냉수 가글링과 젖은 거즈를 이용한 구강간호가 비강수술 환자의 갈증 및 구강상태에 미치는 효과 비교

이인선,심명숙,나은희,강재연,김지혜,황민영,윤계숙,성영희 병원간호사회 2006 임상간호연구 Vol.11 No.2

Purpose: This study researched the comparison of oral care methods between the wet gauze and the water gargling for nasal surgery patients. It executed to find out more effective method to relieve thirst. Method: We divided two groups; the wet gauze and the cold water garaling. We assessed patient's oral cavity state and sebjective oral dryness for three times; firstly before the intervention, secondly 15 minutes after 1st intervention and thirdly 15 minutes afrer 2nd intervention. Result: As the intervention, there was no difference on oral condition subhectvely, but there was a difference on thirsty reduction objectively. As the aral dryness has relieved through both methods. It showed the repeated gargling helps more to relieve oral dryness effectively than the wet gauge. At PACU, post nasal surgery patient's oral dryness was decreased with gauze more than two times, patient's oral dryness was relieved. Whereas the dryness was relieved after applying the cold water gargling for just one time. Conclusion: The water gargling is more effective intervention than the wet gauze. Especially, oral dryness was improved in the section of objetive oral assessment index.

음료 개발을 위한 가공용 쌀의 수화, 호화 및 당화특성 비교

신동선,최예지,심은영,오세관,김시주,이석기,우관식,김현주,박혜영,Shin, Dong-Sun,Choi, Ye-Ji,Sim, Eun-Yeong,Oh, Sea-Kwan,Kim, Si-Ju,Lee, Seuk Ki,Woo, Koan Sik,Kim, Hyun-Joo,Park, Hye-Young 한국식품영양학회 2016 韓國食品營養學會誌 Vol.29 No.5

쌀음료베이스 개발을 위한 품종별 가공용 쌀의 기초자료 확보를 위해 국내산 쌀 7종(삼광, 일품, 설갱, 안다, 다산1호, 고아미4호, 단미)과 수입쌀 3종(미국쌀, 중국쌀, 태국쌀)을 대상으로 수화, 호화 및 당화 관련 특성을 살펴보았다. 품종별쌀의 수분함량은 11.88~15.26% 범위로 나타났으며, 수분흡수율은 안다, 미국쌀이 가장 높게 나타났다. 수분결합력은 태국쌀이 가장 높았으며, 단미, 고아미4호 및 설갱은 낮은 수분결합력을 나타내었다. 용해도는 10종의 시료 중 단미가 월등히 높은 26.6%를 나타내었으며, 팽윤력은 설갱, 안다, 미국쌀이 유의적으로 높은 수준을 나타냈다(p<0.05). 품종별 쌀가루의 아밀로오스 함량은 고아미4호와 태국쌀이 가장 높은 반면, 단미가 가장 낮았다. RVA를 측정한 결과, 호화온도는 단미와 고아미4호가 각각 $91.6^{\circ}C$와 $78.5^{\circ}C$로 가장 높았고, 그 외 품종은 $68.0{\sim}71.1^{\circ}C$로 나타났다. 최고점도와 최종점도는 다산1호가 가장 높았고, 단미가 가장 낮게 나타났다. 치반점도는 일품과 미국쌀이 낮게 나타나, 노화가 더디게 진행될 것으로 예상되었다. 