보조호르몬요법을 받는 여성 유방암 환자의 모발 변화와 치료 실태에 대한 기초 연구

이재경 ( Jae Kyung Lee ),김창현 ( Chang-hyun Kim ),홍동균 ( Dongkyun Hong ),정경은 ( Kyung Eun Jung ),서영준 ( Young-joon Seo ),김창덕 ( Chang-deok Kim ),이진선 ( Jin Sun Lee ),권인선 ( In Sun Kwon ),박상현 ( Sanghyun Park ),이영 대한피부과학회 2021 대한피부과학회지 Vol.59 No.7

Background: Hormone therapy, which includes tamoxifen and aromatase inhibitors, is the most common adjuvant therapy used for breast cancer. However, only a few studies have reported endocrine therapy induced alopecia. Objective: We investigated the effects of long-term adjuvant hormone therapy on hair in patients with breast cancer, in addition to patients’ concerns and current treatment for hair loss. Methods: Patients completed a questionnaire that included information on self-perceived hair changes after each adjuvant therapy session, distress, and current treatment for hair loss. Using a folliscope, we measured hair density and thickness in each patient and in healthy controls. Results: The study included 93 patients with breast cancer (mean age 51.9±9.8 years). The density and hair thickness were 106.36±21.85 hairs/cm2 and 0.07±0.01 mm in the patient group and 147.86±30.67 hairs/cm2 and 0.07±0.01 mm in the control group (n=98, mean age 52.10±8.40 years), respectively. The mean hair density was significantly lower in the patient group than in the control group; however, no statistically significant intergroup difference was observed in hair thickness. Among 76 patients who perceived hair changes after adjuvant therapy, 71.1% (n=54) were distressed with regard to hair changes. However, only 7.8% of the patients, including two who were treated by dermatologists, currently received treatment for hair changes. Conclusion: Dermatologists should be familiar with hair changes in patients with breast cancer and provide appropriate education to encourage patients to consult dermatologists for hair loss and thinning after breast cancer treatment. (Korean J Dermatol 2021;59(7):521∼526)

항공사진을 이용한 방포항 인근 해빈의 장기간 해안선 변화 분석

김백운 ( Baeck Oon Kim ),윤공현 ( Kong Hyun Yun ),이창경 ( Chang Kyung Lee ) 대한원격탐사학회 2013 大韓遠隔探査學會誌 Vol.29 No.5

장기간 해안선 변화 자료의 구축을 통해 해안선의 시·공간적인 변화 양상을 분석하고, 이에 근거하여 해안침식의 향후 경향을 파악하는 일은 연안관리에 매우 중요한 역할을 한다. 본 연구에서는 수치항공사진을 이용하여 방포항 인근 해안지역의 장기간(1985년 ~ 2009년) 해안선 변화 탐지를 위해 항공삼각측량, 지상기준점측량, 수치도화, 그리고 해안선 변화율을 산정하였다. 그 결과 방포해빈과 꽃지해빈의 해안선은 각각 0.2 m/yr와 최대 0.8 m/yr로 침식된 것으로 파악되었다. 또한 등고선 변화 통하여 꽃지 해빈의 북부지역에서 침식현상이 가장 뚜렷하게 나타났으며 표고 1 m 간격의 등고선은 최대 45 m 후퇴하였음을 알수 있었다. 이러한 변화는 다양하고 복합적인 요인에 의해 발생할 수 있으며 주된 요인은 1990년대 말에 설치된 해변 옹벽이 해안침식을 일으키는 주요 원인으로서 추정되고 있다. To analyze tendency of temporal and spatial change of shorelines and to estimate rate of shoreline changes using long-term shoreline change data is very important for the coastal environmental management. In this study, investigation was conducted to estimate the rate of shoreline changes using long-term shoreline change data from the year 1985 to 2009 aerial photographs. In this process aerial triangulation, GPS surveying and digital mapping was done for the estimation of changes. As the results, shorelines of Bangpo and Kkotji Beach retreated at a maximum rate of 0.2 m/yr and 0.8 m/yr, respectively. The shoreline could be changed by various factors. However, it was presumed that coastal erosion has been mainly affected by retaining wall constructed in the late 1990s.

