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Kang, Eun-Young,Jee, Sung Ju,Kim, Cuk-Seong,Suh, Kwang-Sun,Wong, Alex W.K.,Moon, Jae Young Elsevier 2018 Journal of critical care Vol.44 No.-
<P><B>Abstract</B></P> <P><B>Purpose</B></P> <P>Early cognitive assessment in the intensive care unit (ICU) is essential to monitor cognitive dysfunction after critical illness. We have implemented a Computer Cognitive Senior Assessment System–Screen (CoSAS–S) which is a brief, objective, and tablet-based cognitive screening test as a mobile platform to detect any cognitive problems in ICUs. This study aimed to evaluate the feasibility and initial validation of a tablet-based CoSAS–S in critically ill patients with sepsis.</P> <P><B>Materials and methods</B></P> <P>Thirty-six eligible patients completed CoSAS–S, Mini-Mental State Examination–Korean Version (MMSE–K) and Korean Version of Montreal Cognitive Assessment (K-MoCA) for validity testing at the ICU.</P> <P><B>Results</B></P> <P>Eighty-eight percent of programmed assessments were completed by the sample. Spearman correlations of the CoSAS–S with MMSE–K (rho=0.613–0.874, p<0.00) and K–MoCA scores (rho=0.666–0.897, p<0.001) were moderate to high. Intra-class correlation coefficient (ICC) of total CoSAS–S score between two raters was 0.93 (p<0.001; 95% CI=0.82–0.97), suggesting the inter-rater reliability of CoSAS-S was excellent.</P> <P><B>Conclusions</B></P> <P>Support was found for the feasibility and validity of CoSAS-S. The application of CoSAS-S could identify the cognitive functioning of the patients. Utility of CoSAS-S in other clinical populations should be tested.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Cognitive Senior Assessment System–Screen (CoSAS–S) is a mobile flat-form, tablet-based cognitive screening test. </LI> <LI> This study supports the feasibility and validity of tablet-based cognitive screening, ‘CoSAS-S’ in patients with sepsis. </LI> <LI> CoSAS-S could identify the critically ill patients without cognitive dysfunction in the ICUs. </LI> <LI> Utility of CoSAS-S in other clinical settings should be studied in the future study. </LI> </UL> </P>
Ui-Gum Kang,Hyang-Mi Park,Jee-Yeon Ko,Jae-Saeng Lee,Weon-Tai Jeon,Chang-Young Park,Ki-Do Park,Vladimir K. Chebotar 한국토양비료학회 2017 한국토양비료학회지 Vol.50 No.3
In order to obtain promising rice growth-promoting microbial strains that can be used as substitutes for chemical fertilizers, 172 bacterial strains were isolated from rice roots grown in Korean and Russian soils. Out of them, the strains KR076, KR083, KR181 and RRj228 showed plant growth-promoting activities on maize seedlings. Bacillus megaterium KR076 and Bacillus sp. KR083 showed both nitrogen-fixing and plant growth-promoting activities, while Rhizobium sp. KR181 and Pseudomonas sp. RRj228 appeared to support only plant growth-promotion, but not N2 fixation. Especially, RRj228 showed high growth promoting activity at low concentrations. Inoculation studies with KR083 and RRj228 revealed a high affinity to the Japonica rice variety such as Junambyeo than the Korean Tongil type variety such as Arumbyeo. Both KR083 and RRj228 strains showed rhizoplane and/or endophytic colonization in Japonica and Tongil types rice when soaked with the bacterial suspension of 1.1 × 10<SUP>5</SUP> cfu ml<SUP>-1</SUP> for six and twelve hours. However, the total bacterial cell numbers were higher in the roots of Japonica variety than in the Tongil type. In inoculation trials with Daesanbyeo rice variety, the seedlings inoculated with KR181 and RRj228 at the rate of 2.0 × 10<SUP>6</SUP> cfu ml-1 showed yield increment of 35% and 33% (p < 0.01), respectively, so that they contributed to the replacement of chemical fertilizer at half doses of N, P₂O<SUP>5</SUP>, and K2O in pots. In Junambyeo rice seedlings, the strain RRj228, when inoculated with a cell suspension of 1.8 × 10<SUP>6</SUP> cfu ml<SUP>-1</SUP>, promoted 3.4% higher yield at 70% dose than at a full dose level of N 110 kg ha<SUP>-1</SUP> in field. These results suggest that the rhizobacteria KR181 and RRj228 are prospective strains for enhancing rice performance.
