염색체 7번 장완의 부분적 역위 중복 1례

김현지,이소영,김미영,백청순,김원덕,이동석,김두권,최성민,Kim, Hyun Ji,Lee, So Young,Kim, Mi Young,Baek, Chung Sun,Kim, Won Duck,Lee, Dong Seok,Kim, Doo Kwun,Choi, Sung Min 대한소아청소년과학회 2003 Clinical and Experimental Pediatrics (CEP) Vol.46 No.5

Duplication of chromosome 7q has been reported as either partial or complete. Partial 7q duplication was first described by Carpentier in 1972. Pure partial duplication of the long arm of chromosome 7 is extremely rare and only 16 cases with a pure partial duplication of different 7q segment have been described in the literature. Pure partial duplication of the long arm of chromosome 7 is characterized by growth and developmental retardation, muscular hypotonia, distinct craniofacial dysmorphic features, a short neck and skeletal abnormalities. A 3 month-old male was referred to our department of Pediatrics because of dyspnea, hypotonia and delayed development. He shows growth and developmental delay, hypertelorism, a depressed nasal bridge, low set ears, a short neck and muscular hypotonia. Karyotype revealed 46, XY, dup(7)(q36q33) by GTC-banding. We report a case of a partial inverted duplication of chromosome 7q. 저자들은 호흡곤란, 근력저하, 발달지체로 병원에 온 3 개윌된 남아의 염색체 핵형분석에서 46, XY, dup(7)(q36q33)으로 진단된 1례를 경험하였기에 보고하는 바이다.

괴화(槐花) 추출물의 투여(投與)가 Streptozotocin으로 유발된 당뇨쥐에 미치는 영향

김현지,김경준,Kim, Hyun-Ji,Kim, Kyung-Jun 대한한방안이비인후피부과학회 2007 한방안이비인후피부과학회지 Vol.20 No.1

Objective : The present study was carried out to investigate the preventive effect of Sophorae Flos on streptozotocin - induced Diabetes mellitus. Method : Sophorae Flos was given to rats with oral administration. The experimental animals were divided into 3groups : normal group of rats, control group of Streptozotocin-induced diabetic rats, sample group with Sophorae Flos . The effect of Sophorae Flos on Streptozotocin-induced diabetes was observed by measuring the survival rate of rats, weight of rats, FER, blood glucose, each organ weight of rat, total cholesterol, HDL, GOT, GPT & creatinine. Result : Streptozotocin caused hyperglycemia and hypoinsulinemia by a selectively destroying pancreatic ${\beta}-cell$. Sophorae Flos treatment don't protected them from hyperglycemia and hypoinsulinemia. Organ weight liver, kidney, heart & spleen shows no significant changes. Sophorae Flos significantly don't recoverd the increase of several biochemical parameters such as blood glucose, total cholesterol, HDL, GOT, GPT, antioxidant & creatinine is vice versa. Conclusion : Sophorae Flos extract group did not show significant decrease than Streptozotocin control group.

원인불명의 호흡곤란을 호소한 증례 보고 1례

김현지,이해자,박은정,Kim, Hyun-Ji,Lee, Hai-Ja,Park, Eun-Jung 대한한방소아과학회 2007 대한한방소아과학회지 Vol.21 No.3

Objectives The purpose of this study is to report a case showed significant consult in treating Idiopathic chronic hyperventilation patient with oriental medicine. Methods The patient had suffered from dysypnea for 7 months, so we treated her with herbal medicine, acupuncture, laser, CEP nebulizer and cupping. Results and Conclusions This study shows that oriental medicine works for treating Idiopathic chronic hyperventilation. For more accurate studies, further studies are needed with more clinical cases.

적록 색각 이상자를 위한 HSV색공간을 이용한 색변환 기법

김현지,조재영,고성제,Kim, Hyun-Ji,Cho, Jae-Young,Ko, Sung-Jea 대한전자공학회 2013 전자공학회논문지 Vol.49 No.11

본 논문에서는 적록색각 이상자를 위한 색 변환 알고리즘을 제안한다. 적록색각 이상자는 원추세포의 이상으로 인해 색상과 명도를 일반인과 다르게 인지하기 때문에 적색과 녹색의 구분에 어려움을 겪는다. HSV 색공간은 이러한 특성을 파악할 수 있는 인간의 색지각과 유사한 색 공간으로, 제안하는 방법에서는 HSV 색 공간에서 색상과 명도를 보정하여 색을 변환 한다. 이때 색상과 명도 보정정도는 개개인의 색각이상 심각도에 따라 다르게 결정된다. 색각 이상자 개개인에 따라 다른 보정정도를 적용함으로서 기존 이미지의 자연스러움은 유지 하고 구분하기 힘들었던 색상들도 구분 가능하게 변환된다. 제안하는 방법을 색각 이상자에게 적용하여 시뮬레이션으로 확인한 결과, 색각 이상자가 구분하기 힘든 색상들이 색상의 자연스러움을 유지하면도 색차를 인지할 수 있는 색으로 변환되는 것을 확인할 수 있었다. This paper proposes a new re-coloring method for the people with the red-green color vision deficiency (CVD). These people have difficulty in discriminating the red and green colors since they abnormally perceive the hue and luminance value of the colors. We introduce a color transformation that adjusts the hue and luminance value in HSV color space. The color transformation is determined according to the severity of CVD. Our aim is to maintain the color differences in original image while maintaining the recolored image to be natural to the people with normal color vision. Experimental results show that the proposed method can yield more comprehensible images for the people with red-green CVD while maintaining the naturalness of the recolored images.

