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RISS 인기검색어
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- 저자 : Hyunhee Kim (검색결과 275 건)
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Kim, Kook Hwan,Jeong, Yeon Taek,Oh, Hyunhee,Kim, Seong Hun,Cho, Jae Min,Kim, Yo-Na,Kim, Su Sung,Kim, Do Hoon,Hur, Kyu Yeon,Kim, Hyoung Kyu,Ko, TaeHee,Han, Jin,Kim, Hong Lim,Kim, Jin,Back, Sung Hoon,Ko Nature Publishing Group, a division of Macmillan P 2013 Nature medicine Vol.19 No.1
Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding autophagy-related 7). Unexpectedly, these mice showed decreased fat mass and were protected from diet-induced obesity and insulin resistance; this phenotype was accompanied by increased fatty acid oxidation and browning of white adipose tissue (WAT) owing to induction of fibroblast growth factor 21 (Fgf21). Mitochondrial dysfunction induced by autophagy deficiency increased Fgf21 expression through induction of Atf4, a master regulator of the integrated stress response. Mitochondrial respiratory chain inhibitors also induced Fgf21 in an Atf4-dependent manner. We also observed induction of Fgf21, resistance to diet-induced obesity and amelioration of insulin resistance in mice with autophagy deficiency in the liver, another insulin target tissue. These findings suggest that autophagy deficiency and subsequent mitochondrial dysfunction promote Fgf21 expression, a hormone we consequently term a 'mitokine', and together these processes promote protection from diet-induced obesity and insulin resistance.
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Hyunhee Kim(Hyunhee Kim),Jaebum Lee(Jaebum Lee),Heejung We(Heejung We) J-INSTITUTE 2022 International Journal of Human & Disaster Vol.7 No.2
Purpose: This study was analyzed with a qualitative research method by applying a phenomenological method to examine the experiences and perceptions and attitudes about health care of workers participating in rehabil-itation exercises after suffering an industrial accident while working in the K automobile manufacturing industry in Korea. Method: As for the selection of research participants, a total of 12 participants were selected as the final research participants, including 1 female and 11 male, who could provide a wealth of information on the subject of the study. For data collection and analysis, Colaizzi's six-step analysis method was used to identify the partic-ipants' experiences and cognitive changes who participated in the rehabilitation program. Also, the participants' facial expressions and actions were recorded so that they could be used as additional observational data and reflected in the results of further research. Results: As a result of the study, 5 categories, 13 topic collections, 32 topics, and 97 construct meanings were finally confirmed. Specifically, the importance of strengthening the intrinsic motivation of the participants was emphasized in order to continuously practice health promotion after an industrial accident in the automobile manufacturing industry. In addition, it appears that a method of self-awareness of the necessity of exercise, giving fun of the complex program, and preventing and managing it in daily life is needed. Conclusion: The contents derived from the results of this study represent the changing perception of workers toward continuous health promotion management and improvement after an industrial accident. Through the research results, it was an opportunity to confirm the changing perception of health care among workers, and it is expected to be actively used in the future by developing rehabilitation exercise programs at the workplace in the automobile industry.
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Cytoplasmic molecular chaperones in Pseudomonas species
Hyunhee Kim,Seongjoon Moon,Soojeong Ham,Kihyun Lee,Ute Römling,Changhan Lee 한국미생물학회 2022 The journal of microbiology Vol.60 No.11
Pseudomonas is widespread in various environmental and host niches. To promote rejuvenation, cellular protein homeostasis must be finely tuned in response to diverse stresses, such as extremely high and low temperatures, oxidative stress, and desiccation, which can result in protein homeostasis imbalance. Molecular chaperones function as key components that aid protein folding and prevent protein denaturation. Pseudomonas, an ecologically important bacterial genus, includes human and plant pathogens as well as growth-promoting symbionts and species useful for bioremediation. In this review, we focus on protein quality control systems, particularly molecular chaperones, in ecologically diverse species of Pseudomonas, including the opportunistic human pathogen Pseudomonas aeruginosa, the plant pathogen Pseudomonas syringae, the soil species Pseudomonas putida, and the psychrophilic Pseudomonas antarctica.
