한국사람 손바닥문의 생김새

이제만,정민석,정호근,이경종,신동훈,안미선,김도윤,이민석,정구영,정연무,조한범,유상준,박성식 아주대학교 1997 아주의학 Vol.2 No.2

Palm prints have been used for personal identification because they are unique to each individual. Palm prints have also been used for diagnosing genetic disorders and for revealing physical anthropological characteristics, due to their specific appearance characteristic of genetic factors and nationality. Therefore, several analytical methods of palm prints have been developed and applied for the purpose described. However, in the previous reports, the analytical methods of palm prints and the numbers of subjects were insufficient to find Standard values for Korean palm prints. In this study, in order to determine the Standard value for Korean palm prints, we examined palm prints of 3216 Korean adults (2095 males and 1121 females), analyzed the data according to sex and side of hand, and compared with those of foreigners. The results are s follows: 1) The incidence of 7, 9, and 11 of D was 41.8%, 33.5%, and 20.4%, respectively. Comparing the incidences 017, 9, and 11 of D in Koreans with those of foreigners, the Korean belong to the Asians including the Japanese, the Chinese, and the Philippine, however, the Korean was doser to the Blacks and distant from the Whites than the other Asians. 2) The palm prints were classified into the open type in which B terminates at the ulnar border of hand, and the dosed type in which B does not. Open type, 7-5-5 (male 37.6%, female 39.5%) and 9-7-5 (male 23.9%, female 25.5%), was more frequent in female than in male, while dosed type, 11-9-7 (male 9.8%, female 9.1%), was more frequent in male than in female. Also, open type, 7-5-5 (right 28.9%, left 47.6%), was more frequent in left hand than in right hand, while dosed type, 11-9-7 (right 17.1%, left 2.1%), was more frequent in right hand than in left hand. Consequently, open type was more frequent in the weak hand, whereas dosed type was more frequent in strong hand. 3) Because a-b (39.2) and c-d (35.0) were more numerous than b-c (27.8), distance between a and b and between c and d were longer than that between c and d. The long distance of a, b and c, d could be resulted by wide moving range of second finger and fifth finger, respectively. Also, there was a tendency that the palmar ridge counts of right hand was more numerous than those of left hand, which could be resulted by wide moving range of right fingers in the right-handed persons who were more frequent than the left-handed persons. 4) O, in which there was no triradius, and X, in which dermal ridge from a triradius was blocked and terminated at the other dermal ridge, were frequent in C (O 7.8%, × 7.2%) than in D (O 0.1%, × 0.1%) or in B (O 0.4%, X 1.2%). The frequency of 0 and X in C was thought to be related with the location of ein the narrow space between d and b. The narrow space between d and b was known because c-d and b-c was less numerous than a-b. 5) The distances between adjacent triradii were longer in male than in female, however, the palmar ridge counts for a-b, b-c, and c-d were less numerous in male than in female. Consequently, dermal ridges were thought to be thicker in male than in female. The Standard values of Korean palm prints obtained from this study are expected to be used for both diagnosing genetic disorders and for revealing physical anthropological characteristics in Korea. Further studies to clarify the relationship between the palm prints and the power of hand as well as the moving range of fingers are in need.

타리비드 정(오플록사신 100㎎)에 대한 파비드 정의 생물학적동등성

박완수,조성희,이헌우,임호택,홍성제,서성훈,류재환,이경태 한국약제학회 2005 Journal of Pharmaceutical Investigation Vol.35 No.1

The purpose of the present study was designed to evaluate the bioequivalence of two ofloxacin tablets, Tarivid (Jell Pharm. Co., Ltd.) and Favid (ILHWA Co., Ltd.), according to the guidelines of Korea Food and Drug Administration (KFDA). Twenty-four normal male volunteers, 23.67±3.12 year in age and 68.50±7.23 kg in body weight, were divided into two groups and a randomized 2x2 cross-over study was employed. After four tablets containing 100 mg of ofloxacin were orally administered, blood was taken at predetermined time intervals and concentrations of ofloxacin in plasma were deter mined using HPLC. Pharmacokinetic parameters such as AUC_(t) and T_(max) were calculated and ANOVA test was utilized for the statistical analysis of the parameters using logarithmically transformed AUC_(t), and C_(max) and untransformed T_(max). There were no sequence effects between two formulations in these parameters. The 90% confidence intervals for the log transformed data were acceptance range of log 0.8 to log 1.25 (e.g., log 0.94-log 1.04 and log 0.90-log 1.07 for AUC_(t) and C_(max) respectively). The major parameters. AUC_(t) and C_(max) met the criteria of KDFA for bioequivalence indicating that Favid tablet is bioequivalent to Tarivid tablet.

