Interleukin-2가 Mouse 폐장의 폐포간 중격의 미세구조에 미치는 영향

황세진,김종우,정호삼,이규식 한양대학교 의과대학 1990 한양의대 학술지 Vol.10 No.1

Interleukin-2, a kind of lymphokine which is produced by activated T-lymphocytes during an immune response, is known to act not only as a growth factor for many cells of immune system but stimulates differentiation of cells of immune system. Although interleukin-2 is a useful agent for cancer immunotherapy and inhibiting agent of tumor cell metastasis, administration of interleukin-2 to cancer patient may cause various side effects such as pulmonary edema due to capillary leakage. In this experiment the author pursued the effects of interleukin-2 on ultrastructure of interalveolar septum in lung of mouse. Healthy male mice weighing about 20gm were used as experimental animals and divided into control group and experimental group. During the experiment water and foods were given ad libitum. Animals of control group were injected 0.2 ml of distilled water and animals of experimental grouup were injected 2 million units per kg body weight of interleukin-2 intraperitoneally Experimental animals were sacrified at 3 hours, 6 hours, 12 hours, 24 hours, 48 hours and 72 hours after administration and lung specimens were obtained. All specimens, which were prefixed in 2% glutaradehyde-2.5% paraformaldehyde and postfixed in osmium tetraoxide were dehydrated and embedded in Epon Araldite 502. Ultrathinsection about 600-800 in thickness, and uranyl acetate and lead citrate double stain were performed and all electron microscopic specimens were observed with JEM 100cx-II electron microscope. The results obtained were as follows: 1. The type I pneumocyte of interalveolar septum of lungs in interleukin-2 treated mice were swollen, separated from basal lamina. 2. Capillary endothelial cell of interalveolar septum of lungs in interleukin-2 treated mice were swollen, and pinocytic vesicles in endothelial cell were enlarged and increased in number. 3. Lamellar bodies of type II pneumocytes of interalveolar septum of lungs in interleukin-2 treated mice were enlarged, and vacuolized. 4. Mitochondria and microvilli of type II pneumocytes of interalveolar septum of lungs in interleukin-2 treated mice were decreased in number. It is consequently suggested that interleukin-2 induces intracellular edema of both the type I pneumocyte and the endothelial cell and damages to type II pneumocyte of interalveolar septum of lung in mice but alveolar epithelial cells and endothelial cells are recover as time goes by.

사춘기전 Ⅰ,Ⅱ급 부정교합 아동의 기도 면적, 혀의 위치와 안면 형태에 관한 연구

황용인,이규홍,이기준,김상철,조형준,천세환,박양호 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.2

