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levEffectiveness of Electroconvulsive Therapy Augmentation on Clozapine-Resistant Schizophrenia
HyeSung Kim,SeHyun Kim,NamYoung Lee,TakYoun,JeoungHyuk Lee,Seunghyun Chung,YongSik Kim,InWon Chung 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.1
Objective-This retrospective case series study of the effectiveness of electroconvulsive therapy (ECT) augmentation on clozapine-resistant schizophrenia was conducted by EMR review. Methods-Clozapine-resistance was defined as persistent psychotic symptoms despite at least 12 weeks of clozapine administration with blood levels over 350 ng/mL in order to rule out pseudo-resistance. Seven in-patients who were taking clozapine and treated with ECT were selected. We analyzed the psychopathology and subscales changed by ECT. Results-The average number of ECT sessions was 13.4 (±4.6). Total Positive and Negative Syndrome Scale (PANSS) score was significantly reduced by 17.9 (±12.8) points (p=0.0384) on average, which represented a reduction of 25.5% (±14.3). 71.4% (5/7) of patients were identified as clinical remission, with at least a 20% reduction in PANSS score. PANSS reduction was associated with number of ECT sessions, stimulus level in the final session, and blood clozapine levels before ECT. However, the negative subscale on the PANSS were not reduced by ECT in any patient. We did not observe any persistent adverse cognitive effects. Conclusion-This study supports that ECT augmentation on clozapine-resistant schizophrenia reveals clinically effective and safe. Further research should be done involving a larger number of patients to investigate the effectiveness of clozapine/ECT combination therapy.
Comparative characterization of 3D chromatin organization in triple-negative breast cancers
Kim Taemook,Han Sungwook,Chun Yujin,Yang Hyeokjun,Min Hyesung,Jeon Sook Young,Kim Jang-il,Moon Hyeong-Gon,Lee Daeyoup 생화학분자생물학회 2022 Experimental and molecular medicine Vol.54 No.-
Triple-negative breast cancer (TNBC) is a malignant cancer subtype with a high risk of recurrence and an aggressive phenotype compared to other breast cancer subtypes. Although many breast cancer studies conducted to date have investigated genetic variations and differential target gene expression, how 3D chromatin architectures are reorganized in TNBC has been poorly elucidated. Here, using in situ Hi-C technology, we characterized the 3D chromatin organization in cells representing five distinct subtypes of breast cancer (including TNBC) compared to that in normal cells. We found that the global and local 3D architectures were severely disrupted in breast cancer. TNBC cell lines (especially BT549 cells) showed the most dramatic changes relative to normal cells. Importantly, we detected CTCF-dependent TNBC-susceptible losses/gains of 3D chromatin organization and found that these changes were strongly associated with perturbed chromatin accessibility and transcriptional dysregulation. In TNBC tissue, 3D chromatin disorganization was also observed relative to the 3D chromatin organization in normal tissues. We observed that the perturbed local 3D architectures found in TNBC cells were partially conserved in TNBC tissues. Finally, we discovered distinct tissue-specific chromatin loops by comparing normal and TNBC tissues. In this study, we elucidated the characteristics of the 3D chromatin organization in breast cancer relative to normal cells/tissues at multiple scales and identified associations between disrupted structures and various epigenetic features and transcriptomes. Collectively, our findings reveal important 3D chromatin structural features for future diagnostic and therapeutic studies of TNBC.