급성 림프구성 백혈병 환자에서 발생한 침습성 국균 심내막염 2예

신성철,백경란,정재홍,송봉근,김동희,전경만,채제욱,손준성,정숙인,오원섭,송재훈 대한감염학회 2003 감염과 화학요법 Vol.35 No.5

국균은 호흡기를 통해 유입되며 심한 면역기능저하 환자에서 기회감염을 일으키는 진균이며 주로 혈관을 따라 폐를 침범하고 심장과 골침범은 매우 드문 것으로 알려져 있다. 저자들은 급성 림프구성 백혈병 환자에서 발생한 침습성 국균 심내막염을 2예을 경험하였다. 19세 남자환자로 동종 조혈모세포이식 후 발생한 고열과 요통의 원인으로 감염성 심내막염 진단하에 수술결과 국균에 의한 감염으로 확증되어 수술적 절제술과 liposomal amphotericin B로 치료하였으나 국균 심내막염의 재발과 국균 척추염의 악화, 뇌 출혈로 사망하였다. 23세 남자환자로 관해요법 후 발생한 고열과 요통의 원인으로 국균 심내막염과 국균 척추염 진단하에 수술적 절제술과 amphotericin B로 치료하여 1년 2개월 동안 국균 심내막염의 재발은 없었으나 지속적인 백혈병의 재발과 국균 척추염의 악화, 침습성 폐 국균증으로 사망하였다. Although Aspergillus endocarditis has rarely been reported, it can cause fatal complications in hematologic malignancy patients and allogeneic stem cell transplant recipients. We experienced two cases of aspergillus endocarditis developed in acute lymphoblastic leukemia patients. Case; A 19-year-old patient developed Aspergillus endocarditis after allogenic hemopoietic stem cell transplantation. He was treated with surgical intervention and liposomal amphotericin B. He died of recurred Aspergillus endocarditis and cerebral hemorrhage probably related with aspergillosis of central nervous system. Case 2; A 23-year-old patient developed invasive Aspergillus endocarditis after induction chemotherapy. Aspergillus endocarditis was successfully treated by surgical intervention and amphotericin B. He died of refractory neutropenic fever and sepsis after the third relapse of leukemia and repetitive chemotherapy. He probably had invasive pulmonary aspergillosis without evidence of endocarditis recurrence. Because the mortality of Aspergillus endocarditis is very high, early diagnosis and surgical intervention are very important for better outcome.

Prokaryotic DNA methylation and its functional roles

Seong Hoon Je,Han Sang-Wook,설우준 한국미생물학회 2021 The journal of microbiology Vol.59 No.3

DNA methylation is known as a universal mechanism of epigenetic regulation in all kingdoms of life. Particularly, given that prokaryotes lack key elements such as histones and nucleosomes that can structurally modify DNA, DNA methylation is considered a major epigenetic regulator in these organisms. However, because DNA methylation studies have focused primarily on eukaryotes, the mechanism of prokaryotic DNA methylation has been less studied than in eukaryotes. DNA methylation in prokaryotes plays an important role in regulating not only the host defense system, but also the cell cycle, gene expression, and virulence that can respond directly to the environment. Recent advances in sequencing techniques capable of detecting methylation signals have allowed for the characterization of prokaryotic genome-wide epigenetic regulation. In this review, we describe representative examples of cellular events regulated by DNA methylation in prokaryotes, from early studies to current applications.

Methylome Analysis of Two Xanthomonas spp. Using Single-Molecule Real-Time Sequencing

Seong, Hoon Je,Park, Hye-Jee,Hong, Eunji,Lee, Sung Chul,Sul, Woo Jun,Han, Sang-Wook The Korean Society of Plant Pathology 2016 Plant Pathology Journal Vol.32 No.6

