건축공간내 길찾기(Wayfinding)를 고려한 디자인 인자분석에 관한 연구

최상헌,조은경 中央大學校 建設環境硏究所 1998 環境科學硏究 Vol.9 No.1

This study attempts to propose the guideline as design elements and applications for wayfinding in large general hospitals for the purpose of making them comfortable environmental space. Wayfinding at large complex hospital construction is made up as a order of plan configuration , physical shape element and sign system. And it seems that three elements are essential interdependent design element for wayfinding.

하청 근로자들의 건강수준 평가

최홍열,고상백,장세진,차봉석,임형준,이상윤,김재용,강동묵,조수헌 大韓産業醫學會 2001 대한직업환경의학회지 Vol.13 No.1

목 적 : 하청노동을 이용한 노동 유연화 전략은 근로자들의 고용을 불안정시키고, 근로자들의 삶에 부정적 영향을 미치고 있다. 따라서 이 연구는 하청업체 근로자들의 고용현황을 조사하고, 기존의 업체중심의 건강평가의 문제점을 지적하고자 하였다. 또한 하청업체 근로자들의 건강평가의 현재적 의미와 사회적 배제의 특성을 알아보고자 하였다. 방 법 : 모기업과 하청업체 근로자들의 건강수준을 비교하기 위하여, 정기건강진단(일반, 특수)과 채용건강진단 자료를 이용하고자 하였다. 건강진단에서 누락된 비정규직을 포괄하기 위하여 SF-36을 이용하여 건강설문조사를 시행하였다.결 과 : 조선업 하청업체 근로자들의 고용기간은 짧고, 빈번한 노동이동 현상을 보였다. 3년간 건강진단 수검 현황을 통해 살펴볼 때, 1998년 수검자중 2000년까지 연속해서 검진 받은 수검자는 40.3%였다. 건강진단 결과 유소견자 규모를 통해 모기업과 하청업체간의 건강수준을 비교해 보았다. 모기업은 일반질병 요관찰자와 질병자를 포함한 유소견자가 1,011명으로 약 10 %의 유소견율을 보이고 있고, 질병자의 경우 596명으로 유병률이 5 %를 상회하고 있다. 반면 하청업체의 경우 1,967명의 수검자중 유소견자가 115명으로 6 %의 유소견율을 보이고있고, 질병자는 82명으로 4 %의 유병률을 보이고있다 채용건강진단을 받은 수검자는 6,260명 이었으며, 이 중 유소견자 수는 2,373명으로 전체 수검자의 37.9 %를 차지하였다. 건강설문지의 경우는 전체 건강수준의 총합은 하청보다 원청 근로자가 높았고 통계적으로 유의하였다. 결 론' 정기건강검진 결과는 하청근로자들이 고용형태에 따라 검진을 받지 못한 경우가 많아, 건강 근로자 효과로 표현될 가능성이 있다. 따라서 채용건강진단 결과는 다른 측면에서 하청업체 근로자들의 건강수준의 현실적 반영이라고 할 수 있다. 향후 하청업체 근로자들의 건강문제를 감시하고 개선하려면 기존의 업체 중심의 접근으로는 하청 근로자의 건강문제를 제대로 다룰 수 없고, 업종과 지역을 동시에 고려하여 접근할 필요가 있다. 또한 단기 고용 근로자 및 비정규직 근로자를 사회보장의 확충과 모기업의 연대책임 강화 및 기업복지 차원에서 포괄하는 방안이 모색되어야 하겠다. Objectives : The strategy for the labor flexibility through subcontracted labor have brought a negative effect on the lives of the workers, such as the increase of the unstable employment. This study was conducted to analyze the relationship between the employment of subcontracted firms and the health status of them, and to find out some problems which have been caused in the process of health evaluation and the characteristics of social exclusion. Methods : We reviewed the periodical health examination and preemployment health examination in order to compare health status of the subcontracted workers with those of the parent firm workers. The SF-36 questionnaire was administered to assess the self-perceived health status. Results : The result shows that compared to the working duration of the parent firm workers, those of the subcontracted workers were shorter, and the job transfer rate was higher. In the periodical health examination, the prevalence of occupational and general disease was higher in the parent firm(10%) than in the subcontracted firms(6%). Preemployment health examination plays an important role in worker's health manage- ment. Among 6,260 workers who received preemployment health examination, the prevalence of disease was 37.9%. Mean scores of health status measured by SF-36 were lower in the subcontracted firm than in the parent firm. Conclusions : Due to social exclusion of the subcontracted workers from the periodical health examination, there is a possibility that the periodical health examination have the healthy worker effect. These results suggests that the preemployment health examination could be a more appropriate indicator which is able to assess the health status of the subcontracted workers than the periodical health examination.

