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- 저자 : Joon‑Young Heo (검색결과 453 건)
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Joon‑Young Heo,Min‑Seok Baek,Kwang‑Jun Euh,Kee‑Ahn Lee 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.5
This study investigated the microstructure, tensile and fatigue properties of Al–5 wt.%Mg alloy manufactured by twin rollstrip casting. Strips cast as a fabricated (F) specimen and a specimen heat treated (O) at 400 °C/5 h were produced andcompared. In the F specimen, microstructural observation discovered clustered precipitates in the center area, while in theO specimen precipitates were relatively more evenly distributed. Al, Al 6 (Mn, Fe), Mg 2 Al 3 and Mg 2 Si phases were observed. However, most of the Mg 2 Al 3 phase in the heat-treated O specimen was dissolved. A room temperature tensile test measuredyield strength of 177.7 MPa, ultimate tensile strength of 286.1 MPa and elongation of 11.1% in the F specimen and167.7 MPa (YS), 301.5 MPa (UTS) and 24.6% (EL) in the O specimen. A high cycle fatigue test measured a fatigue limit of145 MPa in the F specimen and 165 MPa in the O specimen, and the O specimen achieved greater fatigue properties in allfatigue stress conditions. The tensile and fatigue fracture surfaces of the above-mentioned specimens were observed, and thisstudy attempted to investigate the tensile and fatigue deformation behavior of strip cast Al–5 wt.%Mg based on the fi ndings.
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다변량 분석법을 이용한 소양강댐 상류 유역의 하천 수질 평가
최한규,백효선,허준영 江原大學校 産業技術硏究所 2002 産業技術硏究 Vol.22 No.A
The object of this study is to evaluate the factors affecting the water quality and to propose the influence of dominant factor quantitatively. The correlation analysis was performed to know the correlationship among the water quality items. As a result of partial correlation analysis, it was shown that the water quality items are affected by the rainfall item directly. The factor analysis was performed to grasp some number of factors on each point for deducing the items of similar variable characteristics. The four points were divided into different factor groups. It was grasped that NH_3-N and NO_3-N items have different variable characteristics after comparing the items. The Multiple regression analysis can decrease the number of observation. In the deduced multiple regression formula, it was shown that the rate of T-N, NH_3-N and NO_3-N in the independent variable took about 60% among all the regression formulas.
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Structural basis for the selective inhibition of JNK1 by the scaffolding protein JIP1 and SP600125
Heo, Yong-Seok,Kim, Su-Kyoung,Seo, Chang Il,Kim, Young Kwan,Sung, Byung-Je,Lee, Hye Shin,Lee, Jae Il,Park, Sam-Yong,Kim, Jin Hwan,Hwang, Kwang Yeon,Hyun, Young-Lan,Jeon, Young Ho,Ro, Seonggu,Cho, Joon Wiley (John WileySons) 2004 The EMBO journal Vol.23 No.11
<P>The c-jun N-terminal kinase (JNK) signaling pathway is regulated by JNK-interacting protein-1 (JIP1), which is a scaffolding protein assembling the components of the JNK cascade. Overexpression of JIP1 deactivates the JNK pathway selectively by cytoplasmic retention of JNK and thereby inhibits gene expression mediated by JNK, which occurs in the nucleus. Here, we report the crystal structure of human JNK1 complexed with pepJIP1, the peptide fragment of JIP1, revealing its selectivity for JNK1 over other MAPKs and the allosteric inhibition mechanism. The van der Waals contacts by the three residues (Pro157, Leu160, and Leu162) of pepJIP1 and the hydrogen bonding between Glu329 of JNK1 and Arg156 of pepJIP1 are critical for the selective binding. Binding of the peptide also induces a hinge motion between the N- and C-terminal domains of JNK1 and distorts the ATP-binding cleft, reducing the affinity of the kinase for ATP. In addition, we also determined the ternary complex structure of pepJIP1-bound JNK1 complexed with SP600125, an ATP-competitive inhibitor of JNK, providing the basis for the JNK specificity of the compound.</P>
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Heo, Young Mok,Lee, Hanbyul,Lee, Changsu,Kang, Juwon,Ahn, Joon-Woo,Lee, Young Min,Kang, Kyu-Young,Choi, Yoon-E,Kim, Jae-Jin Elsevier 2017 Algal research Vol.27 No.-