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Hyunhee Kim,Yunjung Lee,Taejun Han,Eun-Mi Choi 한국영양학회 2015 Nutrition Research and Practice Vol.9 No.6
BACKGROUND/OBJECTIVES: Increased mass of adipose tissue in obese persons is caused by excessive adipogenesis, which is elaborately controlled by an array of transcription factors. Inhibition of adipogenesis by diverse plant-derived substances has been explored. The aim of the current study was to examine the effects of the aqueous methanol extract of laver (Porphyra yezoensis) on adipogenesis and apoptosis in 3T3-L1 adipocytes and to investigate the mechanism underlying the effect of the laver extract. MATERIALS/METHODS: 3T3-L1 cells were treated with various concentrations of laver extract in differentiation medium. Lipid accumulation, expression of adipogenic proteins, including CCAAT enhancer-binding protein α, peroxisome proliferator-activated receptor γ, fatty acid binding protein 4, and fatty acid synthase, cell viability, apoptosis, and the total content and the ratio of reduced to oxidized forms of glutathione (GSH/GSSG) were analyzed. RESULTS: Treatment with laver extract resulted in a significant decrease in lipid accumulation in 3T3-L1 adipocytes, which showed correlation with a reduction in expression of adipogenic proteins. Treatment with laver extract also resulted in a decrease in the viability of preadipocytes and an increase in the apoptosis of mature adipocytes. Treatment with laver extract led to exacerbated depletion of cellular glutathione and abolished the transient increase in GSH/GSSG ratio during adipogenesis in 3T3-L1 adipocytes. CONCLUSION: Results of our study demonstrated that treatment with the laver extract caused inhibition of adipogenesis, a decrease in proliferation of preadipocytes, and an increase in the apoptosis of mature adipocytes. It appears that these effects were caused by increasing oxidative stress, as demonstrated by the depletion and oxidation of the cellular glutathione pool in the extract-treated adipocytes. Our results suggest that a prooxidant role of laver extract is associated with its antiadipogenic and proapoptotic effects.
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Hyunhee Kim,Pilju Choi,Taejung Kim,Youngseok Kim,Bong Geun Song,Young-Tae Park,Seon-Jun Choi,Cheol Hee Yoon,Won-Chul Lim,Hyeonseok Ko,Jungyeob Ham 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.1
Background: Lung cancer has a high incidence worldwide, and most lung cancer-associated deaths are attributable to cancer metastasis. Although several medicinal properties of Panax ginseng Meyer have been reported, the effect of ginsenosides Rk1 and Rg5 on epithelial-mesenchymal transition (EMT) stimulated by transforming growth factor beta 1 (TGF- β1) and self-renewal in A549 cells is relatively unknown. Methods: We treated TGF-β1 or alternatively Rk1 and Rg5 in A549 cells. We used western blot analysis, real-time polymerase chain reaction (qPCR), wound healing assay, Matrigel invasion assay, and anoikis assays to determine the effect of Rk1 and Rg5 on TGF-mediated EMT in lung cancer cell. In addition, we performed tumorsphere formation assays and real-time PCR to evaluate the stem-like properties. Results: EMT is induced by TGF-β1 in A549 cells causing the development of cancer stem-like features. Expression of E-cadherin, an epithelial marker, decreased and an increase in vimentin expression was noted. Cell mobility, invasiveness, and anoikis resistance were enhanced with TGF-β1 treatment. In addition, the expression of stem cell markers, CD44, and CD133, was also increased. Treatment with Rk1 and Rg5 suppressed EMT by TGF-β1 and the development of stemness in a dose-dependent manner. Additionally, Rk1 and Rg5 markedly suppressed TGF-β1-induced metalloproteinase-2/9 (MMP2/9) activity, and activation of Smad2/3 and nuclear factor kappa B/extra-cellular signal regulated kinases (NF-κB/ERK) pathways in lung cancer cells. Conclusions: Rk1 and Rg5 regulate the EMT inducing TGF-β1 by suppressing the Smad and NF-κB/ERK pathways (non-Smad pathway).
