급성 심근허혈에 의해 윤발된 승모판 폐쇄부전의 기전에 관한 실험적 연구

강덕현,송현,송재관,김현숙,이재환,임희영,이재원,박성욱,박승정,송명근 대한순환기학회 1999 Korean Circulation Journal Vol.29 No.8

한국인 인슐린 비의존형 당뇨병 및 이차성 당뇨병 환자에서 글루코키나제 유전자 변이

남재현(Jae Hyun Nam),이현철(Hyun Chul Lee),김연의(Youn Euy Kim),권석호(Suk Ho Kwon),윤용석(Yong Suk Yoon),박석원(Suk Won Park),원영준(Young Jun Won),차봉수(Bong Su Cha),송영득(Young Duk Song),이은직(Eun Jig Lee),임승길(Sung Kil Lim) 대한내과학회 1998 대한내과학회지 Vol.54 No.6

N/A Objectives: Mutations in the glucokinase (GCK) gene are considered a possible cause of maturity-onset diabetes of the young. The purpose of this study was to evaluate the contribution of this gene to the development of non insulin dependent diabetes mellitus (NIDDM), gestational diabetes mellitus (GDM) and post-renal transplantation diabetes mellitus (PTDM). Method: Identification of GCK mutation was attempted on 39 NIDDM patients, 2 GDM patients and 58 selected renal allograft recipients with PTDM and 45 normal controls. The exons in the GCK gene were examined by polymerase chain reaction (PCR), followed by analysis of single-stranded DNA conformational polymorphism (SSCP). The abnormal bands were also confirmed by DNA sequencing analysis. The exons of affected family members were also investigated for mutations of the GCK gene. Results: Two of the 58 PTDM patients (3.4%) were found to have CKK mutations. One had the mutation on exon 5 and the other on intron 7. One control subject had the mutation on intmn 9. The mutation of exon 5 was identified as a substitution of CCT (proline) for CTT (leucine) at codon 164, which has not ever reported before. The family members of the PFDM patient with mutation of exon 5 were analyzed by PCR followed by SSCP, and two of them revealed the same mutation. The abnormal band on the SSCP analysis of exon 7 was identified as the insertion of base C/T at the 39th nucleotide in intron 7. Two family members of this patients also had same band on SSCP. The one mutation of 45 normal controls was CT located at the 8th nucleotide in intron 9, which was a common polymorphism. Conclusion: We found GCK mutations in subjects with PTDM and we speculate that these mutations may be one of the contributing cause of PTDM.

아동기에 주의력결핍 과잉행동증상을 경험한 성인의 정신병리와 기질 성격 요인

송열매(Yul-Mai Song),이건석(Kounseok Lee),한덕현(Doug Hyun Han),이영식(Young Sik Lee),민경준(Kyung Joon Min),박진영(Jin Young Park),김준원(Jun Won Kim) 대한소아청소년정신의학회 2013 소아청소년정신의학 Vol.24 No.4

Objectives:The objective of this study is to find out the differences in psychopathology, temperament, and character factors between young adults with and without childhood attention-deficit hyperactivity disorder (ADHD) symptoms. Methods:The subjects consisted of 314 university students (male=72, female=242) in Gongju. They were divided into childhood ADHD group (N=54) and normal group (N=260) to the Wender-Utah Rating Scale. Participants were assessed using Korean Adult ADHD Scale, Beck Depression Inventory-II, Beck Anxiety Inventory, Kimberly Young’s Internet Addiction Test, Barratt Impulsiveness Scale, Paranoia Scale, Korean-Schizotypal Ambivalence Scale, Lubben Social Network Scale, and Temperament and Character Inventory-Revised. Descriptive statistics, t-test, chi-square, spearman correlation, and stepwise multiple regression were applied to analyze the data. Results:Participants with childhood ADHD symptoms had high level of adult ADHD symptoms (p<.001), impulsiveness(p=.001), depression (p<.001), anxiety (p<.001), internet addiction (p<.001), paranoia tendency (p<.001) and low level of selfesteem (p<.001) compared to normal group. Self-directedness (p<.001) was lower, Harm avoidance (p=.001) and Self-transcendence (p=.029) were higher in the childhood ADHD group. In correlation and stepwise multiple regression, childhood ADHD symptoms were significantly associated with cooperativeness (r=-0.515 and β=-0.547, p<.001 respectively). Conclusion:This result showed that young adults with childhood ADHD symptoms had various forms of psychopathology and childhood ADHD symptoms were influenced by character such as cooperativeness. Therefore, more thorough evaluation regarding childhood ADHD symptoms is needed.