<P><B>Abstract</B></P> <P>To examine the possibility of better utilizing <I>Chlorella vulgaris</I> biomass including its carbohydrate as well as lipid contents, it was investigated whether cell disruption for lipid extraction could render the remaining microalgal residue (MR) suitable for enzymatic saccharification, possibly due to the disruption of cell wall structures. The <I>C. vulgaris</I> biomass was subjected to lipid extraction with different cell disruption methods (autoclaving, microwave irradiation, osmotic shock, and sonication), and recovered MRs were hydrolyzed using an enzyme produced from <I>Trichoderma koningiopsis</I> KUC21269 in this study. The enzyme was produced on-site with a highly simplified medium of barley straw, an agricultural byproduct. As a result, the saccharification rate of MR treated with microwave was more than twice that of the control group, and microwave irradiation appeared to be a promising method for both lipid extraction and subsequent saccharification. Our results suggested that both lipids and carbohydrates in <I>C. vulgaris</I> can be utilized by applying proper cell disruption method and a fungal enzyme produced on-site using an agricultural byproduct, respectively. This study revealed the high potential of <I>C. vulgaris</I> as an integrated bio-resource for both lipids and glucose, which can be converted to biodiesel and bioethanol, providing clues for overcoming hurdles in economically feasible biofuel production using microalgae.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Both lipids and glucose in <I>C. vulgaris</I> could be obtained with a single treatment. </LI> <LI> Cell disruption for lipid extraction could also damage cell wall structures. </LI> <LI> Lipid-extracted residues were hydrolyzed using a fungal enzyme produced on-site. </LI> <LI> Saccharification rate was more than doubled by microwave irradiation. </LI> <LI> Microwave irradiation enhanced the bioaccessibility of cellulose in the cell walls. </LI> </UL> </P>
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Joon-Young Heo,Jin-Han Gwon,Jong-Kwan Park,Kee-Ahn Lee 대한금속·재료학회 2018 METALS AND MATERIALS International Vol.24 No.3
Hypereutectic Al–Si alloy is an aluminum alloy containing at least 12.6 wt.% Si. It is necessary to evenly control the primarySi particle size and distribution in hypereutectic Al–Si alloy. In order to achieve this, there have been attempts to manufacturehypereutectic Al–Si alloy through a liquid phase sintering. This study investigated the microstructures and high temperaturemechanical properties of hypereutectic Al–14Si–Cu–Mg alloy manufactured by liquid phase sintering process and changesin them after T6 heat treatment. Microstructural observation identifi ed large amounts of small primary Si particles evenlydistributed in the matrix, and small amounts of various precipitation phases were found in grain interiors and grain boundaries. After T6 heat treatment, the primary Si particle size and shape did not change signifi cantly, but the size and distributionof CuAl 2 ( θ ) and AlCuMgSi ( Q ) changed. Hardness tests measured 97.36 HV after sintering and 142.5 HV after heat treatment. Compression tests were performed from room temperature to 300 °C. The results represented that yield strength wasgreater after heat treatment (RT ~ 300 °C: 351 ~ 93 MPa) than after sintering (RT ~ 300 °C: 210 ~ 89 MPa). Fracture surfaceanalysis identifi ed cracks developing mostly along the interface between the primary Si particles and the matrix with somediff erences among temperature conditions. In addition, brittle fracture mode was found after T6 heat treatment.
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췌관-공장 문합술에서 흡인형 췌관 스텐트의 초기 결과 보고
안영준(Young Joon Ahn),황기태(Ki-Tae Hwang),허승철(Seung-Chul Heo),정인목(In Mok Jung),정중기(Jung Kee Chung),장진영(Jin-Young Jang),김선회(Sun-Whe Kim) 대한외과학회 2007 Annals of Surgical Treatment and Research(ASRT) Vol.72 No.6
Purpose: We wanted to evaluate the feasibility of using the suction pancreatic duct stent, which was designed to aspirate pancreatic fluid more actively around the pancreaticojejnostomy site during performance of pancreaticoduodenectomy for preventing pancreatic fistula. Methods: In 7 consecutive pancreaticoduodenectomy patients, we inserted a PVC tube into the remnant pancreatic duct across the duct-to-mucosa type pancreaticojejunostomy at a 2 ㎝ depth as a totally external pancreatic stent. This stent was connected with the aspiration bag of a Jackson-Pratt drain for generating negative pressure. We inserted another Jackson-Pratt drain beneath the pancreaticojejunosomy site and checked the amylase level in the body fluid and the serum at the postoperative 1st and 5th days for evaluating pancreatic leakage. We also checked the daily amount of pancreatic fluid obtained through the suction stent. Pancreatic fistula was defined as an amylase level in the body fluid >10,000 U/L on postoperative 1 day or an amylase level in the body fluid >3 times the serum amylase level on the postoperative 5th day. Results: On postoperative day 1, the mean level of intraabdominal fluid amylase was 1,404 U/L (355∼3,850 U/L). On the postoperative 5th day, the mean level of amylase in the body fluid was 40.3 U/L (12∼144 U/L) and the mean level of serum amylase was 38.3 U/L (19∼71 U/L). Even on the postoperative 1st day, we could collect a considerable amount of pancreatic fluid (mean: 55.6 ㎖ (range: 9∼169 ㎖)). There was no complication associated with pancreatic leakage. Conclusion: The suction pancreatic stent can be a feasible method to prevent pancreatic leakage. Additional randomized studies to compare the conventional pancreatic duct stent with the suction pancreatic duct stent are mandatory.
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