Gender-related Differences in Management of Nonvalvular Atrial Fibrillation in an Asian Population

Lee, Jung Myung,Kim, Tae-Hoon,Cha, Myung-Jin,Park, Junbeom,Park, Jin-Kyu,Kang, Ki-Woon,Shim, Jaemin,Uhm, Jae-Sun,Kim, Jun,Park, Hyung Wook,Lee, Young Soo,Choi, Eue-Keun,Kim, Chang-Soo,Joung, Boyoung,K The Korean Society of Cardiology 2018 Korean Circulation Journal Vol.48 No.6

<P><B>Background and Objectives</B></P><P>Gender-related differences in health care utilization for atrial fibrillation (AF) are increasingly recognized. However, large cohort data for examining gender-related differences in AF are lacking in Asian populations.</P><P><B>Methods</B></P><P>The Registry for Comparison Study of Drugs for Symptom Control and Complication Prevention of AF (CODE-AF Registry) is a prospective observational cohort-study that enrolled participants at 10 tertiary hospitals in South Korea. Baseline characteristics retrieved from the CODE-AF Registry were analyzed.</P><P><B>Results</B></P><P>A total of 6,274 patients were recruited (mean age 67±11 years, mean CHA<SUB>2</SUB>DS<SUB>2</SUB>-VASc score 2.7±1.7, 63% male, 65% paroxysmal AF) from June 2016 to April 2017. Women underwent less electric cardioversion (12.3% vs. 19.6%, p<0.001), less radiofrequency ablation (12.4% vs. 17.9%, p<0.001), and less antiarrhythmic drug therapy (44.7% vs. 49.5%, p<0.001), despite having more severe symptoms (symptom class III or IV, 45.8% vs. 37.5%, p<0.001). Among patients with a CHA<SUB>2</SUB>DS<SUB>2</SUB>-VA score of 2 or more, a slightly higher proportion of women were taking oral anticoagulants than men (85.7% vs. 81.9%, p=0.002), and non-vitamin K antagonist oral anticoagulant (NOAC) use was more prevalent in women than men (70.4% vs. 62.3%, p<0.001). Insufficient NOAC dosing was very common, more so in women than men (61.5% vs. 56.3%, p<0.001).</P><P><B>Conclusions</B></P><P>Female patients with AF were treated more conservatively and rhythm control strategies were used less frequently than in males, even though the female patients with AF had more severe symptoms. While insufficient NOAC dosing was common in both sex, it was significantly more frequent in women.</P>

Comparative occurrence of ischemic stroke with the rhythm versus rate control strategy in a national prospective cohort of atrial fibrillation

( Jae Guk Kim ),( Young Soo Lee ),( Ki-woon Kang ),( Eue-keun Choi ),( Myung-jin Cha ),( Jung-myung Lee ),( Jin-bae Kim ),( Junbeom Park ),( Jin-kyu Park ),( Tae-hoon Kim ),( Jae-sun Uhm ),( Jaemin Sh 대한내과학회 2021 The Korean Journal of Internal Medicine Vol.36 No.1

Background/Aims: Comparative occurrence of ischemic stroke for rhythm versus rate control strategy in patients with non-valvular atrial fibrillation (NVAF) is still inconclusive. The purpose of this study was to investigate whether the rhythm control strategy is associated with a lower risk of ischemic stroke compared to the rate control strategy in NVAF patients. Methods: The CODE-AF registry prospectively enrolled 6,280 consecutive patients who were treated for NVAF at 10 tertiary referral centers in South Korea. Of these, 2,513 NVAF patients (age, 67 ± 10 years; male, 61.8%) were clinically followed up for over 1-year and divided into rate and rhythm control groups. Results: Those treated with the rhythm control strategy were younger and had less proportions of underlying disease compared to those treated with the rate control strategy. After the propensity matching analysis, those treated with the rhythm control strategy had similar baseline characteristics including the CHA₂DS₂-VASC score compared to those treated with the rate control strategy. The rate of oral anticoagulation, all bleeding, and hospitalization were also similarly between the two groups. The incidence rate of ischemic stroke in the rhythm control group was significantly lower than in the rate control group (0.7 vs. 6.9 per 1,000 person-years, p = 0.011). Conclusions: The rhythm control strategy demonstrated a beneficial effect to lower the risk of ischemic stroke during a 1-year follow-up compared to the rate control strategy.

