TiO₂촉매에 의한 유기염소화합물의 광산화

전희동 嶺南大學校 環境問題硏究所 1993 環境硏究 Vol.13 No.1

해당정보 없음

흰쥐 삼차신경 척수감각핵의 미측소핵 세포의 전압의존성 소디움통로와 포타슘통로에 대한 전기생리학적 연구

천상우,최정희,김권수,유용묵,김종구,이동근 대한악안면성형재건외과학회 2002 Maxillofacial Plastic Reconstructive Surgery Vol.24 No.1

The caudal subnucleus of the spinal trigeminal nucleus (medullary dorsal horn ; MDH) receives direct inputs from unmyelinated and thinly myelinated, small diameter primary afferent fibers. Thus, the MDH is implicated in the processing of nociceptive information in the orofacial region. In this study, the types and characteristics of voltage-dependent ion currents were investigated in acutely isolated MDH neurons of postnatal rats by means of the whole cell patch clamp techniques. Coronal slice (400㎛) of the trigeminal caudal subnucleus region was sequentially treated with pronase 0.2㎎/㎖. then single neurons were mechanically dissociated. Voltage-dependent sodium currents showed that the half-maximum activation potential was -41.8±1.8mV and half-maximum inactivation potential was -62.4±3.0mV. And the currents were blocked totally by application of 100nM tetrodotoxin. In a Ca^2+ free solution, low-threshold transient (I_A) and high-threshold sustained (I_K) currents were recorded. The half-maximum activation and inactivation potential of I_K were 2.5±1.9mV and -37.1±2.3mV, respectively. I_A was activated and inactivated more rapidly than I_K. The half-maximum activation and inactivation potential were -21.6±6.3mV and -84.5±5.0mV, respectively. When a 4-aminopyridine of 5mM was applied, I_A was almost totally blocked. These results reveal that MDH neurons express a variety of voltage-dependent ionic currents with distinct physiological and pharmacological properties, and they play an essential role in the transmission and modulation of sensation, especially pain, from trigeminal region.

산업폐수의 재활용을 위한 역삼투막 기술의 적용

전희동 嶺南大學校 環境問題硏究所 1994 環境硏究 Vol.14 No.1

대장암에서 림프절 전이의 위험인자

홍동민,천봉권,장희경 고신대학교 의과대학 2009 고신대학교 의과대학 학술지 Vol.24 No.2

Backgroud: Colonic and rectal cancers recently increase in incidence and motality in Korea. Although a variety of therapeutic modality has been applied, the result of therapy for the patients having lymph node metastases is not good. Especially the patient can have lymph node metastases in spite of early colonic and rectal cancer, and high recurrence rate is expected if non-radical therapy without adjuvent modality is applied to these patient in follow-up period. Therefore it is aimed to identify the risk factor affecting lymph node metastasis and to evaluate the possibility of the nodal metastases preoperatively and postoperatively. Methods: This retrospective study of 463 patients having suffered lower anterior resection, Miles operation or colectomy for colonic or rectal adenocarcinoma. Invasiveness, size of the carcinoma, age, vascular invasion, lymphovascular invasion, perineural invasion , sex, and grade of the carcinoma was evaluated as the possible risk factors of lymph node metastases. Results: Resected colonic and rectal adenocarcinoma reveals regional lymph node metastases in 46.3% cases. The nodal metastasis is statistically correlated with increase in tumor stage, tumor grade, and presence of lymphovascular and perineural invasion, and older age (p<0.05). Conclusion: Invasiveness, tumor grade, age, presence of lymphovascular invasion and perineural invasion would be risk factors expecting the regional lymph node metastasis in the colonic and rectal cancers. Therapeutic modality should be determined especially in tumor stage more than T1 because regional lymph node metastasis is expected.

