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Meng-Ying Yao,Wei-Hong Zhang,Wen-Tao Ma,Qiu-Hong Liu,Li-Hua Xing,Gao-Feng Zhao 생화학분자생물학회 2019 Experimental and molecular medicine Vol.51 No.-
Currently, exosome-enclosed microRNAs (miRs) in exhaled breath have potential for biomarker discovery in patients with pulmonary diseases. This study was performed to investigate the roles of M2 macrophage-derived exosomes expressing miR-328 in pulmonary fibrosis (PF). Microarray-based analysis was used to screen differentially expressed genes (DEGs) and regulatory miRs in PF. The miR-target relationship between FAM13A and miR-328 was confirmed. The expression of FAM13A and miR-328 was measured in PF rats, and gain- and loss-of-function assays were conducted to determine the regulatory effects of FAM13A and miR-328 on PF. In addition, exosomes derived from M2 macrophages were isolated and then cocultured with pulmonary interstitial fibroblasts to identify the role of these exosomes in PF. Furthermore, the effects of M2 macrophage-derived exosomes overexpressing miR-328 on pulmonary fibroblast proliferation and the progression of PF were assessed in vivo. miR-328 might perform a vital function in PF by regulating FAM13A. FAM13A expression was downregulated while miR-328 expression was upregulated in rats with PF, and a miR-target relationship between miR-328 and FAM13A was observed. Additionally, miR-328 overexpression and FAM13A silencing each were suggested to promote pulmonary interstitial fibroblast proliferation and the expression of Collagen 1A, Collagen 3A and α-SMA. Then, in vitro experiments demonstrated that M2 macrophage-derived exosomes overexpressing miR-328 contributed to enhanced pulmonary interstitial fibroblast proliferation and promoted PF. Furthermore, in vivo experiments confirmed the promotive effects of M2 macrophagederived exosomes overexpressing miR-328 on the progression of PF. Collectively, the results showed that
Fractal Structures and Their Computer Simulation in Rapidly Quenched Al - Mn Alloys
Zhang, Meng,Hong, Chunyong,Dai, Hong,Yang, Pinsheng,Tan, Yuxi 대한금속재료학회(대한금속학회) 1999 METALS AND MATERIALS International Vol.5 No.1
The microstructure of rapidly quenched Al-Mn alloys were studied by TEM and SEM. The icosahedral phase in Al-Mn alloys was observed to show various types of fractal morphologies, which may be classified into four kinds: 1) dendritic shape, 2) flower-like shape, 3) granular shape and 4) grain-oscillation shape. After being digitized by a computer, the fractal dimensions (D) of these morphologies were calculated. Based on the traditional diffusion limited aggregation (DLA) model computer simulations were made with two-seeded and many-seeded clusters, which reflect the growing mechanism of some fractal structures in Al-Mn alloys. It is suggested that these fractal structures are formed by many icosahedral particles about 20 nm in size aggregating during the rapid quenching process.
Chaojin Hong,Yimei Meng,Anchen Qiu,Haibo Zhang,Liu Yang,Yupeng Hong,Yumei Huang 생화학분자생물학회 2024 BMB Reports Vol.57 No.7
Lung cancer is one of the most significant malignancies, withboth high morbidity and mortality. CDK10 is closely related tocancer progression and metastasis. However, its role in lungcancer radioresistance demands further clarification. In this study,we demonstrated that CDK10 was downregulated in lung cancertissues, and CDK10 expression level was associated withthe clinical prognosis in lung cancer patients. We also foundthat silencing CDK10 promoted lung cancer cell proliferation,migration, and radioresistance. We further verified that silencingCDK10 facilitated the activation of JNK/c-Jun signaling, and c-Jundepletion could reverse the effects of CDK10 knockdown inlung cancer cells. Our findings revealed that CDK10 plays animportant role in cell growth and radioresistance by inhibitingJNK/c-Jun signaling pathway in lung cancer. Therefore, CDK10might be a promising therapeutic target in lung cancer.
Zhou Meng-jiao,Yang Jia-jie,Ma Ting-yao,Feng Ge-xuan,Wang Xue-lian,Wang Li-Yong,Ge Yu-ze,Gao Ran,Hong-liang Liu,Shan Lin,Kong Lu,Chen Xiao-hong 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
MYB-NFIB fusion and NOTCH1 mutation are common hallmark genetic events in salivary gland adenoid cystic carcinoma (SACC). However, abnormal expression of MYB and NOTCH1 is also observed in patients without MYB-NFIB fusion and NOTCH1 mutation. Here, we explore in-depth the molecular mechanisms of lung metastasis through single-cell RNA sequencing (scRNA-seq) and exome target capture sequencing in two SACC patients without MYB-NFIB fusion and NOTCH1 mutation. Twenty-five types of cells in primary and metastatic tissues were identified via Seurat clustering and categorized into four main stages ranging from near-normal to cancer-based on the abundance of each cell cluster in normal tissue. In this context, we identified the Notch signaling pathway enrichment in almost all cancer cells; RNA velocity, trajectory, and sub-clustering analyses were performed to deeply investigate cancer progenitor-like cell clusters in primary tumor-associated lung metastases, and signature genes of progenitor-like cells were enriched in the “MYC_TARGETS_V2” gene set. In vitro, we detected the NICD1-MYB-MYC complex by co-immunoprecipitation (Co-IP) and incidentally identified retinoic acid (RA) as an endogenous antagonist of genes in the “MYC_TARGETS_V2” gene set. Following this, we confirmed that all-trans retinoic acid (ATRA) suppresses the lung metastasis of SACC by correcting erroneous cell differentiation mainly caused by aberrant NOTCH1 or MYB expression. Bioinformatic, RNA-seq, and immunohistochemical (IHC) analyses of primary tissues and metastatic lung tissues from patients with SACC suggested that RA system insufficiency partially promotes lung metastasis. These findings imply the value of the RA system in diagnosis and treatment.
