흰쥐 Kupffer 세포에 대한 Propofol의 작용

박세훈,지대림,성언기,김희선,송인환,박희영,김준수,이덕희,박대팔 대한마취과학회 2002 Korean Journal of Anesthesiology Vol.43 No.4

Background: Propofol has an antioxidant capacity and can be used for ischemia-reperfusion injury of the liver. However, the effects of propofol on the Kupffer cells have not been establisked. Methods: Kupffer cells were isolated and cultured from male Sprague-Dawley rats. The effects of propofol on the Kupffer cells were evaluated by a phagocytosis assay, TNF-α gene expression, and superoxide anion release after administering propofol in different concentrations on the cultured Kuprrer cells. Results: The latex bead phagocytosis by the Kupffer cells was suppressed when the Kupffer cells were exposed to propofol irrespective of concentrations. Higher propofol concentrations decreased the loss of Kupffer cells after latex bead phagocytosis. Propofol induced TNF-α mRNA expression in the Kupffer cells, but the mRNA expression level after 50㎍/ml of propofol decreased. The pattern of TNF-α mRNA expression induced by propofol was different to that induced by LPS: TNF-α mRNA was expressed continuously in the propofol-treated cells until 16 hours after exposure to propofol, whereas the level of TNF-α mRNA expression induced by LPS was evident after 2 hours and was not found thereafter. TNF-α production after propofol treatment was not higher than that of the control. Formazan presipitation did not show any qualitative differences between cells untreated or treated with propofol concentrations of 0.5, 5.0, and 50 ㎍/ml. Conclusions: These results showed that propofol might inhibit Kupffer cells. This suggests that propofol and be used for patients with ischemia-reperfusion injury of the liver. (Korean J Anesthesiol 2002; 43: 475~484)

[논문]Operational Characteristics of CO2 Laser Adopted by Superposing-Discharge

Hee-Je Kim,Hyun-Ju Chung,Byoung-Dae Min,Jong-Han Joung,Sung- lun Park 釜山大學校生産技術硏究所 2003 生産技術硏究所論文集 Vol.62 No.-

오늘날 현저한 CO2 레이저의 응용 추세에 발맞추어 보다 다양한 형태의 출력 제어 기술이 대두되고 있다. 본연구에서는multi-Pulse Superposing-Discharge 기술을 이용하여 다양한형태의 CO2 레이저의 펄스를 성형 하였다. 펄스 성형을 위한 방법으로 PIC one-chip microprocessor를 이용하여 삼중 PFN 모률의 SCR을 각각 고유의 지연시간을 가지도록 제어하였다. 실험에 사용된 삼중 PFN 모률의 전원 회로는 각각 캐패시터 인덕터,SCR,고압 펄스 트랜스 그리고 고압 트랜스 2차측에 브릿지 정류기로 구성 하였다. 고압 펼스 트랜스의 1차측을 제어하므로서 PFN 모률의 동작을 저 전압에서 수행 할 수 있다. 트랜스의 2차측에 연결된 전파 정류기는 펄스 에너지를 부하에 지속적으로 전달한다. 본 연구에서는 삼중 PFN 모률의 각각의 SCR을 다른 시간 가격을 두고 트리거 하므로서 다양한 Long pulse shaping을 실현하였다. 또한 약 250-1000μs 의 주기를 가지는 다양한 펄스형 레이저 빔을 얻었다.

Algal bioassay 에 의한 조류생장 제한영양염류 결정

오희목(Hee Mock Oh),이석준(Seog June Lee),김성빈(Seong Bin Kim),박미경(Mi Kyung Park),윤병대(Byung Dae Yoon),김도한(Do Han Kim) 한국하천호수학회 1998 생태와 환경 Vol.31 No.2

Determination of Limiting Nutrient for Algal Growth by Algal Bioassay. Oh, Hee-Mock, Seog June Lee, Seong-Bin Kim, Mi- Kyung Park, Byung-Dae Yoon and Do-Han Kim (Environmental Microbiology Research Unit, Korea Research Institute of Bioscience and Biotechnology, Taejon 305-333, Korea and Water Resources Research Institute, Korea Water Resources Corporation, Taejon 305-390, Korea) Water quaiity and algal growth potential (AGP) using Microcystis aeruginosa were investigated from April to September 1997 in Daechung Reservoir. Secchi disk transparency was 1.1 m in August. Chlorophyll-a concentrations were higher than 10㎍/l at all samples. Total phosphorus concentration was in a range of 0.020∼0.027mg/l which is at the approximate value of 0.03 mg/l, the general critical level of eutrophication. These results indicate that Daechung Reservoir is in an eutrophic state except some temporary times and restricted sites. Phosphorus uptake rate of M. aeruginosa was higher in the water from the epilimnion than in the hypolimnion and also higher under light condition than under dark condition. Therefore, phosphorus uptake rate appears to depend on cellular phosphorous content and light condition, a meaning of endergonic process. Phosphorus was the most frequently limiting nutrient: phosphorus was limiting algal gowth in April and May, nitrogen, phosphorus and trace elements were the limiting factors for algae in August, and trace elements in September. If a fast growing alga, M, aeruginosa, is used as a test organism for assaying AGP, in vivo fluorescence instead of dry weight can be measured for algal biomass and incubation period can be reduced from traditional 14 days to 7 days.

