피페라진 유도체의 合成에 관한 硏究

정순량,김현모 又石大學校 1995 論文集 Vol.17 No.-

(±)N-[3-(t-Butyldiphenylchlorosilanyl)(2-oxazolidinonyl)carbonyl] piperazine(10) and N-Dimethyl-3-(4-t-butyloxycarbonylpiperazinyl-1-carbonylmethyl)-N-(ρ-nitrobenzyloxycarbonyl) amino propionate(16) were synthesized as for new piperazine derivatives. Synthetic reaction of (±)N-[3-(t-butyldiphenylchlorosilanyl)(2-oxazolidinonyl)carbonyl] piperazine(10) was followed ; monobenzylation of(±)malic acid, crutius rearrangement of triethylamine and diphenylphospholylazide, TBDPS protection of sodium hydride and TBDPS-chloride, hydrogenation of catalyst of 10% Pd/c DCC coupling of 4-dimethylamino pyridine, deprotection of BOC. Yield of (±)N-[3-(t-butyldiphenylchlorosilanyl)(2-oxazolidinonyl)carbonyl] piperazine(10) identified by nmr peaks, was 88%. Synthetic reaction of N-dimethyl-3-(4-t-butyloxycarbonylpiperazinyl-1-carbonylmethyl)-N-(ρ-nitrobenzyloxycarbonyl), amino propionate(16) was followed ; PNZ protection of ρ-nitrobenzylchloride, amination of triethylamine base and ethylchloroformate, alkylation of sodium hydride base, deprotection of PNZ. It was very difficult to separate the end product. Yield of N-dimethyl-3-(4-t-butyloxycarbonylpiperazinyl-1-carbonylmethyl)-N-(ρ-nitrobenzyloxycarbonyl)amino propionate(16) identified by nmr peaks, was 89%. Key point of these synthetic reactions was the seletion of protecting groups. The protection groups depended entirely on the derivatives attaching at the rear of pyrazine ring. The best one was BOC group.

實科 敎育 課程 詳細化 硏究

鄭聖鳳,宋賢順 韓國實科敎育硏究學會 1996 實科敎育硏究 Vol.2 No.1

교육과정 상세화는 교수의 질을 향상 시키고 교수 내용을 다양화 시키며, 교수 목표 실현을 위해 필요하다. 이 연구의 목적은 초등학교에서 실과 교육과정을 효과적으로 활용하는데 있다. 이 연구는 크게 세부분으로 이루어져 있다. 실과 교육 목적의 상세화, 실과 교육과정의 단원설정, 실과 교육고정 상세화의 실제가 그것이며, 또한 5, 6학년 실과 교육과정 상세화를 부록에 제시하였다. The curriculum specification be needed to promote the instructional quality, to diversify the teaching contents and to be realized the instruction objectives on practical art education. The purpose of this study was to specified the practical art curriculum for the practical use in elementary school. This study was contained three parts: the specification of practical art curriculum, the contents and units establishment of practical art curriculum, practical specification of practical art curriculum. Also, the specifications of practical art curriculum on 5th and 6th grades were presented in appenices.

흰쥐 췌장을 지배하는 운동 및 감각신경세포체의 표지부위

이창현,정순용,차영옥,정승호,송창호,이무삼 대한해부학회 1995 Anatomy & Cell Biology Vol.28 No.6

Body-Concept에 관한 연구 : 부산시내 여대생과 어머니를 대상으로

정순영,배현숙 慶星大學校 1993 論文集 Vol.14 No.2

The purpose of this study was to investigate satisfaction about their body images and to look tendency of actuality and ideal body images in college women. This study also made a comparative analysis of difference between college women and their mother. For this purpose, data were obtained from 105 college women and 57 their mothers in Pusan and analyzed by the statistical methods like Frequency, T-test, and ANOVA The results were as follows 1. All items were dissatisfied except for the waist sizes of college women in their body size and the bust sizes of their mothers. 2. The actual and the ideal size rarely corresponded, many people were dissatisfied between the actual and the ideal body, and the self-estimation image physically was sensible to consciousness difference between college women and their mothers. 3. Most of women though with the ideal size to similarity, the height and weight in actuality in body size were not correlation, and mostly the image was slim. 4. Generally, the height in height in height that based on actual women's one piece and coat size was considered with ideal body size, they didn't know their body size concretely except height and weight, and divided with size of ready-made cloth. 5, The appraisal distribution of actuality was dispersion, but one of the ideal was concentration. The college women in their body sizes was more interested than their mothers. 6. The ideal body image to hope of college women and their mothers had no essential difference, and the similarity of the ideal body image in todays' women was due to role of mass-media.