Direct effectiveness of pneumococcal polysaccharide vaccine against invasive pneumococcal disease and non-bacteremic pneumococcal pneumonia in elderly population in the era of pneumococcal conjugate vaccine: A case-control study

Kim, Jong Hun,Chun, Byung Chul,Song, Joon Young,Kim, Hyo Youl,Bae, In-Gyu,Kim, Dong-Min,Choi, Young Hwa,Jun, Yoon Hee,Choi, Won Suk,Kang, Seong Hee,Kwon, Hyun Hee,Jeong, Hye Won,Kee, Sae Yoon,Hur, Jia Elsevier Ltd. 2019 Vaccine Vol. No.

<P><B>Abstract</B></P> <P><B>Background</B></P> <P>While herd effects and serotype replacement by childhood pneumococcal protein conjugated vaccines (PCVs) continues to accumulate worldwide, direct effectiveness of 23-valent pneumococcal polysaccharide vaccine (PPV23) against pneumococcal diseases in the elderly has been challenged. We estimated the direct effectiveness of PPV23 in the elderly population.</P> <P><B>Methods</B></P> <P>For a hospital-based case-control study, cases of invasive pneumococcal disease (IPD) and non-bacteremic pneumococcal pneumonia (NBPP) (adults ≥ 65 years) were identified in 14 hospitals participated in the pneumococcal surveillance program from March 2013 to October 2015, following implementation of PPV23 national immunization program (NIP) for the elderly in the Republic of Korea. Controls matched by age, sex, and hospital were selected at ratios of 1:2 (IPD) or 1:1 (NBPP). Clinical data and vaccination records were collected. Vaccine effectiveness was calculated as (1-adjusted odds ratio) × 100.</P> <P><B>Results</B></P> <P>We enrolled 148 IPD and 557 NBPP cases, and 295 IPD and 557 NBPP controls for analyses. Overall effectiveness of PPV23 against IPD was 28.5% [95% confidence interval (CI) −5.8%–51.6%] and against NBPP was 10.2% (-15.1-30.6) in all patients ≥ 65 years. However, in subgroup analysis of patients aged 65–74 years, PPV23 was protective against IPD [effectiveness 57.4% (19.4–77.5)] and against NBPP [effectiveness 35.0% (2.3–56.7)]. Furthermore, serotype-specific effectiveness of PPV23 against IPD was 90.6% (27.6–98.8) for PPV23-unique serotypes and 81.3% (38.6–94.3) for PPV23 serotypes excluding serotype 3.</P> <P><B>Conclusions</B></P> <P>This study indicates that PPV23 with broad serotype coverage might be beneficial in preventing IPD and NBPP due to non-PCV13 serotypes in the young-elderly, with potentially increasing effectiveness in the setting of childhood PCV NIP.</P> <P><B>Highlights</B></P> <P> <UL> <LI> National immunization program for PPV23 for the elderly was implemented in Korea. </LI> <LI> PPV23 was effective against IPD and NBPP for young elderly patients aged 65–74. </LI> <LI> Effectiveness of PPV23 against IPD was higher for PPV23 unique serotypes. </LI> <LI> PPV23 was non-protective against IPD caused by PCV13 serotypes. </LI> </UL> </P>

