녹동균 세포외막 단백질 백신 CFC-1-101의 안정성 및 면역원성 검토 : 임상 제 Ⅰ/Ⅱa상 시험

장인진,김익상,유경상,임동석,김형기,신상구,장우현,박완제,이나경,정상보,안동호,조양제,안보영,이윤하,김영지,남성우,김현수 대한감염학회 1998 감염 Vol.30 No.3

목적 : 제일제당에서는 녹농균의 세포외막 단밸질을 유효성분으로 하는 백신인 CFC-101을 개발하였으며, 동물시험에서 이 백신의 안전성과 유효성을 입증하였다. 본 연구에서는 이 녹농균 백신의 인체에 대한 안전성과 면역원성을 평가하는 동시에 인체 접종시의 최적 투여 용량을 결정하기 위하여 제 I/Ⅱa상 임상시험을 수행하였다. 방법 : 건강한 성인 남자를 피험자로 선별하여 각 용량군에 백신투여자 6명, 위약투여자 2명을 배정하였다. 백신 투여군은 0.25mg, 0.5mg 또는 1.0mg 용량의 녹농균 백신을 7일 간격으로 3회에 걸쳐 근육주사 하였으며, 위약 투여군에게는 세포외막 단백질을 제외한 동일한 성분을 투여하였다. 백신접종 후 국소적 또는 전신적인 반응의 발생여부를 관찰하고, 혈액시료를 체취하여 백신의 역가와 유효성을 검정하였다. 결과 : 녹농균 백신 CFC-101은 모든 접종자에서 양호한 내약성을 보였다. 또한 0.5mg 과 1.0mg 백신 투여군에서는 100%의 항체양전율을 나타내었다. 생성된 항체는 녹농균 세포외막단백질에 특이성을 보였고, 녹농균 감염에 대해 방어효능이 있었다. 결론 : 이와같은 결과로부터 이 녹농균 백신은 인체에 안전하게 투여할 수 있으며, 높은 항체 생성능으로 감염방어 효능을 보이고 0.5mg과 1.0mg이 최적용량인 것으로 판단되었다. Background : We developed a Pseudomonas aeruginosa outer membrane protein(OMP) vaccine CFC-101, and the prophylactic efficacy of which has been demonstrated in animal models. In order to evaluate the safety and immunogenicity of the P. aeruginosa vaccine, we carried out a phase I/Ⅱa clinical trial in healthy male volunteers. Methods : Groups of eight volunteers, including two placebo subjects, were vaccinated intramuscularly with three doses of 0.25, 0.5 or 1.0 mg of the vaccine at one week intervals. Sings of systemic and local reactions observed after vaccination were recorded for each vaccinee for 5 days. Physical examinations were performed on days 0, 1, 7, 8, 14, 15, 21, and 42, and clinical laboratory tests were done on days 0, 3, and 21. Blood samples for assay of serum antibody levels were obtained up to 42 days after the first vaccination. Results : The vaccine was generally well tolerated by all vaccinees, showing no significant side effects. In the three dosage groups, all vaccinees, except one receiving the 0.25 mg dose, showed significant elevation in serum IgG antibody titers against the vaccine proteins, indicating 100% seroconversion in 0.5 and 1.0 mg groups. The human antibodies induced by the vaccine were specific for P. aeruginosa OMPs, as confirmed by western blot analysis and immunoprecipitation assays. The capacity of the human antisera to enhance opsonophagocytic killing activity by polymorphonuclear leukocytes and to confer protection against P. aeruginosa infections indicates that the antibodies elicited by the vaccine have protective efficacy. Conclusion : We conclude that the P. aeruginosa OMP vaccine is safe and effective for human use and its optimal dose to be 0.5 or 1.0 mg.

마이크로-컴퓨터를 利用한 Programmable 制御器 開發에 對한 硏究

김성중,황형수,이창구 全北大學校 1984 論文集 Vol.26 No.-

In this paper, we present the new designing method of programmable controller that concentrated on analong signal processing in hardware implementation. Software programmings are partioned into monitor program and control program. Monitor program is composed of systeminitialization, I/O control and key service routine. Control program procedure is concentrated on obtaining the tuning coefficient associated with PI algorithm and ON-OFF algorithm.

릴레이 회로의 EMFG 표현에 관한 연구

백형구,김희정,여정모 釜慶大學校 2001 釜慶大學校 論文集 Vol.6 No.-

It needs a skillful experience to design and implement sequential circuits with a relay circuit. One makes out the operation of relay contacts sequentially in case of analyzing a relay circuit. Still more, the design and analysis of a complex relay circuit are difficult. In this paper, we propose the EMFG(Extended Mark Flow Graph) representation of relay circuits. If one analyzes a relay circuit with the EMFG representation, one can understand the operation of relay contacts graphically and easily simulate a relay circuit with the incident matrix of an EMFG.