본 연구는 사춘기 성장 이전의 I, II급 부정교합을 갖는 아동 환자들의 측모 두부 규격 방사선사진을 이용하여 두개 안면 형태를 조사하고 이들과 혀의 위치 및 면적, 기도의 면적과의 관계를 조사하여 비인두 기도 및 혀의 형태가 악골 및 부정 교합의 형태에 미치는 영향을 알아보았다. 9 - 11세의 교정환자 76명을 대상으로 측모 두부 규격 방사선사진상 ANB difference를 기준으로 대조군(I급 부정교합군: 0 ≤ ANB difference < 4.0)과 실험군(II급 부정교합군: ANB difference ≥ 4.0)으로 분류하였다. 혀 면적, 혀와 구개 사이의 면적, 비인두 기도 면적과 두개안면형태 항목을 측정하고 비교하여 다음과 같은 결과를 얻었다. 혀 면적, 혀와 구개 사이의 면적, 비인두 기도 면적은 II급 부정교합군과 I급 부정교합군 간에 유의한 차이를 보이지 않았다. Hyperdivergent안면 형태일수록 비인두 기도 면적이 좁았다. 안모의 전후방 수직 길이가 길수록 혀의 면적이 넓었고, 전안면 고경이 길수록 혀는 하방위치 하였다. 비인두기도 면적이 좁을수록 혀의 면적도 좁아졌다. 이상의 연구 결과 혀의 면적과 위치, 비인두 기도의 면적은 I급, II급 부정교합 간에 차이를 보이지 않으며 hyperdivergent 안면 형태 및 안모의 전후방 수직 길이와 관련이 있는 것으로 사료된다. Objective: This study examined the craniofacial morphology of young patients in their prepubertal stage showing class I, II malocclusion, by analyzing lateral cephalograms, and analyzed its relationship with tongue position, tongue space, and airway space in order to ascertain the effects of nasopharyngeal airway and tongue morphology on the form of the malocclusion. Methods: Seventy-six patients aging from 9 to 11 were divided into two groups depending on the ANB difference on the lateral cephalogram: Experimental grouP (CI II malocclusion group) showing 0 ≤ ANB difference < 4.0; Control group (CI I malocclusion group) showing 0 ≤ ANB difference < 4.0. The tongue space, space between palate and tongue, nasopharyngeal airway space and craniofacial morphology were compared between the two groups. Results: Tongue space, Palate-tongue space, nasopharyngeal airway space showed no significant differences between class I and class II malocclusion groups. Hyperdivergent faces were associated with smaller nasopharyngeal airway space. Longer anterior facial height and posterior facial height were associated with larger tongue space, and greater anterior facial height were associated with lower tongue position, Smaller nasopharyngeal airway space showed smaller tongue space. Conclusions: Tongue space and nasopharyngeal airway space showed no significant differences between class I malocclusion group and class II malocclusion group. Only anterior facial height and posterior facial height had an influence on tongue space and nasopharyngeal airway space.

A Decision Model for Advertising Expense: From the Perspective of the Blockholder's Private Benefits

Hwang,Joon-Ho,Chun,Se-Hak 한국상품학회 2009 商品學硏究 Vol.27 No.2

This paper examines how the size of private benefits of large owners, measured using block premium, affects changes in advertising expense of the company. If large owners enjoy private benefits through engaging in pet projects, it will result in increased advertising expense. On a sample of 130 firms whose blocks of shares are traded in the U.S., we show that the magnitude of private benefits is not associated with changes in advertising expense.

흰쥐 갑상선 소포세포의 분화에 관한 전자현미경적 연구

황세진,정호삼,유신철,이규식 한양대학교 의과대학 1991 한양의대 학술지 Vol.11 No.1

The thyroid gland is an endocrine organ which is mainly derived from endodermal cell of the primitive pharynx. It is well known that time of morphological and functional maturation of thyroid gland is so variable among the species of animal that functionl maturation of thyroid gland of the rat occurs only after birth of the animal, while the human fetal thyroid gland can secrete thyroid hormones at 10-14 weeks of gestation. In this study the author pursued the ultrastructural differentiation of thyroid follicular cells of rats in the late fetal and early postnatal lives. The fetal rats of 18th and the 20th day of gestation and rats of the 1st, the 7th, the 14th and the 21st day of postnatal life were sacrificed and thyroid glands were extracted. Rats of the 8th weeks of postnatal life were served as control group. All specimens prefixed in 2% glutaraldehyde-2.5% paraformaldehyde and postfixed in osmium tetraoxide, were dehydrated and embeded in Epon Araldite 502. Ultrathin section about 600-800 in thickness were made with LKB ultramicrotome and stained with uranyl acetate and lead citrate and lead citrate All electron microscopic preparations were observed with JEM 100cx-II electron microscope The result obtained were as follows: 1. The nucleus of the follicular cell in the rat thyroid gland was composed of euchromatin at the 18th day of gestation, some unclei with euchromatin and heterochromatin were observed at the 20th day of gestation, and all nuclei of the follicular cells were composed of euchromatin and heterochromatin after the 1st day of postnatal life. 2. Rough endoplasmic reticulum of the follicular cell in the rat thyroid gland was consisted of column shaped scant cisternae at the 18th day of gestation, and rough endoplasmic reticulum with unmerous dilated cisterne was observed at the 7th day of gestation. 3. The Golgi complex of the follicular cell in the rat thyroid gland was composed of narrow cisternae and small sized vesicles at the 18th day of gestation. Folgi complex with wide cisternae and large sized vesicles and vacuoles was observed at the 14th day of posnatal life. 4. Mitochondria of the follicular cell in the rat thyroid gland were scanty at the 18th day of gestation and number of mitochondria increased during development of thyroid gland. 5. Lysosmes of the follicular cell in the rat thyroid gland were observed from the 1st day of postnatal life. 6. Collid lumen and microvilli of the thyroid follicle were observed from the 20th day of gestation and the matured colloid lumen was observed at the 1st day of postnated life. It is consequently suggested that the thyroid follicleis are formed from the 20th day of gestation to the 1st day of postnatal life, and cytoplasmic organelles of the folliculat cell are matured morphologically between the 7th and the 14th day of postnatal life in albino rats.