중추에서 Prostaglandin계가 Renin-angiotensin System에 미치는 영향

최영태,김종승,문성호,오형균,김재훈,전제열,염철호,윤평진 朝鮮大學校 附設 醫學硏究所 1997 The Medical Journal of Chosun University Vol.22 No.1

Role of prostaglandins on the renin-angiotensin system in the central nervous system was examined in normotensive and 2-kidney, 1 clip (2K1C) hypertensive rats. The experiment was done under thiopental (50 ㎎/㎏, IP) anesthesia. Captopril and indomethacin were injected into the right lateral cerebral ventricle. Arterial blood pressure and heart rate were recorded from the femoral artery. Intracerebroventricular (ICV) captopril (1 ㎎) caused a decrease in mean arterial pressure in both normotensive and 2K1C hypertensive rats. The depressor response to captopril was more sensitive in hyper-tensive rats than in normotensive rats. Indomethacin treatment (ICV, 200 ㎎) altered the depressor response to captopril neither in normotensive nor in hypertensive rats. These results suggest that the cardiovascular effect of renin-angiotensin system in the central nervous system may not be mediated via prostaglandin systems in normotensive and 2KlC hypertensive rats.

여가제약 연구의 현재와 과거, 그리고 미래 : 여가제약 연구의 비판적 고찰을 통해

최성훈 서울대학교 스포츠과학연구소 2007 스포츠과학리뷰 Vol.1 No.1

The purpose of this study was to review previous researches regarding leisure constraints and to present future of leisure constraints. For this purpose, definition and types, applications, previous studies of leisure constraints, etc are reviewed here. Especially, foreign studies are divided into early, middle, latter and present terms of study and domestic studies are divided into early, middle and latter terms of study. Firstly, theoretical models of leisure constraints have been great help to advanced leisure studies and these models can be applied to other types of study theoretically. In addition, leisure constraints model can be expected to advance continuously as it has been developed from linear to multilateral relation and from multilateral to hierarchical agreement model. Secondly, development of theoretical leisure constraints model should be accompanied with sufficient amount of studies. Especially, it is necessary to invent study methodology to explain dynamic relationships that may be generated while compromising factors like leisure constraints, leisure motifs, leisure participations, etc and these quantity studies should be followed by quality studies. Unfortunately, there was no quality studies found from domestic leisure journals. Lastly, since leisure constraints draw common interests in various types of study, it seems necessary to connect exercise adherence and exercise behavioral development theory to studies regarding leisure constraints and their compromise.

建築 內部空間디자인에 있어 人間工學的 要素의 適用에 관한 硏究

崔相憲 中央大學校 建設環境硏究所 1995 環境科學硏究 Vol.6 No.-

The purpose of this study is to propose the ideal design method for interior architectural space design. The ideal design method is the application of the Eronomical Elements to the interior architectural space design. There are two divisions for the applications of the ergonomical elements ; physical and psychological. First, the physical elements are related to the human body ; human dimensions, movement area, work area, life area. Second, the psychological elements are related to the five sensations of the human body ; the sense of sight, the sense of hearing, the sense of smell, the sense of touch and feeling.

