Immobilization with Ketamine HCI and Tiletamine-Zolazepam in Cynomolgus Monkeys

Myung-cheol Kim,Sung-hyeok Hong,Soo-jin Lee,Young-suk Kim,Jae-il Lee 대한수의학회 2003 Journal of Veterinary Science Vol.4 No.2

with Ketamine HCl and Tiletamine-Zolazepam in Cynomolgus MonkeysJae-il Lee, Sung-hyeok Hong, Soo-jin Lee, Young-suk Kim and Myung-cheol Kim*Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, KoreaReceived March 4, 2003 / Accepted July 2, 2003J. Vet. Sci. (2003), 4(2), 187-191JOURNAL OFVeterinaryScience*Corresponding author: Myung-cheol Kim Laboratory of Veterinary Surgery, College of Veterinary Medicine, Chungnam National University, Daejeon 305-764, Korea Tel: +82-42-821-6757, Fax: +82-42-822-4216 E-mail: mckim@cnu.ac.kr

Quality of care in inflammatory bowel disease in Asia: the results of a multinational web-based survey in the 2nd Asian Organization of Crohn`s and Colitis (AOCC) meeting in Seoul

( Hye Kyung Song ),( Kang-moon Lee ),( Sung-ae Jung ),( Sung Noh Hong ),( Dong Soo Han ),( Suk-kyun Yang ) 대한장연구학회 2016 Intestinal Research Vol.14 No.3

Background/Aims: The quality of care in inflammatory bowel disease (IBD) has not been systematically estimated. The aim of this study was to investigate the current status of quality of IBD care in Asian countries. Methods: A questionnaire-based survey was conducted between March 2014 and May 2014. The questionnaire was adopted from “An adult inflammatory bowel disease physician performance measure set” developed by the American Gastroenterological Association. If the respondent executed the performance measure in more than 70% of patients, the measure was regarded as well performed. Results: A total of 353 medical doctors from Asia completed the survey (116 from Korea, 114 from China, 88 from Japan, 17 from Taiwan, 8 from Hong-Kong, 4 from India, 3 from Singapore, and 1 each from the Philippines, Malaysia and Indonesia). The delivery of performance measures, however, varied among countries. The documentation of IBD and tuberculosis screening before anti-tumor necrosis factor therapy were consistently performed well, while pneumococcal immunization and prophylaxis of venous thromboembolisms in hospitalized patients were performed less frequently in all countries. Physician awareness was positively associated with the delivery of performance measures. Variations were also noted in reasons for non-performance or low performance of quality measures, and the two primary reasons cited were consideration of the measure to be unimportant and lack of time. Conclusions: The delivery of performance measures varies among physicians in Asian countries, and reflects variations in the quality of care among the countries. This variation should be recognized to improve the quality of care in Asian countries.

Investigation and Monitoring of Norovirus from Agricultural Water and Fresh Produce in Korea

Sung-Youn Kim,Sol Yi Park,Kyong-Suk Hong,Dae-Jung Kim,Hee-Chang Shin,Soon-Kil Cho 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10

Earnings Management and CEO Turnover in Korean Credit Unions

Sang-Choon Park(박상춘),Wan Suk Ko(고완석),Yong-Sik Hong(홍용식) 한국국제회계학회 2018 국제회계연구 Vol.0 No.79

