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Park, Hana,Yoon, Jin Young,Park, Kyeong Hye,Kim, Do Young,Ahn, Sang Hoon,Han, Kwang-Hyub,Chon, Chae Yoon,Park, Jun Yong WJG Press 2012 WORLD JOURNAL OF GASTROENTEROLOGY Vol.18 No.16
<P>To evaluate long-term clinical course of Budd-Chiari syndrome (BCS) and predictive factors associated with the development of hepatocellular carcinoma (HCC) and survival.</P>
( Hana Park ),( Seung Up Kim ),( Jun Jeong Choi ),( Jun Yong Park ),( Sang Hoon Ahn ),( Kwang Hyub Han ),( Chae Yoon Chon ),( Young Nyun Park ),( Do Young Kim ) 대한간학회 2010 Clinical and Molecular Hepatology(대한간학회지) Vol.16 No.4
A 63-year-old man with a history of hepatitis-B-related hepatocellular carcinoma (HCC) in the left lateral portion of the liver received repeated transcatheter arterial chemoembolization (TACE) and salvage radiotherapy. Two months after completing radiotherapy, he presented with dysphagia, epigastric pain, and a protruding abdominal mass. Computed tomography showed that the bulging mass was directly invading the adjacent stomach. Endoscopy revealed a fistula from the HCC invading the stomach. Although the size of the mass had decreased with the drainage through the fistula, and his symptoms had gradually improved, he died of cancer-related bleeding and hepatic failure. This represents a case in which an HCC invaded the stomach and caused a hepatogastric fistula after repeated TACE and salvage radiotherapy. (Korean J Hepatol 2010;16:401-404)
( Hana Park ),( Jae Hyung Jung ),( Min Kyung Jung ),( Jun Yong Park ),( Do Young Kim ),( Sang Hoon Ahn ),( Simon Weonsang Ro ),( Jeon Han Park ),( Eui-cheol Shin ),( Kwang-hyub Han ) 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1
Aims: Regulatory T cell (Treg) play an essential role in regulation of antitumor immunity. Although several studies regarding Treg in hepatocellular carcinoma (HCC) have been reported, knowledge of Treg after transarterial chemoembolization (TACE) is still unrevealed. The aim of this study was to investigate clinical impact of Treg in HCC patients who treated with TACE. Methods: We measured the frequency of peripheral blood Tregs in 23 healthy controls and 27 HCC patients undergoing TACE between 2010 and 2012 at Severance Hospital. The patients were divided into two groups according to tumor response; complete response group and incomplete response group. Results: The frequency of Treg in HCC patients was significantly higher than in healthy controls (7.52±2.62% vs. 4.99±1.4%, P<0.001). In a Treg subpopulation, the frequency of Treg (II) was significantly higher in HCC patients than in healthy controls (2.51±1.08% in HCC vs. 0.60±0.28% in healthy controls, P<0.001). In comparison of Tregs numbers at baseline and post-TACE by tumor response, the change of Treg (III) in complete response group from before to after TACE was statistically significant (63.8±42.2/mm3→53.2±31.9/mm3, P=0.050). The complete response group contained more patients with low post-TACE Treg (III) numbers, and the incomplete response group more patients with high post-TACE Treg (III) numbers, with statistical significance (70.9% vs. 29.4% in complete response group; 30.0% vs. 70.0% in incomplete response group, P=0.040). Patients with high post-TACE Treg (III) exhibited a significantly shorter time to progression than those with high post-TACE Treg (III) (3.8 months vs. 11.6 months, P=0.038). On multivariate analysis, hypoalbuminemia (HR 3.324; 95% CI (1.098-10.063), P=0.034) and high post-TACE Treg (III) (HR 3.080; 95% CI (1.091-8.696), P=0.034) were independent sig-nificant prognostic factors in terms of progression. Conclusions: High peripheral blood Treg (III) levels at 1 month after TACE were independently prognostic of poor progression-free survival.
( Soo-kyung Park ),( Chang Hwan Choi ),( Jaeyoung Chun ),( Heeyoung Lee ),( Eun Sun Kim ),( Jae Jun Park ),( Chan Hyuk Park ),( Bo-in Lee ),( Yunho Jung ),( Dong-il Park ),( Do Young Kim ),( Hana Park 대한장연구학회 2020 Intestinal Research Vol.18 No.1
The treatment of inflammatory bowel disease (IBD) has been revolutionized for the last 10 years by the increasing use of immunomodulators and biologics. With immunosuppression of this kind, opportunistic infection is an important safety concern for patients with IBD. In particular, viral hepatitis is determined by the interaction between the virus and the host’s immunity, and the risk of reactivation increases if immunity is compromised by immunosuppression therapy. Parts of Asia, including Korea, still show intermediate endemicity for the hepatitis A virus and hepatitis B virus compared with the United States and Western Europe. Thus, members of IBD research group of the Korean Association for the Study of Intestinal Diseases have produced a guideline on the prevention and management of viral hepatitis in IBD. (Intest Res 2020;18:18-33)
Microarray analysis of gene expression in 3-methylcholanthrene-treated human endothelial cells
Park, Hye Rim,Yang, Hana,Kim, Gun-Dong,Son, Gun Woo,Park, Yong Seek 대한독성유전단백체학회 2014 Molecular & cellular toxicology Vol.10 No.1
Cigarette smoke has many toxic components that can lead to the disruption of various cellular processes. Increase in oxidative stress due to cigarette smoke causes production of reactive oxygen species, which induce vascular disease. 3-methylcholanthrene (3MC) is an environmental contaminant derived from the incomplete combustion of cigarette smoke and is one of the major polycyclic aromatic hydrocarbons. 3MC activates the aryl hydrocarbon receptor and contributes to carcinogenesis and vascular disease. The present study investigated gene expression in 3MC-treated human umbilical vein endothelial cells by microarray gene expression profiling. We found 1,279 and 717 genes with altered gene expression within 24 h of 100 nM and $1{\mu}m$ 3MC treatment, respectively; these genes were distributed into distinct functional groups. Some of the genes including ICAM1, PTGS2, APOL3, and GPX-1, were related to cardiovascular disease. Our results support the hypothesis that 3MC-stimulated gene expression in endothelial cells may play a role in the development of cardiovascular disease.