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Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Lim, Hara,Jung, Yunu,Youn, Dong-Hyun,Jeong, Mi-Young,Kim, Hyun-Ju,Kim, Sung-Hoon,Kim, Su-Jin,Hong, Seung-Heon,Um, Jae-Young Hindawi Publishing Corporation 2013 Evidence-based Complementary and Alternative Medic Vol.2013 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean Medicine (KM) is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in KM lacks experimental evidence. According to <I>Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, <I>Veratrum nigrum</I> (VN) has antagonistic features against <I>Panax ginseng</I> (PG), and the PG-VN pair is strictly forbidden. In this study, we have shown the effects of PG, VN, and their combination on obesity in high-fat (HF) diet-induced obese mice and in 3T3-L1 cells. PG, VN, and PG-VN combination significantly reduced weight gain and the fat pad weight in HF diet-induced obese mice. They also significantly decreased lipid accumulation and the expressions of two major adipogenesis factors, PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I>, in 3T3-L1 cells. In addition, the PG-VN combination had synergistic effects compared with the mixture of extracts of PG and VN on inhibition of PPAR<I><I>γ</I></I> and C/EBP<I><I>α</I></I> expressions at lower doses. These results indicate a new potential anti-obese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in KM.</P>
Park, Jinbong,Jeon, Yong-Deok,Kim, Hye-Lin,Kim, Dae-Seung,Han, Yo-Han,Jung, Yunu,Youn, Dong-Hyun,Kang, JongWook,Yoon, Daeyeon,Jeong, Mi-Young,Lee, Jong-Hyun,Hong, Seung-Heon,Lee, Junhee,Um, Jae-Young Hindawi Publishing Corporation 2016 Evidence-based Complementary and Alternative Medic Vol.2016 No.-
<P>This study was performed in order to investigate the antiobese effects of the ethanolic extract of Veratri Nigri Rhizoma et Radix (VN), a herb with limited usage, due to its toxicology. An HPLC analysis identified jervine as a constituent of VN. By an Oil Red O assay and a Real-Time RT-PCR assay, VN showed higher antiadipogenic effects than jervine. In high-fat diet- (HFD-) induced obese C57BL/6J mice, VN administration suppressed body weight gain. The levels of peroxisome proliferator-activated receptor gamma (PPAR<I>γ</I>), CCAAT-enhancer-binding protein alpha (C/EBP<I>α</I>), adipocyte fatty-acid-binding protein (aP2), adiponectin, resistin, and LIPIN1 were suppressed by VN, while SIRT1 was upregulated. Furthermore, VN activated phosphorylation of the liver kinase B1- (LKB1-) AMP-activated protein kinase alpha- (AMPK<I>α</I>-) acetyl CoA carboxylase (ACC) axis. Further investigation of cotreatment of VN with the AMPK agonist AICAR or AMPK inhibitor Compound C showed that VN can activate the phosphorylation of AMPK<I>α</I> in compensation to the inhibition of Compound C. In conclusion, VN shows antiobesity effects in HFD-induced obese C57BL/6J mice. In 3T3-L1 adipocytes, VN has antiadipogenic features, which is due to activating the LKB1-AMPK<I>α</I>-ACC axis. These results suggest that VN has a potential benefit in preventing obesity.</P>
Woo Yong Park,Jungtae Leem,Jinbong Park,Jae-Young Um 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
The extract of the Gardenia jasminoides fruit (GJFE) can be consumed as an herbal tea or used as a yellow dye. We evaluated the thermogenic actions of GJFE by focusing on mitochondrial activation and studying the underlying mechanisms. To investigate the role of GJFE on thermogenesis in mice, we used an acute cold exposure model. After 2 weeks of feeding, the cold tolerance of GJFE-fed mice was notably increased compared to PBS-fed mice. Moreover, GJFE significantly increased thermogenic factors such as PPARγ, UCP1, and PGC1α in vitro as well. Factors related to mitochondrial abundance and functions were also induced by GJFE in white and beige adipocytes. However, the treatment of PPARγ inhibitor abolished the GJFE-induced changes, indicating that activation of PPAR γ is critical for the thermogenic effect of GJFE. In conclusion, GJFE induces thermogenic action by activating mitochondrial function via PPARγ activation. Through these findings, we suggest GJFE as a potential anti-obesity agent with a novel mechanism involving thermogenic action in white adipocytes.
