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( Sun-uk Bak ),( Suji Kim ),( Hae-jun Hwang ),( Jung-a Yun ),( Wan-sung Kim ),( Moo-ho Won ),( Ji-yoon Kim ),( Kwon-soo Ha ),( Young-guen Kwon ),( Young-myeong Kim ) 생화학분자생물학회(구 한국생화학분자생물학회) 2017 BMB Reports Vol.50 No.2
Heme oxygenase (HO-1) catalyzes heme to carbon monoxide (CO), biliverdin/bilirubin, and iron and is known to prevent the pathogenesis of several human diseases. We assessed the beneficial effect of heme degradation products on osteoclastogenesis induced by receptor activator of NF-κB ligand (RANKL). Treatment of RAW264.7 cells with CORM-2 (a CO donor) and bilirubin, but not with iron, decreased RANKLinduced osteoclastogenesis, with CORM-2 having a more potent anti-osteogenic effect. CORM-2 also inhibited RANKLinduced osteoclastogenesis and osteoclastic resorption activity in marrow-derived macrophages. Treatment with hemin, a HO-1 inducer, strongly inhibited RANKL-induced osteoclastogenesis in wild-type macrophages, but was ineffective in HO-1<sup>+/- </sup>cells. CORM-2 reduced RANKL-induced NFATc1 expression by inhibiting IKK-dependent NF-κB activation and reactive oxygen species production. These results suggest that CO potently inhibits RANKL-induced osteoclastogenesis by inhibiting redox-sensitive NF-κB-mediated NFATc1 expression. Our findings indicate that HO-1/CO can act as an antiresorption agent and reduce bone loss by blocking osteoclast differentiation. [BMB Reports 2017; 50(2): 103-108]
서울의 Penicillinase Producing Neisseria gonorrhoeae 발생빈도(1998)
김재홍,김준호,반재용,이정우,황성주,정준규,정성태,강진문,조흔정,홍창의,정혜신,이한승,김이선,이봉길,이종호,선영우,한기덕,윤성필,이성훈,안종성,박석범,문승현,조항래,김형섭,류지호,황재영,박준홍,손상욱 한양대학교 의과대학 2001 한양의대 학술지 Vol.21 No.1
In recent years, gonorrhea has been pandemic and remains one of the most common STDs in the world, especially in developing countries. For the detection of a more effective therapeutic regimen and assessing the prevalence of Penicillinase Producing Neisseria gonorrhoeae(PPNG), we have been trying to study the patients who have visited the Venereal Disease Clinic of Choong-Ku Public Health Center in Seoul since 1980 by menas of the chromogenic cephalosporin method. In 1998, 93 strians of N. genorrhoeae were isolated, among which 60(64.5%) were PPNG. The prevalence of PPNG in Seoul, which had been decreased to 39% in 1996 after a peak of 74.3% in 1993, is increased to 64.5% in 1998.
Choi, Seunghwan,Kim, Joohwan,Kim, Ji-Hee,Lee, Dong-Keon,Park, Wonjin,Park, Minsik,Kim, Suji,Hwang, Jong Yun,Won, Moo-Ho,Choi, Yoon Kyung,Ryoo, Sungwoo,Ha, Kwon-Soo,Kwon, Young-Guen,Kim, Young-Myeong Nature Publishing Group 2017 Experimental and molecular medicine Vol.49 No.11
<P>Heme oxygenase-1-derived carbon monoxide prevents inflammatory vascular disorders. To date, there is no clear evidence that HO-1/CO prevents endothelial dysfunction associated with the downregulation of endothelial NO synthesis in human endothelial cells stimulated with TNF-α. Here, we found that the CO-releasing compound CORM-2 prevented TNF-α-mediated decreases in eNOS expression and NO/cGMP production, without affecting eNOS promoter activity, by maintaining the functional activity of the <I>eNOS</I> mRNA 3′-untranslated region. By contrast, CORM-2 inhibited MIR155HG expression and miR-155-5p biogenesis in TNF-α-stimulated endothelial cells, resulting in recovery of the 3′-UTR activity of <I>eNOS</I> mRNA, a target of miR-155-5p. The beneficial effect of CORM-2 was blocked by an NF-κB inhibitor, a miR-155-5p mimic, a HO-1 inhibitor and siRNA against HO-1, indicating that CO rescues TNF-α-induced eNOS downregulation through NF-κB-responsive miR-155-5p expression via HO-1 induction; similar protective effects of ectopic HO-1 expression and bilirubin were observed in endothelial cells treated with TNF-α. Moreover, heme degradation products, except iron and <I>N</I>-acetylcysteine prevented H<SUB>2</SUB>O<SUB>2</SUB>-mediated miR-155-5p biogenesis and eNOS downregulation. These data demonstrate that CO prevents TNF-α-mediated eNOS downregulation by inhibiting redox-sensitive miR-155-5p biogenesis through a positive forward circuit between CO and HO-1 induction. This circuit may play an important preventive role in inflammatory endothelial dysfunction associated with human vascular diseases.</P>
환경가치로 살펴본 총요소생산성의 비교에 관한 연구 : 한ㆍ미 제지산업을 중심으로
황호종,지용선 龍仁大學校 1999 용인대학교 논문집 Vol.17 No.-
Environmentalism is the study of the flows of materials and energy in industrial and consumer activities, of the effects, of these flows on the environment, and of the influences of economic, political, regulatory, and social factors on the flow, use, and transformation of resources. Productivity, which measures the technological and organizational efficiency with which forms transform materials and labor into products, is one of the competitive factors. Managers take a productivity growth seriously because it is the message that their firm's ability to compete with others and to improve profitability and market share is improving. But, in pollution-intensive industries, they insist their views that the environmental protection reduces productivity - no matter how treat the damage that is prevented-and therefore a traditional productivity growth fundamentally misrepresents the industrial process. The main reason is that we now take into account only pollution abatement costs. This study outlined a better approach developed by WRI(World Resource Institute), and reexamined the record of total factor productivity growth, Core studies of the pulp and paper sectors of the U.S and Korea illustrate how this approach influences the record of total productivity growth. The revised estimates of productivity growth are in general higher than the conventional ones both in the U.S and in Korea. However, compared to the results for the U.S, the adjustments of Korea are relatively small. It means that the pulp and paper industry of Korea produced much pollution rather that of the U.S did, That is, the pulp and paper industry of Korea lost the eco-efficiency gains.
