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PTP1B Inhibitory Effect of Abietane Diterpenes Isolated from <i>Salvia miltiorrhiza</i>
Han, Yu Mi,Oh, Hyuncheol,Na, MinKyun,Kim, Beom Seok,Oh, Won Keun,Kim, Bo Yeon,Jeong, Dae Gwin,Ryu, Seong Eon,Sok, Dai-Eun,Ahn, Jong Seog Pharmaceutical Society of Japan 2005 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.28 No.9
<P>Protein tyrosine phosphatase 1B (PTP1B) acts as a negative regulator of insulin signaling, and selective inhibition of PTP1B has served as a potential drug target for the treatment of type 2 diabetes. In the course of screening for PTP1B inhibitory natural products, the MeOH extract of the dried root of <I>Salvia miltiorrhiza</I> B<SMALL>UNGE</SMALL> (Labiatae) was found to exhibit significant inhibitory effect. Bioassay-guided fractionation and purification afforded three related abietane-type diterpene metabolites 1—3. Compounds 1—3 were identified as isotanshinone IIA (1), dihydroisotanshinone I (2), and isocryptotanshinone (3) mainly by analysis of NMR and MS data. Compounds 1—3 non-competitively inhibited PTP1B activity with 50% inhibitory concentration values of 11.4±0.6 μ<SMALL>M</SMALL>, 22.4±0.6 μ<SMALL>M</SMALL> and 56.1±6.3 μ<SMALL>M</SMALL>, respectively.</P>
Influence of Vagotomy on Gastric Mucosal Protection of Diallyl disulfide in the Rat
Han, Sok Won,Sun, Hee Sik,Choi, Myung Gyu,Chung, In Sik,Kim, Boo Sung CATHOLIC MEDICAL CENTER 1990 Bulletin of the Clinical Research Institute Vol.18 No.2
Cisplatin has antineoplastic activity, but many side effects including nephrotoxicity and ototoxicity. Several treatments have been used to minimize nephrotoxicity but reports of ototoxicity have been scarce. The purpose of this study was to investigate morphologically the effect of sodium thiosulfate (575) on ototoxicity induced by cisplatin in guinea pig. The results were as follows: 1. Degeneration of the cochlear hair cells in the group treated with Cisplatin alone were observed in the lower turn, particular in the basal turn. The first row of the outer hair cells were severely damaged, but inner hair cells were intact. Comparison of the degree of degeneratin between each row showed decrease of severity in the following order; first second, thired rows of the outer hair cells. 2. Degenerative changes of cochlear hair cells showed to be histopathologically much less severe in the guinea pigs given both cisplatin combined sodium thiosulfate compared with the guinea pigs given cisplatin alone. 3. There was no significant difference in degenerative change of cochlear hair cell between divided dose group and single dose group. 4. Degenerative changes of cochlear hair cells in group 5 were similar to those of single dose group with cisplatin alone.
( Jong Won Park ),( Jae Hyuck Chang ),( Tae Ho Kim ),( Chang Whan Kim ),( Sok Won Han ) 대한내과학회 2014 대한내과학회 추계학술대회 Vol.2014 No.1
Background: Acute pancreatitis (AP) is a systemic infiammatory disease, and cytokines play an important role in the pathogenesis of AP. Obesity and central fat distribution are associated with an infi ammatory state that could amplify the systemicinfi ammatory response in AP. The aim of this study was to investigate the profile of infiammatory cytokines in AP and to determine their relation with obesity, central fat distribution, and severity of AP. Methods: 61 consecutive patients with AP were enrolled in the study. Cytokines were measured in those patients who presented within the first 72 h of the onset of AP. Plasma levels of infiammatory cytokines: interleukin (IL)-Iß, IL-1ra, IL-6, tumor necrosis factor (TNF)-a, TNFR-I, and TNFR-II were measured on days 1 and 2 of AP. Results: 23 patients (38%) had central fat distribution, 20 patients (33%) had obesity (BMI > 25), and 23 patients (38%) had severe AP. IL-1ra, IL-6, TNF-a, and TNFR-I was significantly higher in central fat distributed patients than in non-central fat distributed patients (P = 0.002, 0.003, 0.004, and 0.018). IL-1ra and IL-6 was significantly higher in obese patients than in non-obese patients (P = 0.040 and 0.026). IL-6 andTNFR-I was significantly higher in severe pancreatitis than in mild pancreatitis (P = 0.006 and 0.042). Among these six cytokines, IL-6 is the common elevated cytokine in central fat distributed, obese, and severe pancreatitis patients. Areas under receiver operating characteristics (ROC) curves of IL-6 to predict central fat distribution, obesity, and severity of pancreatitis were 0.727, 0.677, and 0.711, respectively (P < 0.05). Conclusion: Elevated levels of IL-6 was associatd with central fat distribution, obesity, and severity of pancreatitis in patients with AP and suggested its pathophysiological significance in AP.
박원일(Won Il Park),이종협(Jong Hyup Lee),조심현(Shim Hyun Jo),백봉력(Bong Luck Paik),최충경(Chung Keung Choi),이성근(Seung Geun Lee),문한규(Han Kyu Moon),최영미(Young Mee Choi),정윤석(Yoon Sok Jung),이관우(Kwan Woo Lee),김현만(Hyeon 대한내과학회 2002 대한내과학회지 Vol.62 No.3
N/A Background: There is increasing interest in the use of a very low calorie diet (VLCD) as a treatment regimen for weight loss in obese subjects. This study was designed to investigate the effect s and safety of a traditional Korean very-low-calory diet Methods: Twelve hospitalized obese patients at Dong Eui hospital in Busan city from May 1998 to December 1998 were selected. Height, body weight, blood lipids, blood insulin level, body fat, lean body mass, subcutaneous fat and visceral fat were measured. A traditional Korean VLCD was supplied for 14 days. Results: Patient's body weight was significantly decreased from 83.8 kg to 78.6 kg, body fat from 32.2 kg to 28.6 kg, lean body mass from 32.2 kg to 28.6 kg, and BMI from 31.4 to 29.5, respectively (p <0.05). Total fat was significantly decreased from 807 cc to 659 cc, subcutaneous fat from 567 cc to 473 cc, visceral fat from 273 cc to 185 cc, respectively. However there were no significant changes in minerals. After VLCD intervention, total cholesterol was significantly decreased from 199 mg/dL to 166mg/dL, HDL-cholesterol from 42 mg/dL, to 35mg/dL, triglyceride from 158mg/dL, to 75mg/dL (p<0.05). The insulin area under the curve was also significantly decreased from 205μIU/mL·2hr to 168 μIU/mL·2hr(p <0.05). Conclusion: Above findings suggested that a traditional Korean VLCD is effective and safe for short term use in terms of reducing body fat and improving insulin resistance in obese patients. (Korean J Med 62:250-257, 2002)