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( Hyunhee Kim ),( Yong-chul Jang ),( Jonghyun Choi ) 한국폐기물자원순환학회(구 한국폐기물학회) 2017 한국폐기물자원순환학회 심포지움 Vol.2017 No.1
Many previous studies have shown that various kinds of hazardous chemical substances can be found in concerning levels in end of life vehicles (ELVs), of which approximately 90 million unit of automobile was produced in the whole world in 2014. Among the hazardous chemical substances found in ELVs, polybrominated diphenyl ethers (PBDEs) are gaining global concerns as it was added as a new persistent organic pollutants (POPs) in 4 th meeting of Stockholm convention (2009). In South Korea, recycling and treatment of ELV is regulated by the Korea electronic and ELV recycling law. In Korea RoHS regulation, there is no regulation for PBDEs in automobile where as PBDEs concentration is limited less than 0.1% by weight for waste electrical electronic equipment (WEEE). In addition, there is very few available information regarding PBDEs level in ELVs as well as distribution channel of PBDEs in life-cycle of automobile. From this background, the aim of this study were 1) to investigate the substance flow of PBDEs in automobile through the analyzing the ELV samples as well as statistical assumption of mass flow of automobile, and 2) to identify management practice of PBDEs containing wastes in ELV. 92 automobile component samples and 36 automobile waste samples were taken from 9 ELVs and 14 automobile waste treatment sites. Samples were collected from 6 different types of automobiles from automobile junkyards and 5 different regions of automobile waste treatment facilities in Korea. Automobile seat fabric, seat polyurethane foam(PUF), interior lights cover, floor covering, headliner, seat belt, shredded bumper, ASR(Automobile Shredded Residue), door trim fabric, dash board, sound proof material, fuel line are included in the samples. First, a screening survey of bromine (Br) in each sample was conducted by using a X-ray fluorescence (XRF) analyzer. The samples containing 0.01% by weight of Br were selected for further chemical analysis. Identification and quantification of PBDEs were performed by GC/MS (Gas Chromatography Mass Spectrometry). SFA was conducted by using STAN 2.5 for easy graphical interpretation. The number of automobile of each life cycle with the average weight of each component (ASR, seat fabric) was used to calculate total amount of the input in the system boundary4). In this study, the relevant data were collected from available statistical reports (Korean Statistical Information Service, 2015; KECO, 2015) and literature review (KEI, 2015). Several field site visits to ELVs treatment facilities were made to interviews with the experts. The XRF survey showed that 34 out of 128 samples investigated (27% of the total) contained more than 0.01% by weight of Br, indicating that the use of PBDEs in ELVs is limited. Among the 34 samples exceeding 0.01% by weight of Br, all of the samples employed for further chemical analysis. Subsequent analysis by GC/MS showed that 28 samples were treated with PBDEs(Table 1). Based on the results of PBDEs concentrations in the samples, it was known that PBDEs were used in limited components in automobile. Samples containing PBDEs more than 0.01% by weight such as interior light cover, floor cover, headliners, seatbelt finally would have been disposed in ASR streams. The substance flow analysis of PBDEs in automobile with mass fraction of ASR and seat fabric of whole automobile has been conducted, as Figure 1. In 2014, approximately 371 ton of PBDEs in automobile were put on the domestic market through the manufacture (1,055 ton), export (716 ton), import (32 ton). In use stage, approximately 4,735 ton of PBDEs in automobile were stocked generating approximately 171 ton of PBDEs in ELVs. In disposal stage, approximately 116 ton of PBDEs in ELVs were incinerated, approximately 11 ton of PBDEs in ELVs were landfilled, and 23 ton of PBDEs in ELVs were recycled as energy. As a result of substance flow analysis of PBDEs in automobile, it was investigated that PBDEs containing wastes in automobile were mainly generated in the form of ASR and seat fabric. In case of seat fabric, approximately 66 ton of PBDEs in seat fabric was generated in disposal stage in 2014. Approximately 52 ton of PBDEs in seat fabric (79%) was dismantled in informal area later incinerated or landfilled. Approximately 13 ton of PBDEs in seat fabric (21%) was disposed with ASR. In case of ASR, approximately 110 ton of PBDEs in ASR was generated in disposal stage in 2014. Approximately 66 ton of PBDEs in ASR (60%) was incinerated, 9 ton of PBDEs in ASR (8%) was landfilled, and 23 ton of PBDEs in ASR (21%) was recycled as energy. This study aimed to present current management flow of PBDEs containing wastes in automobile by conducting substance flow analysis of PBDEs in automobile in Korea. The results of the SFA indicate that ASR and seat fabric were the main components of PBDEs containing wastes in automobile. On disposal stage, 116 ton of PBDEs in ELVs (68%) was incinerated, 11 ton of PBDEs in ELVs (6%) was landfilled, and 23 ton of PBDEs in ELVs (13%) was recycled as energy recovery.
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