뮤코다당증(Mucopolysaccharidosis)환아의 치은 증식

송주현,장철호,김영재,한세현,이상훈 대한소아치과학회 2007 大韓小兒齒科學會誌 Vol.34 No.1

뮤코다당증(Mucopolysaccharidosis, MPS)은 gIycosaminoglycans (GAGs)의 분해에 필요한 라이소좀 효소(lysomal enzymes)의 결함으로 GAGs의 대사 산물이 세포의 라이소좀내에 축적되어 점차 세포와 조직, 기관의 기능 이상을 초래하고 신체 질환과 정신 발달 지연을 가져오는 질환이다. 본 증례는 심각한 치은 증식을 가진 뮤코다낭증 환아를 전신 마취 하에 치은 절제술을 시행한 치험례이다. 소아치과 의사는 뮤코다당증 환아의 구강내 증상과 치과 치료시 주의 사항에 대해 숙지해야 하고, 내과의와 연계하여 환아의 전신 상태 변화에 민감하게 대처하여 치과 치료를 시행해야 한다. Mucopolysaccharidosis (MPS) is a disorder of storage in which there is excessive accumulation of glycosaminoglycans(GAGs) from lysosomal enzyme defect. Lysosomal accumulation of GAGs eventually results in cell, tissue and organ dysfunction. This patient may manifest mental retardation and physical disorders. This clinical report presents a girl with MPS having severe gingival hyperplasia. Gingivectomy was performed under general anesthesia. The pediatric dentist must be aware of oral manifestations present in the MPS. The approach to dental management will require teamwork between the dentist and the patient' s physician.

흉부 둔상 후 8년간 지속된 삼첨판폐쇄부전의 치료 1예

송현주,남승현,최영주,박성훈,박시훈,한재진 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.4

저염농도의 자리발효식품의 가공에 관한 연구

송대진,김재하,강영주,김수현,고영환,하진환 濟州大學校 工科大學 産業技術硏究所 1990 産業技術硏究報告 Vol.1 No.-

This study was carried out to obtain the basic data on salted and fermented damsel fish(Jari-Jeot), one of the important traditional marine foods in Cheju-Do. and also to seek salt lowering method for the development of a new local tourist food. The results are as follows : The best organoleptic results were obtained after 60 days' fermentation for 25.0, 12.5 and 10% of salt-added group, and around 45 days for 7.5 and 5% of salt-added group. In raw fish ingredient IMP was abundant which marked 17.7 μmole/g while in fermented fish hypoxanthine was predominant but ATP and ADP were not detected after 30 days' fermentation. Sixteen kinds of free amino acids were detected and identified in Jari-Jeot instead of 17 kinds of those in raw sample. The abundant amino acids in Jari-Jeot after 60 days' fermentation were lysine. alanine, glutamic acid, glycine and leucine, and those were consisted of approximately 60% of the total free amino acids. During fermentation the content of TMAO was decreased gradually and no TMAO was detected after 75 days' fermentation while that of TMA was increased during fermentation up to 45 days' and decreased afterwards. The fatty acid of low-salt Jari-Jeot was composed of 31.9% of saturated acids, 13.2% of monoenoic acids and 54. 9% of of polyenoic acids. While the content of EPA in polyenoic acids was 1.9%, that of DHA was 23.0%. In order to lower salt concentaration of fermented damsel fish, additon of Pediococcus halophilus culture as a starter together with 10-12.596 of salt, 4-5% of KCI, and 2% of glucose gave as good quality as traditionally made Jari-Jeot.

만성적 스트레스 및 불규칙적인 운동이 심혈관 질환의 위험인자에 미치는 영향

송영주,권대근,장창현,정영미,황정윤,성동진 한국스포츠리서치 2003 한국 스포츠 리서치 Vol.20 No.1

This study was conducted to invastigate the effect of everyday life stress level and temporary physical activity by the stress on stress-related hematologic indices. The subjects were 83 male older aged men and they were received a questionaire about everyday life stress level and temporary physical activity by the stress and collected whole blood after overnight fasting state. Obtained results were as follows: 1. CRP level CRP level of MS group was significantly increased compared to SS group(p<.05). However, CRP level between PA and NP was not significant difference. 2. Cholesterol, triglyceride, phospholipid level Cholesterol, triglyceride, phospholipid level of MS group was significantly increased compared to SS group(p<.05). However, Cholesterol, triglyceride, phospholipid level between PA and NP was not significant difference. 3. WBC counts WBC counts of MS group was significantly increased compared to SS group(p<.05). However, WBC counts between OP and PA was not significant difference. From these results, increased stress in everyday life aggravate blood components related cardiovascular risk factors and immune system. In addition, acute exercise for stress attenuation does not improve blood components related cardiovascular risk factors and immune system. In summary, regular exercise and optimal nutrition and rest will be attenuate cardiovascular risk factors and immune system.