현대 실내공간에서 한국성 적용을 위한 혼성(Hybrid) 표현기법에 관한 연구

최은정,최상헌 중앙대학교 건설산업기술연구소 2003 건설산업기술연구소 논문집 Vol.4 No.-

The purpose of this study is to look into closely the character of hybrid in interior space, in order to examine the conception of hybrid, which is appeared by a modernistic pluralized tendency, as an expressional trend in modernistic interior space, and to propose the possibility of the conception of hybrid as an expressional way to design Korean style space based on the correlation between the discussion of Korean nature and the hybrid in the modernistic interior space of Korea. The hybrid to apply the nature of Korea expresses time and space, placing the meaning in history and for the existence of the past for the present, and creates a new space by reiterating the images of the past, present, and future. And a differentiated design can be created by means of making the third effect by mingling the world culture with a regional one. If the expression of the nature of Korea is applied to space from the aspect of cultural interpretation, the breath of expression can be enlarged, and the new way of design and expression can be found.

신생아 말초혈액 T 림프구의 아형 분석

최두영,김종덕,장선일,이신은,조성경,정헌택 최신의학사 1990 最新醫學 Vol.33 No.12

Ciprofloxacin 제제의 생물학적 동등성에 관한 연구

최철희,신재국,신완균,유호진,이경훈,정원석,장인진,신상구 대한화학요법학회 1991 대한화학요법학회지 Vol.9 No.1

국내 시판중인 ciprofloxacin 제제인 Citopcin®(250㎎ tablet)의 동등성을 검토하기 위해 제조원인 Bayer사의 Citopcin®(250㎎ tablet)를 기준제제로 하여 18명의 건강한 남성 피험자를 대상으로 500㎎ 1회 교차 경구 투여후 약동학적 성상을 분석비교한 결과는 다음과 같다. 시험제제의 생체 이용율의 지표인 AUC, C_(mao), T_(max) 및 MRT들의 평균치는 백분율차이에 있어 모든 기준제제 지표의 ± 20% 이내였으며, 이들 생체 이용율 지표들은 분산분석 검정에서 차이를 인지할 수 없었다.생체 이용율 지표들의 기준제제에 대한 백분율 90% 대칭 신뢰구간 검토시 모든 경수들에서 ± 20% 이내의 조건을 만족하였으며 AUC의 경우에는 대칭형 신뢰구간으로 변환시 95% 신뢰구간에서도 동등성의 조건을 만족하였다, 이상의 시험결과로 시험제제인 Citopcin®은 기준제제인 Ciprobay®와 생물학적 동등한 제제로 판단되었다. The pharmacokinetics of ciprofloxacin was studied for the evaluation of the bioequivalence of the generic ciproflocacin products. Two single doses of 500㎎ each of ciprofloxacin(Ciprobay® 250㎎ tablet as a reference compound and Citopcin® 250㎎ tablet s a test compound) were administered orally to ighteen male volunteers in a balanced, randomized crossover design. Pek plasma levels of ciprofloxacin were observed about 1 hour after the doses and the peak concentrations of both products were similar(Ciprobay®, 3.18㎍/㎖; Citopcin®, 2.89㎍/㎖). The values of other pharmacokinetic parameter of ciprofloxacin computed for Ciprobay® are presented in that order: AUC=13.53:12.47㎍·h/㎖, T_(max)=1.28:1.14 hours; MRT=5.30:5.08 hours; t_(1/2)β=3.65:3.47 hours. No satistically significant, differences were detected when AUC and the other parameters were compared with the method of ANOVA. Using the criteria of 90% confidence interval for the assessment of bioequivalence al the parameters were acceptable. The products were found to be equivalent on the premise that no significant difference was detected when the relevant pharmacokinetic parameters were compared, and the confidence limit analysis showed acceptable results.