제왕절개 자궁적출수술의 임상적 고찰

정갑인,남계현,이해혁,이순곤,이권해,김동희 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

Objective: This study was evaluated twenty-six cases of emergency Cesarean hysterectomy to analyse incidence, age distribution, parity, indications, complications, amount of blood transfusion and fetal morbidity. Methods and Materials : This study was carried out on twenty-six cases who underwent emergency Cesarean hysterectomy at department of obstetrics and gynecology, Soonchunhyang University Hospital from January 1987 to November 1997. Results: 1. The incidence of Cesarean hysterectomy was perfomed in 26 cases among total 19,277 deliveries(0.1%). 2. The indications of Cesarean hysterectomy were uterine atony, placenta previa, adhesive placenta and bleeding tendency. 3. There was matenal death in one case and main cause of death was massive bleeding due to disseminated intrabascular coagulopathy. 4. The complications of Cesarean hysterectomy were disseminated intravascular coagulopathy, bladder injury, postoperative infection, wound disruption and postoperative hemoperitoneum. 5. Two cases of fetal and neonatal mortality were intrauterine fetal death and neonatal death. Conclusion : The incidence of Cesarean hysterectomy was increased by increasing parity and maternal age.

측두골 골절에 의한 재발성 뇌막염 1례

정학현,고태옥,서한규,임현호,황순재 한국의학사 1998 診斷과治療 Vol.18 No.2

조산의 예측 지표로서의 fetal fibronectin의 유용성

정집광,이해혁,이정재,이석민,이순곤,남계현,이임순,이권해 순천향의학연구소;Soonchunhyang Medical Research Institute 2000 Journal of Soonchunhyang Medical Science Vol.6 No.1

Objective: The purpose of this study was to evaluate clinical efficacy of fetal fibronectin as a marker to predictor of preterm labor. Materials & Methods: The study group consisted of sixty-eight healthy pregnant women, at gestational age between 24 and 36 weeks, who visited our department with vaginal discharge from April, 1995 to December, 1997. For comparison, we divided all of the pregnant women into two groups by the result of ROM-Check^®, positive groups(N=21) and negative groups(N=47). When preterm labor appeared, 50mg of ritodrine hydrochloride(Yutopar^®) mixed I liter of 5% dextrose solution was administered slowly intravenously. Results: 1) The gestational age at delivery and the interval time from admission to delivery in the positive groups were significantly shorter than those of the negative groups(p<0.05). 2) The positive groups had significantly lower birth weight and Apgar scores than the negative groups(p<0.05). 3) Among the negative groups, in case of tocolytics administration, the interval time from admission to delivery significantly delayed more than that time in case of no tocolytics administration(p<0.05). Conclusions: The detection of the fetal fibronectin in vaginal discharge had a useful method as a predictor of preterm labor. Tocolytics was more effective in the negative groups than in the positive groups.

구급일지를 통한 병원 전 환잔 분류 및 처치의 적절성 평가 연구

민순식,김재광,이근,박철완,양혁준,류일,현성열,이훈규,정환모,김윤 대한응급의학회 2000 대한응급의학회지 Vol.11 No.4

Background: Recently, patients' demands for emergency medicine are increasing, and most of prehospital medical care, including basic life support, cardiopulmonary resuscitation and triage, are provided by paramedics or emergency medical technicians. Evaluation of the adequacy of prehospital management and triage has become important for improving the quality and the effectiveness of the emergency medical system. Methods: The 202 patients who were transferred by ambulance with paramedics, nurses, or emergency medical technicians to the Emergency Department in Gil Medical Center from July 1, 1999, to September 31, 1999, were enrolled. This study was conducted prospectively by using the emergency physician,s log and newly devised protocols recorded by paramedics or nurses. Results: 1) Male to female ratio was 1: 0.8, and the peak age of the patients were the 4th(18.8%) and 6th decade(15.3%). 2) Of the 202 patients, 84 patients were transferred for trauma and 118 for medical problems. The mean transfer time was 6±1.73 minutes. 3) The validities of prehospital triage and decisions using the trauma severity measure and the disease severity measure, were 33.3% in trauma patients and 57.6% in medical patients.4) The results for the adequacy rate in prehospital management analyzed by using the rate of necessity of treatment. performance of treatment, and adequate treatment were as follows: oxygen supply.38.1/41.6/93.8 ; wound dressing. 19.3/71.8/92.9 ; immobilization of the cervical spine, 15.8/56.3/92.9 ; application of a spinal board. 12.9/42.3/72.7 ; application of a splint, 9.9/50.0/60.0 ; manual maintenance of an airway. 9.9/55.0/63.6 ; and CPR, 4.5/66.7/0. 5) Kind of ALS(Advanced Life Support) were not conducted(peripheral IV, EKG. intubation, medical administration. defibrillation, pacing). The rates of necessity of treatment were as follows: peripheral IV, 40.6%; ECG monitoring, 23.3% ; endotracheal intubation, 8.9% ; medical administration, 8.9% ; defibrillation. 3.5%; and pacing. 1.5% Conclusion: The adequacy of prehospital triage and decisions using trauma and disease severity measures was relatively low. To improve the adequacy of BLS(Basic Life Support) and to increase the performance of ALS(Advanced Life Support), we must create challenges to develop new protocols and to supplement new equipment.