Single-molecule real-time (SMRT) sequencing allows identification of methylated DNA bases and methylation patterns/motifs at the genome level. Using SMRT sequencing, diverse bacterial methylomes including those of Helicobacter pylori, Lactobacillus spp., and Escherichia coli have been determined, and previously unreported DNA methylation motifs have been identified. However, the methylomes of Xanthomonas species, which belong to the most important plant pathogenic bacterial genus, have not been documented. Here, we report the methylomes of Xanthomonas axonopodis pv. glycines (Xag) strain 8ra and X. campestris pv. vesicatoria (Xcv) strain 85-10. We identified $N^6$-methyladenine (6mA) and $N^4$-methylcytosine (4mC) modification in both genomes. In addition, we assigned putative DNA methylation motifs including previously unreported methylation motifs via REBASE and MotifMaker, and compared methylation patterns in both species. Although Xag and Xcv belong to the same genus, their methylation patterns were dramatically different. The number of 4mC DNA bases in Xag (66,682) was significantly higher (29 fold) than in Xcv (2,321). In contrast, the number of 6mA DNA bases (4,147) in Xag was comparable to the number in Xcv (5,491). Strikingly, there were no common or shared motifs in the 10 most frequently methylated motifs of both strains, indicating they possess unique species- or strain-specific methylation motifs. Among the 20 most frequent motifs from both strains, for 9 motifs at least 1% of the methylated bases were located in putative promoter regions. Methylome analysis by SMRT sequencing technology is the first step toward understanding the biology and functions of DNA methylation in this genus.

Methylome Analysis of Two Xanthomonas spp. Using Single-Molecule Real- Time Sequencing

Hoon Je Seong,박혜지,홍은지,이성철,설우준,한상욱 한국식물병리학회 2016 Plant Pathology Journal Vol.32 No.6

Single-molecule real-time (SMRT) sequencing allowsidentification of methylated DNA bases and methylationpatterns/motifs at the genome level. Using SMRTsequencing, diverse bacterial methylomes includingthose of Helicobacter pylori, Lactobacillus spp., andEscherichia coli have been determined, and previouslyunreported DNA methylation motifs have been identified. However, the methylomes of Xanthomonas species,which belong to the most important plant pathogenicbacterial genus, have not been documented. Here, we report the methylomes of Xanthomonas axonopodispv. glycines (Xag) strain 8ra and X. campestrispv. vesicatoria (Xcv) strain 85-10. We identified N6-methyladenine (6mA) and N4-methylcytosine (4mC)modification in both genomes. In addition, we assignedputative DNA methylation motifs including previouslyunreported methylation motifs via REBASEand MotifMaker, and compared methylation patternsin both species. Although Xag and Xcv belong to thesame genus, their methylation patterns were dramaticallydifferent. The number of 4mC DNA bases in Xag(66,682) was significantly higher (29 fold) than in Xcv(2,321). In contrast, the number of 6mA DNA bases(4,147) in Xag was comparable to the number in Xcv(5,491). Strikingly, there were no common or sharedmotifs in the 10 most frequently methylated motifs ofboth strains, indicating they possess unique speciesorstrain-specific methylation motifs. Among the 20most frequent motifs from both strains, for 9 motifs atleast 1% of the methylated bases were located in putativepromoter regions. Methylome analysis by SMRTsequencing technology is the first step toward understandingthe biology and functions of DNA methylationin this genus.

만성 비판막성 심방세동의 전기적 심율동전환후 장기 추적관찰 성적

전성희(Seong Hee Jeon),현민수(Min Su Hyon),이상훈(Sang Hoon Lee),조성제(Sung Je Cho),고경환(Kyung Whan Ko),윤재형(Jae Hyung Yoon),이수금(Su Geum Lee),김명아(Myung A Kim),박성훈(Seong Hoon Park) 대한내과학회 1999 대한내과학회지 Vol.56 No.4