위탁급식전문업체 인증제도 도입을 위한 급식운영 평가 모형 기준항목 선정

양일선,박문경,차진아,이경태,박상용 한국조리과학회 2004 한국식품조리과학회지 Vol.20 No.3

The foodservice industry is changing more and more from on-site foodservice management to contract foodservice management. However there are differences according to the level of management and operation of contract foodservice management company (CFMC), The necessity of certification on CFMC is increasing to enable fair discrimination of CFMC among most clients that want to contract with CFMC. This study was performed to identify the foodservice operation evaluation model's criteria items for certifying CFMC. The analysis research methods included literature review, content analysis, individual interview, Delphi technique, and brain storming. First, the following infrastructure items were prepared in the contractor's viewpoint: procurement, transparency of operation, menu development and operation system, nutrition service system, professional employee education, sanitation and safety management system, customer satisfaction system, facility system, management information system (MIS), business and economics. Second, the evaluation criteria required by the contractor on the client's view point was similar to school foodservice, hospitalfoodservice, and business andindustry foodservice except extraordinary items of field. Third, evaluation criteria and detail categories and items were identified such as financial focus, customer focus, process focus, human focus, and renewal and development by grafting on intellectual capital evaluation methodology for CFMC.

청소년자녀와 어머니를 위한 세대간 이해증진 프로그램 개발 및 실시

김명자,이정우,계선자,박미선,송말희,김경아,박수선,유을용,정진희 대한가정학회 2003 Human Ecology Research(HER) Vol.41 No.1

The relationship between adolescent children and parents has a profound effect on not only the adolescents development into healthy adults but also the psychological welfare of the parent. A program focused to improve adolescents relationship with parents has not been developed until now. To achieve the educational goals enhancing mutual understanding, it is more effective to educate both the parents and adolescent childern. Thus, this study developed and carried out a program in which adolescent children and mothers, being fully in charge of raising children, participated. The study analyzed the program effects after implementing on 6 pairs of adolescent children and mothers. The results are as follows: 1) adolescent children and mothers placed high values on the fact that they can understand each other well, 2) both parties accepted each other by recognizing the inevitability of the generation gap, and 3) the program gave them a chance to admit that they should try to communicate openly. Most of all, adolescent children could find self-confidence while mothers could collect valuable data essential to raise children and build a new mother's role model adapting to social changes.

서울시내 고등학교 위탁급식의 급식비와 투자비의 실태 및 위탁업체의 기대수준 비교 분석

양일선,배환미,김현아,신서영,조미나,박수연,차진아,이보숙 한국식생활문화학회 2002 韓國食生活文化學會誌 Vol.17 No.5

The purposes of this study were to a) find out the operational characteristics of the contract-managed highschool foodservice in Seoul, b) investigate the expected level of meal-price and facilities investment cost perceived by contract-managed highschool foodservice managers c) compare the present level and expected level of meal-price and facilities investment cost. From October 12 to November 13 in 2001, the questionnaires were mailed to 249 high schools which was managed by contract foodservice company with respondent rate 40.2%. Data were analyzed using SPSS Win(10.0) for descriptive analysis and one group paired t-test. The results of this study were as follows ; 1. The student enrollment of highschools run by contract-managed foodservice was 1,243 with 72.6% participation rate of school lunch program. The average meal-price was 2,138 won. The average annual period of school foodservice operation was 156.78 days per year. The average contracting period was about 3 years. 2. The average cost concerned in the facilities investment amounts 169,578,180 won at the initial investment and 25,204,092 won at the repairs and maintenance cost in the course of operation. 3. The present level of meal-price and facilities investment cost were respectively 2,136won/meal and 171,157,336.72 won. And expected level.of meal-price and amount of facilities investment cost were 2,418.75 won and 121,353,215.19 won. Comparing the present level with expected level of the meal-price and facilities investment cost, expected level of meal-price was significantly higher than the present level of meal-price(p<.001) and expected level of facilities investment cost was significantly lower than present level of facilities investment cost(p<.001).

