(+)-Chromen 유도체의 합성 및 이들의 Wnt/β-catenin pathway 억제 활성 평가

이지현,조수현,윤은주,오유석,송규용 충남대학교 약학대학 의약품개발연구소 2013 藥學論文集 Vol.28 No.-

(+)-Decursin and GCK062, which is decursin derivative, showed strong inhibitory activity for Wnt/β-catenin signaling and suppressed concentration-dependently PC3 cell growth. These compounds have pyranocoumarin ring as backbone and acryloyl group as side chain. In this study, we introduced (+)-chromen ring as backbond, that is more simplified than pyranocoumarin, and synthesized (+)-chromen derivatives. As a results, in most cases, (+)-chromen derivatives disappeared or lowered the inhibitory activities for Wnt/β -catenin signaling. However (+)-chromen derivative (SLC-G005, 92.0%), introduced 3,4-dihydroxycinnamoyl group, showed potent inhibitory activity, not as much as GCK062 (99.5%).

면접조사를 통한 초등학생의 영양교육 실태 및 실천도 조사

오유진,이영미,김정현,안홍석,김정원,박혜련,서정숙,김경원,권오란,박혜경,이은주,성현이 대한지역사회영양학회 2008 대한지역사회영양학회지 Vol.13 No.4

This study investigated the experience and practice of elementary school students on nutrition education. The data were collected from 217 male and female students attending 5-6th grade elementary schools in Seoul and Kyunggi-Do from March to June 2007, interviewing face to face by a nutrition teacher and 3 interns of a nutrition teacher. The results were as follows: 86.5% of the subjects learned about ‘Table etiquette’, ‘Reasons for eating fruits and vegetables’ (78.7%), ‘Food waste and environment’ (72.3%), ‘Healthy snacks’ (55.7%), ‘Food sanitation’ (52.3%), ‘Food culture of foreign countries’ (48.1%). Nutrition education experience was significantly different by gender. A total of 43.5% boys responded that they never learned about ‘basic food preperation’ (p < 0.01). They had learned ‘Nutrients for body’ and ‘Food waste and environment’ in school, ‘Healthy weight loss’, ‘Food culture of foreign countries’, ‘Food circulation’ on television, Most content (‘Table etiquette’, ‘Simple cooking’, ‘Food sanitati n’, ‘Eating behaviors for health’, ‘Reasons for eating fruits and vegetables’, ‘Healthy snacks’) was learned from parents. The practice after nutrition education was higher in ‘Table etiquette’ (2.14), ‘Eating fruits and vegetables’ (2.07) than others compared with education experience. The most reason of non-practice on nutrition information was ‘Troublesome’. In ‘Nutrients for body’, a boy answered ‘Difficult for practice’ 20.0%, a girl answered ‘Difficult to understand’ 32.6%, showing a significant difference between the gender groups (p < 0.001). They remembered the ‘Nutrients for body’ (49.6%), ‘Food sanitation’ (44.5%) because of ‘important content’,‘Basic food preparation’ (40.6%), ‘Food culture of foreign countries’ (36.3%) because of ‘interesting content’, ‘Healthy weight loss’ (52.0%), ‘Eating behavior for health’ (44.5%) and ‘Healthy snacks’ (33.7%) because of ‘need for my health’.

경막 내 colistimethate 투여로 치료한 다제 내성 cinetobacter baumannii 뇌실염

홍유아,유진홍,김진진,모은영,안건희,정희경,김진석,이현정,정미향,윤승배 대한감염학회 2009 감염과 화학요법 Vol.41 No.4

Acinetobacter species is a non-fermentative aerobic gram-negative coccobacillus that is an important pathogen found in nosocomial infections. Recently, multi-drug resistant Acinetobacter baumannii (MDR-AB) infections have been increasing and pose a serious problem. Most such infections present as bacteremia, pneumonia, or a wound infection; however, CNS infections are very rare. We herein present a case of ventriculitis caused by MDR-AB in a 37-year old man after a neurosurgical intervention. The patient was successfully treated with intrathecal colistimethate.