만성 승모판 패쇄부전증 환자에서의 안지오텐신 전환효소 억제제의 장기 투여 효과

김대희,이명묵,이해영,조현재,박승정,서재빈,서정원,양한모,윤창환,조상호,이준희,김용진,김명아,손대원,오병희,박영배 대한순환기학회 2004 Korean Circulation Journal Vol.34 No.2

서초동(서울시 서초구)의 거미상

김주필(Joo Pil Kim),정혜리(Hye ri Jeong),김대희(Dae Hee Kim),박동우(Dong Woo Park),서재웅(Jae Woong Seo),이현우(Hyun woo Lee) 한국거미연구소 2017 한국거미 Vol.33 No.1

2016년 3월 31일부터 7월 31일까지 서울특별시 서초구 서초동에 위치한 서울고등학교 교정 일대를 서울고등학교 환경생물부 부원들이 채집 조사한 결과 20과 43속 53종의 거미가 조사 연구되어 이에 보고하는 바이다. From March 31st to July 31st in 2016, members of an environmental biology club at Seoul High School located in Seocho-gu, Seoul, Dae-Hee Kim, Dong-Woo Park, Jae-Woong Seo and Hyun-woo Lee, collected 20 families 43 genera 53 species of spiders and report the result of the study here.

도전성고분자의 전자물성 및 광학적특성에 관한 연구

박대희 圓光大學校 1996 論文集 Vol.31 No.2

이 논문은 Alkyl chain으로 치환되는 poly(3-alkythiophene)의 전자물성과 광학적 특성을 온도 및 치환 chain길이 의존성을 요약하였다. 전기전도는 Alkyl chain길이의 증가와 함께 감소하는 경향을 나타낸다. 또한, 광학적인 성질은 Alkyl cahin길이와 온도상승과 함께 따라 흡수단의 변화를 일으킨다. 이와같이 전자 및 광학적인 물성의 변화는 poly(3-alkythiophene)의 conformation에 의한 것으로 사료된다. In the paper, it observed electronic and optical properties, which substituted from poly(3-alkylthiophene) to Alkyl chain with dependence of temperature and Alkyl chain length. The electrical conductivity shows tendency to decrease with the increase of Alkyl chain length. In addition to, optical properties arise the change of edge energy according to the Alkyl chain length and the rise of temperature. In these ways, the changes of electronic and optical properties of materials suggest by dint of the conformation of poly(3-alkylthiophene).

선천성상부요로기형에서 발생한 요석에 대한 체외충격파쇄석술

박희수,박경민,정용호,김철성,장대수 조선대학교 부설 의학연구소 1999 The Medical Journal of Chosun University Vol.24 No.1

Purpose: We sought to determine the efficacy of extracorporeal shock wave lithotripsy(ESWL) in the treatment of urolithiasis with congenital upper urinary tract anomalies. Materials and Methods: Using the Northgate SD-3 lithotriptor, 43 patients with calculi with upper urinary tract anomalies were treated with extracorporeal shock wave lithotripsy(ESWL) at Chosun University Hospital from 1996 to 1998. The upper urinary tract anomalies were duplicated ureter in 12 cases, bifid pelvis in 10, malrotated kidney in 4, ureterocele in 3, UPJ obstruction in 3, caliceal diverticulum in 3, horseshoe kidney in 3, pelvic kidney in 2, medullary sponge kidney(MSK) in 2 and polycystic kidney in 1. The age range of the patients was from 22 to 70 years of age(mean of 49.6 years). There were 23 men and 20 women. The mean size of the stone was 10.1x8.6±4.9x4.3mm, General or regional anesthesia was not required. Results: The average frequency was 2.3 sessions and the average number of shock wave was 2258±1404 shock. The 3-month stone free rate was 90.7%, Complications of stone removal were petechia in 43 cases, gross hematuria in 36, severe flank pain in 9 and urinary infection in 2. All complications were treated successfully with conservative management. Conclusion: We conclude that ESWL monotherapy is a safe and successful modality as a noninvasive management of urolithiasis in patients with upper urinary tract anomalies.