한국과 C.I.S 우수 레슬링 선수들의 엉치걸이 동작에 대한 운동학적 요인 분석

윤희중,전해섭,김동건,김영란 韓國體育大學校附屬 體育科學硏究所 1992 韓國體育大學校附屬 體育科學硏究所論文集 Vol.11 No.1

This study investigated kinemtic factors of hip throw as a representative skill to make a comparative study between Korean and C. I. S wrestlers Four elite wrestlers were filmed using high - speed cinematography. Kinematic data for the each phase were derived from the digitized film. Analyzing variables included center of gravity(CG) displacement and velocity, hip joint, angular displacement and angular velocity The results were as followers ; 1. Elapse time of CG at conducting hip throw were showed similar result between two nations. 2. C. I. S wrestlers showed more displacement than Korean wrestlers in the harizontal phase (P<0.001) but, Korean wrestlers showed large movemnet, in the vertical phase(P <0.001). 3. In average velocity at whole phase, Korean wrestlers showed rapid velocity in the vertical phase(P<0.001) but, C. I. S wrestlers at conducting throw partner down showed rapid velocity in the horizontal phase(P<0.05). 4. C. I. S wrestlers showed large angular displacement in the hip joint at Ph. I. (P <0.001). 5. C. I. S wrestlers showed rapid angular velocity in the hip joint at Ph. I (P<0.001).

각종 난치성 혈액 질환에서의 비혈연간 골수이식

김동욱,한훈,김정아,김희제,민창기,엄현석,최정현,이종욱,한치화,홍영선,최일봉,신완식,민우성,김학기,김춘추,김원일,김동집 대한조혈모세포이식학회 1997 대한조혈모세포이식학회지 Vol.2 No.1