한국과 일본의 거시경제변수의 관련성 분석

최형원,김병구 啓明專門大學 産業開發硏究所 2000 啓明硏究論叢 Vol.18 No.1

본 연구는 일본의 거시경제변수들의 움직임이 한국경제에 미치는 파급경로와 영향력을 환율제도에 따라 분석하였다. 분석결과 첫째, 일본의 거시경제변수 중 한국의 경기변동을 민감하게 반영하는 산업생산지수에 통계적으로 유의한 영향을 주는 변수로는 전체 분석기간(1970. 1 - 99. 3)에서는 산업생산지수와 대미환율, 고정환율제도(1970. 1 - 79. 4) 실시기간에서는 대미환율과 공채수익률이었다. 그리고 변동환율제도(1980. 1 - 99. 3)하에서는 산업생산지수, 대미환율, 공채수익률이었다. 둘째, 이들 변수 중 한국의 산업생산 지수에 대한 영향력이 상대적으로 높은 변수로는 산업생산지수와 대미환율이었다. 한국의 산업생산지수와의 관련성 검토에서는 일본의 산업생산지수는 정(+)의 관계. 그리고 대미환율은 부(-)의 관계에 있는 것으로 분석되었다. This paper tests for correlation between Korea and Japan macro economic variables according to exchange system. As a result of analysis, first, we found that Japan macro economic variables has influences on Korean economy are industrial production index and Yen exchange rate to dollar from 1970. 1 to 1999. 3 and are Yen exchange rate to dollar and yields of government bonds for fixed exchange rate system from 1970 1 to 1979. 4 and are industrial production index Yen exchange rate to dollar and yields of government bonds for floating exchange rate system from 1980. 1 to 1999. 3 Second, we also found that industrial production index and Yen exchange rate to dollar of Japan had an very strong effect on Korea industrial index that reflects business cycle.

라운드 리클라이너 개발을 위한 정적 강도 해석 및 안전성 평가

정윤구,임재규,김형종 江原大學校 産業技術硏究所 2004 産業技術硏究 Vol.24 No.A

Seat is one of the most important part of an automobile for passenger's safety especially when an accident happens. A recliner is a part of the seat assembly, having the function of adjusting the back-plate angle of a seat. Recently, many kinds of vehicles have adopted the round recliner module rather than the conventional types of recliners because of its broad compatibility and structural simplicity. In this study a two-dimensional finite element strength analysis has been performed using a commercial code ABAQUS/Standard for the purpose of developing a new round recliner model. The loading condition for the analysis is the same as the FMVSS 301 regulation. The finite element result for the round recliner has been compared with that for the conventional type.

전문가 시스템을 이용한 제어기 설계

황형수,김성중,이창구 圓光大學校 1990 論文集 Vol.24 No.2

PID제어기의 동조방법에 대한 이론적인 발전에도 불구하고 PID 제어기가 좀더 좋은 성능과 견실성을 유지하기 위해서는 수동 동작과 자동 동작의 매끄러운 연결, 계수 변화에 따른 과도현상, 비선형 Actuator의 영향, 적분항의 Wind-up, 그리고 극한값의 선정등에 대한 현장 엔지니어의 경험 지식이 제어 알고리즘에 반영되어야 한다. 제어시스템에 현장 운전자의 경험 지식을 효율적으로 반영하기 위한 방법으로 인공지능(Artificial Intelligence)의 전문가 시스템을 이용하였다. 본 논문에서는 논리부분과 수치 알고리즘 부분이 분리된 지식기반 제어기를 구성하였다. 이 방법은 IBM-PC상에서 설치되도록 하였으며 IBM-PC와 통신기능을 갖는 Programmable Controller에 연결하여 PID 제어계수를 자동 동조하도록 하였다. 이 방법은 공정조건이 변하거나 동특성을 갖는 공정제어에서 우수한 특성을 보인다. The idea of expert control is to incorporate a rule based expert system in a feedback control system. In this paper, the expert system concepts are instead used as an element of the feedback loop in a single controller. The algorithms are coded in as pure from as possible and the heuristic logic is implemented as rules. This paper reports on effort to produce an implementation of an expert controller on microcomputer based system, including an industrial programmable controlled.

뇌졸중 위험인자를 가진 어지럼 환자에서의 확산강조 자기공명영상

강형구,윤유상,이진희,박인철,이경룡,정상원,구홍두,김승호 대한응급의학회 2001 대한응급의학회지 Vol.12 No.4

Background: The management of vertiginous patients is a great challenge to emergency physicians. We evaluated the diagnostic value of a diffusion-weighted image(DWI) in differentiating central vertigo from the peripheral vertigo in patients who presented no neurological symptoms other than risk factors for stroke. Methods: From March 2000 to February 2001, we retrospectively analyzed the cases of 68 patients who visited the emergency department with symptoms of isolated vertigo and who had risk factors for stroke. DWIs, computed tomograms(CT), and medical records were reviewed, and the final diagnose, the DWIs and the CT readings, the risk factors for stroke, and the time it took waiting for a DWI or CT scan were analyzed. Results: Of the 68 patients, 21(30.8%) had central vertigo: 15 vertebrobasilar transient ischemic attacks(VB-TIA), 4 brain stem infarctions, 1 cerebellar infarction, and 1 cerebellopeduncular infarction. The DWI showed a 28.6% sensitivity, a 97.9% specificity, and an 85.7% positive predictive value in diagnosing central vertigo. It also had a 100% sensitivity in detecting infarctions. Conclusion: A DWI had a comparable sensitivity to MRI in detecting central vertigo and small, but potentially, lethal infarctions in our patient population. We recommend clinical application of DWI in the emergency department evaluation of isolated vertigo patients with risk factors for stroke.

