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( Jin Hwa Moon ),( Dae Won Jun ),( Tae Yeob Kim ),( Joo Hyun Sohn ),( Kang Nyeong Lee ),( Hang Lak Lee ),( Oh Young Lee ),( Byung Chul Yoon ),( Ho Soon Choi ) 대한간학회 2013 춘·추계 학술대회 (KASL) Vol.2013 No.1
Background: The cerebral function in patients with liver cirrhosis (LC) ranges from normal to severe encephalopathy and an arbitrary classification of hepatic encephalopathy (HE) does not support the mechanism of patient`s neurocognitive impairment. The aim of this study is to reveal the early changes of cognitive process in cirrhotic patients without clinical symptoms of encephalopathy by event related potential (ERP) parameters. Patients and Methods: The patients were 21 adult LC patients without clinical encephalopathy (M: F=16: 5), (56.5±6.9 years) and 29 normal controls (51.5±6.4 years). For neuropsychological tests, NCT-A, NCT-B, line tracing test (LTT), serial dotting test (SDT) and digit symbolic test (DST) were performed. For ERP measures, 3 blocks of auditory oddball paradigm was used. N100, P200, N200 and P300 ERP parameters measured from the Cz electrode were analyzed. Results: In neuropsychiatric tests, LC patients showed the longer performance time on NCT-A (83.0 ± 39.3 vs. 44.5 ± 15.4 seconds, P=0.000), LTT (48.7 ± 19.3 vs. 35.3 ± 7.8 seconds, P=0.002), SDT (43.6 ± 35.1 vs 23.7 ± 7.0 seconds, P=0.005), DST (82.3 ± 62.9 vs. 35.8 ± 14.9 seconds, P=0.000) than in control group. In ERP studies, LC group showed increased latencies of N100 (115.6 ± 10.9 vs. 112.0 ± 9.7 ms, P=0.038), P200 (194.2 ± 28.9 vs. 185.9 ± 18.8 ms, P=0.034), N200 (266.7 ± 41.4 vs. 240.2 ± 30.5 ms, P=0.000), and P300 (358.0±53.8 vs. 325.1±43.3 ms, P=0.000) than in control group, which represent the slower early cortical auditory processing. The ampli- tudes of ERP components in both groups were not significantly different. The results of neuropsychiatric tests were not signifi- cantly correlated with ERP parameters. Among the total 21 LC patients, 13 patients were considered as MHE by neuropsychological tests or P300 latency. The other 8 patients were considered as LC without MHE. We further compared the results of the 8 patients without MHE with that of the controls. The N200 latency of the patients without MHE was significantly increased than in controls (261.5 ± 40.5 vs. 240.2±30.5 ms, P=0.006). Conclusions: The prolonged early ERP parameter latencies in clinically normal LC patients with or without MHE suggest that the slower auditory cortical processing might be the first mechanism of cerebral deterioration. It was found even in clinically normal and without MHE LC patients.
( Jin Hwa Park ),( Kang Nyeong Lee ),( Oh Young Lee ),( Myung-gyu Choi ),( Hyunsoo Chung ),( Suck-chei Choi ),( Nayoung Kim ),( Hyojin Park ),( In-kyung Sung ),( Chong Il Sohn ),( Sam Ryong Jee ),( Ja 대한소화기기능성질환·운동학회(구 대한소화관운동학회) 2021 Journal of Neurogastroenterology and Motility (JNM Vol.27 No.1
Background/Aims Prokinetics such as mosapride citrate CR (conventional-release; Gasmotin) are commonly used in functional dyspepsia (FD). This study aims to evaluate the efficacy and safety of once-a-day mosapride citrate SR (DWJ1252), a sustained-release formulation of mosapride citrate, compared with mosapride citrate CR 3 times a day, in patients with FD. Methods In this multicenter, randomized, double-blind, active-controlled, non-inferiority study, 119 patients with FD (by the Rome III criteria, 60 for mosapride citrate SR and 59 for mosapride citrate CR) were randomly allocated to mosapride citrate SR once daily or mosapride citrate CR thrice daily for 4 weeks in 16 medical institutions. Primary end point was the change in gastrointestinal symptom (GIS) score from baseline, assessed by GIS questionnaires on 5-point Likert scale after 4-week treatment. Secondary end points and safety profiles were also analyzed. Results The study included 51 and 49 subjects in the mosapride citrate SR and mosapride citrate CR groups, respectively. GIS scores at week 4 were significantly reduced in both groups (mean ± SD: -10.04 ± 4.45 and -10.86 ± 5.53 in the mosapride citrate SR and mosapride citrate CR groups, respectively; P < 0.001), and the GIS changes from baseline did not differ between the 2 groups (difference, 0.82 point; 95% CI, -1.17, 2.81; P = 0.643). Changes in GIS at weeks 2 and 4 and quality of life at week 4, and the improvement rates of global assessments at weeks 2 and 4, did not differ between the groups. Adverse events were similar in the 2 groups, and there were no serious adverse events. Conclusion In patients with FD, mosapride citrate SR once daily is as effective as mosapride citrate CR thrice daily, with a similar safety profile. (J Neurogastroenterol Motil 2021;27:87-96)