레이저형광측정을 통한 DIAGNODENT의 우식진단에 관한 생체와 연구

박종석,이광희,김성형,김대업 大韓小兒齒科學會 2000 大韓小兒齒科學會誌 Vol.27 No.1

새로운 레이저형광측정기술을 사용한 Diagnodent의 우식진단능력을 탐침을 사용하는 시진법 및 일반적 방사선사진촬영법과 비교하여 평가하기 위하여, 건전하거나 열구우식이 있는 발거된 대구치와 소구치 103개를 대상으로 위의 세 가지 방법의 검사를 각각 시행하고 그 성적을 비교하였다. 시진 및 방사선검사 성적이 증가할수록 Diagnodent성적도 함께 증가하는 분포를 나타내었다(P<0.01). 시진 성적과 Diagnodent 성적간에는 피어슨 상관계수 0.676, 스피어만 순위상관계수 0.694의 상관성이 있었고, 방사선검사 성적과 Diagnodent 성적간에는 각각 0.623,0.658의 상관성이 있었다(P<0.01,전체). Diagnodent 검사법은 민감도가 매우 높은 것으로 나타났으나, 가양성의 측정치가 많아 특이도가 낮게 나타났으며, 우식단계별 진단기준을 제시하기 위하여는 더 많은 연구가 필요하다고 평가되었다. The purpose of study was to compare the laser fluorescence detection by Diagnodent (KaVo. Germany). visual inspection using dental explorers, and conventional dental radiography as diagnostic tests for dental caries. One hundred and three human premolars and molars which had no caries or fissure caries were tested by the three methods. Diagnodent scores increased as the scores of the other two tests increased(P<0>01). There were significant relationships between visual inspection scores and Diagnodent scores (Pearson 0.676. Spearman 0.694) and between radiography scores and Diagnodent scores(Pearson 0.623. Spearman 0.658) (P<0.01. all.> Diagnodent test proved to have high sensitivity and low specificity and more studies are necessary to present the diagnostic criteria for progressive caries stages.

Cao-MgO-SiO₂-P₂O -CaF₂계 생체활성 결정화 유리의 기계적 성질에 미치는 ZrO₂및 Al₂O₃의 분산 강화 효과

박찬운,강건구,원대희,이민호,배태성 대한치과기재학회 1998 대한치과재료학회지 Vol.25 No.2

Bioactive glass-ceramics can form tight chemical bonds with bone, however, their poor mechanical properties may limit their clinical applications. Alumina ceramics show good biocompatibility and high strength but can't form chemical bonds with bone. Hydroxyapatite ceramics and bioglass form chemical bonds with bone but their strength and fracture are relatively low. Glass ceramics containing apatite and wollastonite crystals can form tight chemical bonds with bone and show relatively high strength and fracture toughness. Bioactive glass-ceramics toughened by alumina and tetragonal zirconia polycrystals show relatively high mechanical strength. Both bioactive and high strength ceramics will be widely applicable to many clinical applications. In this study, bioactive glass-ceramics toughened by alumina and zirconia polycrystals were fabricated, and crystallization behavior, biaxial flexure strength, fracture toughness, and bioactivity were measured. The results obtained were summarized as follows; 1. The major crystaline phase in the matrix glass were observed to be apatite, wollastonite, and β-TCP. 2. Biaxial flexure strength and fracture toughness values were more improved by the dispersion toughening of alumina and zirconia, and the improvement of mechanical strength was more higher in the dispersion toughening of zirconia than that of alumina. 3. The bioactivity, which was evaluted from apatite formation in the simulated body fluid, was higher in the dispersion toughening of Zr-O₂than that of Al₂O₃.

ERP 시스템 도입을 위한 주성공 요인

박대석,김희철 木浦大學校 情報産業硏究所 1999 情報産業硏究誌 Vol.7 No.-

Recent years, companies need dynamic strategies to meet the challenges of the fast to respond quickly to customer needs and seize market opportunities. This study is focused to discriminate the Critical Success Factors for the induction of ERP(Enterprise Resource Planning) System. ERP is a set of application designed to bring business function into balance and represents the next generation of business systems. ERP also supports companies operating multiple sites around the world, global souring for parts and services, international distribution and different metrics for measuring performance around the globe to against Mega-Competition. In this paper, extensive literature review is performed to identify the CSFs of ERP system, Therefore, ERP enables the company to understand and manage the customer needs.