고등어 염장중 N-Nitrosodimethylamine 생성 및 그 전구물질들의 변화

金洙賢,吳昌璟 제주대학교 1993 논문집 Vol.36 No.-

여러 식품에서 아질산염과 제2급 및 제3급 아민 또는 제4급 암모니윰 화합물과의 상호작용에 의해 형성 되어지는 N-nitrosamine은 상당한 관심의 대상이 되고 있다. 본 연구는 5℃에 저장된 염장고등어에서 발암성 N-nitrosamine의 생성과 이의 전구물질인 DMA-N, TMA-N, betaine-N choline-N 및 총 creatinine의 변화를 10일 주기로 조사하였다. 또한, Ames의 표준평판 혼성시험법의 변법인 예비배양법을 이용하여 NDMA의 돌연변이유발 활성을 검정하였다. 본 연구에서 얻은 결과를 요약하면 다음과 같다. 1) pH는 10% 및 20% 염장품이 각각 5.62-5.73과 5.68-5.93으로 N-nitrosamine 생성 최적 pH보다 높은 범위에서 변화하였다. 수분은 생시료에 비해 훨씬 낮은 양으로 변화하였다. 수분은 생시료에 비해 훨씬 낮은 양으로 변화하였다. 염도는 각각 저장 20일 경과후에 5.7 및 11.4%이었고, 이 후 서서히 증가하여 저장 말기에는 각각 7% 및 13%의 염분침투가 이루어 졌다. V.B.N.은 저장초기에 급격히 증가하였으며 전반적으로 V.B.N.은 10%가 20% 염장품보다 약간 높은 함량 변화를 보였으나, 어류의 초기 부패치인 30mg/100g을 초과하지 않은 것으로 보아 저장기간 전반에 걸쳐 부패가 진행되지 않았음을 알 수 있었다. 2) 총 creatinine-N과 betaine-N 등의 제4급 암모니윰 화합물은 저장 중기에 상당히 증가하였으나, 저장 중기 이후에는 감소한 반면, cholone-N는 저장중에 조금씩 계속 증가하였다. 3) TMAO-N와 TMA-N 함량은 저장 초기에 변화가 심하였으나, 대체적으로 TMAO-N는 증가하고 TMA-N는 감소하는 역상관관계를 보였다. 4) DMA-N 함량은 저장중에 계속 증가하였으며, 10%과 20% 염장품간의 차이는 거의 없었다. 5) NDMA는 10% 및 20% 염장품이 각각 저장 20일 및 30일 경과시부터 검출되었으며 그 함량은 극히 낮았다. 반면, 아질산염 첨가구의 경우, 비첨가구 보다 약 500배 낮은 함량 변화를 보였으며, 대체적으로 저장기간중에 조금씩 증가하였다. 6) 돌연변이유발 활성은 plate당 1㎍(10ppm)의 NDMA를 첨가한 TA100 균주에서 가장 높게 나타났다. 결론적으로, 고등어 염장중 NDMA 생성 가능성은 아질산염과 DMA간의 상호작용에 의해서는 물론, 아질산염과 제3급 amine 및 제4급 ammonium염과의 상호작용에 의해 영향을 받으며, 저염 및 고염 염장품의 차이는 거의 없는 것으로 나타나기 때문에 저염고등어 제법을 개발하였을 때 NDMA 생성과는 무관하다고 판단되었다. NDMA의 돌연변이유발 활성은 10-100ppm의 농도에서 나타났다. The possibility of formation of carcinogenic N-nitrosodimethylamine and changes of their precursors in salted mackerel, Scomber japonicus, stored at 5℃ were periodically investigated, and changes of precursors between low (10%) and high (20%) salted mackerel was compared. The results were as follow; 1) Changes of pH were in the ranges of 5.62-5.73 and 5.68-5.93 in 10% and 20% salted mackerel during their storage, respectively. 2) Moisture changes in very low contents in compared with fresh sample. 3) Salinity gradually increased in low and high salted mackerel and salt permiation of 7 percent and 13 percent was accomplished during storage of both groups, respectively. 4) The contents of total creatinine and betaine remarckably increased at the middle of storage, while choline contents was scarcely changed. 5) The contents of trimethylamine oxide and trimethylamine severely varied at the beginning of storage. Changes of contents between TMAO and TMA showed, apparently, reverse relationship. 6) The contents of dimethylamine showed nearly same increasing pattern and continuously increased during storage in both groups. 7) In the low salted mackerel, N-nitrosodimethylamine was detected from 20 days of storage, while in the high salted mackerel, it was detected from 30 day of storage. In both salted mackerel added sodium nitrite, the contents of NDMA were more 500 times than those in both salted mackerel without sodium nitrite. In conclusion, it was found by this study that the possibility of formation of NDMA might be affected not only by the interaction between nitrite and DMA but also by the interaction between nitrite and TMA, TMAO, choline, betaine, and creatinine in salted mackerel during storage. No difference of the contents of precursors and NDMA between both Samples(10% & 20% NaCl) was nearly.