본 연구는 신용협동조합(신협)이 대손충당금설정액의 재량적 조정에 의하여 이익조정을 행하고 있는가를 실증적으로 검증하였다. 본 연구는 신협의 특유한 측면을 살펴 검증하였다. 먼저, 신용협동조합의 설립기반인 조합원의 특별한 관계, 즉 공동유대(지역․단체․직장)와 관련하여, 본 연구는 공동유대 유형에 따라 이익조정이 달라지는지 살펴보았다. 다음, 신용협동조합의 최고경영진 및 그 임기 횟수는 매 4년마다 조합원 직접선거에 의해 결정되므로, 이러한 선거가 이익조정 유인에 어떤 영향을 미치는지 검증하였다. 본 연구의 연구방법으로 금융회사의 이익조정관련 선행연구에서 많이 쓰이는 개별발생액접근법을 이용하였는데, 경영자의 재량성이 큰 기말대손충당금설정액(대손상각비)을 종속변수로, 비재량적이익을 주요 설명변수로 두고, 대손충당금을 조정하여 이익조정하는지 여부를 검증하였다. 분석을 위한 표본은 2015년 말 정상 영업 중인 지역조합 및 단체조합을 대상으로 2006년부터 2015년까지 10년 동안 7,445개 신협-연도 자료를 이용하였다. 실증분석 결과, 신용협동조합의 경영자들은 재량성이 큰 대손상각비를 이용하여 이익조정을 행하고 있음이 발견되었는데, 이사장은 초임기간(4년) 중 다음 선거를 의식하여 연임 기간(4년)에 비해, 그리고 초임기간 중 마지막 연도는 초임 또는 연임기간의 다른 연도에 비해, 이익조정을 더 크게 하는 것으로 검증되었다. 그리고 지역조합이 단체조합보다 이익조정을 더 활발하게 행하는 것으로 나타났다. 위와 같은 신협 경영자의 이익조정의 증거를 바탕으로, 본 연구는 다음의 시사점을 제공하고 있다. 금융당국은 경영자의 이익조정 재량권을 축소하기 위해 자산건전성 분류기준 및 회수예상가액 산정기준을 보다 명확하고 객관화하여 개선하여야 한다. 아울러 조합의 규모나 공동유대 특성 등을 고려한 차등 감독도 시행할 필요가 있다. This study empirically tests whether and how CEOs of credit unions manage their reported earnings through management of allowance for bad debts (ABD) by examining distinct features of credit unions. With regard to the common ties of their members on which the unions are established, it tests whether credit unions’ earnings management differs by type of establishment ties. Then, because the CEOs of unions and their number of terms of office are determined by the direct election by their members, the study examines how earnings management is affected by the existence of the election. The study uses a specific accruals approach widely used in the literature on earnings management of financial companies. It uses bad debt expense (BDE), a major discretionary item, as the dependent variable and non-discretionary earnings as a primary explanatory variable to test the hypotheses. The sample comprises 7,445 Korean credit union firm-years spanning 2006 to 2015. The empirical results revealed that credit unions manage their reported earnings by using BDE, especially more in the first office term of their CEOs than in the consecutive term, and in the last year of the first term, and that earnings were more actively managed in regional unions than in association ones. This study provides policy implications. Financial supervisory authorities should improve the objectivity and clarity of asset soundness criteria, and provide better and objective estimation methods for expected loan recovery so as to minimize CEOs’ discretion in earnings management. They should also provide differential supervision for credit unions depending on their types of common ties and size.

Study between Remnant Stomach Volume and Gastroesophageal Reflux

Sang-Ho Jeong,Ji-Ho Park,Tae-han Kim,Young-Suk Kim,Sang-Kyung Choi,Soon-Chan Hong,Eun-Jung Jung,Young-tae Ju,Chi-Young Jeong,Woo-Song Ha,Ji Eun Kim,Kyungsoo Bae,Young-Joon Lee 대한외과학회 2018 대한외과학회 학술대회 초록집 Vol.2018 No.11

Immunochip Meta-Analysis of Inflammatory Bowel Disease Identifies Three Novel Loci and Four Novel Associations in Previously Reported Loci

Hong, Myunghee,Ye, Byong Duk,Yang, Suk-Kyun,Jung, Seulgi,Lee, Ho-Su,Kim, Byoung Mok,Lee, Soo Bin,Hong, Jeonghoon,Baek, Jiwon,Park, Sang Hyoung,Han, Buhm,Li, Yi,Liu, Wenting,Haritunians, Talin,Taylor, Oxford University Press 2018 JOURNAL OF CROHNS AND COLITIS Vol.12 No.6

<P>Conclusions: Our findings of new loci not previously associated with IBD support the importance of studying inflammatory bowel disease genetics in diverse populations.</P>

Development and Optimization of High-Voltage Power Supply System for Industrial Magnetron

Sung-Roc Jang,Hong-Je Ryoo,Suk-Ho Ahn,Jongsoo Kim,Geun Hie Rim IEEE 2012 IEEE transactions on industrial electronics Vol.59 No.3

<P>This paper describes the design and analysis of a 42-kW (14 kV, 3 A) high-voltage power supply for a 30-kW industrial magnetron drive. The design is based on a series resonant converter in discontinuous conduction mode (DCM) to take advantage of both the superior arc protection stemming from the current source characteristics and the high power density owing to the use of parasitic elements such as the leakage inductance in the high-voltage transformer. The detailed design procedure for the resonant tank and high-voltage transformer with respect to the input and output specifications is described on the basis of a simplified analysis of the DCM series resonant converter. Special considerations for designing high-power high-voltage power supplies are provided, such as series stacking of diodes for a voltage doubling rectifier and insulation between each winding of the high-voltage transformer. In addition, a comparative study using theoretical equations, simulation, and experimental results was carried out. This study yielded the output voltage and current characteristics at different switching frequencies and verified the advantages of this topology, such as arc protection without an additional protection circuit and high efficiency due to zero-current or zero-voltage switching. Moreover, the parallel operation of two converters with phase shifted gating signal is proposed to reduce the output current ripple and increase power capability for higher power magnetron drive. Additionally, the design considerations of two auxiliary power supplies (a filament power supply: 15 V, 150 A and a magnet power supply: 50 V, 5 A) are also provided and optimized for effective driving industrial magnetron. Finally, the developed power supply was tested with a 30-kW industrial magnetron, and the results prove the reliability and robustness of the proposed scheme.</P>