Objectives : We performed a prospective observation for the patients with chronic nonvalvular atrial fibrillation who underwent electrical cardioversion after failed pharmacological cardioversion with amiodarone. The aim of this study was to look at the immediate sinus conversion rate, the maintenance rate of sinus rhythm at long-term follow-up, and the clinical and echocardiographic parameters that influence on the rate of immediate sinus conversion and maintenance of sinus rhythm. At simultaneously, we intended to evaluate the efficacy of electrical cardioversion for the patients with chronic nonvalvular atrial fibrillation. Methods : After anticoagulation therapy with coumadine for four weeks before cardioversion, we tried pharmacological cardioversion with amiodarone first. Failed cases included in this study. The direct current cardioversion was performed under transesophageal echocardiography monitoring to exclude the left atrial thrombus and to measure various echocardiographic parameters. After successful sinus cardioversion, we prescribed amiodarone with maintenance doses and coumadine at least 4 weeks. Transthoracic echocardiography was performed before cardioversion and one day, one month, 3 months, 6 months, and 9 months after sinus conversion. The minimum duration of atrial fibrillation was one month before the trial of pharmacological cardioversion. Results : 1) The total number of patients was forty three (male : 28, female : 15, average age : 60±9). The initial success rate of sinus conversion was 88 %. 2) The maintenance rate of sinus rhythm with maintenance dose of amiodarone was 52 % after 9 months follow-up. 3) The direct current cardioversion was performed to 10 patients among 17 patients who recurred atrial fibrillation after sinus conversion. Among 10 patients, 5 patients of them were converted to sinus rhythm and maintained sinus rhythm after 9 months follow-up. 4) The initial success rate of sinus conversion was significantly higher in patients with lone atrial fibrillation compared with those patients with other associated heart disease (100 % vs. 83 %, p < 0.05), but the long-term maintenance rate of sinus rhythm was not influenced by the presence of associated disease. 5) The duration of atrial fibrillation before cardioversion was shorter in patients who were naintained sinus rhythm than that of those who were recurred atrial fibrillation. 6) The initial energy requirement at sinus conversion was lower in the patients who were maintained sinus rhythm than that of those who were recurred atrial fibrillation at 9 months follow-up. Conclusions : Direct current cardioversion was an effective treatment modality for patients with chronic nonvalvular atrial fibrillation after failure of pharmacological cardioversion with amiodarone.

확률통계기반 내열사이클 열화물성 해석모델 개발

이제성(Je Seong Lee),최주호(Joo Ho choi),황성순(Seong Soon Hwang),최원종(Won jong Choi),박성훈(Sung Hoon Park) 대한기계학회 2014 대한기계학회 춘추학술대회 Vol.2014 No.11

유전자 재조합 B 형 간염 바이러스 표면 항원 , CJC-50100 의 일반약리작용

정성학(Seong Hak Jeong),최재묵(Jae Mook Choi),이남중(Nam Jung Lee),전형수(Hyung Soo Jeon),김연희(Yon Hee Kim),김재승(Jae Seung Kim),하석훈(Suk Hoon Ha),김영훈(Young Hoon Kim),이나경(Na Gyung Lee),김제학(Je Hak Kim),박완제(Wan Je Park 한국응용약물학회 2001 Biomolecules & Therapeutics(구 응용약물학회지) Vol.9 No.1

N/A CJC-50100 is a recombinant hepatitis B virus surface antigen (HBsAg) expressed in yeast. The general pharmacological properties of CJC-50100 were evaluated in mice, rats, dogs and isolated guinea pig ileum. The doses were 0.33∼33.3 ㎍/㎏ i.m. for mice and rats and 3.3∼9.9 ㎍/㎏ i.v. for dogs. The concentrations of 0.002∼0.02 ㎍/mlwere used for the assay with guinea pig ileum. Intramuscular administration of CJC-50100 at the doses did not alter general behavior and the responses for central nervous system, smooth muscle, gastrointestinal system, cardiovascular and respiratory system, and water and electrolytes excretion. In summary, CJC-50100 had no pharmacological effect in these studies even up to the 100-fold of the expected clinical dose, 20 ㎍/man/60 kg.

안지오텐신 2 수용체 길항약 CJ-10513 이 고빈도 심실 pacing 견에서의 혈행동태에 미치는 영향

김영훈(Young Hoon Kim),정성목(Seong Mok Jeong),신재규(Jae Kyu Shin),최재묵(Jae Mook Choi),정성학(Seong Hak Jeong),배훈(Hoon Bae),이건호(Gun Ho Lee),김제학(Je Hak Kim),안양수(Yang Soo An) 한국응용약물학회 1998 Biomolecules & Therapeutics(구 응용약물학회지) Vol.6 No.2

Acute hemodynamic effects of CJ-10513, a non-peptide angiotensin II receptor antagonist, were examined in mongrel dogs treated with high frequency ventricular pacing for one week. Rapid ventricular pacing reduced mean blood pressure (mBP), LVdP/dt and cardiac output (CO), and increased the left ventricular end-diastolic pressure (LVEDP) and pulmonary capillary wedge pressure (PCWP). Continuous infusion of CJ-10513 at doses of 10 and 20 ㎍/kg/min, respectively, for 30 minutes reduced mBP, LVEDP and myocardial oxygen consumption rate (MVO₂) and shifted the cardiac function curve (CO-LVEDP curve) to the left in this dog model. In conclusion, CJ-10513 decreased the preload and afterload and increased the cardiac function in dogs with pacing-induced heart failure.