조사광이 통과하는 치질의 두께와 광조사시간에 따른 광중합형 복합레진의 중합률에 관한 연구

황기환,장인호,이세준,이광원 大韓齒科保存學會 2002 Restorative Dentistry & Endodontics Vol.27 No.1

Physical properties of composite resins such as strength, resistance to wear, discoloration, etc depend on the degree of conversion of the resin components. The purpose of this study was to evaluate the degree of conversion of the composite resins according to the thickness of tooth structure penetrated by light and applied light curing time. The coronal portions of extracted human teeth( one anterior tooth, three posterior tooth) was embedded by pink denture material. the mounted teeth were cut into three illumination sections (1mm thickness enamel section, 1mm thickness dentin section, 2mm thickness dentin section) and one backing section with cutting wheel. Thin resin films were made by using 6kg pressure between slide glass during 5 minutes. Thin resin film was light cured on coupled illumination section during 40sec, 80sec and 120sec. each illumination section was coupled as follows: no tooth structure(X), ename section(E), enamel section + 1mm dentin section(ED1), enamel section + 2mm dentin section(ED2), enamel section + 1mm dentin section + 2mm dentin section(EDD). To simulate the clinical situation more closely, thin resin film was cured against a backing section of tooth structure. The degree of conversion of carbon double bonds to single bonds in the resin films were examined by means of Fourier Transform Infrared Spectrometer. The results were obtained as follows; 1. As curing time was increased, conversion rate was increased and as tooth thickness which was penetrated by curing light was increased, conversion rate was decreased. 2. At all tooth thickness groups, conversion rate between 80sec and 120sec was not significantly increased(P>0.05). 3. At 40sec group and 80sec, conversion rate between no tooth structure(X) group and 1mm enamel section(E) group was not significantly decreased(P>0.05). 4. At 80sec group and 120sec, conversion rate between 1mm enamel section(E) group and 1mm enamel section + 1mm dentin section(ED1) group was not significantly decreased(P>0.05).

프라이 휠에 의한 전차 회생에너지 유효이용

성세진,고석진,황인호 충남대학교 공업교육연구소 1986 論文集 Vol.9 No.1

Results on the fly-wheel energy storage system driven by a high speed, and high frequency dual-inverter are summarized in this paper. The purposes of this system are mainly to achieve effective use of braking energy of electric railway locomotives, and additionally to reduce the peak load demand and the cost of electric utility. Economic evaluation is performed compared with the battery storage system. Basic characteristics of the Dual-inverter system, for the high power and high speed drive of fly wheel studied and the opening and closing method of the inverter from the induction machine during, the energy storing period, is suggested.