계층화된 퍼지 인지도를 이용한 신뢰기반 경매시스템

김현준,류정섭,권효석,조형래 경상대학교 생산기술연구소 2003 工學硏究院論文集 Vol.19 No.-

This paper introduces trust measurement that is composed of trust variables and fuzzy cognitive map. The improved trust measuring method using a stratified FCM can be used to measure the level of risk involved in a specific auction transaction concerned. To reduce the auction transaction cost and time, the proposed system recommends a differentiated transaction protocol according to the risk based on trust measurement. In this system, trust measurement can also be applied for differentiated and varied auction services.

로타바이러스 원내 감염과 지역사회 획득 감염의 비교 연구

유재성,진현주,강호석,오지은 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2

Purpose: This study was performed to investigate the epidemiologic and clinical characteristics of rotaviral infection, the most common nosocomial gastroenteritis. Method: We retrospectively reviewed the records of 983 patients who were diagnosed as rotavirus gastroenteritis from January 2006 to March 2010. We divided them into two groups: group A for community-acquired rotavirus infection (N=810), group B for nosocomial infection (N=173). We investigated the characteristics of both groups. Results: The percentage of nosocomial infection among rotavirus gastroenteritis was 18% in our study. Rotaviral infection in both groups was more common in winter. The average age (±SD) of group A and B was 25.8±23.3 and 17.8±15.7 months old, respectively. The average hospital days (±SD) were 4.3±2.0 days for group A and 9.0±3.5 days for group B. Nosocomial infection symptoms of group B started at 4.6±1.7 hospital days on average. Fever, vomiting, abdominal pain, convulsion, elevation of serum CRP (C-reactive protein) or AST (Aspartate aminotransferase) were observed more common in group A than B. Conclusion: The nosocomial rotavirus infection rate did not decrease as we expected in spite of our effort of strict hygiene control. Nosocomial infection showed more favorable prognosis than community-acquired infection but demanded longer days of hospitalization and more cost.

Co/Mn/Br계 촉매상에서 p-자일렌 액상산화반응의 공정변수에 관한 연구

손용배,박경린,류태공,김정희,오인석,김영호,양현수 忠南大學校 産業技術硏究所 2001 산업기술연구논문집 Vol.16 No.2

Liquid phase oxidation of p-xylene using molecular oxygen has been carried out on the Co/Mn/Br-based catalyst system in acetic acid as a solvent. Process parameters(total pressure, partial pressure of oxygen and temperature) and kinetics of the reaction were studied as a basic study in the viewpoint for the development of new catalyst system and process. The total pressure above 20atm and the partial pressure of oxygen above 5atm were required to keep the reactant in the liquid phase and to overcome the mass transfer limitation of oxygen. The oxidation rate conversion were increased with increasing reaction temperature to the 100∼190℃ range. For a given initial concentration of p-xylene, the oxidation rate and the apparent activation energy were found to be of first-order and 4.24 ㎉/㏖, respectively. The effect of the third components added to the Co/Mn/Br catalyst was also studied. It was found that Ni is only a good additive that can promote the catalyst performance.

한국 소아에서 보행발달 과정의 삼차원 동작분석 특성

박창일,박은숙,김유철,신지철,조상현,박진석 大韓再活醫學會 1998 Annals of Rehabilitation Medicine Vol.22 No.6

사후분해 시체에 대한 법의학적 접근

최영식,이상용,김유훈,조갑래,이봉우,양경무,정낙은,서중석,이한영,이원태,강현욱 大韓法醫學會 2000 대한법의학회지 Vol.24 No.2

Disposal of a homicide victim by dismemberment is rare, but individual cases are on record in most major medicolegal departments. Recognition of postmortem mutilation may be of importance in the interpretation of certain murders committed by sexual perverts and other mentally deranged individuals and sometimes performed for the sole reason of easier disposal of the body. Postmortem dismemberment is usually readily recognizable as such; The edges of the injuries are dry and lack evidence of bleeding. The joints may be disarticulated without fracture, or the use of an axe or saw may be evident from examination of bones. Parallel horizontal or oblique furrows in the bone surface are caused by skipping of the saw prior to establishing depth. Such patterns on the bone may assist in identifying the particular saw involved. So we report 25 dismembered corpses that autopsied in National Institute of Scientific Investigation. This paper can help in attempting to establish not only the first criminal investigation steps but also the medicolegal approach methods in unidentified and dismembered deaths.