Network Utility Maximization With Asymmetric User Satisfaction
Hyesung Kim,Seung-Woo Ko,Seong-Lyun Kim IEEE 2015 IEEE communications letters Vol.19 No.7
<P>This letter revisits a network utility maximization considering asymmetric user satisfaction (AUS), i.e., a user is more sensitive to a quality of service (QoS) decrement than an increment. Reflecting AUS, we propose a novel fairness criterion called asymmetrically proportional fairness (APF). To achieve APF resource allocation, we devise a utility function and design a bandwidth allocation algorithm. Analytic and numerical results verify that our algorithm achieves APF equilibrium.</P>
Polymeric nanoparticles for protein kinase activity
Kim, Jong-Ho,Lee, Seulki,Kim, Kwangmeyung,Jeon, Hyesung,Park, Rang-Woon,Kim, In-San,Choi, Kuiwon,Kwon, Ick Chan Royal Society of Chemistry 2007 Chemical communications Vol.2007 No.13
<P>Nanoparticles were prepared from poly-ion complexes, possessing both PEI–FITC–(PKA-specific substrate) (kemptide) and PAA–TRITC, which produce intermolecular FRET; the nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors.</P> <P>Graphic Abstract</P><P>Nanoparticles were prepared from poly-ion complexes. The nanoparticles were dissociated by phosphorylation, presented a strong FITC intensity and can be applied to high-throughput screening for large chemical libraries, for drug discovery of kinase inhibitors. <IMG SRC='http://pubs.rsc.org/services/images/RSCpubs.ePlatform.Service.FreeContent.ImageService.svc/ImageService/image/GA?id=b612773h'> </P>
Kim Youngdong,Kim Kyungdoh,Seok Hyesung 대한전기학회 2023 Journal of Electrical Engineering & Technology Vol.18 No.4
The share of renewable energy has already exceeded that of nuclear power in the United Kindom, Germany (by 30%), and Japan (10%), whereas the supply of alternative energy in South Korea is significantly less than that of advanced countries. In 2011, South Korea ended the feed-in-tariff operation and implemented renewable portfolio standards (RPSs), which require producers or sellers of electricity to supply a specified percentage of electricity generated or sold from renewable energy sources. Each operator receives renewable energy certificates corresponding to the amount of electricity supplied from renewable energy sources, allowing them to sell excess electricity or buy electricity to manage a deficit. Although the RPS ensures fairness by specifying separate quantities that can be sold based on each operator’s capacity, it focuses more on effectiveness. In this study, RPSs are investigated from the perspectives of effectiveness and fairness, and a new bidding model that further considers fairness is developed.
Kim, Mi-Hee,Na, Hee-Kyung,Kim, Young-Kwan,Ryoo, Soo-Ryoon,Cho, Hae Sung,Lee, Kyung Eun,Jeon, Hyesung,Ryoo, Ryong,Min, Dal-Hee American Chemical Society 2011 ACS NANO Vol.5 No.5
<P>Among various nanoparticles, the silica nanoparticle (SiNP) is an attractive candidate as a gene delivery carrier due to advantages such as availability in porous forms for encapsulation of drugs and genes, large surface area to load biomacromolecules, biocompatibility, storage stability, and easy preparation in large quantity with low cost. Here, we report on a facile synthesis of monodispersed mesoporous silica nanoparticles (MMSN) possessing very large pores (>15 nm) and application of the nanoparticles to plasmid DNA delivery to human cells. The aminated MMSN with large pores provided a higher loading capacity for plasmids than those with small pores (∼2 nm), and the complex of MMSN with plasmid DNA readily entered into cells without supplementary polymers such as cationic dendrimers. Furthermore, MMSN with large pores could efficiently protect plasmids from nuclease-mediated degradation and showed much higher transfection efficiency of the plasmids encoding luciferase and green fluorescent protein (pLuc, pGFP) compared to MMSN with small pores (∼2 nm).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2011/ancac3.2011.5.issue-5/nn103130q/production/images/medium/nn-2010-03130q_0009.gif'></P>
Kim, Sun Mi,Mun, Jeong Ho,Lee, Si Woo,An, Hyesung,Kim, Hyun You,Kim, Sang Ouk,Park, Jeong Young The Royal Society of Chemistry 2018 Chemical communications Vol.54 No.97
<P>We present a straightforward approach for fabricating AuPd nanocatalysts based on self-assembled block copolymer nanopatterning. CO oxidation was carried out on AuPd alloy nanoparticles and the activity increased with increasing Pd content; this synergistic activity can be precisely tuned by varying the chemical composition. Theoretical calculations suggest that Pd clusters are required to bind and dissociate O2 for oxidation of coadsorbed CO molecules. Our results suggest that the geometric configuration of the Pd atoms on the surface are a key factor in the catalytic activity.</P>