Improvement of chaperone activity of 2-Cys peroxiredoxin using electron beam

Hong, Sung Hyun,An, Byung Chull,Lee, Seung Sik,Lee, Jae Taek,Cho, Jae-Hyun,Jung, Hyun Suk,Chung, Byung Yeoup Elsevier 2012 Radiation physics and chemistry Vol.81 No.8

<P><B>Abstract</B></P><P>The peroxiredoxin protein expressed in <I>Pseudomonas aeruginosa</I> PAO1 (PaPrx) is a typical 2-cysteine peroxiredoxin that has dual functions as both a thioredoxin-dependent peroxidase and molecular chaperone. As the function of PaPrx is regulated by its structural status, in the present study, we examined the effects of electron beam radiation on the structural modifications of PaPrx, as well as changes to PaPrx peroxidase and chaperone functions. It was found that the chaperone activity of PaPrx was increased approximately 3- to 4-fold at 2kGy when compared to non-irradiated PaPrx, while its peroxidase activity decreased. This corresponded to a shift from the low molecular weight PaPrx species that acts as a peroxidase to the high molecular weight complex that functions as a chaperone, as detected using polyacrylamide gel electrophoresis. We also investigated the influence of the electron beam on physical protein properties such as hydrophobicity and secondary structure. The exposure of the PaPrx hydrophobic domains in response to irradiation reached a peak at 2kGy and then decreased in a dose-dependent manner at higher doses. In addition, the exposure of β-sheet and random coil elements on the surface of PaPrx was significantly increased following irradiation with an electron beam, whereas exposure of α-helix and turn elements was decreased. These results suggest that irradiated PaPrx may be a potential candidate for use in bio-engineering systems and various industrial applications, due to its enhanced chaperone activity.</P>

S-420 Red blood cell distribution width is associated with carotid atherosclerosis in type 2 diabetes

( Sang Bae Lee ),( Ji Hong You ),( Minyoung Lee ),( Eun Jung Kim ),( Min Jin Kim ),( Minkyung Kim ),( Ji Sun Nam ),( Jong Suk Park ),( Chul Woo Ahn ),( Kyung Rae Kim ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1

Objectives:?Red blood cell distribution width (RDW) is a measure of the size variability of circulating erythrocytes, recent studies have shown that increased RDW levels are independent predictors of overall and cardiovascular disease in the general and high risk populations. CVD is one of the most common causes of mortality in patients with type 2 diabetes,and carotid atherosclerosis determined by intima media thickness (IMT) is used to predict CVD risk and related outcomes. However, no study has investigated the association between RDW and IMT in type 2 diabetic patients.Therefore, we aimed to investigate the relationship between RDW and subclinical atherosclerosis in patients with type 2 diabetes.?Methods:?We analyzed the data of 469 patients with type 2 diabetes from Seoul, Korea. We excluded subjects with a history of cardiovascular or cerebrovascular disease. Anthropometric and various biochemical profiles including RDW were measured. B-mode ultrasound measurement of carotid intima-media thickness (C-IMT) was used to evaluate subclinical atherosclerosis. Carotid atherosclerosis was defined as C-IMT ≥ 1.0 mm, as assessed by B-mode ultrasound.?Results:?The subjects were stratified into 3 groups according to RDW values. Compared with subjects in the lowest tertile of RDW, those in the highest tertile were older, more likely to be smokers, had higher SBP and BMI, longer duration of diabetes, and higher prevalence of hypertension. The C-IMT values for the first, second and third RDW tertiles were 0.74±0.12 mm, 0.77±0.13 mm, and 0.79±0.14 mm, respectively and showed the increasing trend across the RDW tertiles ( P for trend <0.01). In multiple linear regression analysis, RDW was independently associated with C-IMT. After adjusting for age and sex, the OR for carotid atherosclerosis in the highest tertile of RDW was significantly increased compared to that of the lowest tertile. These relationships remained significant after further adjustments for other risk factors (OR (95% CI), 1.35 (1.01-2.23), 2.04 (1.06-3.94), P for trend <0.05).?Conclusions:?This study showed that RDW is independently associated with subclinical atherosclerosis in type 2 diabetes.

Corrigendum to “Paricalcitol Pretreatment Attenuates Renal Ischemia-Reperfusion Injury via Prostaglandin E ₂ Receptor EP4 Pathway”

Hong, Yu Ah,Yang, Keum Jin,Jung, So Young,Park, Ki Cheol,Choi, Hyunsu,Oh, Jeong Min,Lee, Sang Ju,Chang, Yoon Kyung,WheePark, Cheol,Yang, Chul Woo,Kim, Suk Young,Hwang, Hyeon Seok Hindawi 2017 Oxidative medicine and cellular longevity Vol.2017 No.-