4D 체감형 콘텐츠에 대한 3D Sweetening 연구 실험 절차
맹휘 ( Meng Hui ),송승근 ( Seung Keun Song ),채일진 ( Eel Jin Chae ),김기홍 ( Ki Hong Kim ),박홍식 ( Hong Sik Park ) 한국정보처리학회 2011 한국정보처리학회 학술대회논문집 Vol.18 No.2
3D 입체영상은 영화관에서 시작되어 최근에는 방송, 게임, 테마파크에 이르기 까지 널리 확산되고 있다. 하지만 3D 입체영상에 대한 응용기술의 발전은 입체영상에 쉽게 접근하게 하였음에도 불구하고 3D 입체영상을 시청하는 사용자에 대한 근본적인 연구가 미흡한 실정이다. 이러한 문제로 인하여 3D 입체영상을 접한 대부분의 시청자들이 안구통증, 어지러움 증을 호소하지만 이에 대한 근본적인 대책을 제시하지 못하는 것이 현실이다. 따라서 이러한 입체피로를 해결하기 위한 3D Sweetenig을 다양한 연구방법으로 진행되고 있고, 그 중 4D 체감형 콘텐츠에 대한 감성연구실험 절차를 소개하고자 한다.
A Network Intrusion Detection Model Based on K-means Algorithm and Information Entropy
Gao Meng,Li Dan,Wang Ni-hong,Liu Li-chen 보안공학연구지원센터 2014 International Journal of Security and Its Applicat Vol.8 No.6
Many factors could influence the clustering performance of K-means algorithm, selection of initial cluster centers was an important one, traditional method had a certain degree of randomness in dealing with this problem, for this purpose, information entropy was introduced into the process of cluster centers selection, and a fusion algorithm combining with information entropy and K-means algorithm was proposed, in which, information entropy value was used to measure the similarity degree among records, the least similar record would be regarded as a cluster center. In addition, a network intrusion detection model was built, it could make cluster centers change dynamically along with the network changes, and the model could real-time update the cluster centers according to actual needs. Experiment results show that the improved algorithm proposed is better than the traditional K-means algorithm in detection ratio and false alarm ratio, and the network intrusion detection model is proved to be feasible.
Hong-Zhong Huang,Xudong Zhang,Debiao Meng,Zhonglai Wang,Yu Liu 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.6
Reliability based design optimization (RBDO) has been widely implemented in engineering practices for high safety and reliability. It is an important challenge to improve computational efficiency. Sequential optimization and reliability assessment (SORA) has made great efforts to improve computational efficiency by decoupling a RBDO problem into sequential deterministic optimization and reliability analysis as a single-loop method. In this paper, in order to further improve computational efficiency and extend the application of the current SORA method, an enhanced SORA (ESORA) is proposed by considering constant and varying variances of random design variables while keeping the sequential framework. Some mathematical examples and an engineering case are given to illustrate the proposed method and validate the efficiency.
Column-loss response of RC beam-column sub-assemblages with different bar-cutoff patterns
Meng-Hao Tsai,Jun-Kai Lu,Bo-Hong Huang 국제구조공학회 2014 Structural Engineering and Mechanics, An Int'l Jou Vol.49 No.6
Static loading tests were carried out in this study to investigate the effect of bar cutoff on the resistance of RC beam-column sub-assemblages under column loss. Two specimens were designed withcontinuous main reinforcement. Four others were designed with different types of bar cutoff in the mid-span and/or the beam-end regions. Compressive arch and tensile catenary responses of the specimens under gravitational loading were compared. Test results indicated that those specimens with approximately equal moment strength at the beam ends had similar peak loading resistance in the compressive arch phase but varied resistance degradation in the transition phase because of bar cutoff. The compressive bars terminated at one-third span could help to mitigate the degradation although they had minor contribution to the catenary action. Among those cutoff patterns, the K-type cutoff presented the best strength enhancement. It revealedthat it is better to extend the steel bars beyond the mid-span before cutoff for the two-span beams bridgingover a column vulnerable to sudden failure. For general cutoff patterns dominated by gravitational and seismic designs, they may be appropriately modified to minimize the influence of bar cutoff on the progressive collapse resistance.
Meng Li,Hong-Sik Shin,Kwang-Seok Jeong,Sung-Kwen Oh,Horyeong Lee,Kyumin Han,Ga-Won Lee,Hi-Deok Lee 대한전자공학회 2014 Journal of semiconductor technology and science Vol.14 No.1
Different kinds of post-deposition annealing (PDA) by a rapid thermal process (RTP) are used to enhance the field-effect passivation of Al2O3 film in crystal Si solar cells. To characterize the effects of PDA on Al2O3 and the interface, metalinsulator semiconductor (MIS) devices were fabricated. The effects of PDA were characterized as functions of RTP temperature from 400~700 °C and RTP time from 30~120 s. A high temperature PDA can retard the passivation of thin Al2O3 film in c-Si solar cells. PDA by RTP at 400 °C results in better passivation than a PDA at 400 °C in forming gas (H2 4% in N2) for 30 minutes. A high thermal budget causes blistering on Al2O3 film, which degrades its thermal stability and effective lifetime. It is related to the film structure, deposition temperature, thickness of the film, and annealing temperature. RTP shows the possibility of being applied to the PDA of Al2O3 film. Optimal PDA conditions should be studied for specific Al2O3 films, considering blistering.