The Emergence of a New U.S. Multilateralism : The Case of PSI(Proliferation Security Initiative)

Hyun-Seok Yu(유현석) 경희대학교 인류사회재건연구원 2008 OUGHTOPIA Vol.23 No.1

이 논문의 취지는 미국 다자주의의 진화와 현재 사태를 점검하는 것이다. 그리고 9.11 사건 이후 기존의 전통적인 다자주의 정책보다 신다자주의가 성립되고 있다는 것을 주장하고자 한다. 이러한 취지에서 이 연구는 PSI를 통한 신다자주의의 특성들을 살펴보고자 한다. 미국의 신다자주의는 냉전 시대 이후에 나타났고 9.11 사건과 이후의 미국 정책의 목표들이 자기 민족 중심주의로 되면서 이러한 현상이 더욱 더 두드러지게 나타났다. 미국이 정하는 목표나 원칙들, 또한 주변 나라들의 참여를 부추기는 행동들은 진정으로 다자주의라고 말하기 어렵다. 그리고 일방주의가 신다자주의에 뿌리를 두고 있기 때문에 국제사회를 설득할 수 있는 정당성이 부족하다. 다자주의적 프레임은 테러 행위를 맞서는 것을 비롯해 마치 미국의 국민적인 관심만을 쫓는 것 같이 되어버렸다. 현재 신다자주의의 정당성은 논쟁상의 여지가 있고 기존의 국제적인 규범과 법을 어기기도 하는 이론을 바탕으로 하고 있다. 이는 또한 국제법과 기존의 다자주의적 기관들과 잦은 충돌이 있기도 한다. 끝으로 유엔의 역할은 신다자주의에 있어서 아주 미미하다. 유엔은 정당하게 일방주의를 펼치기 위한 하나의 수단으로 밖에 여겨지지 않는다. 미국의 현 대외 정책의 방향이 일방적인 것도 아니고(최소한 형식상으로라도) 진정한 다자주의가 아니라면 우리는 미국 외교 정책을 이해하는 데 있어서 단순한 이분법(다자주의 대 일방주의)은 배제해야 할 것이다. The main goal of this study is to discuss the evolution and the current state of U.S. multilateralism. I argue that after the 9.11, we can observe the emergence of a new multilateralism which is different from traditional multilateralism. This study aim to show the traits of “new multilateralism” with the case of Proliferation Security Initiative(PSI). The new multilateralism emerged after the end of Cold War and has intensified after the 9.11 is characterized by the promotion of the U.S. defined goals which are not necessarily for the benefit of all within multilateral framework. In the sense that the U.S. single-handedly defines the goal and principles and solicits participation it is not a genuine multilateralism. Since the elements of unilateralism are rooted in the new multilateralism, it often lacks enough legitimacy to persuade international community. Multilateral framework seems to be adopted only to achieve U.S. goal such as fighting terrorism effectively. The legitimacy of the new multilateralism is based on creative doctrines which are controversial and often violate existing international norms and laws. It often is in conflict with international law and existing multilateral institutions which have same purpose. Finally, the role of the U.N. is marginal in the new multilateralism. The U.N. is invited only for the purpose of legitimizing unilateral actions. If we accept that current U.S. foreign policy orientation is neither a unilateralism(at least in form) nor a genuine multilateralism, we should reject simple dichotomy(unilateralism vs. multilateralism) in understanding the U.S. foreign policy orientation.

Evaluating the Role of Regional Expert Network in Regional Security Institution Building

Yu Hyun Seok 한국국제정치학회 2009 國際政治論叢 Vol.49 No.3