목적: 비혈연간 골수이식은 혈연내에 적절한 골수공여자가 없는 만성골수성백혈병, 고위험군의 급성별혁병, 면역억제치료에 실패한 재생불량성빈혈 및 각종 난치성 조혈모세포질환의 완치를 위한 표준적인 치료방법으로 정착되고 있다. 혈연간 표준적인 동종 이식에 비하여 비혈연간 이식시에는 생착부전, 이식편대숙주반응과 감염이 더 빈번하게 발생하며, 국내에서는 아직까지 체계적인 임상연구결과가 보고된 바 없었다. 이에 본 센터에서는 1995년 10월 이후로 약 20개월간 26예의 비혈연간 골수이식을 시행하였으며 3개월 이상의 추적관찰이 가능하여 이식초기 합병증의 관찰 및 분석이 가능하였던 20예의 환자를 대상으로 이식성적 및 문제점을 보고함으로써 새롭게 확대되고 있는 이 분야의 임상연구 및 진료의 활성화를 꾀하고자 한다. 방법: 각종 혈액 종양질환으로 비혈연간 이식을 시행한 총 26예의 환자중 3개월이상의 추적관찰이 가능하였던 20예를 대상으로 후향적으로 임상경과를 분석한 후 생존 분석을 시행하였고, 환자의 연령, 성별, 질병의 상태, 조식 적합 항원의 일치정도, 이식편대 숙주 반응의 유무와 생존기간과의 상관관계를 살펴보았다. 또한 표준위험군과 고위험군으로 나누어 생존율을 비교하였고 이식과 관계된 생착 부전, 이식편대숙주반응, 감염의 발생과 양상 그리고 그 합병증을 관찰하였다. 결과: 1. 환자와 공여자간에 HLA 불일치가 20예 중 4예에서 있었으며, 생착여부의 확인이 가능했던 17예 중 16예에서 생착이 확인되어 94.1%의 생착율을 보였다. 2. 급성이식편대숙주반응은 62.5%(10/16예)에서 발생하였으며 111도 이상의 급성의 이식편대숙주 반응은 25%(4/16예)에서 발생하였다. 만성이식편대숙주반응은 40%(2/5예)의 환자에서 발생하였으며 이들 모두 국소형으로 중증의 진행형 만성이식편대숙주반응이 관찰된 환자는 없었다. 3. 호흡기 합병증은 10예(50%)에서 발생하였으며 감염성 폐렴을 포함한 호흡기 합병증이 가장 흔한 일차적인 사망 원인이었다. 호흡기 합병증이 발생했던 10예중 6예가 감염에 의한 폐렴이 의심되었고 나머지 4예는 특발성 간질성 폐렴이었다. 4. 8.5개월의 중앙추적기간 중 35%의 생존율을 관찰할 수 있었고, 생존기간은0.5개월에서 15개월 (중앙치:4개월)이었다. 한편 고위험군은 25%(3/12예), 표준위험군은 50%(4/8)의 생존율을 관찰할 수 있었다. 5. 가장 흔한 사망 원인은 감염성 폐렴을 포함한 호흡기 합병증(6예)이었고, 이외의 사망 원인으로는 급성 이식편대숙주반응과 다장기부전이 각각 2예, 생착 부전, 간정맥 폐쇄, 그리고 재발이 각각 1예였다. Unrelated bone marrow transplantation(UBMT) has been increasingly recognized as the standard treatment for cure of chronic myelogenous leukemia, high risk acute leukemia, aplastic failed on immunotherapy, and the variety of refractory hematologic diseases in patients lacking a related donor. However, as compared to HLA identical sibing transplantation, UBMT carries higher incidence of graft failure, graft versus host disease(GVHD), and infection. In our center, 26 patients underwent UMBT between October 1995 and June 1997. The minimum follow-up of 3 months was possible in 20 patients, for whom early complications and clinical outcomes were assessed. The median age of the 20 patients was 24 years. 8 patients had standard risk disease and 12 patients had high risk disease. All patients received various preparative regimens including total body irradiation according to disease and disease status. 19 patients received CsA + short course MTX for GVHD prophylaxis. One patient received marrow that was depleted of T cells ex vivo using avidinbiotin column. The class I loci were typed by serological methods and HLA-A, HLA-B and HLA-DRB1. 3 additional pairs were one minor mismatched at the HLA-B locus. Another one patients was one major mismatched at the DRBI alleles. 17 patients were evaluable for engraftment. Successful enfraftment was confirmed in 16 patients(94.1%). Only one patient who was performed one major DRBI mismatched transplants experienced graft rejection. 16 patients were evaluable for acute GVHD. The overall incidence of acute GVHD developed in 4 patients(25%). Five patients were evaluable for the development of Ⅳ acute GVHD developed in 4 patients (25%). Five patients were evaluanle for the development of chronic GVHD. 2 patients(40%) developed limited chronic GVHD. Respiratory complications including pulmonary infection developed in 10 patients(50%) and these complications were the most common primary cause of death. Of these 10patients, 6 had pneumonia due to fungus(4 patients), pacterial (1 patient), and CMV infection (1 patient) and 4(20%) had idiopathic interstitial pneumonitis and/or adult respiratory distress syndrome. The duration of median follow- up was 8.5 months and 7 of 20 patients(35%) are alive at the time of this analysis with survival duration of 0.5 to 15 months(median survival duration: 4 months). The overall survival was 25% (3/12 patients) in high risk group and 50%(4/8 patients) in standard group. From these results, we can predict that the incidence and severity of GVHD in Korea are lesser than multiracial countries and the long-term survival of patients with standard risk disease can approach that of HLA matched sibling transplants. For the past two years, the performance of UBMT has been rapidly increasing and it will be possible to analyze much larger number of patients soon in Korea. In the future the problems of graft failure, GVHD, and infection due to long lasting immunocompromised status will need to be overcome by continued medical research. In addition, the volunteer donor pool will have to be expanded by the promotion of the national awareness of its need.