작업장 누적소음 노출과 혈압과의 관련성

이상윤, 김재용*, 임형준, 윤기정, 최홍렬*, 고상백**, 강대희, 조수헌 대한산업의학회 2001 대한직업환경의학회지 Vol.13 No.2

목적 : 작업장에서의 누적소음노출값과 혈압의 변화 사이의 관계를 관찰하기 위한 단면 연구를 시행하였다. 방법 : 소음발생 제조업체의 남성근로자 중 건강진단 자료, 설문지 자료, 인사기록이 모두 갖추어진 852명을 연구대상으로 하였다. 작업장 소음측정값은 34개 지점에서 측정된 작업환경 측정 보고서 값을 사용하였고, 혈압은 건강진단시 측정한 수축기 혈압과 이완기 혈압 각각의 평균을 이용하였다. 가능한 교란변수들을 건강진단시 설문조사를 통하여 조사하였다. 근로자의 근무기간과 근무했던 작업부서의 소음노출값을 이용하여 누적소음노출값을 추정하였고, 이에 따라 전체 연구대상 근로자를 저소음노출군, 중등도소음노출군, 고소음노출군, 과다소음노출군으로 구분하였다. 누적소음노출값으로 구분한 소음노출군 사이에 평균 수축기 혈압 및 이완기 혈압의 차이가 있는 지를 나이, 비만도지수, 혈중 콜레스테롤값, 고혈압의 가족력, 흡연력, 음주력 등의 가능한 교란변수들의 영향을 통제한 상태에서 비교하였다. 결과 : 가능한 교란변수들을 보정한 상태에서 저소음노출군에서 과다소음노출군으로 갈수록 수축기 혈압 및 이완기 혈압의 증가가 있는지를 관찰하기 위해 일반선형모델을 이용하여 분석하였을 때, 수축기 혈압 및 이완기 혈압 모두 소음노출군이 혈압 변화의 유의한 설명변수였고, 수축기 혈압 및 이완기 혈압 모두 저소음노출군에 비해 과다소음노출군이 각각 2.1 mmHg, 2.7 mmHg 만큼 높았다. 결론 : 이는 만성적으로 누적된 고소음에의 노출로 인하여 혈압 상승의 가능성이 있음을 시사한다. Objectives : The association of workplace cumulative noise exposure and blood pressure was investigated in this study using cross-sectional design. Methods : The study population comprised 852 manufacturing male workers of whom occupational health examination data, questionnaire and personnel records were available. Workplace ambient noise monitoring data was used for calculating individual cumulative noise exposure level. Mean of each systolic and diastolic blood pressure of occupational health examination data was used for individual systolic and diastolic blood pressure level. Possible confounding variables including family history of hypertension, smoking habit, alcohol drinking habit were collected by questionnaire. On the basis of job location and duration of work at the location, a cumulatlve time-weighted average noise level was calculated for each workers. According to this cumulative noise exposure level, each study subject was categorized as low noise exposure group, moderate noise exposure group, high noise exposure group, very high noise exposure group. Among noise exposure groups, mean of systolic and diastolic blood pressure was compared after adjusting possible confounding variables such as age, body mass index, serum cholesterol level, family history of hypertension, smoking history, alcohol drinking habit. Results : After adjusting possible confounding variables, noise exposure group was signnificant explanatory variables for both systolic and diastolic blood pressure, and mean of both systolic and diastolic blood pressure of very high exposure group was higher than that of low exposure group. Conclusions : These findings suggested that the high cumulative noise exposure might elevate the blood pressure.

冬蟲夏草의 抗轉移와 免疫增進에 關한 硏究

최우진,유화승,이용연,서상훈,조정효,이연월,손창규,조종관 대전대학교 한방병원 2000 惠和醫學 Vol.9 No.2

This experimental study was carried out to evaluate the effects of Cordiceps sinensis on the antimetastasis and immune activity. In order to investigate the effect of Cordiceps sinensis, the followings were performed; Cytotoxicity, inhibition of MMP-2 & MMP-9 gene expression, fraction of CD4+, CD8+, CD19+ in splenic cell, the moprphological change of splenic cells, gene expression of IL-12(p35), IL-12(p40), IFN-?? and splenic cell proliferation by CS-E. The results were obtained as follows. 1. CS-E did not present cytotoxic effect on L+14, B16-F10 melanoma cells and HMCB. 2. CS-E inhibited MMP-2 and MMP-9 gene expression more effectively compared with control group. 3. CS-E inhibited invasion of B16-F10 melanoma cells more effectively compared with control group. 4. CS-E helped CD4+, CD8+, CD19+ expression more effectively compared with control group. 5. CS-E activated phagocytic cells in spleen more effectively compared with control group. 6. CS-E helped IL-12(p35), IL-12(p40), IFN-?? gene expression in splenic cell more effectively compared with control group. 7. CS-E activated splenic cell proliferation more effectively compared with control group. From above findings, it is suggested that CS-E is able to inhibit metastasis of cancer and activate immune response system.