Kim, Dae-Seung,Kim, Sung-Hee,Kee, Ji-Ye,Han, Yo-Han,Park, JinBong,Mun, Jeong-Geon,Joo, Moon-Jung,Jeon, Yong-Deok,Kim, Su-Jin,Park, Sang-Hyun,Park, Sung-Joo,Um, Jae-Young,Hong, Seung-Heon Institute for Advanced Research in Asian Science a 2017 The American journal of Chinese medicine Vol. No.
<P><I>Eclipta prostrata</I> (EP) and its compounds are known to have several pharmacological effects including anti-inflammatory effects. In the present study, we demonstrated that EP improves the dextran sulfate sodium (DSS)-induced colitis symptoms such as body weight loss, colon length shortening and disease activity index. In DSS-induced colitis tissue, EP controls the protein expressions of cyclooxygenase-2 (COX-2) and hypoxia inducible factor-1<TEX>$ \alpha $</TEX> (HIF-1<TEX>$ \alpha $</TEX>). In addition, the release of prostaglandin E<SUB>2</SUB> and vascular endothelial growth factor-A were significantly reduced by EP administration. EP also inhibited COX-2 and HIF-1<TEX>$ \alpha $</TEX> expressions in the tumor necrosis factor-<TEX>$ \alpha $</TEX> stimulated HT-29 cells. These inhibitory effects of EP occurred by reducing the phosphorylation of I<TEX>$ \kappa $</TEX>B and the translocation of the nuclear factor-<TEX>$ \kappa $</TEX>B (NF-<TEX>$ \kappa $</TEX>B). Additionally, we found through HPLC analysis that wedelolactone, which is an inhibitor of NF-<TEX>$ \kappa $</TEX>B transcription, was contained in water extract of EP. These results indicate that EP can improve colitis symptoms through the modulation of immune function in intestinal epithelial cells and suggests that EP has the potential therapeutic effect to intestinal inflammation.</P>
Recent advances in extracellular vesicles for therapeutic cargo delivery
김효인,Park Jinbong,Zhu Yin,Wang Xiaoyun,Han Yohan,Zhang Duo 생화학분자생물학회 2024 Experimental and molecular medicine Vol.56 No.-
Exosomes, which are nanosized vesicles secreted by cells, are attracting increasing interest in the field of biomedical research due to their unique properties, including biocompatibility, cargo loading capacity, and deep tissue penetration. They serve as natural signaling agents in intercellular communication, and their inherent ability to carry proteins, lipids, and nucleic acids endows them with remarkable therapeutic potential. Thus, exosomes can be exploited for diverse therapeutic applications, including chemotherapy, gene therapy, and photothermal therapy. Moreover, their capacity for homotypic targeting and self-recognition provides opportunities for personalized medicine. Despite their advantages as novel therapeutic agents, there are several challenges in optimizing cargo loading efficiency and structural stability and in defining exosome origins. Future research should include the development of large-scale, quality-controllable production methods, the refinement of drug loading strategies, and extensive in vivo studies and clinical trials. Despite the unresolved difficulties, the use of exosomes as efficient, stable, and safe therapeutic delivery systems is an interesting area in biomedical research. Therefore, this review describes exosomes and summarizes cutting-edge studies published in high-impact journals that have introduced novel or enhanced therapeutic effects using exosomes as a drug delivery system in the past 2 years. We provide an informative overview of the current state of exosome research, highlighting the unique properties and therapeutic applications of exosomes. We also emphasize challenges and future directions, underscoring the importance of addressing key issues in the field. With this review, we encourage researchers to further develop exosome-based drugs for clinical application, as such drugs may be among the most promising next-generation therapeutics.
Sanghee Park,Jinbong Choi 한국언론학회 2013 Asian Communication Research Vol.10 No.1,2
This study compared attitudes toward mobile phone ildl’advertising among college students in South Korea and the United States. This study also determines attitudes, uses and buying behaviors related to mobile phone advertising in South Korea and the United States. To analyze the effect of advertising on mobile phones, this study hypothesizes that the level of exposure to mobile phone advertising messages will affect attitudes toward mobile phone advertising messages, and mobile phone users’ attitudes toward mobile phone advertising messages will affect their buying behaviors. This research surveyed a total of 253 college students, 144 participants from South Korea and 109 participants from the United States. By comparing respondents in South Korea and the United States, this study found that both countries have differences in the frequency of mobile phone use, the level of exposure to advertising messages, attitudes toward advertising messages, and buying behavior based on mobile phone advertising messages.