알코올 및 인삼액이 효소활성도에 미치는 영향에 관한 연구

신경현,조만희,김창세 순천향대학교 1994 논문집 Vol.17 No.2

This study was investigated for the change of r-GTP, CPK activity and CPK-isoenzyme by alcohol and Ginseng administration, The normal white S.D rats were classified with four groups; ethanol treated was group A, ethanol pretreated group combined pretreated with Ginseng extract was group B, Ginseng extract treated was group C, and Ginseng extract treated group combined pretreated with ethanol was group D. The white rats of four groups were treated with 20%, 30%, 40% ethanol and/or 1% Ginseng extract. Then enzyme activities such as r-GTP, CPK and CPK-isoenzyme had been measared in serum, hepatic, and renal tissues. The sample was collected by 5 day intervalus for 25 days. The following results were obtained. 1. The changes of serum r-GTP activities were significantly increased in ethanol-treated group, decreased in Ginseng-treated group. 2. The changes of hepatic r-GTP activites were significantly increased in ethanol-treated group, decreased in Ginseng-treated group. 3. The changes of renal r-GTP activites were significantly increased in ethanol-treated group, decreased in ginseng-treated group. 4. The changes of serum CPK activites were significantly increased in ethanol-treated group, decreased in ginseng-treated group. 5. The changes of hepatic and renal tissue CPK activites were not significant. 6. The changes of serum and hepatic tissue CPK-isoengyme were significantly increased in ethanol-treated group, decreased in ginseng-treated group combined pretreated with ethanol. 7. The changes of CPK-isoengyme, CPK 1 and CPK 2 were not significant.

Association Between Gut Regulatory Hormones and Post-operative Weight Loss Following Gastrectomy in Patients With Gastric Cancer

Hye-Kyung Jung,Chung Hyun Tae,Hye Ah Lee,Ko Eun Lee,Chang Mo Moon,Seong Eun Kim,Ju Young Seoh,Joo-Ho Lee 대한소화기 기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.3

Background/AimsPost-operative weight loss in patients with gastric cancer lead to a poor quality of life and long-term survival. This study aims to evaluate the effects of gut regulatory hormones on post-operative weight loss in patients with subtotal gastrectomy for gastric cancer. MethodsThis prospective study was conducted for 12 months post-surgery in 14 controls and 13 gastrectomy patients who underwent subtotal gastrectomy for gastric cancer. Serum plasma ghrelin, glucagon-like peptide-1, gastric inhibitory peptide-1, peptide YY, insulin, and homeostatic model assessment for insulin resistance responses to a standardized test meal were recorded at multiple time points before and after gastrectomy at 4 and 12 months. ResultsThe mean weight difference between the pre-operative state and the 4-month period was significantly reduced to 6.6 kg (P = 0.032), but significant weight reduction was not observed from 4 months to 12 months. The plasma levels of glucagon-like peptide-1, gastric inhibitory peptide-1, and peptide YY were significantly increased 4 months postoperatively compared to the pre-operative state (all P = 0.035); however, pre-operative levels and relative changes over a period of 0-4 months of hormones were not correlated with body weight changes. Only the pre-operative ghrelin at peak had a negative correlation with changes in weight reduction in the 4 months after surgery (ρ = −0.8, P = 0.024). ConclusionsSignificant weight reduction was common after subtotal gastrectomy for gastric cancer with a negative correlation pre-operative plasma ghrelin levels. Incretin hormones are modestly but significantly increased after subtotal gastrectomy; however, these changes did not affect the weight changes.