유성견 소구치 정출시 치아 및 치주 조직의 초기 조직학적 변화 및 재생에 관한 연구

윤병선,차경석,이진우 대한치과교정학회 1998 대한치과교정학회지 Vol.28 No.3

본 실험은 유성견에서 인위적인 정출 시 조직학적 , 임상학적인 반응과 시간경과에 따른 치아 및 치아 주위조직의 회복을 연구하기 위해 생후 평균 10개월 웅성 잡종 유성견 하악 소구치를 대상으로 Energy chain을 이용한 정출 실험으로, 실험 1 군은 힘을 작용 시킨 후 일주일만에 희생시키고, 실험 2군은 정출력을 가한 후 일 주일 후, 정출력이 제거되고 3주간의 회복 기간 경과 후에 희생시켰다. HE 및 Masson`s Trichrome 염색법을 이용하여 치아와 주위조직의 반응을 치경부, 치근 중앙부, 치근단부, 치수부로 분류하여 광학 현미경하에서 관찰하여 다음과 같은 결과를 얻었다. 1. 힘을 가한 후 일 주일 후, 모든 부위에서 치주인대의 주행방향이 치아를 향하여 사선 방향을 나타내 주었으며 치주인대의 간격이 전반적으로 증가되었다. 또 부분적인 치주 인대의 파열이 치근단부에서 뚜렷하게 관찰되었다. MT소견에서는 대조군에 비해 치조능 부위에서 미성숙 골의 형성을 보여주었다. 주위 치조골에서는 편측으로 활발한 골조직의 형성이 관찰되었다. 치수에서는 치근단 부위에서 많은 혈관의 파열을 보여 주었고 공포의 형성과 충혈을 나타냈다. 2. 힘을 제거된 후 3주간의 보정을 한 군의 모든 치주인대의 주행 방향과 간격이 대조군과 같이 회복되었으며 밀도는 치밀하게 나타났다. MT 소견에서 1군에서 형성된 치조능의 미성숙 골이 석회화가 이루어짐을 보여주었고 치수의 공포와 충혈의 감소를 보여주었다. 수복과정에서의 치수의 섬유화가 더욱 진행되었다. 이상의 결과를 종합해 볼 때, 3주간의 회복 기간 중에도 치주 인대 부위에서는 대조군과 유사한 조직 소견을 보여 상당한 회복능력을 보였지만 치수에서는 섬유화가 진행됨을 보여 더욱 긴 회복 기간이 필요함을 보여주었다. This study was carried out in order to study early histologic changes and repair reaction appling to extrusive force for 3rd premolar of adult dogs. After 1 week of extrusive force with elastic chain, one of dogs was sacrified and after 3 weeks retention period, another dog was sacrified. The paraffin sections of samples were stained with Hematoxylin - Eosin and Masson`s Trichrome and were examed by light microscopy. The obtained results as follows 1. In Hematoxylin - Eosin and Masson Trichrome stain of control group, the periodontal ligament width was constant from apical third to cervical third of the root and periodontal fiber arrangement was horizontal or oblique in cervical third, oblique in middle third, oblique in apical third of root, in alveolar bone, smooth appearance was shown. 2. In Group 1, all periodontal fiber arrangement was oblique toward tooth, and the periodontal ligament width increased. Partially P D L was ruptured in apex. In MT stain, immature bone formation was seen at alveolar crest area. Active bone formation was observed along the one side of alveolus, and apical portion of pulp was involved with blood vessel rupture, vacuolization of pulp tissue and hyperemia. 3. In Group 2, most periodontal ligament arrangement and P D L width was repaired and fiber density increased. In MT stain, mineralization of immature bone on the alveolar crest was progressed. In pulp, vacuole and hyperemia was diminished and fibrotic change was diminished. 4. After 3 week periodontal ligament has more repair ability than pulp tissue pulp was involved with vacuolization and fibrosis, so it takes more time for repair.

대기오염중의 산화질소가스가 섬유제품의 변색에 미치는 영향 : 블루진을 중심으로

양진숙,차옥선 漢陽大學校 韓國生活科學硏究所 1997 韓國 生活 科學 硏究 Vol.- No.15

The blue jean garments are favered not only by young people but also by almost every walk of life. In the early years they are casually worn on most occasions, but became universal recently. Such blue jean garments are finished with various treatment process to give it optimal softness and color contrast of blue and white. Discoloration and yellowing by NOx gas may well be generated during storage or use and thereby, their appearance may be damaged much. So, this study was aimed at finding the solutions to reduce the discoloration problem by NOx gas. To this end, sample blue jean were made to be finished with various wet treatment and then, be subjected to daylight and NOx gas to check their yellowing. The results of this test can be summarized as follows ; It was found that the discoloration of blue jean due to the softening process rather than the oxidation of blue jean and that would be more accelerated by fluorescent brightening. The longer the blue jean was exposed to NOx gas, the more it became yellow. And when the denim was exposed dually to the gas and daylight, it was more yellowed. However, when the blue jean was treated by the citric acid to be weak-acid about pH 5.6 ~6.0, the yellowing due to NOx gas was almost prevented. Here, the reduce of tensile strength of the blue jean due to the acid was trifle.

