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RAW 264.7 세포에 대한 중국산 천연 광물성 섬유 TAFMAG의 독성효과
임영,한진구,김지홍,김현욱,김은경,김경아,장황신 大韓産業醫學會 1999 대한직업환경의학회지 Vol.11 No.3
Objectives : This study was designed to evaluate cytotoxicity of TAFMAG, which is a trade name of natural mineral fiber mined and produced in China. Methods : The cytotoxicity of TAFMAG was evaluated by measuring iron content, lipid peroxidation, erythrocyte hemolysis, and cytotoxicity in vitro. These results were compared with the data of chrystotile and wollastonite as a positive and negative control, respectively. Results : There was significant increase of Fenton activity in TAFMAG and chrysotile with dose-response pattern. The iron chelating agent, desferrioxamine, significantly decreased Fenton activity of the particulates except wollastonite. TAFMAG and chrysotile fibers significantly increased malondialdehyde concentration from lipid peroxidation of the red blood cell membrane. In erythrocyte hemolysis test, TAFMAG & chrysotile had stronger effect on erythrocyte hemolysis than wollastonite with the concentration of 1,000g/ml. Furthermore, TAFMAG was more hemolytic than chrysotile with the concentration of 5,000g/ml. There was a significant cytotoxic effect in TAFMAG and chrysotile on RAW cell compared with wollastonite. Conclusions : In vitro study suggested that TAFMAG may have a similar health hazard as usual asbestos.
사영필터를 이용한 2차원 트러스 구조물의 2단계 손상 추정
임은지,서일교 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)
In this paper, a study of 2-step damage measures for 2-Dimensional truss structures using the Projection filter theory is presented. Many researchers are interested in inverse problems and one of solution procedures for inverse problems that are very effective is the approach using the filtering algorithm in conjunction with numerical solution methods. In this paper, the Projection filtering in conjunction with structural analysis is applied to the identification of damages in 2-D truss structures. And, damage detection take use of 2-step damage assessment method. First, kinetic energy change ratio are used to find damage region including damaged member and then detect damaged member in damage region. The effectiveness of proposed method is verified through the numerical example.
석면함유 슬레이트 지붕 물받이 퇴적물 중 석면 섬유 함유율
임지현,한솔민,김현석,신유민,박시은,허정윤,김민영,장봉기 순천향대학교 기초과학연구소 2022 순천향자연과학연구 논문집 Vol.28 No.1,2
This study attempted to determine the degree of asbestos release from the aging slate roof by comparing the asbestos content in the slate roof rain gutter with a colored steel plate (tin plate) over the slate roof. Four slate roof houses located in Haengmok-ri, Asan-si, Chungcheongnam-do, and one house constructed with a colored steel plate on the slate roof were selected to collect the sediment of the roof rain gutter. The asbestos fiber content was calculated by a point counting method using a polarization microscope after pretreatment with conversion treatment and hydrochloric acid treatment. The average asbestos content of the four slate roof rain gutter were 1.89%. However, asbestos was not detected in the Slate covering roof rain gutter, which were constructed on the slate roof. Asbestos fiber content was the highest at 2.89% in the slate roof rain gutter installed in 1976, followed by 2.44% in 1953. From the above results, it is necessary to minimize secondary damage as asbestos fibers released from slate roof houses to the surrounding atmosphere or leaked from slate roofs as rainwater may cause soil pollution and seriously affect residents' health. Although covering with colored steel plates (tin plates) has been shown to prevent the leakage of asbestos fibers to some extent, it is believed that a policy alternative to remove the slate roof as soon as possible is needed to solve the fundamental problem.
지준호,이화정,박승찬,박정철,최은정,서혜진,이원식,이정림,배병조,손경락,이경희 영남대학교 의과대학 2008 Yeungnam University Journal of Medicine Vol.25 No.2
Primary retroperitoneal mucinous cystadenocarcinoma is a very rare malignancy, and little is known concerning its Pathogenesis, optimal treatment, and prognosis. A 29-year-o1d pregnant woman (21 weeks) Presented with abdominal discomfort CA 19-9, CA 125, and CEA were normal Abdominal CT scanning revealed a 19x15x13 cm retropentoneal tumor Exploratory laparotomy and tumor excision were performed. Mucinous retropentoneal implants were removed as completely as possible Histologically, the tumor showed focal areas of capsular invasion, but free resection margins The uterus and both ovaries were normal in appearance No adjuvant therapy was pursued. Six months later, Peritoneal and bilateral ovarian metastases were discovered. Hence, we report the details of this case of primary retroperitoneal mucinous Cystadeno-carcinoma and present a review of the literature.