황호종,지형선 용인대학교 산업경영연구소 1998 산업경영논총 Vol.3 No.-
The purpose of this study is to analyze the problems of domestic retailers as well as to propose the alternatives to increase competitiveness of retailers, The retail channel structure is characterized on its high density and small business, which lead to low productivity, 1ow sales, and low morale of management. To solve these problems, small retailers should try to systematize organization by central buying system, point of sale, electronic ordering system and so on. Furthermore, they should cooperate with regional retailers by establishing central institution. Finally, they focus their business on specialization rather than generalization.
무용전공 여대생들의 체중조절 관심도와 섭취식품 기호도 조사연구
황지영,신호주 명지대학교 교육대학원 1998 敎育大學院 論叢 Vol.1 No.-
The objective of the current study consists in inquiring into how Korean traditional dance and ballet majors are interested in their weight control and what preference they have for ingestion, to articulately elucidate physical management for weight control and dietary habits in those college students who major in dance. Analysis of differences between the two groups revealed findings, as follows; 1. Both the Korean traditional dance majors group and ballet majors group take the time of physical weight control fifteen days ahead of the date of their exhibition or performance, by 64.5%. The Korean traditional dance group show the period of the most interest in weight control while studying in senior high school by 61.0%, whereas the ballet major group by 51.0%. Concurrently with this they were most affected by school lessons by 45.0% or mass communication by 30.0%, and it was carried out by their own judgment by 76.5%. The number of students who think they are 'fat' wish a loss of weight by 55.0% in the Korean traditional dance majors group, and by 43.0% in the ballet majors group. For the techiques of physical weight reduction, the employ 'reduction of the quantity of food intake' by 54.5%, and 'an increase of the quantity of motion' by 20.0%, which indicates that diet and exercise are considered the most effective method. 2. They generally prefer two meals a day, one meal less than the normal number of meals, three time. The lenth of mealtime reveals '10 to 20 minute', by 64.0% in Korean traditional dance group, and by '20 to 30' by 60.0% in the ballet majors gorup, which indicates a longer time in the former group than in the latter. Almost all the dance majors eat snacks by 98.5%, and the reason for that gives the highest responses in 'habitually' by 37.0%. Most of dance majors represent irregularity in taking meals, and the reason for going without a meal is ascribed to 'no time to eat' or 'weight control'. Furthermore, mooted points on dietary habits are most reflected from 'irregular mealtime' by 39.0%, and 'the ingestion of finished food and instant food' by 30.5%. From these, they are well aware of the need to improve. 3. The highest preference for food is put on the generalized food, whereas food on a low level of recognition gives a low level of preference for that food. In general, fruit gives a high preference, for the foods that dance majors abhor include animal liver, bacon, dried slices of seasoned white bait, margarine, soybean milk, jam, etc. But a great preference is shown from yofle(yogurt) by forming 83.0%.
가와사끼병에서 면역글로불린 사용 후 ASO 수치의 변동에 관한 고찰
황성욱,이지웅,송민섭,김철호 인제대학교 2006 仁濟醫學 Vol.27 No.-
Objective : Since Kawasaki disease was first described in 1967, the cause and prognostic factors have not been known despite many researches and efforts. The introduction of high-dose intravenous gamma-globulin (IVGG) was an epoch and IVGG is now a standard therapy. But the mode of action of IVGG in reducing inflammatory response is not clearly understood. Understanding of the mechanism should supply the clues that indicate the cause, prognosis, the better treatment of this disease. At present, the correlation of CRP, ESR and change of leukocyte numbers to Kawasaki diseases were known, but the correlation studies of ASO titers are rare. To discover this, we evaluated the interrelationship between the ASO titer and IVGG therapy. Methods and Materials : The subjects included 35 patients with Kawasaki disease who were treated by IVGG at department of pediatrics, Inje university, Busan Paik hospital from June, 2004 to December, 2005. Before and after IVGG administration, ASO titers were evaluated. Results: In the 32 among 35 patients, ASO titers checked before IVGG administration were increased prominently after IVGG therapy. Conclusion : Remarkably increased ASO titers after IVGG administration for the treatment of Kawasaki diseases were found. And changes of ASO titers seem to be due to immunoglobulin instead of streptococcal infection. Further studies will be necessary to clarify the pathogenic mechanisms of increased ASO titers.