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( Myung Jin Lee ),( Kye Hyung Kim ),( Jong Youn Yi ),( Su Jin Choi ),( Chung Jong Kim ),( Nak Hyun Kim ),( Kyoung Ho Song ),( Pyoeng Gyun Choi ),( Ji Hwan Bang ),( Wan Beom Park ),( Eu Suk Kim ),( San 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
In Vitro Antiviral Activity of Ribavirin Against Severe Fever with Thrombocytopenia Syndrome Virus Myung Jin LEE1, Kye-Hyung KIM1, Jongyoun YI2, SuJin CHOI1, Chung-Jong KIM1, Nak- Hyun KIM1, Kyoung-Ho SONG1, Pyoeng Gyun CHOI1, Ji-Hwan BANG1, Wan Beom PARK1, Eu Suk KIM1, Sang-Won PARK1, Hong Bin KIM1, Nam Joong KIM1, Myoung- Don OH1 Seoul National University College of Medicine, Korea1, Pusan National University School of Medicine, Korea2 Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease caused by a novel Bunyavirus, severe fever with thrombocytopenia syndrome virus (SFTSV). No effective antiviral therapy is proven yet, but clinical use of ribavirin (RBV) has been tried. We investigated the antiviral effect of RBV against SFTSV in vitro. Methods: To test for cytotoxicity of RBV, Vero cells were treated with different concentrations of RBV (3.90 to 500 μg/mL, two-fold dilution) and analyzed by cell viability MTS assay 48h post-infection. To determine antiviral activity of RBV against SFTSV, Vero cells were infected with SFTSV strain Gangwon/Korea/2012 at 100 TCID50 (50% tissue culture infective dose) per well in a 96-well plate, and RBV was added at the concentrations showing no or minimal cytotoxicity. Viral RNAs were extracted from the culture supernatants and quantifi ed using one-step real-time reverse transcription- PCR to amplify the partial large segment of SFTSV. Statistical analysis was done by one-way ANOVA with Tukey`s post hoc test. Results: Cytotoxicity due to RBV was not observed at RBV concentration =31.3 μg/ mL. Viral RNAs at 24h post-RBV treatment were reduced with increasing RBV concentrations (1-32 μg/mL), compared with those of mock-treated cells (P <0.01, Figure). Half maximal inhibitory concentration (IC50) of RBV was 3.69 μg/mL at 24h post-RBV treatment. Conclusions: Our study shows that RBV has antiviral effect against SFTSV in a dose-dependent manner. Further studies are required to evaluate the effi cacy of RBV in SFTS.
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이용환(Yong-Hwan Lee),최인호(In-Ho Choi) 한국환경관리학회 2006 環境管理學會誌 Vol.12 No.4
본 연구는 수중에 용해된 인과 질소 제거효과를 갖는 세라믹소재를 개발하기 위하여 수행되었다. 감람석을 이용한 인의 제거효과는 “이”와 “최”의 연구에서 수행된바 있으며, 제올라이트를 이용한 질소제거에 관한 연구는 국내외적으로 많이 수행되어 왔다. 본 연구에서는 감람석(Olivine)과 제올라이트(Zeolite)를 서로 다른 부피 혼합비에 따라 혼합한 후 소성하여 얻어진 세라믹을 이용하여 수중에 용해된 총인(Total-Phosphorus)과 총질소(Total-Nitrogen)의 제거효과를 회분식 실험(batch reactor system)을 통해 분석하였다. 연구결과 총인의 경우 감람석과 제올라이트의 부피 혼합비가 1:2의 경우 최고의 제거효율을 보였으며, 시험개시 30분 일 때 96.0%, 4시간일 때 95.1% 의 인이 제거되었다. 총질소의 경우 감람석과 제올라이트가 1:6일 때 시험개시 30분일 때 93.6%, 4시간일 때 97.4%의 질소가 제거되었다. This study was performed to develop ceramic material to be able to eliminate phosphorus and nitrogen in water. Olivine was found to remove phosphorus in aqueous phase, which was demonstrated by Lee and Choi.1) The nitrogen removal using zeolite has been demonstrated by many researchers.2,3) Hence, utilization of mixed-typed material of Olivine and Zeolite is expected to achieve simultaneous elimination of phosphorus and nitrogen in water. In this study, the removal efficiencies of T-P(Total phosphorus) and T-N(Total nitrogen) were investigated using ceramic material in batch reactor system, which was produced by incinerating after mixing Olivine and Zeolite with different ratio. The highest removal efficiency of phosphorus was achieved under the condition of 1: 2 mixing volume ratio of Olivine to Zeolite. The phosphorus of 93.6% and 97.4% (as T-P) was removed for 0.5hr and 4hr, respectively. For the nitrogen, the nitrogen removal efficiencies of 93.6% and 97.4% (as T-N) were obtained under the condition of 1:6 mixing volume ratio of Olivine and Zeolite.
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Primary intraosseous carcinoma of the mandible
Hwang, Eui-Hwan,Choi, Yong-Suk,Lee, Sang-Rae 대한구강악안면방사선학회 2005 Imaging Science in Dentistry Vol.35 No.4
A very uncommon tumor, primary intraosseous carcinoma (PIOC), is a carcinoma arising within the jaw. The definite diagnosis of PIOC is often difficult as the lesion must be distinguished from alveolar carcinoma that may invade the bone from the overlying soft tissues or from the tumors that have metastasized to the jaw from a distant site. A case of PIOC arising in the mandible is presented. The clinical, radiologic, and histologic features are described. This rare lesion should be considered in any differential diagnosis of a jaw radiolucency.