비복신경이식을 이용한 긴 거리의 말초신경 결손부 수복

이종호,이세영,김명진,이은진,안강민,김성민,최원재,명훈,황순정,서병무,최진영,정필훈 大韓顎顔面成形再建外科學會 2003 Maxillofacial Plastic Reconstructive Surgery Vol.25 No.2

The surgery of oral and maxillofacial area poses the risk of cranial nerve damage such as trigeminal nerve or facial nerve. Inferior alveolar nerve is prone to damage in the third molar extraction, implant installation, orthognathic surgery, open reduction and rigid fixation, and tumor ablation surgery. On the other hands,facial nerve is likely to be damaged or sacrificed with trauma or parotidectomy. In case of inferior alveolar nerve injury, the incidence is reported to be about 1.3%. The nerve function will almost recover in minimal damage, but it won't recover at last in total damage of a part of nerve unit. In latter cases, nerve regeneration in intended by allograft as nerve substitute or various route of merve condit. But the recovery with autograft is believed to be most relialbe mrthod in the rapair of long-span(longer than 15㎜)nerve defect. We have performed autologous sural nerve graft in the repair of nerve defect, which is caused by resection of benign or malignant tumor. Hereby we report the method of nerve harvesting, recovery of defected peripheral nerve and the complications of donor site with the discussion of sural nerve anatomy.

고속철도 건설과 관련하여 지하수위 분포를 이용한 지하수환경 변화 분석

함세영,류상민,정재열,강래수,문상호,황학수 부산대학교 환경문제연구소 2002 環境硏究報 Vol.20 No.-

This study is aimed for estimating change of groundwater environment in relation to constructing Honam express railway in Cheonan-Iksan section. This study was conducted by measuring depth to water and by calculating groundwater level anomaly. Depth to water ranges from 0.03 to 21.1 m and ranges from 0.17 to 227.95 m mean sea level. Distributions of depth to water, of groundwater elevation and of groundwater level anomaly were analyzed to estimate water-level change due to express railway construction. High water-level anomaly section is found in Jangjae(Cheonan)-Daejeon-Iksan section with anomaly index 85.39. High water-level change is anticipated in 22.22-24.19 km, 25.1-25.53 km, 25.53-26.46 km, 26.46-27.77 km, 28.7-29.29 km, 30.18-30.26 km, and 30.26-32.4 km sections from the start of Jangjae(Cheonan).

응급의료센터에서 신경색의 조기진단

최경호,오동렬,이원재,박규남,박승현,황두영,김형국,정시경,김영민,김세경 大韓應急醫學會 1998 대한응급의학회지 Vol.9 No.4

To evaluate appropriate diagnostic studies for renal infartion in emergency medical center, we analysed 33 patients of renal infarction treated in this hospital for last 8 years. Eleven patients, 4 trauma associated and 7 aortic disease associated patients were excluded. They are 11 males and 11 females with a mean age of 51 years. Fourteen came to the emergency medical center and seven came to the outpatient department, in the other one patient renal infarction was developed during hospitalization with other disease. On their past history they had hypertension in 9, valvular heart disease in 5, and diabetic mellitus in 4 patients. Abdominal or flank pain was noted in 17 of 22(77%). The other symptoms were vomiting, nausea, fever and so on. On microscopic examination of initial urine in hospital, 5 patients showed more than 10 red blood cells by high power field examination. The mean lactic dehydrogenase level was 1,239 I.U/L(normal range 218-472 I.U/L), while the mean aspartate aminotransferase and mean alanine aminotransferase were 51 I.U/L(normal range 13-36 I.U/L) and 44 I.U/L(normal range 5-33 I.U/L). Abdominal ultrasonography showed positive findings in 5 of 16(31%), of which 3 were confirmed by Doppler ultrasonography. In 18, computed tomography was done and all those showed positive findings of renal infarction(100%). In conclusion, it is important that identify the elevated lactic dehdrogenase level in case of any suspicion about renal infarction and confirm by computed tomography.

Silver-PDT Effect on Co-Evaporated CIGS IGS(Cu(In,Ga)Se₂) Thin Film Solar Cells

Jiseon Hwang,Yunae Cho,Jae Ho Yun,Young-Joo Eo,Jihye Gwak,Ara Cho,Joo Hyung Park,Se Jin Ahn,Jin Su Yoo,Seung Kyu Ahn,Jun Sik Cho,Kihwan Kim,Kyuseung Han 한국신재생에너지학회 2019 AFORE Vol.2019 No.11