유구치 치수절단시 치관부 치수의 임상, 혈액 및 병리 조직학적 관찰

송민호,김영진,김현정 大韓小兒齒科學會 1993 大韓小兒齒科學會誌 Vol.20 No.1

현제, 소아치과의 임상에서 유치치수 절단술시 치수상태를 객관적으로 파악할 수 있는 진단방법이 없으나 적절한 적응증을 선택하기 위해서는 반드시 필요하다. 따라서 저자는 생활치수 절단처치가 필요하다고 단단되는 유구치 52례를 동통의 병력,구내표준방사선사진,전기치수검사,온,냉자극검사,치수노출유무,치수내 혈액상 및 치관부 치수제거 후 지혈곤란도를 병리조직학적 소견과 비교하여 유치치수염의 감별진단의 지표로 삼고자 실험하여 아래와 같은 결과를 얻었다. 1. 유규치 치관부 치수의 병리조직상 염증정도를 단계로 분류하여(-)14례(26.9%),(+)26례(50.0%),(++)5례(9.6%)이고,(+++)7례로 나타났다. 2. 동통의 병력은 치관부 치수 염증정도별에 따라(-)35.7%,(+)30.8% (++)80.0%,(+++)85.7%로 염증이 심할수록 동통이 발생하는 비율이 높게 나타났다(p<0.05). 3. 구내표준방사선 사진상에 의한 우식부 하방의 잔존상아질 양과 염증정도 사이에는 유의한 차이가 없었다(p<0.05). 4. 연화상아질 제거 후의 치수노출은 염증정도에 따라 (-)7.1%,(+)26.9%,(++)80.0%,(-+++)71.4%로 염증이 심할수록 치수노출되는 비율이 높게 나타났다(p<0.05). 5. 전기치수검사와 온, 냉자극검사는 염증정도에 검사치 사이에 유의성이 없었다(p>0.05). 6. 치수혈액상 림프구 백분율의 평균은 염증정도에 따라(-)53.6%,(+)50.8%,(++)48.2%,(+++)37.4%로 염증이 심할수록 림프구 백분율이 감소하는 것으로 나타났다(p<0.05). 따라 (-)7.1%,(+)11.5%,(++)0%,(+++)71.4%로 염증이 심할수록 높게 나타났다(p<0.05). The purpose of the present investigation was to study the diagnosis of deciduous tooth pulpitis by the clinical examination,blood picture and histopathologic features in the coronal pulp. It makes sure of the extent of the inflammation for more appropriate pulp therapy. The subjects were 52 decayed deciduous teeth of 26 normal healthy children aged from sy5m to 10y8m. which justified the vital pulp amputation therapy. The pain history,periapical radiograph,EPT,thermal test,pulp exposure,hemogram and bleeding control were compared with the histopathologic structure of the coronal pulp. The results were as follows: As to the histologic structure of the removed moronal pulp, the inflammatory degree was divided into 4 types; (-)no evedence of inflammation,(+)slightly confined infiltration on inflammatory cells,(++)slightly or moderately diffused infiltration,(++)severely diffused infilration,when the numbers of the case respectively at degree type were(-)14,(+)26,(++)5,(+++)7 cases. The ratio of cases which have pain history is significantly higher according to the severity of inflammation(p<0.05). The ratio of cases in which the pulp is exposed is significantly higher according to the severity of inflammation(p<0.05). As the results of the X-ray examination, EPT and thermal test show, they had no correlation with the inflammatory state(p>0.05). The mean of the lymphocyte ratio was significantly decreased according to the severity of inflammation(p<0.05). The ratio of cases in which it was difficult to control bleeding at the coronal pulp amputations were significantly higher according to severity of inflammation(p<0.05).

다핵균 및 단핵균으로부터 고protease 생산균주의 Screening

송상호,임현수,최명락,유은정,김성영 여수대학교 1998 論文集 Vol.13 No.2

4 multinucleate and 7 mononuclear fungi were investigated for screening of high protease productive strains. The protease activity of mononuclear strains was generally greater than that of multinucleate strains. For acid proteinase, Aspergillus awamori AOK 1007 and Asp. oryzae shoyu 2 as mononuclear strains were selected in glucose-polypeptnoe medium. For acid carboxypeptidase, two mononuclear strains were screened as Asp. awamori AOK 1007 and Asp. usamii mut. shirousami AOK 1011 in glusose-sodium glutanate medium. In this result, mononuclear fungi appeared higher protease production than that of multinuclear fungi. So, mononuclear fungi may gave many merits to improve protease activity by using of mutation or cell fusion technology.