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Kim, Min Hwan,Bae, Dong Hun,Choi, Hyoung Jin,Seo, Yongsok Elsevier 2017 Polymer Vol.119 No.-
<P><B>Abstract</B></P> <P>Poly(diphenylamine) (PDPA) particles were synthesized as a novel semiconducting electro-responsive electrorheological (ER) material by a chemical oxidative polymerization process and their ER characteristics were investigated at various electric fields. Surface morphology of these <I>N</I>-aryl-substituted polyaniline-derived PDPA particles was examined by scanning electron microscopy and their chemical structure and thermal properties were confirmed by Fourier-transform infrared spectroscopy and thermogravimetric analysis, respectively. Their susceptibility to electric fields and the chain formation of dispersed particles were observed directly using optical microscopy. Rheological analysis of the PDPA-based ER fluid was performed using a combination of steady shear and oscillation tests in a Couette-type rotational rheometer with a high-voltage power supply. The measurements were performed in controlled shear stress and shear rate modes under the varied electric field strengths. The Cho–Choi–Jhon model was found to determine the stress behavior more clearly. Dielectric analysis provided additional information about the electrical polarization properties and thus also the ER performance of the PDPA-based ER fluid.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Semiconducting poly(diphenylamine) (PDPA) particles were synthesized by chemical oxidation. </LI> <LI> PDPA particles show typical electrorheological (ER) property examined using a rotational rheometer. </LI> <LI> PDPA particles are directly applied into ER fluid without dedoping process. </LI> <LI> Dielectric analysis was proceeded to confirm electrical polarization of PDPA particles. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
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The prediction of the tooth size in the mixed dentition for Korean
Moon, Sung-Hwan,Kim, Seong-Oh,Yu, Hyung-Seong,Choi, Byung-Jai,Choi, Hyung-Jun,Lee, Jae-Ho 大韓小兒齒科學會 2006 大韓小兒齒科學會誌 Vol.33 No.2
이번 연구의 목적은 혼합치열기 아동에서 미맹출된 견치와 소구치의 크기를 예측하는데 있어서 한국인에 맞는 방정식을 만들기 위함이다. 미맹출 치아의 크기를 예측하는 것은 혼합치열기 교정 진단과 치료계획 수립에 있어서 매우 중요하다. 미맹출된 견치와 소구치 크기를 예측하는 방법은 몇가지가 있지만 그중에서도 가장 흔하게 쓰이는 것이 모이어의 예측표와 다나카와 존스턴의 방정식이 있다. 하지만 그것들은 백인을 위해서 제작된 것이고 치아 크기는 인종에 따라서 다르다고 알려져 있다. 이번 연구에서는 치아크기를 측정하여 하악 영구 절치의 크기 합과 견치 및 소구치의 크기 합 사이의 상관관계를 구하고 회귀방정식을 이용해서 한국인에 맞는 예측표를 만들었다. 연세대학교 치과대학에 재학중인 178명의 한국 학생(남 108명, 여 70명, 평균연령 21.63)을 대상으로 실험하였다. 영구치의 근원심 폭경을 석고모형상에서 calipers를 이용해서 측정하였다. 성별간의 치아 크기는 차이가 있었다(p<0.05). Correlation coefficient는 0.57에서 0.64의 범위였고, standard errors of the estimates 는 여성에서 0.6으로써 남성보다 우수하였다. r^(2)값은 0.27에서 0.41의 범위를 나타내었다. Estimating the size of unerupted teeth is an essential aspect of orthodontic diagnosis and treatment planning in the mixed dentition. Several methods were introduced and used for the prediction. The most common methods among these would be Moyers probability chart and Tanaka and Johnston equations. These are currently used widely, but they were developed for Caucasians. Because there are clear racial differences in teeth size, the objectives of this study were to produce correlation coefficients between the combined mesiodistal widths of the permanent mandibular incisors and those of the canines and premolars for each quadrant, and prediction tables with regression equations, specifically for Korean. 178 young adults (70 women, 108 men, mean age 21.63 years) were selected from the College of Dentistry, Yonsei University, Seoul, Korea. The mesiodistal crown diameters of the permanent teeth were measured with calipers. Significant sexual dimorphism was found in tooth sizes. The correlation coefficients between the total mesiodistal width of the mandibular permanent incisors and those of the maxillary and mandibular canines and premolars were found to be between 0.52 and 0.64. The standard error of the estimatation was better (0.60) for women and the r^(2) values ranged from 0.27 to 0.41 for both sexes, Prediction tables were prepared for Korean. This study showed larger canine and premolar diameters than Tanaka and Johnston's and Moyers' studies which might be due to the racial differences. Further investigations with a larger sample size will be needed for more representative data on the Korean population.
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최성혜,정환묵 대구효성가톨릭대학교 응용과학연구소 1993 응용과학연구논문집 Vol.2 No.-
In this paper, we study the fuzzy logic function that are represent a infinite multi-valued logic function. The infinite multi-valued logic function takes a truth value of proposition in fuzzy set of close interval[0,1]. Assuming that the Boolean function is the number system of modulus-2, the infinite multi-valued logic fouction is expanded the number system of modulus-M. Using the concept off the differential of extended Boolean function, we study of the properties and differentiations of fuzzy logic function, the structure of the function is analyzed. Finally, it shown that the proposed fuzzy logic function is an efficient rule selection method for fuzzy reasoning.
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