한편, 쌀, 수침처리 쌀, 건식쌀가루, 습식쌀가루로 가공용 쌀 전처리를 달리하고, 수침시 흡수되는 수분량을 고려하여 물을 첨가하고, 고온용 ${\alpha}$-amylase 처리 후 당화특성을 비교하였다. 당화액의 pH는 일품을 제외한 모든 품종에서 습식쌀가루가 유의적으로 높게 나타났다(p<0.05). 가용성 고형분 함량은 대부분 수침처리한 것보다 수침처리하지 않는 것, 쌀보다는 쌀가루의 효소처리가 더 효과적으로 높게 나타났다. 환원당 함량은 전처리 방법에 따라 수침처리하지 않는 것보다 수침처리한 것, 쌀보다는 쌀가루가 유의적으로 더 높게 나타났다(p<0.05). 색도는 L값의 경우 고아미4호를 제외한 대부분 품종에서 쌀보다 수침처리한 쌀이 낮은 값을 보였다. a값은 수침처리하지 않는 쌀과 습식쌀가루에서 낮은 값을 보였으며, b값은 쌀보다 수침처리한 쌀, 건식쌀가루보다 습식쌀가루가 품종에 따라 다소 차이가 있는 것으로 나타났다(p<0.05). 이러한 연구결과를 종합해 보면, 쌀을 원료로 한 음료베이스 개발을 위해서는 원료곡의 호화, 액화 및 당화에 영향을 주는 여러 가지 인자와 품종별 특성을 고려한 접근이 이루어져야 할 것이다. This study evaluated the hydration, gelatinization, and saccharification properties of rice processing for beverage development. The properties of rice were studied on 10 rice cultivars (Samkwang, Ilpum, Seolgaeng, Anda, Dasan-1, Goami-4, Danmi, American rice, Chinese rice, and Thai rice) and employing four kinds of pre-treatment methods (dry grain, wet grain, dry flour, and wet flour). The results showed that moisture content of rice was between 11.88~15.26%. Increase in soaking time along with highest water absorption was noted in American rice cultivar (46.81%). The water binding capacity of Thai rice was higher when compared to that of other rice flours. In addition, solubility and swelling power of rice were 4.52~26.65% and 0.19~2.05%, respectively. The amylose content of Goami-4 was higher in rice processing. Using a rapid visco analyzer (RVA), the initial pasting temperature of Danmi cultivar was found to be the highest; the peak viscosities of Anda cultivar and Dasan-1 cultivar, and Chinese rice were higher than of those of other rice flours. After saccharification, the pH, soluble solids content, and reducing sugar content of rice processed through different pre-treatment methods were in the range of 6.22~7.08, $4.67{\sim}16.07^{\circ}Brix$, and 0.35~11.67% (w/w), respectively. In terms of color values, the L-value of dry grain, a-value of wet (grain, flour), and b-value of dry sample (grain, flour) were found to be the highest. Assessment of various factors and cultivars characteristics of the raw grains are of importance in the development of rice beverage.