Case Report : Low-dose steroid-induced tumor lysis syndrome in a hepatocellular carcinoma patient
( Jin Ok Kim ),( Dae Won Jun ),( Hye Jin Tae ),( Kang Nyeong Lee ),( Hang Lak Lee ),( Oh Young Lee ),( Ho Soon Choi ),( Byung Chul Yoon ),( Joon Soo Hahm ) 대한간학회 2015 Clinical and Molecular Hepatology(대한간학회지) Vol.21 No.1
Tumor lysis syndrome is rare in hepatocellular carcinoma (HCC), but it has been reported more frequently recently in response to treatments such as transcatheter arterial chemoembolization (TACE), radiofrequency thermal ablation (RFTA), and sorafenib. Tumor lysis syndrome induced by low-dose steroid appears to be very unusual in HCC. We report a patient with hepatitis-C-related liver cirrhosis and HCC in whom tumor lysis syndrome occurred due to low-dose steroid (10 mg of prednisolone). The patient was a 90-year-old male who presented at the emergency room of our hospital with general weakness and poor oral intake. He had started to take prednisolone to treat adrenal insufficiency 2 days previously. Laboratory results revealed hyperuricemia, hyperphosphatemia, and increased creatinine. These abnormalities fulfilled the criteria in the Cairo-Bishop definition of tumor lysis syndrome. Although the patient received adequate hydration, severe metabolic acidosis and acute kidney injury progressed unabated. He finally developed multiple organ failure, and died 3 days after admission. This was a case of tumor lysis syndrome caused by administration of low-dose steroid in a patient with HCC. (Clin Mol Hepatol 2015;21:85-88)
한 대학병원에서 급성 폐색전증으로 진단된 환자들의 임상적 특성 및 예후
채진녕 ( Jin Nyeong Chae ),최원일 ( Won Il Choi ),박지혜 ( Jie Hae Park ),조병학 ( Byung Hak Rho ),김재범 ( Jae Bum Kim ) 대한결핵 및 호흡기학회 2010 Tuberculosis and Respiratory Diseases Vol.68 No.3
Background: Pulmonary embolism (PE) is a common clinical problem in the West that is associated with substantial morbidity and mortality. The diagnostic modality has been changed since 2001. This study retrospectively reviewed the PE mortality with the aim of identifying the risk factors associated with mortality since the multidetector computed tomography (MDCT) was introduced. Methods: We analyzed 105 patients with acute PE proven by multidetector CT or ventilation perfusion scan. The primary outcome measure was the all-cause mortality at 3 months. The prognostic effect of the baseline factors on survival was assessed by multivariate analysis. Results: The main risk factors were prolonged immobilization, stroke, cancer and obesity. Forty nine percent of patients had 3 or more risk factors. The overall mortality at 3 months was 18.1%. Multivariate analysis revealed low diastolic blood pressure and the existence of cancer to be independent factors significantly associated with mortality. Forty two PE patients were examined for the coagulation inhibitors. Four of these patients had a protein C deficiency (9.5%), and 11 had a protein S deficiency (26%). Conclusion: PE is an important clinical problem with a high mortality rate. Close monitoring may be necessary in patients with the risk factors.
QTL analysis of shank color variation in five lines of Korean native chicken
Shil Jin,Hee Bok Park,Dong Won Seo,Nu Ri Choi,Cahyadi Muhammad,Kang Nyeong Heo,Bo Seok Kang,Cheorun Jo,Jun Heon Lee 한국가금학회 2013 한국가금학회 정기총회 및 학술발표회 Vol.2013 No.11
한국재래닭은 깃털색 표현형을 기초로 다섯 계통으로 나누어져 있다. 이들 계통을 구축할 때 정강이 색에 대한 선발은 브로일러와의 차별성을 위해 회흑색 또는 암녹색의 개체를 선발해왔다. 그러나 여러 세대를 거듭한 선발에도 불구하고 모든 계통에서 다양한 정강이 색을 가진 개체들이 나타나고 있다. 본 연구는 한국재래닭 다섯 계통에서 나타나는 정강이 색의 변이를 조사하고 QTL분석을 통하여 정강이 색에 영향을 미치는 후보유 전자를 탐색하고자 실시하였다. 총 596마리 F1 개체들을 이용하여 양적형질좌위(QTL) 분석을 실시한 결과 총 8(GGA 1, 3, 4, 7, 14, 17, 24, 27)개의 염색체에서 정강이 색에 영향을 미치는 12개의 QTL을 확인하였다. 본 연구의 결과는 확인된 QTL영역에 존재 하는 후보유전자 동정을 거쳐 차후 정강이 색과 관련된 마커도움선발에 이용될 수 있을 것으로 판단된다.