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족관절 내과골절에서 피질골 나사못을 이용한 변형된 긴장대 고정술
최호림,도현우,김병흠,김규현,박종석,송준민 대한골절학회 2004 대한골절학회지 Vol.17 No.4
목적 : 전위된 족관절 내과골절에 대해 피질골 나사못을 이용한 변형된 긴장대 고정술을 이용한 치료결과를 분석해 보고자 하였다. 대상 및 방법 : 2001년 1월부터 2003년 1월까지 전위된 내과골절에 대해 변형된 긴장대 고정술을 시행 받고 최소 1년 이상 추시관찰 가능 하였던 24례를 대상으로 하였다. 남자 13례, 여자 11례로 평균 연령은 46세였다. 골절은 Lauge-Hansen 분류법을 사용하였으며, 결과는 Meyer와 Kumler의 평가 방법을 이용하였다. 결과 : 13례 (54%)에서 우수의 결과를 얻었고, 9례 (38%)에서 양호의 결과를 얻었으며, 운동범위의 제한이 발생한 1례에서 보통, 후외상성 관절염이 발생한 1례에서 불량의 결과를 얻었다. 결론 : 전위된 족관절 내과골절에서 피질골 나사못을 이용한 변형된 긴장대 고정술은 견고한 내고정과 조기 관절 운동이 가능한 효과적인 수술 방법이 될 수 있을 것으로 사료된다. Purpose : To evaluate the clinical results of modified tension band wire technique using cortical screw for treatment of displaced medial malleolar fractures of the ankle. Materials and Methods : From January 2001 to January 2003, 24 patients were treated by modified tension band wiring using cortical screw for medial malleolar fracture. The follow-up period was 12~35 months (average 18 months). There were 13 males and 11 females, and the mean age was 46 years. Fractures were classified by Lauge-Hansen's classification. The results were analyzed by Meyer and Kumler's criteria. Results : There were 13 cases (54%) of excellent, 9 cases (38%) of good, and one case of fair because of limitation of motion of the ankle joint and one case of poor which showed post-traumatic arthritis of the ankle. Conclusion : Modified tension band wire technique using cortical screw can be an effective operative method for the treatment of displaced medial malleolar fractures of the ankle.
액체소듐속에서 소듐-물반응에 의한 재질의 Wastage현상
정경채,정지영,김병호,김태준,최병해,최종현,김의식 한국공업화학회 2003 응용화학 Vol.7 No.1
In this study we observed and analyzed the corrosion phenomena in leak site and the effect on temperature at the target surface of heat transfer tube material by sodium-water reaction through water leakage in liquid sodium atmosphere. Surrounding of leak hole of the specimen was damaged by the wastage phenomena due to corrosion and erosion of material, and hole size by damage of leak site was extended from 150㎛ to about 200㎛. Also, the damaged size appeared in the target surface was observed to about 1000㎛ diameter. The temperature of target surface increased about 70~80℃ by the heat of sodium-water reaction even with the small leakage of 15㎖ water. From the results of EPMA and EDX analysis, damaged area are found to covered with complex compounds such as (NaOH+Na_2O) FexOy or (NaCrO_2+nA_2CrO4) mixed up with the sodium oxides by sodium-water reaction and the Fe or Cr element by matrix of tube sodium oxides by matrix of tube material.
정지영,정경채,김병호,김태준,최종현,박남국 한국공업화학회 2002 응용화학 Vol.6 No.2
An experimental study for the investigation of the sodium-steam reaction phenomena was carried out. No significant aggressive explosion phenomena were observed as compared with that of sodium-water reactions. It was also observed that the rate of increase of reaction temperature decreases with increasing initial temperature of liquid sodium and that the temperature of the target depends upon the flow rate of injected steam.
폴록사머 및 프로필렌글리콜을 이용한 클로트리마졸 고형 좌제의 물리화학적 특성
현경희,오유경,김정애,공경환,김지현,양준호,배명수,김호동,이종달,장현욱,용철순,최한곤 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.2
To develop a clotrimazole-loaded solid suppository with poloxamer and propylene glycol, the melting points of various formulations composed of poloxamer 188 (P 188) and propylene glycol were investigated. The dissolution study of clotrimazole delivered by the suppository composed of P 188 and propylene glycol was performed. The mixtures composed of P 188 and propylene glycol were homogeneous. Propylene glycol affected the melting points of poloxamer mixtures. In particular, the mixture [P 188/propylene glycol (70/30%)] with the melting point of about 32°C was a solid form at room temperature and instantly melted at physiological temperature. Furthermore, propylene glycol affected greatly the dissolution rates of clotrimazole from the suppository. Dissolution mechanism analysis showed the dissolution of clotrimazole was proportional to the time. Our results indicated that the solid suppository with P 188 and propylene glycol would be a candidate of rectal dosage form for clotrimazole.
Choi, Jong Hyeun,Park, Jin Ho,Choung, Won Myung,Kang, Yong,Kim, Sang Done 한국화학공학회 1995 Korean Journal of Chemical Engineering Vol.12 No.2
The hydrodynamic properties in the riser and standpipe, and the cyclone efficiency have been determined in a circulating fluidized bed (CFB) unit consisting of a riser (0.05 m-ID×3.8 m high), a standpipe (0.0068 m-ID×2.5 m high) as a primary cyclone/bubbling fluidized bed, and a secondary cyclone. Silica gel powder (mean diameter=46 ㎛) was used as the bed material. The effects of gas velocity in the riser and initial solid loading on the solid circulation rate, and the solid holdups in the riser and standpipe have been determined. The effects of gas velocity in the standpipe on the efficiencies of primary and secondary cyclones have been also determined as functions of solid circulation rate and solid entrainment rate. The solid circulation rate increases with increases in the gas velocity in the riser and in the initial solid Loading. The efficiencies of primary and secondary cyclones increase with an increase in the gas velocity in the riser. However, the efficiency of primary cyclone decreases and that of secondary cyclone increases slightly, with an increase in the gas velocity in the standpipe.