보리와 밀 혼합막걸리의 품질특성

신동선,최예지,정석태,심은영,이석기,김현주,우관식,김시주,오세관,박혜영,Shin, Dong-Sun,Choi, Ye-Ji,Jeong, Seok-Tae,Sim, Eun-Yeong,Lee, Seuk Ki,Kim, Hyun-Joo,Woo, Koan Sik,Kim, Si-Ju,Oh, Sea-Kwan,Park, Hye-Young 한국식품영양학회 2016 韓國食品營養學會誌 Vol.29 No.4

본 연구에서는 보리와 밀 혼합막걸리의 품질특성으로 이화학적 특성, 색도, 환원당, 유기산, 효모수, 관능적 특성을 조사하였다. 보리는 흰찰쌀보리를 이용하였고, 금강밀, 백중밀, 조경밀을 1:1로 혼합하고 수입밀과 쌀을 대조구로 하여 $25^{\circ}C$에서 7일간 발효 후 착즙한 술덧을 시료로 하였다. 이화학적 특성으로 pH, 총산, 당도 및 알코올 함량을 측정한 결과, pH는 4.04~4.12로 밀 품종에 따른 유의적인 차이는 없었고, 총산은 0.94~1.06%로 나타났다(p<0.05). 당도는 밀 혼합막걸리가 $12.67{\sim}13.44^{\circ}Brix$ 수준으로 쌀 혼합 막걸리 $11.76^{\circ}Brix$에 비해 높게 나타났으며, 알코올 함량은 15.13~16.53%의 범위로 나타났다. 밀 품종간 색도 L값의 유의적인 차이는 없었고, a값은 0.26~0.60 범위를 보였으며, b값은 밀 혼합막걸리가 쌀 혼합막걸리 보다 유의적으로 높아 좀 더 황색에 가까웠다(p<0.05). 환원당은 5.65~7.85 mg/mL의 범위로 나타났으며, 유기산은 금강 밀 혼합막걸리에서 lactic acid를 제외한 citric acid, malic acid, pyruvic acid가 가장 높게 검출되었다. 효모수는 밀이 혼합된 막걸리가 7.17~7.46 logCFU/g으로 쌀이 혼합된 막걸리 6.06 logCFU/g 보다 더 높았다. 관능적 특성에서 우리밀과 수입밀 간의 유의적은 차이는 없었으나, 맛은 백중밀이 가장 높게 나타났다(p<0.05). 이러한 결과로 보리 막걸리 제조 시 황색도, 효모수, 맛 등에서 높은 수준을 보였던 우리밀이 보리 막걸리 제조 시 혼합 곡물로 더 적합하였다. 따라서 밀 원료를 수입밀에서 금강밀이나 백중밀로 대체 시 일부 품질 증대와 함께 원료국산화에 따른 막걸리 프리미엄화 전제조건을 충족시킬 수 있을 것으로 기대된다. This study was conducted to evaluate the quality of barley (Huinchalssalbori) and domestic wheats (Keumkangmil, Baegjoongmil, Jogyeongmil). The pH and total acidity of mixed Makgeolli were 4.04~4.12% and 0.94~1.06%, respectively. The total acidity, sugar and alcohol contents of Makgeolli, but not pH, varied significantly by wheat cultivar (p<0.05). In terms of color values, the L-value of Baegjoongmil, a-value and b-value of Keumkangmil were highest. The reducing sugar contents was approximately 5.65~7.85 mg/mL, and those of Jogyeongmil and imported wheat were approximately 5.70 mg/mL lower. The yeast cell numbers did not differ significantly, with the exception of in the rice Makgeolli (p<0.05). Among the organic acids (citric, malic, pyruvic and lactic acids) in Makgeolli, citric acid was present at the highest concentration. Regarding the sensory characteristics of Makgeolli mixed with barley and wheat, taste and overall acceptability were highest in Baegjoongmil, and appearance and flavor were highest in Keumkangmil. The rice Makgeolli showed the lowest sensory values, with the exception of appearance. The results of this study suggest that mixing Makgeolli with barley and wheat is an expected to replace the wheat materials in the domestic wheat to be imported.

Human cardiac stem cells rejuvenated by modulating autophagy with MHY-1685 enhance the therapeutic potential for cardiac repair

Park Ji Hye,Kim Hyeok,Moon Hyung Ryong,박봉우,Park Jae-Hyun,Sim Woo-Sup,Kim Jin-Ju,Lim Hye Ji,Kim Yeon-Ju,지승택,장웅비,Rethineswaran Vinoth Kumar,Van Le Thi Hong,Giang Ly Thanh Truong,Yun Jisoo,Ha Jong Seong 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-

Stem cell-based therapies with clinical applications require millions of cells. Therefore, repeated subculture is essential for cellular expansion, which is often complicated by replicative senescence. Cellular senescence contributes to reduced stem cell regenerative potential as it inhibits stem cell proliferation and differentiation as well as the activation of the senescence-associated secretory phenotype (SASP). In this study, we employed MHY-1685, a novel mammalian target of rapamycin (mTOR) inhibitor, and examined its long-term priming effect on the activities of senile human cardiac stem cells (hCSCs) and the functional benefits of primed hCSCs after transplantation. In vitro experiments showed that the MHY-1685‒primed hCSCs exhibited higher viability in response to oxidative stress and an enhanced proliferation potential compared to that of the unprimed senile hCSCs. Interestingly, priming MHY-1685 enhanced the expression of stemness-related markers in senile hCSCs and provided the differentiation potential of hCSCs into vascular lineages. In vivo experiment with echocardiography showed that transplantation of MHY-1685‒primed hCSCs improved cardiac function than that of the unprimed senile hCSCs at 4 weeks post-MI. In addition, hearts transplanted with MHY-1685-primed hCSCs exhibited significantly lower cardiac fibrosis and higher capillary density than that of the unprimed senile hCSCs. In confocal fluorescence imaging, MHY-1685‒primed hCSCs survived for longer durations than that of the unprimed senile hCSCs and had a higher potential to differentiate into endothelial cells (ECs) within the infarcted hearts. These findings suggest that MHY-1685 can rejuvenate senile hCSCs by modulating autophagy and that as a senescence inhibitor, MHY-1685 can provide opportunities to improve hCSC-based myocardial regeneration.