호중구 감소성 발열환자에게 경험적으로 투여한 Teicoplanin의 효과

이동건,임동석,최수미,박선희,유진홍,최정현,민우성,신완식,김춘추 대한감염학회 2004 감염과 화학요법 Vol.36 No.2

목적 : 호중구감소성 발열 환자에게 경험적으로 teicoplanin을 투여할 때의 효과를 알아보고자 전향적 연구를 시행하였다. 방법 : 2003년 7월부터 12월까지 가톨릭조혈모세포이식센터에 입원하여 항암치료 혹은 조혈모세포이식을 시행하고 호중구감소성 발열이 있는 환자 중 초기 항균요법에 반응이 없어 경험적 teicoplanin 투여가 필요한 49명을 대상으로 A, B 제조회사에서 제공한 teicoplanin을 무작위로 어느 한 쪽 치료군에 배정하여 투여하였다. 용량은 첫날 400㎎ 부하용량을 정맥내 bolus로 투여하고 매 24시간마다 200㎎ 유지용량을 투여하였다. 결과 : A군 27명, B군 22명이 연구에 참여하였고 대부분의 환자가 신독성이 있는 약제를 병용하고 있었다. A군 8명, B군 7명에서 그람양성균이 동정되었고, teicoplanin에 대한 내성률은 A군 22.2%, B군 28.6%로 유의한 차이는 없었다(P=1.00; 0.61<95%CI<1.95). 미생물학적 확인 감염이 있었던 환자 중 평균 53.3%에서 완치 혹은 개선의 반응이 있었고 양 군간 유의한 차이는 없었다(A군 4명 [50.0%], B군 4명 [57.1%], P=1.00; 0.29<95%CI<2.60). 미생물학적 제거율은 평균 62.5% (A군 55.6%, B군 71.4%)이었고 그 외 미생물학적 효과는 A군에서 제거 후 재발 2명(22.2%), 내성 2명(22.2%)이었고 B군에서 각각 0명(0.0%), 2명(28.6%)이었으며 양 군간 유의한 차이는 없었다(P=0.28). 발열기간(P=0.89), teicoplanin 사용기간(P=0.47) 및 전체적인 사망률(P=1.00; 0.78<95%CI<1.24)도 양 군간 유의한 차이는 없었다. 이상반응 중 신독성은 16.3% (A군 18.5%, B군 13.6%)에서 나타났고 양 군에 차이는 없었으며(P=0.72; 0.39<95%CI<3.51), 신기능 이상과 관련있는 약제를 적어도 2개 이상 병용하고 있었다. 피부발진은 A군에서 1명, B군에서 3명 발생하였다(P=0.31; 0.93<95%CI<1.34). 결론 : 호중구감소성 발열환자에게 teicoplanin을 투여하였을 때 임상적 반응률은 평균 53.3%(A군 50.5%, B군 57.1%), 미생물학적 제거율은 평균 62.5%(A군 55.6%, B군 71.4%)이었고 두 제조회사간 차이가 없었고 이상반응도 양 군간 차이가 없었다. 앞으로 국내 호중구감소증 환자에서의 teicoplanin의 적정 용량, 용법 등을 알기 위한 집단 약동학 등의 연구를 시행할 예정이다. Background : This study was done to elucidate the efficacy of teicoplanin as the empirical treatment for febrile neutropenia. Methods : Patients were randomized to two groups according to pharmaceutical company (company A or B). Total of 49 patients (A, 27; B, 22) with neutropenic fever were studied prospectively for 6 months (Jul. 2003-Dec. 2003). Patients received 400 mg i.v. once, then 200 mg i.v. once daily. Results : Groups were matched for all demographic variables. Most of the patients were concurrently receiving nephrotoxic drugs. Gram positive microorganisms were isolated in 8 patients for A and 7 patients for B. Resistance rate against teicoplanin was 22.2% in A and 28.6% in B (P=1.0; 0.61 < 95% confidence interval [Cl] < 1.95). Among the patients with microbiologically documented infection, clinical cure or improvement was seen in 4 (50%) of 8 patients for A and 4 (57.1%) of 7 patients for B (P=1.00; 0.29 <95%CI <2.60). Bacteriologic efficacy was assessed as follows; elimination in 5 (55.6%), elimination with relapse in 2 (22.2%), resistance in 2 (22.2%) out of 9 gram-positive bacteria for A and 5 (51.4%), 0 (0.0%), 2 (28.6%) out of 7 bacteria for B, respectively (P=Q.28). There were no significant differences in duration of fever, duration of use of teicoplanin, and overall mortality. The incidence of nephrotoxicity and ototoxicity was not significant. Conclusion : For using teicoplanin as the empirical therapy for febrile neutropenia, the rate of clinical, microbiological response, and nephrotoxicity was 53.3%, 62.5%, and 16.3% respectively with no significant differences between the 2 preparations of teicoplanin. Supplementary evaluation on the adequate dose and duration of teicoplanin may be required.