모유수유아의 비타민 D 섭취에 대한 한국형 가이드라인 제안

김현지,조선영,Kim, Hyun-Ji,Cho, Sun-Young 대한한방소아과학회 2012 대한한방소아과학회지 Vol.26 No.1

Objectives Recently, vitamin D supplements to breast-fed infants are being encouraged in Korea, and other countries. However, the reliability and validity assessment of supplements is insufficient. Therefore, this study suggests new Korean guidelines for vitamin D supplements of breast-fed infant. Methods The roles of Vitamin D for bone metabolism in children and the correlation between breast milk and Vitamin D were examined throughout domestic and international literature review. In addition, the efficacy and safety of vitamin D supplements were reviewed. Results Preventive effects of rickets by vitamin D supplementation remain unclear. Furthermore, concerns about the safety of vitamin D supplements intake have been raised. Korean guideline suggests breast-fed infants can get vitamin D through the skin safely, but maternal intake of vitamins through sunbath and diet is more effective and safe. Conclusions Limiting sunlight excessively and applying foreign countries' medical guideline for vitamin D supplements are not valid to apply as a domestic guideline for Korean breast-fed infants without considering ethnic and cultural characteristics.

계획행동이론을 적용한 하동지역 농업유산관광객의 행동의도 - 농업유산에 대한 지각된 가치와 사전적 지식의 역할을 중심으로 -

김현지,황길식,Kim, Hyun-Ji,Hwang, Kil-Sik 한국농촌계획학회 2018 농촌계획 Vol.24 No.2

The study aims to predict the behavior of tourists in Hadong County, which is registered as KIAHS. Based on the theory of planning behavior, we intend to verify the theory of planned behaviour, which adds descriptive parameters of the perceived value and prior knowledge of an agricultural heritage. In detail, first, the perceived value and prior knowledge of tourists about an agricultural heritage understand the influence of tourists' Attitude. Second, we could see the role of the behavioral factors in the causal relationship of the planned behavioral theory. We have identified the planned behavioral theory that attitudes, subjective norms, and perceptual behavior controls affect the intention of the revisit. Hadong should remember that by sending and providing various information about Hadong Green Tea and World Agricultural Heritage sites, it is possible to elicit changes in visitor attitudes and revisit visits.

단독주택 공부방의 조명환경 실태조사

김현지,안옥희,Kim, Hyun-Ji,An, Ok-Hee 한국조명전기설비학회 2005 조명·전기설비학회논문지 Vol.19 No.7

본 연구에서는 단독주택 공부방을 대상으로 조명환경 실태조사를 실시하였다. 그 결과, 공부방은 주로 형광등을 사용하였으며 배광방식은 직접조명 방식을 사용하고 있었다. 또한 국부조명을 사용하는 비율은 48.2[%]로 시작업이 효과적이지 못하였다. 내부공간 조도는 평균 131.41[lx]이며, 책상면 조도는 322.57[lx]로 최저허용조도의 54[%]에 해당하는 열악한 실정이었다. 또한 사용자의 조명환경에 비해 만족도는 높아 조명에 대한 인식이 매우 부족한 것으로 사료된다. In this study, we investigated the actual conditions of illumination environment of study rooms in detached houses. From the results, fluorescent lamp as a lighting source and direct lighting method were mainly used. The additional use of local lighting was 48.2[%], and it was not efficient for detailed work. The average illuminance of general lighting and local lighting were 131.41[lx] and 322.57[lx], respectively, and these level were only 54[%] of the lowest illumination standard. This indicates that the lighting levels and the environment are so poor. The satisfaction level of users, however, was relatively high, suggesting insufficient recognition of importancy of lighting for efficient work.