Lee, Jueun,Park, Jinbong,Park, Hyewon,Youn, Dong-Hyun,Lee, Jaehoon,Hong, Seokbeom,Um, Jae-Young Hindawi 2018 Evidence-based Complementary and Alternative Medic Vol.2018 No.-
<P>Obesity has become a major health threat in developed countries. However, current medications for obesity are limited because of their adverse effects. Interest in natural products for the treatment of obesity is thus rapidly growing. Korean medicine is characterized by the wide use of herbal formulas. However, the combination rule of herbal formulas in Korean medicine lacks experimental evidence. According to<I> Shennong's Classic of Materia Medica</I>, the earliest book of herbal medicine, Bupleuri Radix (BR) and Scutellariae Radix (SR) possess the Sangsoo relationship, which means they have synergistic features when used together. Therefore these two are frequently used together in prescriptions such as Sosiho-Tang. In this study, we used the network pharmacological method to predict the interaction between these two herbs and then investigated the effects of BR, SR, and their combination on obesity in 3T3-L1 adipocytes. BR, SR, and BR-SR mixture significantly decreased lipid accumulation and the expressions of two major adipogenic factors, peroxisome proliferator-activated receptor-gamma (PPAR<I>γ</I>) and CCAAT/enhancer-binding protein-alpha (C/EBP<I>α</I>), and their downstream genes,<I> Adipoq</I>,<I> aP2,</I> and<I> Lipin1</I> in 3T3-L1 cells. In addition, the BR-SR mixture had synergistic effects compared with BR or SR on inhibition of adipogenic-gene expressions. BR and SR also inhibited the protein expressions of PPAR<I>γ</I> and C/EBP<I>α</I>. Furthermore, the two extracts successfully activated AMP-activated protein kinase alpha (AMPK <I>α</I>), the key regulator of energy metabolism. When compared to those of BR or SR, the BR-SR mixture showed higher inhibition rates of PPAR<I>γ</I> and C/EBP<I>α</I>, along with higher activation rate of AMPK. These results indicate a new potential antiobese pharmacotherapy and also provide scientific evidence supporting the usage of herbal combinations instead of mixtures in Korean medicine.</P>
Secoisolariciresinol diglucoside inhibits adipogenesis through the AMPK pathway
Kang, JongWook,Park, Jinbong,Kim, Hye-Lin,Jung, Yunu,Youn, Dong-Hyun,Lim, Seona,Song, Gahee,Park, Hyewon,Jin, Jong Sik,Kwak, Hyun Jeong,Um, Jae-Young Elsevier 2018 european journal of pharmacology Vol.820 No.-
<P>Flaxseeds are used to treat metabolic diseases such as type 2 diabetes, fatty liver, hyperlipidemia and obesity. Secoisolariciresinol diglucoside (SDG) is a main substance of lignan which belongs to the phytoestrogen family and exists abundantly in flaxseeds. In this study, SDG reduced the body weight and size of adipose tissue, and decreased protein expressions of peroxisome proliferator-activated receptor gamma (PPAR gamma) and CCAAT-enhancerbinding protein alpha (C/EBP alpha) in the high fat diet-fed-induced obese mice model. In the vitro study, we examined the anti-adipogenic effect of SDG during differentiation of 3T3-L1 cells into adipocytes. 3T3-L1 preadipocytes were differentiated and treated with various concentrations of SDG. Oil Red O staining was done to measure the quantity of lipid contents. As a result, SDG reduced lipid accumulation and decreased the expressions of adipogenic- related genes such as adipocyte fatty-acid-binding protein 2, adiponectin, and resistin. SDG also decreased the mRNA and protein levels of PPAR gamma and C/EBP alpha. Furthermore, phosphorylation levels of AMPactivated protein kinase a (AMPK a) and its upstream activator, liver kinase B1, were significantly increased by SDG in 3T3-L1 cells. These results suggest that SDG inhibits adipogenesis by activating AMPK alpha, suggesting it could be an attractive therapeutic candidate for the treatment of obesity.</P>