Aldrin의 광증감 분해에 관한 연구

이춘식,김영희,김성우,이동근 경상대학교 환경보전연구소 1999 環境保全硏究所報 Vol.7 No.-

Sensitized photooxidation of aldrin was carried out using anions as sensitizers. Persulfate, nitrate ions were proved to be effective to enhance the photooxidation of aldrin. Nitrite ion was inhibited to the photooxidation of aldrin. In the case of sulfate and chloride ion, however, no significant enhancement effect was observed. The sensitizing effect increased with increasing persulfate and nitrate concentration. Nitrite ion was oxidated to nitrate by photolysis reaction. The sensitized effect decreased with increasing nitrite concentration.

cis-Dichlorodiammineplatinum(Ⅱ)이 발정주기에 따른 흰쥐 난관섬모 세포의 형태 및 섬모형성에 미치는 영향에 관한 전자현미경적 및 면역조직화학적 연구

김동옥,송양주,전영희,정호삼 한양대학교 의과대학 1995 한양의대 학술지 Vol.15 No.1

electron microscope for morphological changes of cytoplasmic organelles and with light microscope for detection of tubulin substances in the cytoplasm during estrous cycle. Experimental animals(weighting 200gm. female albino rats) divided into 4 groups by the estrous cycles. Ampullar oviducts of these animals were excised at each estrous cycles. The specimen was made into immunocytological reaction slides for detection of tubulin in the cytoplasm, and the other specimen were made to ultrathin section for electron microscopy. All of specimens were examined with light and electron microscope. The results obtained are as follows. 1. The tubulin substances in ciliated cells of oviducts revealed strong reactions during proestrus and estrus but weak reactions during metestus and diestrus. 2. After cis-Platin treatment, tubulin substances in the cytoplasm of oviductal ciliated cells showed weak stain reactions but at diestrus, moderate reactions were seen similar to that of the control group. 3. The cilia and basal bodies of ciliated cells of ampulla oviducts after cisplatin treatment were decreased in number at all stages of estrous cycle. 4. Ciliated cells in cis-Platin treated rat revealed hypertropies of mitochondria, atrophies of Golgi complex, decrease of polyribosomes and segmented cisternae of rough endoplasmic reticulum at proestrus, estrus and metestrus. It is consequently suggested that cis-Platin would induce inhibition of ciliogenesis in oviductal ciliated cells during estrous cycles.

조직시민행동에 영향을 미치는 선행변수 도출을 위한 다원적 접근

林昌喜,이동규,김영천 홍익대학교 경영연구소 2001 경영연구 Vol.26 No.-

The main purpose in this study is to investigate relationship between exchange(economic and social) in organization and organizational citizenship behavior of employees. Two research questions are addressed in this study : (1) Do procedural justice, trust about supervisor, and empowerment positively associated with organizational citizenship behavior? and (2) What are the factors that more effective antecedents of organizational citizenship behavior? This study Blau(1964)'s "social exchange theory" to derive theoretical background, and consider that organizational citizenship behavior is explained economic exchange theory and social exchange theory. We considered procedural justice as economic exchange variables, and trust about supervisor and empowerment as social exchange variables. Data obtained from a survey of 205 employees of 33 korean firms is used to construct final variable measures and test the hypothesized relationships. The statistical results show that procedural justice, trust about supervisor, and empowerment are positively associated organizational citizenship behavior, and that derives procedural justice and trust about supervisor are more effective antecedents than procedural justice.