임지숙,조은자 동아시아식생활학회 2005 동아시아식생활학회지 Vol.15 No.1
The effect of medicinal herb powder addition on the physicochemical characteristics of silk-tofu was investigated. Moisture content of silk-tofu decreased during the storage. The pH value of silk-tofu decreased a little until 2 days' storage, and then increased rapidly. The chromaticity of L value decreased for all silk-tofu during the storage. The a value increased a little at initial storage, and then tended to decrease, while b values increased significantly during storage. The contents of free amino acid were 4 times higher in silk-tofu than those in market tofu. Hardness, gumminess and chewiness of all silk-tofu increased rapidly during storage. Cohesiveness values decreased a little at initial storage, and then kept to increase upon storage. Generally, the total plate counts of bacteria of all silk-tofu increased during storage, and those of silk tofu with added medicinal herb powder were shown to be significantly lower than those in control. In sensory evaluation, color, structure, softness and overall acceptability of silk tofu with added dangui powder(dang-T) and control(con-T) were about to be high, and nutty taste and flavor of control silk-tofu was the highest in score.
마이크로니들의 형태 및 적용방법이 약물의 피부 투과에 미치는 영향
임지호,이경록,이은주,조정원 충남대학교 약학대학 의약품개발연구소 2012 藥學論文集 Vol.27 No.-
The purpose of this study is to develop the microneedle using biodegradable and biocompatible polymer and to pioneer the new route of drug delivery through the research to apply the most desirable administration form of small molecules, peptides, proteins, genes, biological products including vaccines. Various biocompatible microneedles were manufactured. To apply drug to microneedle, drug formulation using ethylene vinyl acetate patch or polyacryl acid gel was developed. Drug permeation into rat skin based on the application method of patch or gel with microneedle was studied using Franz diffusion cell system. In vitro drug permeation results showed that the permeation by the application of hollow microneedle was not increased compared with solid microneedle. When G60 or G60*2 microneedle was used, the permeated amount of calcein was increased compared to when solid microneedle was used. The permeated amount of lidocaine HCl in 12 hr was increased when microneedle was used was increased. Skin irritation followed by microneedle showed there was little difference in the decrease of redness after microneedle application based on application time.
김은지,임성규 慶北大學校 師範大學 科學敎育硏究所 2007 科學敎育硏究誌 Vol.31 No.-
To help middle school students understand concept of tide, we developed a model of tide, and applied it to students in a middle school in Daegu city to find its effectiveness. The subjects consisted of 136 students of the 7th grade, divided into the experimental group and the control group. The experimental group (N=68) were given a learning cycle model, and the control group (N=68) were given a traditional lecture. The formative evaluation of the experiment was as follows: the average score of the experimental group was 6.43, and that of the control group was 5.68 (its full score 9), The result shows that the teaching method using the tidal model is more effective than the lecture-centered traditional one in helping the students understand the concept of tide. 이 연구는 조석개념에 대한 중학생들의 이해를 돕기 위해 수업에 사용할 조석모형을 개발하였다. 이 조석 모형을 활용한 수업이 중학생들의 조석의 이해에 얼마나 효과적인지 현장에 적용해 보았다. 이 연구의 적용은 대구 시내에 있는 한 중학교의 7학년 136명을 실험집단과 통제집단 의 두 집단으로 나누어 실시하였다 실험 집단(N=68)은 조석 모형을 순환학습 모형의 수업으로 실시하고 통제 집단(N=68)은 전통적 강의식 수업으로 실시하였다. 수업 후에 실시한 형성평가의 결과는,조석모형을 적용한 실험 집단의 평균점수는 6.43점(9점 만점),전통적 강의식으로 수업한 통제집단 은 5.68점으로 실험집단의 평균점수가 더 높았다. 그러므로 조석모형이 7학년 중학생 들의 조석현상의 개념이해에 효과적이었음을 보여준다.