1990년대 fashion에 나타난 여성수트의 형식적 특성에 관한 연구

김차주,이선경,김옥진 全南大學校家政科學硏究所 1996 生活科學硏究 Vol.6 No.-

Five pairs of coordinate concept for classifying the mode by H. Wolfflin who combines the aesthetics with the history of art are adopted to understand the characteristics of the modem suit which have been appeared with the various aspects due to the effects of the post- modernism since the latter half of the 20th century and as a result of applying them to the women's suit shown in A/W collection from 1990 to 1996, the modern suit could be divided into two; Quasi-Renaissance from and quasi-Baroque one. While the suit of Renaissance propensity showed the typical characteristics of 'suit' that the components of the jacket and skirt - collar, lapel, pocket, texture, hemlines etc.- emphasize the symmetry of human body itself, open and non-constructional concept of the Baroque propensity expressed the constructional elements of human body to the incidental thing. The rising designers avoided the existing idea through the effect of natural pleates of row cloth and the use of surface decoration and gave the design a change. Such a suit form has the meaning in that it gives the sense of flexible movement to the structure of the fixed suit and it pursues the aesthetic concept of a new design by escaping from the typical suit form. Kal Lagerfeld after Chanel, Gianfranco Ferre after Christian Dior and Claude Montana after Lanvin follow their masters in the concept of painiting and the trend of ambiguity and non-construction are found in the works of Jean-Paul Gaultier, Christian Lacroix, Chantal Thomas and Gianni Versace who are the experimentalist designers and the concept of openness and non-construction are in those of Issey Miyake, Vivienne Westwood, Oscar de la Lenta and Pacco Rabanne. It is found the design of the women's suit shows the quasi-Baroque propensity based on the traditional suit design depending on the characteristics of the rising designers' group succeeding to the existing designers' brands. And it can be confirm through this study that formalism of Wolfflin based on the thought of formal aesthetics is the useful standard for analyzing the forms of the modern suit.

청소년을 위한 교육 프로그램 개발·실시 및 평가에 관한 연구

계선자,이정우,김명자,박미석,송말희,유을용,김경아,정진희 대한가정학회 2003 Human Ecology Research(HER) Vol.41 No.8

The main goal of this program is to build a healthy adolescent culture by broadening the understanding of adolescents and recognition of the environment as well through the development of educational programs centering on the domains of peer relationships, intimacy in dating relationships and sex, leisure activities, and consumption life of adolescents. The program was carried out to 10 young boys and girls for two days/one night and the major findings of the effects of the program through a qualitative evaluation were as follows: First, the program provided adolescents with a proper opportunity to promote a sense of self-confidence through the self-reevaluation process. Secondly, the program provided adolescents with a chance to firmly recognize to become good friends with others though the enhancement of self-esteem, which helped them to build a healthy peer relationship. Thirdly, adolescents were able to promote their views on sex and sexual decision-making by acquiring a proper knowledge of intimacy in dating relationships and of sex, and by candidly expressing their own opinions on sex with instructors. Fourthly, the program provided adolescents with an opportunity to look back on their leisure life with family members which had been neglected thus far and to renew their recognition of active leisure activities. Fifthly, the program provided adolescents with a chance to reflect on their unplanned consumption life and to be firmly determined to refrain from impulsive purchasing and extravagance.

주요 식이섬유질원이 첨가된 식이가 노화 흰쥐의 장내효소 및 유해산물에 미치는 영향

강어진,이상선,양차범,신현경 한국식품영양학회 1998 韓國食品營養學會誌 Vol.11 No.5

한국에서 주로 섭취되고 있는 주요 식이섬유질원으로서 장내 유익균의 생육을 촉진한다고 알려진 사과, 미역, 쑥, 머위를 천연 형태로 건조분말화하여 식이내에 5%, 15%가 되게 첨가한 후 노화가 진행된 흰쥐에게 4주간 급여하였다. 그 결과 β-glucuronidase는 셀를로스군과 미역 15% 첨가군에서 가장 낮은 활성을 나타냈으며 β-glucuronidase의 경우는 쑥 15% 첨가군에서 유의적으로 현저한 증가를 보였다. 부패산물인 인돌 함량 변화는 쑥 섭취군에서 현저하게 낮은 경향을 보여 β-glucuronidase와는 다른 양상을 보였다. 수분함량은 미역섭취군과 쑥5%, 머위15% 섭취군에서 높았으며 pH는 쑥 15% 섭취군이 가장 낮은 값을 보여주었다. 쑥 15% 섭취군이 장내균총 조성을 개선시킬 수 있을 것으로 보고되어 그 유의성을 밝히고자 하였으나 본 실험에서는 부패산물, 유해효소등과 장내균총의 조성과의 뚜렷한 관계는 발견하지 못하였다. This study was performed to investigate the influence of various dietary fiber sources in Korea for activities of bacterial enzymes (β-glucosidase, β-glucuronidase) and amounts of putrefactive product (indole) in aged rats β-Glucosidase activity in the intestinal content was significantly lower in the sea mustard 15% group than in other groups whereas the activity of β-glucuronidase was higher in the mugwort 15% group than other experimental groups. The amount of indole and pH in the intestinal content of aged rats were significantly lower in mugwort groups than in other groups.