전호(前胡)가 Bleomycin에 의한 폐 섬유화에 미치는 영향

김현지,이해자,박은정,Kim, Hyun-Ji,Lee, Hai-Ja,Park, Eun-Jung 대한한방소아과학회 2008 대한한방소아과학회지 Vol.22 No.2

Objectives : Idiopathic pulmonary fibrosis (IPF) is chronic fibrotic interstitial pneumonia and the pathogenesis is unknown. Peucedani Radix is well-known for the treatment of respiratory diseases and pulmonary hypertension. This study was to evaluate the effectiveness of Peucedani Radix on the bleomycin-induced lung fibrosis model (BLFM) in mouse. Methods : We induced lung fibrosis by intratracheal instillation of bleomycin in C57BL/6J. We compared two groups BLFM without Peucedani Radix (group I) and BLFM with Peucedani Radix (group II). We performed bronchoalveolar lavages (BAL) and obtained lung specimens from both group I and II on the 7th (A) and 21st (B) day, and also for the normal group. We compared with group I and II to find BAL by using ANOVA test and to find pathologic symptoms by using semiquantitative histological index (SHI). Results : In BAL, total cell counts, lymphocytes, and neutrophils was increased in both group I and II comparing with normal group. However, lymphocyte level was decreased more in group IIB than group IB. It was statistically significant. In microscopic findings, scores of SHI in normal group, group IB and IIB were 0.33, 4.47, and 1.96 each. Conclusions : Peucedani Radix might have inhibitory effect on lung fibrosis by reducing inflammatory cells in bleomycin-induced lung fibrosis model in mouse.

해수침투와 농업활동에 의한 사천-하동 해안지역 지하수의 오염 특성

김현지,함세영,김남훈,정재열,이정환,장성,Kim, Hyun-Ji,Hamm, Se-Yeong,Kim, Nam-Hoon,Cheong, Jae-Yeol,Lee, Jeong-Hwan,Jang, Sung 대한자원환경지질학회 2009 자원환경지질 Vol.42 No.6

연구지역인 사천-하동지역은 농업지역으로서 오랫동안 농업용 지하수를 사용하여 왔으며, 또한 남해에 인접해 있다. 본 연구에서는 해수침투와 농업활동에 의한 오염을 고찰하기 위해 연구지역의 지하수 화학성분을 분석하였다. 대부분의 지하수 시료들은 해안으로 갈수록 전기전도도($227{\sim}7,910\;{\mu}S/cm$)가 증가하는 경향을 보이며 해수(0.55)와 비슷한 Na/Cl 농도를 보였다. 또한, Cl과 $HCO_3$ 농도 확률누적곡선의 통계학적 해석에 의하면, 연구지역 지하수의 30.1%가 해수의 영향을 많이 받은 영역에 속하는 것으로 나타났다. 지하수 유형은 Ca-Cl과 Na-Cl 형을 나타냈으며, 이는 해수의 영향과 이에 수반된 양이온교환을 지시한다. 수소 산소동위원소 분석 결과, 사천-하동 지역 지하수의 산소 수소 동위원소비는 $\delta^{18}O$가 -8.53~-6.13‰, ${\delta}D$가 -58.7~-43.7‰로서 우리나라 전체 평균 산소 수소 동위원소비에 비해서 약간 더 무거운 경향을 보인다. 질소동위원소 분석 결과, $\delta^{15}N-NO_3$값이 -0.5~19.1‰의 범위로 나타나 질산염 오염의 기원은 주로 토양의 유기질소와 분뇨 기원 그리고 이들의 혼합기원으로 나타났다. 그러나, 부분적으로는 탈질효과도 있는 것으로 보인다. 요인분석 결과 4개의 요인이 도출되었으며, 전체 분산을 가장 많이 설명하는 요인 1 (고유치 6.21)은 해수침투의 영향을 지시한다. 군집분석 결과, 연구지역의 지하수는 담수, 담수-해수의 혼합지하수로 분류된다. Groundwater has been extracted for irrigation in Sacheon-Hadong area, which is close to the South Sea. We analyzed chemical components of groundwater to examine the effects of seawater intrusion and agricultural activities in the study area. Most groundwater samples displayed the Na/Cl concentration ratios similar to that of seawater (0.55) with an increasing tendency of electrical conductivity ($227-7,910\;{\mu}S/cm$) towards the coast. In addition, statistical interpretation of the cumulative frequency curves of Cl and $HCO_3$ showed that 30.1% of the groundwater samples were highly affected by seawater intrusion. Groundwaters in the study area mostly belonged to the Ca-Cl and Na-Cl type, demonstrating that they were highly influenced by seawater intrusion and cation exchange. The result of oxygen-hydrogen isotope analysis demonstrated slightly higher $\delta^{18}O$ ((-8.53)-(-6.13)‰) and ${\delta}D$ ((-58.7)-(-43.7)‰) comparing to mean oxygen-hydrogen isotope ratios in Korea. As a result of nitrogen isotope analysis, the $\delta^{15}N-NO_3$ values ((-0.5)-(19.1)‰) indicate two major sources of nitrate pollution (organic nitrogen in soil and animal and human wastes) and mixed source of the two. However, denitrification may partly contribute as a source of nitrogen. According to factor analysis, four factors were identified among which factor 1 with an eigenvalue of 6.21 reflected the influence of seawater intrusion. Cluster analysis indicated the classification of groundwater into fresh, saline, and mixed ones.

빛공해의 인식 및 문제점에 관한 조명전문가 의식조사

김현지,Kim, Hyun-Ji 한국조명전기설비학회 2010 조명.전기설비 Vol.24 No.5