Flowers of Inula japonica Attenuate Inflammatory Responses
Choi, Jeon-Hyeun,Park, Young-Na,Li, Ying,Jin, Mei-Hua,Lee, Ji-Ean,Lee, Youn-Ju,Son, Jong-Keun,Chang, Hyeun-Wook,Lee, Eun-Kyung The Korean Association of Immunobiologists 2010 Immune Network Vol.10 No.5
Background: The flowers of Inula japonica (Inulae Flos) have long been used in traditional medicine for the treatment of inflammatory diseases. In the present study, we investigated the anti-inflammatory properties of Inulae Flos Extract (IFE). Methods: The anti-inflammatory effects of IFE against nitric oxide (NO), $PGE_2$, TNF-${\alpha}$, and IL-6 release, as well as NF-${\kappa}B$ and MAP kinase activation were evaluated in RAW 264.7 cells. Results: IFE inhibited the production of NO and the expression of inducible nitric oxide synthase (iNOS) in LPS-stimulated RAW264.7 cells. In addition, IFE reduced the release of pro-inflammatory cytokines, such as TNF-${\alpha}$ and IL-6. Furthermore, IFE inhibited the NF-${\kappa}B$ activation induced by LPS, which was associated with the abrogation of $I{\kappa}B-{\alpha}$ degradation and subsequent decreases in nuclear p65 and p50 levels. Moreover, the phosphorylation of ERK, JNK, and p38 MAP kinases in LPS-stimulated RAW 264.7 cells was suppressed by IFE in a dose-dependent manner. Conclusion: These results suggest that the anti-inflammation activities of IFE might be attributed to the inhibition of NO, iNOS and cytokine expression through the down-regulation of NF-${\kappa}B$ activation via suppression of $I{\kappa}B{\alpha}$ and MAP kinase phosphorylation in macrophages.
ACE Inhibition of the Aqueous Extracts from Fruit Bodies of Ganoderma Iucidum
Hyeun-Jong Bae, Tae-Ho Choi, Yu-Soo Shin, Masakazu Aoyama, Nam-Seok Cho 忠北大學校 農業科學硏究所 2010 農業科學硏究 Vol.26 No.1
To elucidate the chemical properties of antihypertensive components in the crude drug, Ganoderma Iucidum. we have studied the inhibitory effect of the aqueous extracts from the fruit bodies of G Iucidum on angiotensin 1 converting enzyme (ACE) activity. The aqueous extracts moderately inhibited the activity of ACE with respect to Hippuryl-histidyl-leucine(HHL) substrate. G Lucidium obtained from Hwasung showed higher ACE inhibitory activity in terms of higher IC50 values. The kinetics of ACE inhibition by the aqueous extracts from the crude drugs was plotted according to Lineweaver and Burk. The aqueous extracts inhibited the ACE activity. Mannitol and arabitol acting as moderate ACE inhibitors were found in the aqueous extracts. However, these polyhydric alcohols inhibited the ACE activity to a lesser extent compared with the aqueous extracts, suggesting that another type of more potent inhibitors exist in the aqueous extract of the crude drug.
Jong-Hyeong Lee,Byoung-Rourl Choi,Gwang-Grae Cho,Eun-Kyu Jang,Young-Rok Kim,Jung-Hyeun Ji,Hong-Sik Na,Sang-Eun Lee,Hyun-Hwoi Ku 한국토양비료학회 2020 한국토양비료학회지 Vol.53 No.4
Improving the nitrogen use efficiency (NUE) of crops is a technology that improves crop productivity and prevent environmental pollution simultaneously. A way to improve NUE is to develop and use a controlled release fertilizer. We developed a controlled release fertilizer in terms of controlled-release coated fertilizer for rhizosphere application (CRFR) which is a mineral fertilizer applying just under the plant root zone. In order to test effect of the developed CRFR on crop yield and NUE, field experiments were conducted with six levels of N (N 0, N 190, CRFR-N 16, CRFR-N 22, CRFR-N 27, and CRFR-N 33 ㎏ ㏊<SUP>-1</SUP>) at the experimental station of Gyeonggi-do Agricultural Research & Extension Services (GARES) for two years (2017 to 2018). The fruit yield and NUE of red pepper were obtained using agronomic measurements. To determine optimum N rate of CRFR we applied linear-plateau model. Results showed that the yield was not significantly different between the two levels of CRFRs (N 22 and 27) and N 190 in 2017. Similarly, the yield was not different between the three levels of CRFRs (N 22 and 27) and N 190 in 2018 although almost six times as much N rate was applied in the N 190. Meanwhile, NUEs in the CRFRs were ranged from 69.8 to 88.5% which were much higher than the N 190 treatment (14.8%). Since CRFRs showed no different yields as compared to N 190, we analyzed the optimum rate of CRFR using the linear plateau model and CRFR applied at 23.1 ㎏ N ㏊<SUP>-1</SUP> was optimal for the yield. Our results suggest that CRFR was able to significantly increase crop productivity while reduce environmental pollution because of remarkably high NUE.