K. K. Asanka Sanjeewa,I. P. S. Fernando,Seo-Young Kim,Won-Suck Kim,Ginnae Ahn,Youngheun Jee,You-Jin Jeon 한국조류학회I 2019 ALGAE Vol.34 No.1
Ecklonia cava (EC) has been widely utilized as an ingredient in commercial products such as functional foods and cosmeceuticals. Recently it has been found that Sargassum horneri (SH) has been invading on Jeju Island coast area by itshuge blooming. Moreover, both seaweeds are considering as important ingredients in traditional medicine specificallyin East-Asian countries (China, Japan, and Korea). In the present study, we attempted to compare anti-inflammatoryproperties of 70% ethanolic extracts of EC (ECE), SH (SHE), and their different combinations on lipopolysaccharide(LPS)-activated RAW 264.7 cells. Results indicated that 8 : 2 combinations of ECE : SHE significantly inhibited LPS-activatedinflammatory responses (cytokines, protein, and gene expression) in RAW 264.7 macrophage cells compared tothe respective extracts and other combinations. The synergistic effect of ECE and SHE was found to be prominent thanthe effects of ECE or SHE alone. These observations provide useful information for the industrial formulation of functionalmaterials (functional foods and cosmeceuticals) using these two particular seaweeds in Jeju Island of South Korea.
Sanjeewa, K.K. Asanka,Fernando, I.P.S.,Kim, Seo-Young,Kim, Hyun-Soo,Ahn, Ginnae,Jee, Youngheun,Jeon, You-Jin Elsevier 2018 INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES Vol.107 No.1
<P><B>Abstract</B></P> <P>Recent studies on crude and pure compounds from <I>Sargassum horneri</I> have shown promising bioactive properties. However, anti-inflammatory potentials of fucose-rich sulfated polysaccharides from <I>S. horneri</I> have not yet been discovered. In the present study, we evaluated the <I>in vitro</I> and <I>in vivo</I> anti-inflammatory activities of four polysaccharide fractions separated from membrane filters according to their molecular weights (<5kDa (f1), 5–10kDa (f2), 10–30kDa (f3), and >30kDa (f4)). According to the results, F4 fraction inhibited the lipopolysaccharides (LPS)-induced nitric oxide (NO) (IC<SUB>50</SUB> =87.12μg/mL) and prostaglandin E<SUB>2</SUB> production as well as pro-inflammatory cytokine production in RAW 264.7 cells through down-regulating nuclear factor-κB signaling cascade. According to the results, f4 has a potential to down-regulate LPS-induced toxicity, cell death and NO production levels in LPS-induced <I>in vivo</I> zebrafish embryo model. These results suggest that f4 fraction has the potential to develop functional materials or drugs to treat inflammatory diseases.</P>
Sanjeewa, K.K. Asanka,Kang, Nalae,Ahn, Ginnae,Jee, Youngheun,Kim, Young-Tae,Jeon, You-Jin Elsevier 2018 Food hydrocolloids Vol.81 No.-
<P><B>Abstract</B></P> <P>Genus <I>Sargassum</I> is a group of edible brown seaweeds, which are an important component of Korean, Chinese, and Japanese cuisines. In addition, <I>Sargassum</I> spp also play an important role in the tropical sea water eco-systems. Other than as a food source, recent studies have shown that <I>Sargassum</I> spp are a rich source of novel bioactive compounds. Among the isolated bioactive components, sulfated polysaccharides (SPs) have gained considerable attention due to their proven health benefits. Also, a number of publications have shown promising health effects of SP isolated from this brown seaweed. However, industrial range utilization of the SP from brown seaweeds are limited due to the lack of collective information about the SP collected from brown seaweeds. Therefore, in the present review attempts were made to discuss the bioactive properties of SPs separated from genus <I>Sargassum</I> in relation to human health improvement applications. Furthermore, anticoagulant, antioxidant, anticancer, antibacterial and antiviral activities of SPs from genus <I>Sargassum</I> were reviewed to update current information on these valuable natural components. Thus, information in this paper might be useful to fill the knowledge gap between research studies and industrial application.