Acer pictum community in the 3 community units. The Q. mongolica Community was subdivided into the Pinus densiflora group and Typical group and A. pictum community was also subdivided into the Euonymus sachalinensis group and Typical group. NYNRF were classified into 3 communities and 4 groups and 5 VU(vegetation units). According to the result of importance value analysis between vegetation units, VU 1 P. densiflora(65.1%), VU 2 Q. mongolica(73.6%), VU 3 Q. variabilis(75.1%), VU 4 E. sachalinensis(33.3%) and VU 5 Lindera erythrocarpa(27.1%) were highly showed in tree layer and VU 1 Rhododendron mucronulatum (19.3%), VU 2 Calamagrostis arundinacea (16.9%), VU 3 Indigofera kirilowii(75.1%), VU 4 and VU 5 Pseudostellaria heterophylla(each other 14.8% and 24.7%) were highly showed in herb layer. In INSPAN(INdicator SPecies ANalysis) of vegetation units, 33 species were analyzed significantly(p<0.05)

Spin-coating법에 의한 $TiO_2$의 광촉매 효율

김범준,변동진,이중기,박달근,Kim, Beom-Jun,Byeon, Dong-Jin,Lee, Jung-Gi,Park, Dal-Geun 한국재료학회 2000 한국재료학회지 Vol.10 No.4

TiO$_2$thin films were prepared on the glass by a conventional spin coating method with $TiO_2$ sol(30wt%, anatase). The thickness of the thin films were controlled by the number of coating cycles: one cycle is composed of spin coating, drying, and heating process. The reaction rate of the film was obtained by the photodecomposition of gaseous benzene under 0.44 and 2.0mW/$\textrm{cm}^2$ UV light on the film surface. For an incident UV light intensity of 0.44mW/$\textrm{cm}^2$, the reaction rate was increased with the thickness of the film, caused by extent of surface area, but there was no change over the thickness of about 4$\mu\textrm{m}$. The porous $TiO_2$ thin film has comparatively vast effective surface area, which under relatively high-intensity UV illumination causes the reaction rate to be controlled by the film thickness. $TiO_2$sol(30wt%, anatase)을 이용하여 스핀코팅으로 유리기판에 $TiO_2$박막을 제조하였다. 박막의 두께는 코팅주기의 횟수가 조절하였다. 한 코팅주기는 스핀코팅, 건조, 열처리를 포함한다. 박막의 반응성은 막 위에서의 자외선강도가 0.44와 2.mW/$\textrm{cm}^2$인 조건에서 벤젠기체의 광분해 속도를 통해 조사하였다. 박막의 두께가 증가할수록 표면적으로 증가로 인해 반응성은 증가하였으며, 0.44mW/$\textrm{cm}^2$일 때 4$\mu\textrm{m}$정도 이상의 두께에서 반응성은 더 이상 증가되지 않았다. porous한 $TiO_2$박막은 비교적 넓은 유효표면적을 가지고 있으며, 그것은 비교적 높은 자외선 강도하에서 박막두께에 따라 반응속도를 증가시키는 결과를 낳았다.