FC 2-8 : Factors associated with inflammatory change of epidermal cyst

( Jisang Yun ),( Kyung-nam Bae ),( Jin-hwa Son ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byungsoo Kim ),( Moon-bum Kim ),( Kihyuk Shin ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.-

Background: Epidermal cysts (EC) are the most common tumors found on the skin and accompanying inflammation is also frequent. However, the predictors for inflammatory change have not been investigated yet. Objectives: This study was performed to investigate the difference between inflamed and uninflamed epidermal cysts, and to assess associated factors for inflammatory change. Methods: We analyzed the biopsy-proven 1723 epidermal cysts (515 inflamed and 1208 uninflamed) at two tertiary hospitals from 2011 to 2021. Results: The proportion of inflamed epidermal cysts (IEC) and uninflamed epidermal cyst (UIEC) were 29.9 % and 70.1 %, respectively. Inflammatory change was less frequently observed on the face (25.5 %) than the other sites (32.1 %) (p=0.0046). The anatomic location with the highest rate of inflammatory change was back (40.8 %, p=0.0004). Mean duration of inflammatory change from UIEC to IEC on the face was shorter than the other sites (12.5 months vs 17.9 months, respectively, p= 0.0473). On ultrasonography, long axis of IEC (20.7mm) was generally longer than that of UIEC (15.7mm) (p=0.0218). Moreover, Inflammatory change was more frequent on the EC with punctum compared to those without punctum (35.3 % vs 30.3 %, P=0.0471). Conclusion: Based on the location, size and presence of punctum, decision on the optimal treatment strategies can be established when encountering patients with EC.

Factors associated with inflammatory change of epidermal cyst

( Jisang Yun ),( Kyung-nam Bae ),( Jin-hwa Son ),( Hoon-soo Kim ),( Hyun-chang Ko ),( Byungsoo Kim ),( Moon-bum Kim ),( Kihyuk Shin ) 대한피부과학회 2021 대한피부과학회 학술발표대회집 Vol.73 No.1

Background: Epidermal cysts (EC) are the most common tumors found on the skin and accompanying inflammation is also frequent. However, the predictors for inflammatory change have not been investigated yet. Objectives: This study was performed to investigate the difference between inflamed and uninflamed epidermal cysts, and to assess associated factors for inflammatory change. Methods: We analyzed the biopsy-proven 1723 epidermal cysts (515 inflamed and 1208 uninflamed) at two tertiary hospitals from 2011 to 2021. Results: The proportion of inflamed epidermal cysts (IEC) and uninflamed epidermal cyst (UIEC) were 29.9 % and 70.1 %, respectively. Inflammatory change was less frequently observed on the face (25.5 %) than the other sites (32.1 %) (p=0.0046). The anatomic location with the highest rate of inflammatory change was back (40.8 %, p=0.0004). Mean duration of inflammatory change from UIEC to IEC on the face was shorter than the other sites (12.5 months vs 17.9 months, respectively, p= 0.0473). On ultrasonography, long axis of IEC (20.7mm) was generally longer than that of UIEC (15.7mm) (p=0.0218). Moreover, Inflammatory change was more frequent on the EC with punctum compared to those without punctum (35.3 % vs 30.3 %, P=0.0471). Conclusion: Based on the location, size and presence of punctum, decision on the optimal treatment strategies can be established when encountering patients with EC.