콘크리트 패널의 단열 성능 향상을 위한 열메타 구조체의 최적 상세 제시

심지혜(Sim, Ji-Hye),김종원(Kim, Jong-Won),양근혁(Yang, Keun-Hyeok) 대한건축학회 2022 대한건축학회논문집 Vol.38 No.5

This study examined the flexural strength and thermal transfer resistance of thermal-meta structures developed for enhancing the insulation capacity of concrete walls and panels. The thermal-meta structure consisted of a paper honeycomb, laminated to be waterproof and incombustible with infilling materials. Lateral deformation of thermal-meta structures was analyzed from the finite element analysis under the simulation of concrete lateral pressure calculated for walls to determine the thickness, size, and height of the honeycomb cells. The effect of different infilling materials, such as air, EPS bead, urethane foam, paraffin, mixture of paraffin and aerogel, on the thermal transfer resistance of thermal-meta structures was also examined from thermal conductivity tests conducted in accordance with KS F 9016. Considering the structural safety against concrete lateral pressure and better thermal resistance, the details of a thermal-meta structure indicated the thickness, size, and height of the honeycomb cells was 4.5 mm, 50 mm, and 70 mm, respectively. The laminate thickness attached on both sides of the honeycomb was 0.8 mm; and no infilling materials were required for the honeycomb cells to form the closed-pore system.

스티로폼 비드와 경량골재를 활용한 프리캐스트 경량 판넬의 휨 거동 평가

심지혜(Sim, Ji Hye),양근혁(Yang, Keun Hyeok),이성진(Lee, Sung Jin) 한국콘크리트학회 2022 한국콘크리트학회 학술대회 논문집 Vol.34 No.1

사교육 참여와 활용 전략의 국가 간 차이에 영향을 미치는 요인 분석

심지혜(Ji-Hye Sim),김안나(Anna Kim) 한국교육학회 2022 敎育學硏究 Vol.60 No.6

사교육은 대중적인 공교육의 확산에 대응하여 세계적으로 팽창하고 있지만, 사교육의 제도적 확산에도 불구하고 각 국가가 처한 교육, 경제, 사회문화적 상황에 따라 사교육 활용에는 국가 간 차이가 나타난다. 그러므로 국제비교연구를 통해 보편적 현상으로서 사교육 수요의 원인을 밝히는 것은 사교육 현상을 이해하고 국내의 과도한 사교육 문제에 대한 대책 마련을 위해 필요하다. 이 연구는 이러한 필요성을 바탕으로 사교육 활용의 세계적 동향과 국가적 차이, 그리고 국가적 차이를 유발하는 요인이 무엇인지를 밝히고자 하였다. 이를 위해 2019년 TIMSS 자료 및 World Bank 자료를 활용하여, 38개국 8학년 학생 180,194명을 표본으로 다수준 로지스틱 회귀분석(multilevel logistic regression analysis)을 진행하였다. 그 결과, 국가의 공교육 투자, 경제 수준, 학력중심 문화, 소득 불평등 등이 사교육 활용에 미치는 영향을 확인하였다. 전체 국가의 평균 사교육 참여율은 43.91%로 나타났고, 가난한 국가일수록, 고등교육 등록률이 낮을수록, 소득 불평등이 심할수록 사교육에 참여할 가능성이 상승하는 것으로 나타났다. 사교육 활용 전략의 경우 국가의 공교육 투자가 높을수록, 부유한 국가일수록 사교육을 보충전략으로 활용하는 경향성이 높아지며, 고등교육 등록률이 높은 국가일수록 사교육을 강화전략으로 활용하는 경향성이 높아지는 것으로 확인되었다. 이러한 연구 결과를 토대로 사교육 연구 및 정책에 주는 시사점에 대해 논의하였다. In modern society, along with the expansion of mass public schooling, shadow education is also increasing worldwide. Since shadow education is affected by a country's educational, economic, and socio-cultural environment, there are differences in the use of shadow education in different countries. With the need for a cross-national study, this paper aims to reveal global trends and national differences in shadow education. For this purpose, we used multi-level logistic regression analysis with data from the 2019 Trends in International Mathematics and Science Study (TIMSS). Through this analysis, the impact of national factors such as public expenditure on education, economic level, credentialism, and income inequality on the use of shadow education was determined. Specifically, the lower the GDP per capita, the lower the post-secondary education enrollment rate, and the higher the income inequality, the higher the likelihood of participation in shadow education. In regard to shadow education utilization strategies, the higher the public expenditure on education and GDP per capita, the higher the tendency to use shadow education as a remedial strategy. On the other hand, the higher the post-secondary education enrollment rates, the higher the tendency to use shadow education as a enrichment strategy. We suggest policy implications and further research based on these results.