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Bioactive properties of sulfated polysaccharides separated from <I>Sargassum</I> spp. </LI> <LI> Fucoidan is one of the bioactive sulfated polysaccharides present in <I>Sargassum</I> spp. </LI> <LI> Future applications of fucoidan isolated from <I>Sargassum</I> spp as a functional material. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Sanjeewa, K.K. Asanka,Jayawardena, Thilina U.,Kim, Hyun-Soo,Kim, Seo-Young,Ahn, Ginnae,Kim, Hak-Ju,Fu, Xiaoting,Jee, Youngheun,Jeon, You-Jin The Korean Society of Fisheries and Aquatic Scienc 2019 Fisheries and Aquatic Sciences Vol.22 No.2
Background: This study is aimed at identifying the anti-inflammatory properties of 70% ethanol extract produced from an edible brown seaweed Sargassum horneri (SJB-SHE) with industrial-scale production by Seojin Biotech Co. Ltd. S. horneri is a rich source of nutrient and abundantly growing along the shores of Jeju, South Korea. Methods: Here, we investigated the effect of SJB-SHE on LPS-activated RAW 264.7 macrophages. The cytotoxicity and NO production of SJB-SHE were evaluated using MTT and Griess assays, respectively. Additionally, protein expression and gene expression levels were quantified using ELISA, Western blots, and RT-qPCR. Results: Our results indicated that pre-treatment of RAW 264.7 macrophages with SJB-SHE significantly inhibited LPS-induced NO and $PGE_2$ production. SJB-SHE downregulated the proteins and genes expression of LPS-induced iNOS and COX2. Additionally, SJB-SHE downregulated LPS-induced production of pro-inflammatory cytokines (tumor necrosis factor-${\alpha}$, interleukin (IL)-6, and IL-$1{\beta}$). Furthermore, SJB-SHE inhibited nuclear factor kappa-B (NF-${\kappa}B$) activation and translocation to the nucleus. SJB-SHE also suppressed the phosphorylation of mitogen-activated protein kinases (ERK1/2 and JNK). Conclusions: Collectively, our results demonstrated that SJB-SHE has a potential anti-inflammatory property to use as a functional food ingredient in the future.
Asanka Sanjeewa, K.K.,Fernando, I.P.S.,Kim, Seo-Young,Kim, Won-Suck,Ahn, Ginnae,Jee, Youngheun,Jeon, You-Jin The Korean Society of Phycology 2019 ALGAE Vol.34 No.1
Ecklonia cava (EC) has been widely utilized as an ingredient in commercial products such as functional foods and cosmeceuticals. Recently it has been found that Sargassum horneri (SH) has been invading on Jeju Island coast area by its huge blooming. Moreover, both seaweeds are considering as important ingredients in traditional medicine specifically in East-Asian countries (China, Japan, and Korea). In the present study, we attempted to compare anti-inflammatory properties of 70% ethanolic extracts of EC (ECE), SH (SHE), and their different combinations on lipopolysaccharide (LPS)-activated RAW 264.7 cells. Results indicated that 8 : 2 combinations of ECE : SHE significantly inhibited LPS-activated inflammatory responses (cytokines, protein, and gene expression) in RAW 264.7 macrophage cells compared to the respective extracts and other combinations. The synergistic effect of ECE and SHE was found to be prominent than the effects of ECE or SHE alone. These observations provide useful information for the industrial formulation of functional materials (functional foods and cosmeceuticals) using these two particular seaweeds in Jeju Island of South Korea.