알코홀이 r-GTP 활성에 미치는 인삼의 영향

이상한,조만희,신경현,김창세 순천향대학교 1989 논문집 Vol.12 No.3

This study was carried out to investigate the effects on the changes of the r-glutamyl transpeptidase activity of ethanol-administered white rats. There was classified into group; ethanol treated group(group A), ethanol treated group which was pretreated with ginseng extract(group B), ginseng extract treated group(group C), and ginseng extract treated group which was pretreated with ethanol(group D). White rats of four groups were treated with combined 1% ginseng extract and / or 20% ethanol for 30 days, and were measured the changes of r-GTP activity on the serum, hepatic and renal tissue sample collected at 5 days interval. Following results have been obtained. 1. The changes of serum r-GTP activity were significantly decreased in ethanol treated group B which was pretreated with ginseng extract than in ethanol treated group A. The values were highly significant at the 20th day of feeding. 2. The changes of hepatic r-GTP activity were more increased in group A and decreased in group D. The values were found significantly lowest in 10th and highest in 5th days. 3. The changes of renal r-GTP activity were more increased in group A and decreased in group D. The values were significantly highest in 10th and lowest in 20th days. Based on these results it was found that the changes of r-GTP activity between serum and hepato-renal tissue were exist and the protective action of ginseng against alcohol degradative effects was noted.

측두하악장애 치료 후 하악 안정위의 고경 변화에 관한 연구

김창현,한경수 원광대학교 치의학연구소 2003 圓光齒醫學 Vol.12 No.3

This study was performed to investigate the change of the mandibular vertical dimension, especially at the several rest positions, induced by speech and swallowing after treatment of temporomandibular disorders and to compare the vertical dimemion among those several mandibular rest positions. Thirty patients with temporomandibular disordem participated in this study, and the mean follow-up period after the first visit was 9.7 months. Clinical parameters related to pain, mandibular mobility, occlusion, and parafunction were examined. Subjects were asked to sit upright with relaxed natural head posture and then the two mandibular movements were performed, and recorded with BioEGN of Biopak system(Bioresearch Inc., Milwaukee, USA). A sentence of 'Sue is missing her house' was used to record the speech pattern. The positions observed and named in speech movement were rest, 'ssi', 'her', 'ha', and 's' position, and in swallowing movement were rest before swallowing, swallowing-early, swallowing-late, 0.5 sec. after swallowing, and rest after swallowing. Data obtained were processed and analysed by SPSS windows(ver. 10.0) program, and the results of this study were as follows: The mandibular positions showing vertical difference between before and after treatment were 'her', 'ha', and 's' in speech, and were swallowing-late, 0.5 sec. after swallowing, and rest after swallowing in swallowing. All these positions were located in the late half of the movements and the vertical dimension of rest positions in swallowing were increased after treatment. Rest positions in both of the movements did not show any significant difference for the vertical distance from habitual intercuspal position among them before treatment, however, which were changed and allowed differentiation after treatment. The vertical dimension of rest positions ranged 1.0-2.5mm in both of the movements. The ratio of the maximum opening range at the swallowing-late position in swallowing movement to the maximum Opening range at the 'ha' position in speech before and after treatment were 31% and 36%, respectively. Correlation between the vertical dimension of rest positions and the clinical maximum opening range were significantly negative at the 'mi' and 's' position only in speech movement before treatment. In conclusion, it was not easy to decide which position of all the mandibular positions observed in speech and in swallowing was the optimal mandibular rest position. However, the author suggested that the optimal mandibular rest position could be induced by and after swallowing movement.

오징어젓 숙성 중 제4급 암모늄 화합물의 변화

김성수,오창경,오명철,송대진,김수현 濟州大學校 産業技術硏究所 1996 산업기술연구소논문집 Vol.7 No.1

The changes in precursors of N-nitrosarnines, such as choline-N, betaine-N and total creatinine-N, during the fermentation of high salt-fermented squid, sepiell maindroni, group with 20% of salt and low salt-fermented squid group with 10% of salt, 6% of ethanol, 6% of sorbitol and 0.5% of lactic acid were investigated. During the fermentation, the contents of VBN were rapidly increased from the beginning of the fermentation until 140 days, and these contents were more in high salt groups as compared with low salt groups. The contents of choline-N were little changed until 80 days of the fermentation and slowly decreased after 80 days of the fermentation to 120 days, but the different of the contents between both salt groups were little. Betaine-N also showed the similar tendency to choline-N, but the changes in low salt groups were slowly increased and decreased as compared with these in high salt group. Total creatinine-N was slowly increased from the beginning of the fermentation until 60 days in both salt groups, but rapidly decreased after this to 120 day.