음낭부종을 동반한 Henoch-Schonlein 자반증 1례 : A Case Report

박치영,조형구,김홍섭 건국대학교 의과학연구소 1993 건국의과학학술지 Vol.3 No.-

Henoch-Schonlein purpura, or anaphylactoid purpura, is a systemic vasculitis characterized by nonthrombocytopenic purpura and skin, joint, intestinal, and genitourinary involvement. There is unknown etiology and its urologic significances include renal parenchymal involvement, urethritis, renal pelvis bleeding, and acute pain and swelling of the spermatic cord and scrotum. Scrotal involvement has been reported in up to one third of patients. The disease is self-limiting, but it is important to distinguish it from testicular torsion because of similar symptoms and prevalent age, and different treatment option. We have experienced one case of Henoch-Schonlein purpura with scrotal swelling. The patient was a 3 year old boy and his chief complaints were purpuric skin rash, arthralgia, abdominal pain, and scrotal swelling. The scrotal swelling was improved without complication for 4 days hospitalization. So we reported this case with literatures.

초전도 저장장치의 신경회로망 모형 및 이를 이용한 안정도해석 앨고리즘 개발에 관한 연구

林裁尹,張勝燦,金正勳,姜亨求 弘益大學校 科學技術硏究所 1997 科學技術硏究論文集 Vol.8 No.-

Recently the need of energy storage device such as the pumped-storage has more and more increased in power system in order to aid a side reliability. But it has the problem of environment. As an alternative way of installing it, the Superconducting Magnetic Energy Storage(SMES) is widely study in a power system. Generally the SMES might divide in two class ; the storage use and the stability use. For use in storage SMES never has been construct, because of its expensive cost. Actively progressing the field of the study is for use in stability SMES, so as construction cost is relatively inexpensive. In order to application of the SMES in the power system, it has to be proven of stability efficiency through stability analysis. Stability analysis need modelling of the SMES. The existing model has been used only mathematical model that presented by first order delay time function, so that the SMES has fast response characteristic. But this kind of mathematical model of dynamic system have some problems when stability analysis requests more precision analysis. The problems are the complexity of equation, long calculus time and error of model-decision. For the purpose of settling this problems, this paper proposed an artificial neural network(ANN) methodology to make SMES modelling. ANN is presented using the input-output power characteristics of SMES. when it uses ANN which functions as a model-free system, network construction and parameters determination are carefully chosen to represent the complicated nonlinear input-output relation from the black-boxed SMES system. So far medelling of SMES by ANN never used stability analysis. In this paper, the proposed ANN-based SMES model is applied to analyze the power system stability and the simulation results provide the property of this approach.

전국 응급의학과 수련병원의 응급실 병력지에 대한 분석

임태호,임훈,이종호,강형구,장문준,조광현,장석준,김승호,정상원 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: This study was designed to analyze the current emergency department(ED) medical records of teaching hospitals in Korea. Methods: The five-item questionnaires were mailed to the EDs of 40 hospitals. Among them, 27 questionnaires and 35 ED medical records were returned for reply rates of 67.5% and 87.5%, respectively. Results: 1) The actual number of data elements in the ED medical records used by each hospital varies widely. It ranges from 1 to 15 data elements with an average of 7.5 data elements. 2) Thirteen data elements, signature of nurse, checklist style in review of systems, checklist style in physical examination, neurologic examination, figure of face, Glasgow coma scale, trauma scale, treatment plan, mode of transfer, condition on transfer, documents sent with patient, condition on discharge or discharge instruction, use of pediatric chart and vaccination history are used by less than 50% of the medical records examined. 3) There was no difference in the total number of data elements or in redesign and computerization of ED medical record based on the location of the hospital, the type of hospital administration, or the number of years since the start of EM residency program. 4) There was a statistically increased number of data elements in redesigned medical records. 5) In the survey, 89% of the residents replied that medical records needed to be redesigned. With respect to uniformity, 58% of the residents disagreed. A well-designed checklist chart rather than a descriptive chart was preferred by 89% of the residents. Conclusion: The currently used ED medical records have much room for improvement. The age of the ED had little impact on the quality of ED medical records. More attention and effort in this field are needed. In addition, The Korean Society of Emergency Medicine should provide guidelines for ED medical records.