농흉과 종격동염이 합병된 viridans streptococcus에 의한 인후농양 1예

임상현,유진홍,권순석,김연식,신완식,강문원,정명희 대한화학요법학회 1997 대한화학요법학회지 Vol.15 No.2

최근 저자들은 viridans streptococcus에 의한 인후농약으로 인하여 발생한 종격동염 및 농흉을 보인 47세 여자 환자를 적절한 배농과 항생제로 치료한 국내 최초의 1예를 치험하였기에 문헌 고찰과 함께 보고하는 바이다. Since the antibiotic era, retropharyngeal abscess became a rare disease entity nowadays. But it may often progress to lethal complications involving vital structure if diagnosis or treatment is delayed. We experienced a case of empyema and mediastinitis complicating retropharyngeal abscess caused by viridans streptococcus in a 47-year-old female patient with diabetes mellitus. She was successfully treated with appropriate antibiotic therapy combined with percutaneous abscess drainage. To our knowledge, such a complication of retropharyngeal abscess has not been reported in Korea yet and we present this unusual case herein followed by a review of the related literature.

HMG-CoA 환원효소 억제제에 의한 ICAM-1 유전자의 발현조절

김현진,정효균,홍우정,김군순,조영석,김도희,채수흥,구본정,송민호,노흥규,김영건 충남대학교 의과대학 지역사회의학연구소 2001 충남의대잡지 Vol.28 No.1

Background : ICAM-1 act as one of major adhesion molecules in the atherosclerotic lesion. ICAM-1 expression is mainly regulated at the level of transcription and depend on IFN-γ signal transduction pathway in which the STAT1 transcrption factor is a critical intermediate. IFN-γreceptor not only initiates tyrosine 701 phosphorylation of STAT1 by Jak1 and Jak2, but also phosphorylates serine 727 through the activation of Raf-1/MAP kinases. HMG-CoA reductase inhibitors have anti-atherosclertic effects, beyond normalization of hypercholesterolemia, by directly acting on endothelial cells, macrophages and vascular smooth muscle cells. HMG-CoA reductase inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibitors suppress the synthesis of isoprenoid intermediates such as geranylgeranyl-pyrophosphate or farnesylpyrophosphate. These effects results inhibition posttranslational farnesylation and geranyl-geranylation processing of small GTP-binding preoteins and inhibition of normal signaling activities. Method : We made several 5'-deletion constructs of rat ICAM-1 promoter and analyzed the promoter activities by measuring the luciferase activity after transfection into ECV304 cells and smooth muscle cells. We checked the level of total and phosphorylated STAT1 protein by immunoblot analysis using specific antibodies. Results : Lovastatin inhibits IFN-γ-induced ICAM-1 gene expression in the ECV304cell. The cells pretreated with PD98059, MEKK inhibitor showed significantly low ICAM-1 RNA induction with IFN-γ stimulatio. IFN-γ induced phosphorylation of tyrosine 701 was not significantly changed by the pretreatment of lovastatin. But lovastatin suppresses IFN-γ-induced phosphorylation of ERK1/ERK2 which are responsible for the seine 727 phosphorylation in STAT1. Conclusion : We showed that HMG-CoA reductase inhibitors, lovastatin, suppresses IFN-γ mediated ICAM-1 gene expression through the inhibition of transcription. HMG-CoA reductase inhibitor suppresses IFN-γ-induced phosphorylation of serine 727 in STAT1 through the modulation of MAP kinases.