TiO₂ 혼입률에 따른 투수 블록의 질소 산화물(NO<SUB>X</SUB>) 제거 성능 평가

심지혜(Sim, Ji Hye),양근혁(Yang, Keun Hyeok) 한국콘크리트학회 2021 한국콘크리트학회 학술대회 논문집 Vol.33 No.2

이 연구에서는 TiO₂ 혼입률에 따른 투수 블록의 질소산화물(NOX) 제거 성능을 평가하였다. This study evaluated the removal capacities of nitrogen oxide(NOx) from the permeable block according to the TiO₂ mixing ratio.

열메타 구조체의 열전도율에 대한 충진재의 영향

심지혜(Sim, Ji Hye),양근혁(Yang, Keun Hyeok),이혜진(Lee, Hye Jin) 한국콘크리트학회 2021 한국콘크리트학회 학술대회 논문집 Vol.33 No.1

Efficacy and Safety of Sublingual Immunotherapy in Elderly Rhinitis Patients Sensitized to House Dust Mites

Kim, Ji Hye,Lee, Ji Ho,Ye, Young-Min,Lee, Jae-Hyun,Park, Jung Won,Hur, Gyu-Young,Kim, Joo-Hee,Lee, Hyn-Young,Shin, Yoo Seob,Yang, Eun-Mi,Park, Hae-Sim The Korean Academy of Asthma, Allergy and Clinical 2018 Allergy, Asthma & Immunology Research Vol.10 No.6

<P><B>Purpose</B></P><P>This study aims to determine the efficacy and safety of house dust mite (HDM)-sublingual immunotherapy (SLIT) in elderly patients with AR.</P><P><B>Methods</B></P><P>A total of 45 patients aged ≥ 60 years with HDM-induced AR who had ≥ 3 A/H ratio on skin prick test and/or ≥ 0.35 IU/L to both <I>Dermatophagoides farinae</I> and <I>Dermatophagoides pteronyssinus</I> by ImmunoCAP were enrolled in 4 university hospitals. To evaluate additional effects of HDM-SLIT, they were randomized to the SLIT-treated group (n = 30) or control group (n = 15). Rhinoconjunctivitis total symptom score (RTSS), rhinoscopy score, Korean rhinoconjunctivitis quality of life questionnaire, rhinitis control assessment test, asthma control test scores, and adverse reactions, were assessed at the first visit (V1) and after 1 year of treatment (V5); for immunological evaluation, serum levels of HDM-specific immunoglobulin A/IgE/IgG1/IgG4 antibodies and basophil response to HDMs were compared between V1 and V5 in both groups.</P><P><B>Results</B></P><P>There were no significant differences in demographics, RTSS, skin reactivity to HDMs, or serum total/specific IgE levels to HDMs (<I>P</I> < 0.05, respectively) between the 2 groups. Nasal symptom score and RTSS decreased significantly at year 1 in the 2 groups (<I>P</I> < 0.05). There were no significant differences in percent decrease in nasal symptom score and RTSS at year 1 between the 2 groups (<I>P</I> < 0.05); however, rhinoscopic nasal symptom score decreased significantly in the SLIT-treated group (<I>P</I> < 0.05). Immunological studies showed that serum specific IgA levels (not specific IgE/IgG) and CD203c expression on basophils decreased significantly at V5 in the SLIT-treated group (<I>P</I> = 0.011 and <I>P</I> = 0.001, respectively), not in the control group. The control group required more medications compared to the treatment group, but there were no differences in adverse reactions.</P><P><B>Conclusions</B></P><P>It is suggested that HDM-SLIT for 1 year could induce symptom improvement and may induce immunomodulation in elderly rhinitis patients.</P>